Autore	Lee Mike S. <1960->
Pubbl/distr/stampa	New York, : J. Wiley & Sons, c2002
Descrizione fisica	1 online resource (257 p.)
Disciplina	615.19 615/.19
Collana	Wiley-Interscience series on mass spectrometry
Soggetto topico	Drug development - Methodology Drugs - Analysis Liquid chromatography Mass spectrometry Combinatorial chemistry Gel permeation chromatography Drugs - Testing - Methodology
ISBN	1-280-36642-7 9786610366422 0-470-35636-7 0-471-45930-5 0-471-21881-2
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	LC/MS APPLICATIONS IN DRUG DEVELOPMENT; CONTENTS; Preface; Acknowledgments; 1. Introduction; Emerging Analytical Needs; Integration of LC/MS into Drug Development; Partnerships and Acceptance; Overview; 2. Drug Development Overview; Analysis Perspectives; The Four Stages of Drug Development; Drug Discovery; Preclinical Development; Clinical Development; Manufacturing; 3. Accelerated Drug Development; Accelerated Development Strategies; Quantitative and Qualitative Process Elements; Quantitative Process Pipeline; Qualitative Process Pipeline; Motivating Factors Analysis Opportunities for Accelerated DevelopmentFull-Time Equivalent; Sample Throughput Model; Elimination Model; Rate-Determining Event Model; Accelerated Development Perspectives; 4. LC/MS Development; The Elements of LC/MS Application; HPLC; Mass Spectrometry; LC/MS Interface; LC/MS Growth; 5. Strategies; Standard Methods; Template Structure Identification; Databases; Screening; Integration; Miniaturization; Parallel Processing; Visualization; Automation; Summary; 6. LC/MS Applications; Drug Discovery; Proteomics; Protein Expression Profiling; Quantitation; Glycoprotein Mapping Natural Products DereplicationLead Identification Screening; Bioaffinity Screening; Combinatorial Library Screening; Open-Access LC/MS; Structure Confirmation; High Throughput; Purification; Combinatorial Mixture Screening; In Vivo Drug Screening; Pharmacokinetics; In Vitro Drug Screening; Metabolic Stability Screening; Membrane Permeability; Drug-Drug Interaction; Metabolite Identification; Preclinical Development; Metabolite Identification; Impurity Identification; Degradant Identification; Clinical Development; Quantitative Bioanalysis-Selected Ion Monitoring Quantitative Bioanalysis-Selected Reaction MonitoringQuantitative Bioanalysis-Automated Solid-Phase Extraction; Quantitative Bioanalysis-Automated On-Line Extraction; Metabolite Identification; Degradant Identification; Manufacturing; Impurity Identification Using Data-Dependent Analysis; Peptide Mapping in Quality Control; Patent Protection; 7. Future Applications and Prospects; Workstations; Multidimensional Analysis; Miniaturization; Information Management; Strategic Outsourcing; Summary; 8. Perspectives on the Future Growth of LC/MS; 9. Conclusions; Glossary; References; Index
Record Nr.	UNINA-9910841279703321

Edizione	[Second edition.]
Pubbl/distr/stampa	Amsterdam, Netherlands : , : Elsevier, , 2017
Descrizione fisica	1 online resource (xxiii, 784 pages) : illustrations
Disciplina	543.84
Collana	Handbooks in Separation Science
Soggetto topico	Analytical chemistry Liquid chromatography
ISBN	0-12-809345-5
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Record Nr.	UNINA-9910297384403321

Pubbl/distr/stampa	Amsterdam, : Elsevier, [2013]
Descrizione fisica	1 online resource (683 p.)
Disciplina	543/.84
Altri autori (Persone)	FanaliSalvatore
Soggetto topico	Liquid chromatography Proteins - Chemistry
Soggetto genere / forma	Electronic books.
ISBN	1-283-94827-3 0-12-415866-8
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	Front Cover; Liquid Chromatography: Applications; Copyright; Contents; Contributors; Chapter 1 - Affinity Chromatography; 1.1.INTRODUCTION; 1.2.BASIC COMPONENTS OF AFFINITY CHROMATOGRAPHY; 1.3.BIOAFFINITY CHROMATOGRAPHY; 1.4.IMMUNOAFFINITY CHROMATOGRAPHY; 1.5.DYE-LIGAND AND BIOMIMETIC AFFINITY CHROMATOGRAPHY; 1.6.IMMOBILIZED METAL-ION AFFINITY CHROMATOGRAPHY; 1.7.ANALYTICAL AFFINITY CHROMATOGRAPHY; 1.8.MISCELLANEOUS METHODS AND NEWER DEVELOPMENTS; Acknowledgment; References; Chapter 2 - Derivatization in Liquid Chromatography; 2.1.INTRODUCTION; 2.2.REAGENT SELECTION 2.3.POSTCOLUMN REACTION DETECTORS2.4.CONCLUSIONS; References; Chapter 3 - Validation of Liquid Chromatographic Methods; 3.1.TRADITIONAL METHOD VALIDATION; 3.2.QUALITY BY DESIGN AND ANALYTICAL METHODS; 3.3.CONCLUSION; References; Chapter 4 - Liquid Chromatographic Separation of Enantiomers; 4.1.INTRODUCTION; 4.2.A SHORT HISTORY OF CHIRAL SEPARATIONS BY LIQUID CHROMATOGRAPHY; 4.3.MATERIALS FOR THE LIQUID CHROMATOGRAPHIC SEPARATION OF ENANTIOMERS; 4.4.MODES OF LIQUID CHROMATOGRAPHIC SEPARATION OF ENANTIOMERS; 4.5.SEPARATION OF ENANTIOMERS BY SUPERCRITICAL FLUID CHROMATOGRAPHY 4.6.SUMMARY AND FUTURE TRENDSReferences; Chapter 5 - Liquid Interaction Chromatography of Polymers; 5.1.INTRODUCTION; 5.2.THEORETICAL ASPECTS OF ISOCRATIC LIQUID CHROMATOGRAPHY OF POLYMERS; 5.3.APPLICATIONS OF LIQUID CHROMATOGRAPHY OF POLYMERS; 5.4.HYPHENATED TECHNIQUES; 5.5.SUMMARY; References; Chapter 6 - Amino Acid and Bioamine Separations; 6.1.INTRODUCTION; 6.2.DIRECT SEPARATION OF AMINO ACIDS AND AMINES; 6.3.INDIRECT SEPARATION OF AMINO ACIDS AND AMINES; 6.4.ENANTIOSELECTIVE LIQUID CHROMATOGRAPHIC ANALYSIS OF AMINO ACIDS; 6.5.CONCLUSIONS; References Chapter 7 - Protein and Peptide Separations7.1.INTRODUCTION; 7.2.METHODS OF PROTEIN LIQUID CHROMATOGRAPHY; 7.3.CONCLUSIONS; Acknowledgments; References; Chapter 8 - Glycans and Monosaccharides; 8.1.INTRODUCTION; 8.2.TYPES OF GLYCANS; 8.3.ANALYSIS AND CHARACTERIZATION OF GLYCANS; 8.4.MONOSACCHARIDE COMPOSITION ANALYSIS; 8.5.CONCLUSIONS; References; Chapter 9 - Separation of Lipids; 9.1.INTRODUCTION AND CONTENTS; 9.2.DEFINITIONS AND CLASSIFICATION; 9.3.STRUCTURES AND OCCURRENCE; 9.4.SAMPLE EXTRACTION AND HANDLING; 9.5.LIPID ANALYSIS BY LIQUID CHROMATOGRAPHY 9.6.CONCLUSIONS AND FUTURE PERSPECTIVESReferences; Chapter 10 - Forensic Toxicology; 10.1.GENERAL DRUG SCREENING; 10.2.LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY IN FORENSIC TOXICOLOGY; 10.3.TESTING FOR DRIVING UNDER THE INFLUENCE OF DRUGS USING ORAL FLUID; 10.4.TOXICOLOGICAL ANALYSIS OF HAIR IN THE INVESTIGATION OF DRUG FACILITATED CRIMES; 10.5.TARGETED POISONS; 10.6.CONCLUSIONS; References; Chapter 11 - Compositional Analysis of Foods; 11.1.INTRODUCTION; 11.2.CARBOHYDRATES; 11.3.VITAMINS; 11.4.AMINO ACIDS, PEPTIDES, AND PROTEINS; 11.5. LIPIDS; 11.6.MINOR COMPONENTS OF FOOD; 11.7.FOOD ADDITIVES 11.8.CONCLUSIONS AND FUTURE TRENDS
Record Nr.	UNINA-9910462814803321

Pubbl/distr/stampa	Amsterdam ; ; Boston, : Elsevier, [2013]
Descrizione fisica	1 online resource (xii, 504 pages) : illustrations (some color)
Disciplina	543.84
Collana	Gale eBooks
Soggetto topico	Liquid chromatography Chemistry, Analytic
ISBN	1-283-94830-3 0-12-415867-6
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	Front Cover; Liquid Chromatography: Fundamentals and Instrumentation; Copyright; Contents; Contributors; Chapter 1 - Milestones in the Development of Liquid Chromatography; 1.1.INTRODUCTION; 1.2.HPLC THEORY AND PRACTICE; 1.3.COLUMNS; 1.4.EQUIPMENT; 1.5.DETECTORS; APOLOGIES AND ACKNOWLEDGEMENTS; References; Chapter 2 - Kinetic Theories of Liquid Chromatography; 2.1.INTRODUCTION; 2.2.MACROSCOPIC KINETIC THEORIES; 2.3.MICROSCOPIC KINETIC THEORIES; 2.4.COMPARISON OF THE MICROSCOPIC AND MACROSCOPIC MODELS; References; Chapter 3 - Column Technology in Liquid Chromatography; 3.1.INTRODUCTION 3.2.COLUMN DESIGN AND HARDWARE3.3.COLUMN PACKING MATERIALS AND STATIONARY PHASES; 3.4.COLUMN SYSTEMS AND OPERATIONS; 3.5.CHROMATOGRAPHIC COLUMN TESTING AND EVALUATION; 3.6.COLUMN MAINTENANCE AND TROUBLESHOOTING; 3.7.TODAY'S COLUMN MARKET-AN EVALUATION, COMPARISON, AND CRITICAL APPRAISAL; References; Chapter 4 - Secondary Chemical Equilibria in Reversed-Phase Liquid Chromatography; 4.1.INTRODUCTION; 4.2.ACID-BASE EQUILIBRIA; 4.3.ION-INTERACTION CHROMATOGRAPHY; 4.4.MICELLAR LIQUID CHROMATOGRAPHY; 4.5.METAL COMPLEXATION; Further Reading; Chapter 5 - Hydrophilic Interaction Liquid Chromatography 5.1.INTRODUCTION5.2.PRINCIPLES OF HILIC; 5.3.MOBILE AND STATIONARY PHASES COMMONLY EMPLOYED IN HILIC; 5.4.APPLICATION EXAMPLES; References; Chapter 6 - Hydrophobic Interaction Chromatography; 6.1.INTRODUCTION; 6.2.PRINCIPLES OF HYDROPHOBIC INTERACTION CHROMATOGRAPHY; 6.3.MAIN FACTORS THAT AFFECT HYDROPHOBIC INTERACTION CHROMATOGRAPHY; 6.4.PURIFICATION STRATEGIES; 6.5.PRACTICAL ASPECTS OF HYDROPHOBIC INTERACTION CHROMATOGRAPHY PURIFICATION; 6.6.SELECTED APPLICATIONS; 6.7.FUTURE TRENDS; References; Chapter 7 - Liquid-Solid Chromatography; 7.1.INTRODUCTION; 7.2.RETENTION AND SEPARATION 7.3.METHOD DEVELOPMENT7.4.PROBLEMS IN THE USE OF NORMAL-PHASE CHROMATOGRAPHY; References; Chapter 8 - Ion Chromatography; 8.1.INTRODUCTION; 8.2.BASIC PRINCIPLES AND SEPARATION MODES; 8.3.INSTRUMENTATION; 8.4.APPLICATIONS; References; Chapter 9 - Size-Exclusion Chromatography; 9.1.INTRODUCTION; 9.2.HISTORICAL BACKGROUND; 9.3.RETENTION IN SIZE-EXCLUSION CHROMATOGRAPHY; 9.4.BAND BROADENING IN SIZE-EXCLUSION CHROMATOGRAPHY; 9.5.RESOLUTION IN SIZE-EXCLUSION CHROMATOGRAPHY; 9.6.SIZE-EXCLUSION CHROMATOGRAPHY ENTERS THE MODERN ERA: THE DETERMINATION OF ABSOLUTE MOLAR MASS 9.7.SIZE-EXCLUSION CHROMATOGRAPHY TODAY: MULTIDETECTOR MEASUREMENTS, PHYSICOCHEMICAL CHARACTERIZATION, TWO-DIMENSIONAL TECHNIQUES9.8.CONCLUSIONS; ACKNOWLEDGEMENT AND DISCLAIMER; References; Chapter 10 - Solvent Selection in Liquid Chromatography; 10.1.ELUTION STRENGTH; 10.2.COLUMNS AND SOLVENTS IN RPLC, NPLC, AND HILIC; 10.3.ASSESSMENT OF THE ELUTION STRENGTH; 10.4.SCHOENMAKERS'S RULE; 10.5.ISOELUOTROPIC MIXTURES; 10.6.SOLVENT-SELECTIVITY TRIANGLES; 10.7.PRACTICAL GUIDELINES FOR OPTIMIZATION OF MOBILE PHASE COMPOSITION; 10.8.ADDITIONAL CONSIDERATIONS FOR SOLVENT SELECTION; References Chapter 11 - Method Development in Liquid Chromatography
Record Nr.	UNINA-9910786170903321

Autore	Romero-González R
Pubbl/distr/stampa	New York, : Nova Science Publishers, c2010
Descrizione fisica	1 online resource (75 p.)
Disciplina	664.001/579
Altri autori (Persone)	Martínez VidalJ. L Garrido FrenichA
Collana	Food science and technology series
Soggetto topico	Food - Microbiology Mycotoxicoses Liquid chromatography Food contamination
Soggetto genere / forma	Electronic books.
ISBN	1-61728-442-4
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	Presence of mycotoxins in food -- Sample preparation -- Chromatographic methods for mycotoxin analysis.
Record Nr.	UNINA-9910465676303321