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Novel Therapeutic Strategies for Chronic HBV Infection: an Immunological Perspective
| Novel Therapeutic Strategies for Chronic HBV Infection: an Immunological Perspective |
| Autore | Kew Yoon Seung |
| Pubbl/distr/stampa | Frontiers Media SA, 2020 |
| Descrizione fisica | 1 electronic resource (144 p.) |
| Soggetto topico |
Medicine
Immunology |
| Soggetto non controllato |
hepatitis B virus
innate immunity adaptive immunity antigen-specific immune response treatment |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Novel Therapeutic Strategies for Chronic HBV Infection |
| Record Nr. | UNINA-9910557215003321 |
Kew Yoon Seung
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| Frontiers Media SA, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Nrf2 and its Modulation in Inflammation [[electronic resource] /] / edited by Huai Deng
| Nrf2 and its Modulation in Inflammation [[electronic resource] /] / edited by Huai Deng |
| Edizione | [1st ed. 2020.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 |
| Descrizione fisica | 1 online resource (210 pages) |
| Disciplina | 572.8845 |
| Collana | Progress in Inflammation Research |
| Soggetto topico |
Immunology
Cell physiology Gene expression Oxidative stress Cell Physiology Gene Expression Oxidative Stress Expressió gènica Proteïnes Immunitat cel·lular |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-44599-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Chapter 1. Molecular mechanisms of Nrf2 in inflammation: Interactions between Nrf2 and inflammatory mediators -- Chapter 2. Nrf2 in immune responses during inflammation -- Chapter 3. Nrf2 and Nrf2-interacting network in respiratory inflammation and diseases -- Chapter 4. Nrf2 in the regulation of endothelial cell homeostasis during inflammation -- Chapter 5. The roles of Nrf2 in cardiovascular system and atherosclerosis -- Chapter 6. Nrf2 and inflammation-triggered carcinogenesis -- Chapter 7. Role of Nrf2 in oxidative and inflammatory processes in obesity and metabolic diseases -- Chapter 8. Modulators of Nrf2 Activation during Inflammation. |
| Record Nr. | UNINA-9910409692703321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Nuclear medicine and immunology / / Sara Harsini, Abass Alavi, Nima Rezaei, editors
| Nuclear medicine and immunology / / Sara Harsini, Abass Alavi, Nima Rezaei, editors |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , 2022 |
| Descrizione fisica | 1 online resource (532 pages) : illustrations |
| Disciplina | 616.07575 |
| Soggetto topico |
Nuclear medicine
Immunology Nuclear Medicine Immunotherapy Allergy and Immunology |
| ISBN | 3-030-81261-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Preface -- Acknowledgment -- Contents -- 1: Introduction on Nuclear Medicine and Immunology -- 1.1 The Immune System: Building Blocks and Mechanisms -- 1.1.1 Inflammation -- 1.1.2 Infection -- 1.1.3 Immuno-Oncology -- 1.2 Nuclear Medicine in Immune-Mediated Conditions -- 1.2.1 Infectious Diseases -- 1.2.2 Inflammatory Diseases -- 1.2.3 Radioimmunoimaging -- 1.3 Radioimmunotherapy -- 1.4 Evaluation of Tumor Response to Immunotherapy -- 1.5 Concluding Remarks -- References -- 2: Nuclear Imaging of Endogenous Markers of Lymphocyte Response -- 2.1 Introduction -- 2.2 Strategies for Imaging Endogenous Immune Biomarkers -- 2.2.1 Cell Surface Immune Markers -- 2.2.2 Intracellular Metabolic Pathways -- 2.2.3 Secreted Biomarkers -- 2.2.4 Strengths and Limitations Compared to Ex Vivo Labeling Approaches -- 2.3 Imaging T Cell Responses -- 2.3.1 Overview of T Cell Biology -- 2.3.2 T Cell Activation and Proliferation -- 2.3.2.1 Targeting Cell Surface Lineage Markers -- 2.3.2.2 Targeting Cell Surface Activation Markers -- 2.3.2.3 Targeting Intracellular Metabolic Pathways -- 2.3.3 T Cell Cytotoxicity -- 2.3.4 T Cell Inhibition and Control -- 2.4 Imaging B Cell Responses -- 2.4.1 Overview of B Cell Biology -- 2.4.1.1 Targeting Cell Surface Lineage Markers -- 2.5 Imaging Natural Killer (NK) Cell Responses -- 2.5.1 Overview of NK Cell Biology -- 2.5.1.1 Emergence of NK Cell Therapies -- 2.5.1.2 Candidate Endogenous Targets for NK Cell Imaging -- 2.6 Priorities and Future Considerations -- 2.7 Conclusion -- References -- 3: Radioimaging of Activated T Cells in Preclinical and Clinical Cancer Investigations -- 3.1 Introduction -- 3.2 Direct Labeling -- 3.3 Indirect Labeling -- 3.3.1 Reporter Genes -- 3.3.1.1 Thymadine Kinase Reporter Gene Tracers -- FIAU -- FHBG -- FEAU -- 3.3.1.2 T Cell Receptor Targeting.
3.3.1.3 hNIS Reporter Gene Tracer: [99mTc]TcO4− -- 3.3.1.4 hNET Reporter Gene Tracer: MIBG -- 3.3.2 Deoxyribonucleotide Salvage Pathway Reporters -- 3.3.2.1 FAC -- 3.3.2.2 CFA -- 3.3.2.3 AraG -- 3.3.2.4 FMAU -- 3.3.2.5 FLT -- 3.3.3 Interleukins -- 3.3.4 Antibodies, Antibody Fragments, and Peptides -- 3.3.4.1 PD-1 -- 3.3.4.2 Anti-CD152 (CTLA-4) mAb -- 3.3.4.3 Anti-CD3 mAb -- 3.3.4.4 Anti-CD8 mAb -- 3.3.4.5 OX40 (CD134) -- 3.3.4.6 T Cell Receptor Targeting -- 3.3.4.7 Granzyme B -- 3.4 Conclusions -- References -- 4: Gallium Imaging of Infection and Inflammation -- 4.1 Introduction -- 4.2 Infection Imaging -- 4.3 Preclinical Studies in Infection -- 4.3.1 Chlamydia -- 4.3.2 Aspergillosis -- 4.3.3 Intra-abdominal Infections -- 4.4 Clinical Studies Using Infection Imaging -- 4.4.1 Osteomyelitis -- 4.4.2 Tuberculosis -- 4.4.3 Fever of Unknown Origin (FUO) -- 4.5 Inflammation Imaging -- 4.5.1 Nonspecific Inflammation Processes and Tracers -- 4.5.2 Specific Inflammatory Processes and Tracers -- 4.5.3 Tumor-Related Inflammation -- 4.6 PET Imaging of Inflammation -- 4.6.1 Central Nervous System -- 4.6.1.1 Preclinical -- 4.6.1.2 Clinical -- 4.6.2 Cardiovascular System -- 4.6.2.1 Atherosclerosis -- 4.6.2.2 Vulnerable Plaque -- 4.6.2.3 Post-myocardial Infarct Inflammation -- 4.6.2.4 Post-medical Device Implantation -- 4.6.2.5 Platelet and Thrombus Imaging -- Clinical -- 4.6.3 Respiratory System -- 4.6.4 Gastrointestinal Tract (GIT) -- 4.6.5 Inflammatory Joint Diseases -- 4.7 Summary and Future Considerations -- References -- 5: 111Indium-Labeled Leukocyte Imaging of Infection and Inflammation -- 5.1 Introduction -- 5.2 Inflammation -- 5.3 Radiolabeled Leukocytes -- 5.4 Normal Distribution and Kinetics of Radiolabeled Leukocytes -- 5.5 Pathological Distribution of Radiolabeled Leukocytes. 5.6 Clinical Applications -- 5.6.1 Clinical Guidelines -- 5.6.2 Fever of Unknown Origin (FUO) -- 5.6.3 Infective Endocarditis and Cardiac Electronic Devices -- 5.6.4 Vascular Graft Infection -- 5.6.5 Joint Prosthesis Infection -- 5.6.6 Diabetic Infections -- 5.6.7 Appendicitis -- 5.6.8 Inflammatory Bowel Disease -- 5.6.9 Rheumatoid Arthritis -- 5.7 Improvements in Leukocyte Scans -- 5.8 Conclusion -- References -- 6: [99mTc]Tc-HMPAO-Labeled Leukocyte Imaging of Infection and Inflammation -- 6.1 Introduction -- 6.2 Leukocyte Labeling Procedure -- 6.3 Biodistribution -- 6.4 Comparison of 99mTc-WBC with 111In-WBC Scintigraphy -- 6.5 Dosimetry -- 6.6 Infection/Inflammation Evaluation-General Considerations -- 6.7 Inflammatory Bowel Disease -- 6.8 Musculoskeletal Infections -- 6.8.1 Peripheral Bone Infections -- 6.8.2 Neuropathic Joint Versus Osteomyelitis -- 6.8.2.1 Combined WBC-Marrow Imaging -- 6.8.3 Postoperative/Prosthesis Infections -- 6.8.4 Spondylodiscitis -- 6.8.5 Chronic Infection/CMRO -- 6.8.5.1 SPECT and SPECT/CT -- 6.9 Fever of Unknown Origin (FUO) -- 6.10 Cardiovascular Infections -- 6.10.1 Infectious Endocarditis (IE) -- 6.10.2 Mycotic Aneurysm -- 6.10.3 Vascular Graft Infection -- 6.10.4 Cardiovascular Implantable Electronic Device (CIED) Infection -- 6.11 Pulmonary Infections -- 6.11.1 Interpretation -- 6.12 Imaging pitfalls -- 6.12.1 Pitfalls in Lung Imaging -- 6.12.2 Pitfalls Elsewhere in the Body -- 6.13 Other Considerations -- 6.13.1 Tumors -- 6.13.2 Eosinophilic Syndromes -- 6.13.3 Graft Versus Host Disease (GVHD) -- 6.13.4 Treatment Monitoring -- 6.14 Pediatric Population -- 6.15 Future Directions -- References -- 7: 2-[18F]FDG PET Imaging of Infection and Inflammation -- 7.1 Introduction -- 7.2 Mechanism of 2-[18F]FDG Uptake in Malignant and Inflammatory Cells -- 7.3 Tissue Infection. 7.4 Osteomyelitis -- 7.5 Cardiac Device Infection and Inflammatory Diseases of the Heart -- 7.6 Vascular Graft Infection (Vascular Prosthesis Infection) -- 7.7 Joint Prosthesis Infection -- 7.8 Tuberculosis (TB) -- 7.9 Sarcoidosis -- 7.10 Autoimmune Diseases -- 7.10.1 Vasculitis -- 7.10.2 Inflammatory Bowel Diseases (IBD) -- 7.10.3 IgG4-Related Disease -- 7.10.4 Rheumatoid Arthritis (RA) -- 7.10.5 Other Autoimmune Diseases -- 7.11 Immune Deficiency (HIV-Related Disease) -- 7.12 Conclusion -- References -- 8: 2-[18F]FDG PET/CT in Fever of Unknown Origin -- 8.1 Introduction -- 8.2 Morphological and Molecular Imaging -- 8.3 2-[18F]FDG PET/CT in FUO -- 8.4 Timing of 2-[18F]FDG PET/CT in FUO -- 8.5 Cost-Effectiveness -- 8.6 Conclusion -- References -- 9: Tumor-Targeting Agents -- 9.1 Introduction -- 9.2 Ligand Targeted Therapy -- 9.3 Antibody -- 9.3.1 Monoclonal Antibody -- 9.3.1.1 Immune Response to Monoclonal Antibodies -- 9.3.1.2 Antibody Engineering -- 9.3.2 Antibody Fragments Variations -- 9.3.2.1 Characteristics of Antibody Fragments -- Conjugated Antibody -- 9.3.3 Pretargeting -- 9.4 Small Molecule Inhibitors Targeting Kinases -- 9.4.1 Structure and Mode of Action of Small Molecule Inhibitors -- 9.4.2 Limitations of Small Molecule Inhibitors as Targeted Cancer Therapy -- 9.5 Development of Newer Drugs -- 9.5.1 Selective High-Affinity Ligand (SHAL) -- 9.5.2 Phage Display Technique for New Targeting Ligands -- 9.6 Selective Small Molecule Targeted Radionuclide Imaging/Therapy -- 9.6.1 Tumor Receptor Targeting with Radiolabeled Peptides -- 9.6.2 Radioligand Targeted Diagnosis and Therapeutics in Prostate Cancer -- 9.6.2.1 Monoclonal Antibodies -- 9.6.2.2 Small Molecule Inhibitors -- 9.7 The Use of Nano-Drug Carrier -- 9.8 Aptamers -- 9.9 Conclusion -- References -- 10: Tumor Architecture and Targeted Delivery. 10.1 Introduction -- 10.2 Organization of the Solid Tumor -- 10.2.1 Parenchymal Component -- 10.2.2 Stromal Component -- 10.2.3 Cancer-Associated Fibroblasts (CAF) -- 10.3 Cancer Metastasis -- 10.4 Angiogenesis -- 10.5 Tumor Vascular Architecture -- 10.6 Transport Across the Microvascular Wall -- 10.7 Transport Across the Stroma -- 10.8 Transport Across the Parenchyma -- 10.9 Strategies to Reduce the Barriers for the Macromolecules to Reach Their Target -- 10.10 Drug Delivery in Cancer -- 10.10.1 Drug Delivery Targeting Tumor Vasculature -- 10.10.1.1 Passive Targeting -- 10.10.1.2 Active Targeting -- 10.10.2 Increase in Blood Circulation Time and Reduced Immunogenicity -- 10.10.3 Drug Release Based on the Tumor Microenvironment -- 10.10.4 Prodrug Mechanism -- 10.10.5 Drug Delivery by Modulation of Tumor Vasculature -- 10.11 Conclusion -- References -- 11: Radionuclide Therapy and Immunomodulation -- 11.1 Introduction -- 11.2 The Role of the Immune System in Radiotherapy -- 11.2.1 External Beam Radiation Therapy and Abscopal Responses -- 11.2.2 Immunomodulation by EBRT Can Contribute to Therapeutic Efficacy -- 11.2.3 Molecular Understanding of Immunomodulation by EBRT -- 11.2.3.1 Increasing Sensitivity of Tumor Cells to Cytotoxic Immune Cells -- 11.2.3.2 Lymphocyte Activation -- 11.2.3.3 Lymphocyte Recruitment -- 11.2.3.4 Innate Immune Activation -- 11.2.3.5 Concurrent Immuno suppressive Effects -- 11.3 Targeted Radionuclide Therapy and the Immune System -- 11.3.1 Understanding the Mechanisms of Immune Activation by TRT (Preclinical Evidence) -- 11.3.2 Clinical Evidence for an Immune Response -- 11.4 Conclusion -- References -- 12: Translational Development and Testing of Theranostics in Combination with Immunotherapies -- 12.1 Introduction -- 12.2 Rationale for Combining Radiation and Immunotherapy. 12.2.1 Immunomodulatory Effects of Radiation on Tumor Cells. |
| Record Nr. | UNINA-9910522981603321 |
| Cham, Switzerland : , : Springer, , 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Nucleic acid sensors and antiviral immunity / / Prakash Sambhara, Takashi Fujita
| Nucleic acid sensors and antiviral immunity / / Prakash Sambhara, Takashi Fujita |
| Autore | Sambhara Suryaprakash <1955-> |
| Edizione | [First edition.] |
| Pubbl/distr/stampa | Boca Raton, FL : , : CRC Press, an imprint of Taylor and Francis, , 2013 |
| Descrizione fisica | 1 online resource (285 p.) |
| Disciplina | 616.079 |
| Altri autori (Persone) | FujitaTakashi <1954-> |
| Collana | Molecular Biology Intelligence Unit |
| Soggetto topico | Immunology |
| Soggetto genere / forma | Electronic books. |
| ISBN |
0-429-08967-8
1-4987-1365-3 1-58706-671-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | BACK COVER |
| Record Nr. | UNINA-9910462574303321 |
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Sambhara Suryaprakash <1955->
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| Boca Raton, FL : , : CRC Press, an imprint of Taylor and Francis, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Nucleic acid sensors and antiviral immunity / / Prakash Sambhara, Takashi Fujita
| Nucleic acid sensors and antiviral immunity / / Prakash Sambhara, Takashi Fujita |
| Autore | Sambhara Suryaprakash <1955-> |
| Edizione | [First edition.] |
| Pubbl/distr/stampa | Boca Raton, FL : , : CRC Press, an imprint of Taylor and Francis, , 2013 |
| Descrizione fisica | 1 online resource (285 p.) |
| Disciplina | 616.079 |
| Altri autori (Persone) | FujitaTakashi <1954-> |
| Collana | Molecular Biology Intelligence Unit |
| Soggetto topico | Immunology |
| ISBN |
0-429-08967-8
1-4987-1365-3 1-58706-671-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | BACK COVER |
| Record Nr. | UNINA-9910786041503321 |
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Sambhara Suryaprakash <1955->
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| Boca Raton, FL : , : CRC Press, an imprint of Taylor and Francis, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Nucleic acid sensors and antiviral immunity / / Prakash Sambhara, Takashi Fujita
| Nucleic acid sensors and antiviral immunity / / Prakash Sambhara, Takashi Fujita |
| Autore | Sambhara Suryaprakash <1955-> |
| Edizione | [First edition.] |
| Pubbl/distr/stampa | Boca Raton, FL : , : CRC Press, an imprint of Taylor and Francis, , 2013 |
| Descrizione fisica | 1 online resource (285 p.) |
| Disciplina | 616.079 |
| Altri autori (Persone) | FujitaTakashi <1954-> |
| Collana | Molecular Biology Intelligence Unit |
| Soggetto topico | Immunology |
| ISBN |
0-429-08967-8
1-4987-1365-3 1-58706-671-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | BACK COVER |
| Record Nr. | UNINA-9910828304703321 |
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Sambhara Suryaprakash <1955->
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| Boca Raton, FL : , : CRC Press, an imprint of Taylor and Francis, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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La nuova immunologia : l'io guarda se stesso per conoscere il mondo / a cura di Franco Celada
| La nuova immunologia : l'io guarda se stesso per conoscere il mondo / a cura di Franco Celada |
| Pubbl/distr/stampa | Milano : Le Scienze, 1992 |
| Descrizione fisica | 293 p. : ill. (some col.); 28 cm |
| Disciplina | 616.079 |
| Altri autori (Persone) | Celada, Franco |
| Soggetto topico | Immunology |
| ISBN | 8870040593 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | ita |
| Record Nr. | UNISALENTO-991001433619707536 |
| Milano : Le Scienze, 1992 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. del Salento | ||
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Nutrition and Anti-Infectious Defence / / I. Gontzea
| Nutrition and Anti-Infectious Defence / / I. Gontzea |
| Autore | Gontzea I |
| Pubbl/distr/stampa | Basel : , : S. Karger, , 1974 |
| Descrizione fisica | 1 online resource (X + 290 pages) : : 45 figures, 13 tables |
| Disciplina | 616.3/9 |
| Altri autori (Persone) | JanteaFlorin R |
| Soggetto topico |
Nutrition
Infectious Diseases Metabolism Allergy Immunology Microbiology Preventive Medicine Social Medicine Veterinary Medicine |
| ISBN | 3-318-04994-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910149649603321 |
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Gontzea I
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| Basel : , : S. Karger, , 1974 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Nutrition and Immunity / / edited by Maryam Mahmoudi, Nima Rezaei
| Nutrition and Immunity / / edited by Maryam Mahmoudi, Nima Rezaei |
| Edizione | [1st ed. 2019.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 |
| Descrizione fisica | 1 online resource (520 pages) |
| Disciplina | 616.079 |
| Soggetto topico |
Clinical nutrition
Immunology Health promotion Clinical Nutrition Health Promotion and Disease Prevention |
| ISBN | 3-030-16073-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Introduction -- Vitamin D and the Immune System -- Vitamin A and the Immune System -- Vitamin K and the Immune System -- Vitamin C and the Immune System -- Vitamin B12, Folic Acid, and the Immune System -- Zinc and the Immune System -- Selenium and the Immune System -- Selenium and Immunity -- Gut Microbiome and Immunity -- Maternal Nutrition, Child Development, and Immunity -- Nutrition, Immunity, and Cancer -- Nutrition and Cancer -- Aging, Immunity, and Neuroinflammation: The Modulatory Potential of Nutrition -- Vitamins and Allergic Asthma -- Nutrition, Immunity, and Food Intolerances -- Potency of T-Cell Epitope-Based Peptide Vaccines in Food Allergy Treatment -- Obesity and Immunity -- Nutrition, Immunity, and Neurological Diseases -- Nutrition for Chronic Critical Illness and Persistent Inflammatory, Immunosuppressed, Catabolic Syndrome -- Nutrition, Immunity, and Autoimmune Diseases -- Immunomodulatory Effects of Flavonoids: Possible Induction of TCD4+ Regulatory Cells through mTor Signaling Pathway Suppression -- Glucan and its Role in Immunonutrition -- Nutrigenomic Immunity -- Nutriepigenomic Immunity. |
| Record Nr. | UNINA-9910349557503321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Nutritional Triggers for Health and in Disease / / editor, A.P. Simopoulos
| Nutritional Triggers for Health and in Disease / / editor, A.P. Simopoulos |
| Autore | Simopoulos A.P |
| Pubbl/distr/stampa | Basel : , : S. Karger, , 1992 |
| Descrizione fisica | 1 online resource (X + 202 pages) : : 41 figures, 22 tables |
| Disciplina |
612.3 s
616.3/9 |
| Altri autori (Persone) | SimopoulosArtemis P. <1933-> |
| Soggetto topico |
Nutrition
Clinical Nutrition Dietetics Immunology Metabolic Diseases Metabolism Pediatrics Physiology |
| ISBN | 3-318-04251-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910158690003321 |
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Simopoulos A.P
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| Basel : , : S. Karger, , 1992 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Soggetto topico
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Immunology
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