Autore	Teutenberg Thorsten
Pubbl/distr/stampa	Cambridge, : RSC Pub., c2010
Descrizione fisica	1 online resource (221 p.)
Disciplina	543.84
Collana	RSC chromatography monographs
Soggetto topico	High performance liquid chromatography High temperature chemistry
ISBN	1-62198-162-2 1-84973-109-8
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	A brief definition of high-temperature liquid chromatography -- System set-up for high-temperature liquid chromatography -- The heating system -- Mobile phase considerations -- Suitable stationary phases -- Method development using temperature as an active variable -- Analyte stability -- Special hyphenation techniques -- Critical outlook and future prospects.
Record Nr.	UNINA-9910792105003321

Autore	Hanai T
Pubbl/distr/stampa	Cambridge, : RSC, 1999
Descrizione fisica	1 online resource (146 p.)
Disciplina	543.0894
Collana	RSC chromatography monographs
Soggetto topico	High performance liquid chromatography
Soggetto genere / forma	Electronic books.
ISBN	1-84755-107-6
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	BK9780854045150-FX001; BK9780854045150-FP001; BK9780854045150-FP005; BK9780854045150-FP007; BK9780854045150-00001; BK9780854045150-00011; BK9780854045150-00031; BK9780854045150-00057; BK9780854045150-00096; BK9780854045150-00109; BK9780854045150-00133
Record Nr.	UNINA-9910454970803321

Autore	Dong M. W.
Edizione	[Second edition.]
Pubbl/distr/stampa	Hoboken, New Jersey : , : Wiley, , [2019]
Descrizione fisica	1 online resource (411 pages)
Disciplina	615.1901
Soggetto topico	High performance liquid chromatography Drugs - Analysis
ISBN	1-5231-2826-7 1-119-31379-1 1-119-31377-5 1-119-31378-3
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Record Nr.	UNINA-9910554821903321

Pubbl/distr/stampa	Weinheim, Germany : , : Wiley-VCH Verlag GmbH & Company KGaA, , [2016]
Descrizione fisica	1 online resource (411 p.)
Soggetto topico	High performance liquid chromatography
Soggetto genere / forma	Electronic books.
ISBN	3-527-67763-1 3-527-67761-5 3-527-67762-3
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	Title Page; Copyright; Table of Contents; List of Contributors; The structure of "The HPLC-Expert"; Preface; Chapter 1: LC/MS Coupling; 1.1 State of the Art in LC/MS; 1.2 Technical Aspects and Pitfalls of LC/MS Hyphenation; 1.3 LC Coupled to MS - A User Report; References; Chapter 2: Optimization Strategies in RP-HPLC; 2.1 Introduction; 2.2 LC Fundamentals; 2.3 Methodology of Optimization; 2.4 Outlook; References; Chapter 3: The Gradient in RP-Chromatography*; 3.1 Aspects of Gradient Optimization; 3.2 Prediction of Gradients; References Chapter 4: Comparison and Selection of Modern HPLC Columns4.1 Supports; 4.2 Stationary Phases for the HPLC: The Historical Development; 4.3 pH Stability and Restrictions in the Use of Silica; 4.4 The Key Properties of Reversed Phases; 4.5 Characterization and Classification of Reversed Phases; 4.6 Procedure for Practical Method Development; 4.7 Column Screening; 4.8 Column Databases; References; Chapter 5: Introduction to Biochromatography; 5.1 Introduction; 5.2 Overview of the Stationary Phases; 5.3 Reversed-Phase Chromatography of Peptides and Proteins 5.4 IEC Chromatography of Peptides and Proteins5.5 Size-Exclusion Chromatography of Peptides and Proteins; 5.6 Further Types of Chromatography - Brief Descriptions; 5.7 Summary; Chapter 6: Comparison of Modern Chromatographic Data Systems; 6.1 Introduction; 6.2 The Forerunners for CDS; 6.3 CDS Today; 6.4 Advantages and Disadvantages of File-Based CDS; 6.5 Advantages and Disadvantages of Database-Supported CDS; 6.6 CDS in a Network Environment; 6.7 Instrument Control; 6.8 Documentation and Compliance; 6.9 Brief Overview of Current Systems; 6.10 The CDS of Tomorrow; 6.11 Special Extensions 6.12 Open Interfaces6.13 The CDS in 20 Years; Acknowledgment; Chapter 7: Possibilities of Integration Today; 7.1 Peak Overlay - Effect on the Chromatogram; 7.2 Separation Techniques for Higher-Level Peaks; 7.3 Application of Separation Methods; 7.4 Chromatogrammsimulation; 7.5 Deconvolution; 7.6 Evaluation of Separation Methods; 7.7 Practical Application of Deconvolution; References; Chapter 8: Smart Documentation Strategies; 8.1 Introduction; 8.2 Objectives of Documentation; 8.3 The Life Cycle Model for Regulated Documents in Practice 8.4 Dealing with Hybrid Systems Comprising Paper and Electronic Records8.5 Preview; References; Chapter 9: Tips for a Successful FDA Inspection; 9.1 Introduction; 9.2 Preparation with the Inspection Model; 9.3 Typical Course of an FDA Inspection; 9.4 During the Inspection; 9.5 Post-Processing of the Inspection; Further Readings; Chapter 10: HPLC - Link List; 10.1 Chemical Data; 10.2 Applications/Methods; 10.3 Troubleshooting; 10.4 Background Information and Theory; 10.5 Literature; 10.6 Databases with Costs; 10.7 Apps; 10.8 Social Media; 10.9 Twitter Pages (Examples) 10.10 Facebook Pages (Examples)
Record Nr.	UNINA-9910136779003321

Pubbl/distr/stampa	Hoboken, N.J., : Wiley-Interscience, c2007
Descrizione fisica	1 online resource (1136 p.)
Disciplina	615.19 615.1901 615/.1901
Altri autori (Persone)	KazakevichYuri LoBruttoRosario
Soggetto topico	High performance liquid chromatography Drugs - Analysis Clinical chemistry
Soggetto genere / forma	Electronic books.
ISBN	1-280-72166-9 9786610721665 0-470-08795-1 0-470-08794-3
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	HPLC FOR PHARMACEUTICAL SCIENTISTS; CONTENTS; PREFACE; CONTRIBUTORS; PART I HPLC THEORY AND PRACTICE; 1 Introduction; 1.1 Chromatography in the Pharmaceutical World; 1.2 Chromatographic Process; 1.3 Classification; 1.4 History of Discovery and Early Development (1903-1933); 1.5 General Separation Process; 1.5.1 Modern HPLC Column; 1.5.2 HPLC System; 1.6 Types of HPLC; 1.6.1 Normal-Phase Chromatography (NP HPLC); 1.6.2 Reversed-Phase HPLC (RP HPLC or RPLC); 1.6.3 Ion-Exchange Chromatography (IEX); 1.6.4 Size-Exclusion Chromatography (SEC); 1.7 HPLC Descriptors (Vr, k, N, etc.) 1.7.1 Retention Volume1.7.2 Void Volume; 1.7.3 Retention Factor; 1.7.4 Selectivity; 1.7.5 Efficiency; 1.7.6 Resolution; References; 2 HPLC Theory; 2.1 Introduction; 2.2 Basic Chromatographic Descriptors; 2.3 Efficiency; 2.4 Resolution; 2.5 HPLC Retention; 2.6 Retention Mechanism; 2.7 General Column Mass Balance; 2.8 Partitioning Model; 2.9 Adsorption Model; 2.10 Total and Excess Adsorption; 2.11 Mass Balance in Adsorption Model; 2.12 Adsorption of the Eluent Components; 2.13 Void Volume Considerations; 2.14 Thermodynamic Relationships; 2.14.1 Effect of the Eluent Composition 2.15 Adsorption-Partitioning Retention Mechanism2.16 Secondary Equilibria; 2.16.1 Inclusion of Secondary Equilibria in the Mass Balance; 2.16.2 Salt Effect; 2.17 Gradient Elution Principles; 2.18 Types of Analyte Interactions with the Stationary Phase; 2.19 Conclusion; References; 3 Stationary Phases; 3.1 Introduction; 3.2 Type of Packing Material (Porous, Nonporous, Monolithic); 3.3 Base Material (Silica, Zirconia, Alumina, Polymers); 3.4 Geometry; 3.4.1 Shape (Spherical/Irregular); 3.4.2 Particle Size Distribution; 3.4.3 Surface Area; 3.4.4 Pore Volume; 3.4.5 Surface Geometry 3.5 Adsorbent Surface Chemistry3.5.1 Surface Chemistry of the Base Material; 3.5.2 Silica; 3.5.3 Silica Hybrid; 3.5.4 Polymeric Packings; 3.5.5 Zirconia (Metal Oxides); 3.5.6 Porous Carbon (or Carbon-Coated Phases); 3.6 Surface of Chemically Modified Material; 3.6.1 Limits of Surface Modification; 3.6.2 Chemical Modification; 3.6.3 Types of Bonded Phases; 3.6.4 Structure of the Bonded Layer; 3.6.5 Density of Bonded Ligands; 3.6.6 Residual Silanoles; 3.6.7 Surface Area of Modified Adsorbent; 3.7 Polymer-Based Adsorbents; 3.8 Stationary Phases for Chiral Separations 3.8.1 Polysaccharide-Coated Phases3.8.2 Pirkle-Type Phases; 3.8.3 Protein Phases; 3.8.4 Molecular Imprinted Polymers for Chiral Separations; 3.9 Columns; 3.9.1 Capillary/Monolithic/Packed Columns; 3.9.2 Column Cleaning; 3.9.3 Column Void Volume; 3.9.4 Mass of Adsorbent in the Column; References; 4 Reversed-Phase HPLC; 4.1 Introduction; 4.2 Retention in Reversed-Phase HPLC; 4.3 Stationary Phases for RPLC; 4.4 Mobile Phases for RPLC; 4.4.1 Eluent Composition and Solvent Strength of the Mobile Phase; 4.4.2 Type of Organic Modifier 4.4.3 Selectivity as a Function of Type and Concentration of Organic Composition
Record Nr.	UNINA-9910143582603321