Pubbl/distr/stampa	[United Kingdom], : Advanstar Communications
Disciplina	543.84
Soggetto topico	Liquid chromatography Gas chromatography
Soggetto genere / forma	Periodicals.
ISSN	2767-7095
Formato	Materiale a stampa
Livello bibliografico	Periodico
Lingua di pubblicazione	eng
Altri titoli varianti	Liquid chromatography, gas chromatography Europe LCGC Europe
Record Nr.	UNINA-9910134115103321

Pubbl/distr/stampa	[Eugene, OR, : Astor Pub. Corp., c1987-
Descrizione fisica	1 online resource
Disciplina	543
Soggetto topico	Chromatographic analysis Separation (Technology) Liquid chromatography Gas chromatography Analytical chemistry Capillary electrophoresis
Soggetto genere / forma	Periodicals.
Formato	Materiale a stampa
Livello bibliografico	Periodico
Lingua di pubblicazione	eng
Altri titoli varianti	Liquid chromatography, gas chromatography international LCGC international
Record Nr.	UNISA-996200456303316

Pubbl/distr/stampa	Duluth, MN, : Advanstar Communications
Disciplina	543/.0894
Soggetto topico	Liquid chromatography Gas chromatography Chromatography, Liquid Chromatography, Gas Chemie
Soggetto genere / forma	Periodical Periodicals.
ISSN	1939-1889
Formato	Materiale a stampa
Livello bibliografico	Periodico
Lingua di pubblicazione	eng
Record Nr.	UNINA-9910131131203321

Autore	McMaster Marvin C
Pubbl/distr/stampa	Hoboken, N.J., : John Wiley, c2005
Descrizione fisica	1 online resource (179 p.)
Disciplina	543.84 543/.84
Soggetto topico	Liquid chromatography High performance liquid chromatography Mass spectrometry
ISBN	1-280-27734-3 9786610277346 0-471-73658-9 0-471-73657-0
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	LC/MS; CONTENTS; Preface; 1 Introduction to LC/MS; 1.1 Why LC/MS?; 1.2 Molecular Weights and Structure Studies; 1.3 LC/MS Systems; 1.4 System Costs; 1.5 Competitive Systems; 2 The HPLC System; 2.1 HPLC System Components; 2.2 Gradient versus Isocratic Systems; 2.3 Micro HPLC Systems; 2.4 HPLC Tubing and Fittings; 3 The HPLC Column and Separation Modes; 3.1 Column Construction; 3.2 Column Packing Materials; 3.3 Normal-Phase Columns; 3.4 Other Bonded-Phase Silica Columns; 3.5 Optimizing Reverse-Phase Column Use; 3.6 Silica Ion-Exchange Columns; 3.7 Silica Size-Separation Columns 3.8 Zirconium Bonded-Phase Columns3.9 Polymer Reverse-Phase Columns; 4 HPLC and Column Maintenance; 4.1 HPLC Maintenance; 4.2 Column Maintenance; 5 Sample Preparation and Separations Development; 5.1 Mobile-Phase Preparation; 5.2 Mobile-Phase pH Control Using Buffers; 5.3 Sample Preparation; 5.4 Cartridge Column Cleanup; 5.5 On-Column Sample Concentration; 5.6 Isocratic and Gradient Methods Development; 5.7 Automated Methods Development; 6 LC/MS Interfaces; 6.1 Solvent Removal and Ionization; 6.2 Atmospheric-Pressure Interfaces; 6.3 Electrospray Interface; 6.4 Ion Spray Interface 6.5 Secondary Detectors7 LC/MS Overview; 7.1 HPLC and the Ionization Source; 7.2 Vacuum Pumps; 7.3 Analyzer and Ion Detector Designs; 7.4 Data and Control Systems; 7.5 Peak Detection, ID, and Quantitation; 8 Mass Analyzers; 8.1 Quadrupole Analyzer; 8.2 Ion Trap Analyzer; 8.3 Linear Ion Trap Analyzer; 8.4 Time-of-Flight Analyzer; 8.5 Fourier Transform Analyzer Design; 8.6 Magnetic Sector Analyzers; 9 Mass Spectrometer Maintenance; 9.1 High-Vacuum Operation; 9.2 MS Hardware Maintenance; 9.3 System Electrical Grounding; 10 Application Areas for LC/MS; 10.1 Compound Discovery 10.2 Identification of Complex Biological Compounds10.3 Analysis of Trace Impurities and Metabolites; 10.4 Arson Residue Investigation; 10.5 Industrial Water and Pesticide Analysis; 10.6 Toxicology and Drugs of Abuse; 10.7 Clinical Therapeutic Drug Screening; 10.8 Pesticide Manufacturing; 11 Trace Analysis and LC/MS/MS; 11.1 LC/MS/MS Triple-Quadrupole System; 11.2 MS/MS Operating Modes; 11.3 Ion Trap MS/MS Operation; 11.4 Hybrid LC/MS/MS Systems; 12 Drug Discovery and Benchtop LC/MS; 12.1 Activity Screening; 12.2 Standardized LC/MS Screening 12.3 Molecular Fragmentation for Structural Determination12.4 Process Monitoring; 13 Proteomics: LC/MALDI/TOF and MS/MS Libraries; 13.1 Protein Molecular-Weight Determination by LC/MS; 13.2 De Novo Protein Purification; 13.3 Protein Analysis by Two-Dimensional GEP and LC/TOFMS; 13.4 LC/MS/MS Identification of Peptide Structures; 13.5 Tracer Labeling for Peptide ID; 13.6 Posttranslational Modified Protein; 13.7 Transient Peptides and Accumulation Proteins; 14 The Future of LC/MS; 14.1 Instrumentation Improvements; 14.2 Affordable Benchtop LC/LITMS; 14.3 User-Customized Data Libraries 14.4 Nucleomics and Restriction Fragment Analysis
Record Nr.	UNINA-9910143569103321

Autore	Lee Mike S. <1960->
Pubbl/distr/stampa	New York, : J. Wiley & Sons, c2002
Descrizione fisica	1 online resource (257 p.)
Disciplina	615.19 615/.19
Collana	Wiley-Interscience series on mass spectrometry
Soggetto topico	Drug development - Methodology Drugs - Analysis Liquid chromatography Mass spectrometry Combinatorial chemistry Gel permeation chromatography Drugs - Testing - Methodology
Soggetto genere / forma	Electronic books.
ISBN	1-280-36642-7 9786610366422 0-470-35636-7 0-471-45930-5 0-471-21881-2
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	LC/MS APPLICATIONS IN DRUG DEVELOPMENT; CONTENTS; Preface; Acknowledgments; 1. Introduction; Emerging Analytical Needs; Integration of LC/MS into Drug Development; Partnerships and Acceptance; Overview; 2. Drug Development Overview; Analysis Perspectives; The Four Stages of Drug Development; Drug Discovery; Preclinical Development; Clinical Development; Manufacturing; 3. Accelerated Drug Development; Accelerated Development Strategies; Quantitative and Qualitative Process Elements; Quantitative Process Pipeline; Qualitative Process Pipeline; Motivating Factors Analysis Opportunities for Accelerated DevelopmentFull-Time Equivalent; Sample Throughput Model; Elimination Model; Rate-Determining Event Model; Accelerated Development Perspectives; 4. LC/MS Development; The Elements of LC/MS Application; HPLC; Mass Spectrometry; LC/MS Interface; LC/MS Growth; 5. Strategies; Standard Methods; Template Structure Identification; Databases; Screening; Integration; Miniaturization; Parallel Processing; Visualization; Automation; Summary; 6. LC/MS Applications; Drug Discovery; Proteomics; Protein Expression Profiling; Quantitation; Glycoprotein Mapping Natural Products DereplicationLead Identification Screening; Bioaffinity Screening; Combinatorial Library Screening; Open-Access LC/MS; Structure Confirmation; High Throughput; Purification; Combinatorial Mixture Screening; In Vivo Drug Screening; Pharmacokinetics; In Vitro Drug Screening; Metabolic Stability Screening; Membrane Permeability; Drug-Drug Interaction; Metabolite Identification; Preclinical Development; Metabolite Identification; Impurity Identification; Degradant Identification; Clinical Development; Quantitative Bioanalysis-Selected Ion Monitoring Quantitative Bioanalysis-Selected Reaction MonitoringQuantitative Bioanalysis-Automated Solid-Phase Extraction; Quantitative Bioanalysis-Automated On-Line Extraction; Metabolite Identification; Degradant Identification; Manufacturing; Impurity Identification Using Data-Dependent Analysis; Peptide Mapping in Quality Control; Patent Protection; 7. Future Applications and Prospects; Workstations; Multidimensional Analysis; Miniaturization; Information Management; Strategic Outsourcing; Summary; 8. Perspectives on the Future Growth of LC/MS; 9. Conclusions; Glossary; References; Index
Record Nr.	UNINA-9910143176103321