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Annals of cardiac anaesthesia
| Annals of cardiac anaesthesia |
| Pubbl/distr/stampa | [New Delhi], : [Indian Association of Cardiovascular Thoracic Anaesthesiologist] |
| Descrizione fisica | 1 online resource |
| Disciplina | 617.96 |
| Soggetto topico |
Anesthesia in cardiology
Anesthesia Heart - Effect of drugs on Heart - Surgery Cardiac Surgical Procedures Heart - drug effects |
| Soggetto genere / forma | Periodicals. |
| ISSN | 0974-5181 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Cardiac anaesthesia |
| Record Nr. | UNISA-996321801903316 |
| [New Delhi], : [Indian Association of Cardiovascular Thoracic Anaesthesiologist] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Annals of cardiac anaesthesia
| Annals of cardiac anaesthesia |
| Pubbl/distr/stampa | [New Delhi], : [Indian Association of Cardiovascular Thoracic Anaesthesiologist] |
| Descrizione fisica | 1 online resource |
| Disciplina | 617.96 |
| Soggetto topico |
Anesthesia in cardiology
Anesthesia Heart - Effect of drugs on Heart - Surgery Cardiac Surgical Procedures Heart - drug effects |
| Soggetto genere / forma | Periodicals. |
| ISSN | 0974-5181 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Cardiac anaesthesia |
| Record Nr. | UNINA-9910142929503321 |
| [New Delhi], : [Indian Association of Cardiovascular Thoracic Anaesthesiologist] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Hensley's practical approach to cardiothoracic anesthesia / / editors, Glenn P. Gravlee, MD (Professor and Vice Chair for Faculty Affairs, Department of Anesthesiology, University of Colorado School of Medicine, Aurora, Colorado), Andrew D. Shaw, MB, FRCA (Professor and Chair, Department of Anesthesiology and Pain Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada), Karsten Bartels, MD, MS (Assistant Professor of Anesthesiology, Medicine and Surgery, Department of Anesthesiology, University of Colorado School of Medicine, Aurora, Colorado)
| Hensley's practical approach to cardiothoracic anesthesia / / editors, Glenn P. Gravlee, MD (Professor and Vice Chair for Faculty Affairs, Department of Anesthesiology, University of Colorado School of Medicine, Aurora, Colorado), Andrew D. Shaw, MB, FRCA (Professor and Chair, Department of Anesthesiology and Pain Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada), Karsten Bartels, MD, MS (Assistant Professor of Anesthesiology, Medicine and Surgery, Department of Anesthesiology, University of Colorado School of Medicine, Aurora, Colorado) |
| Edizione | [Sixth edition.] |
| Pubbl/distr/stampa | Philadelphia : , : Wolters Kluwer, , [2019] |
| Descrizione fisica | 1 online resource (1022 pages) |
| Disciplina | 617.9/67412 |
| Soggetto topico |
Anesthesia, Cardiac Procedures
Heart - drug effects Heart - Effect of drugs on Anesthesia |
| ISBN | 1-4963-7268-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover -- Title Page -- Copyright -- Dedication -- Contributors -- Preface -- Acknowledgments -- Contents -- SECTION I: CARDIOVASCULAR PHYSIOLOGY AND PHARMACOLOGY -- 1. Cardiovascular Physiology: A Primer -- Introduction -- Embryologic development of the heart -- Electrical conduction -- Cardiac myocyte -- Sarcomere -- Organization of myocytes -- Length-tension relationship -- A heart chamber and external work -- The chamber wall -- Atria -- Ventricle -- Preload and compliance -- Ventricular work -- Starling curve -- Myocardial oxygen consumption -- Control systems -- The cardiovascular control system -- Stretch receptors: Pressure sensors -- Atrial baroreceptors -- Arterial baroreceptors -- Effectors and physiologic reserves for the healthy individual -- The cardiovascular system integration -- Effect of anesthesia providers and our pharmacology on the cardiovascular system -- The surgical patient -- The anesthetic choice -- Treating the cause: Goal-directed therapy -- 2. Cardiovascular Drugs -- Introduction -- Drug dosage calculations -- Vasoactive inotrope scoring -- Drug receptor interactions -- Receptor activation -- Pharmacogenetics and genomics -- Guidelines for prevention and treatment of cardiovascular disease -- CAD -- CHF -- Hypertension -- Atrial fibrillation prophylaxis -- Resuscitation of patients in cardiac arrest after cardiac surgery -- Resuscitation after cardiopulmonary arrest -- Vasopressors -- α-Adrenergic receptor pharmacology -- Vasopressin pharmacology and agonists -- Angiotensin II -- Positive inotropic drugs -- Treatment of low CO -- cAMP-dependent agents -- cAMP-independent agents -- β-Adrenergic receptor-blocking drugs -- Actions -- Advantages of β-adrenergic-blocking drugs -- Disadvantages -- Distinguishing features of β-blockers -- Clinical use -- Vasodilator drugs -- Comparison -- Specific agents.
Calcium channel blockers -- General considerations -- Clinical effects common to all CCBs -- Specific intravenous agents -- Pharmacologic control of HR and rhythm -- Overview of antiarrhythmic medications -- Supraventricular arrhythmias -- Diuretics -- Actions -- Adverse effects -- Specific drugs -- Pulmonary hypertension -- SECTION II: GENERAL APPROACH TO CARDIOTHORACIC ANESTHESIA -- 3. The Cardiac Surgical Patient -- Introduction -- Patient presentation -- Clinical perioperative risk assessment-multifactorial risk indices -- Functional status -- Genomic contributions to cardiac risk assessment -- Risk associated with surgical problems and procedures -- Preoperative medical management of cardiovascular disease -- Myocardial ischemia -- Congestive heart failure -- Dysrhythmias -- Hypertension -- Cerebrovascular disease -- Noninvasive cardiac imaging -- Echocardiography -- Preoperative testing for myocardial ischemia -- Cardiac catheterization -- Overview -- Assessment of coronary anatomy -- Assessment of left ventricular function -- Assessment of valvular function -- Interventional cardiac catheterization -- Percutaneous coronary intervention (PCI) -- Preoperative management of patients with prior interventional procedures -- Management of preoperative medications -- β-Adrenergic blockers -- Statins (HMG-CoA inhibitors) -- Anticoagulant and antithrombotic medication -- Antihypertensives -- Antidysrhythmics -- 4. Monitoring the Cardiac Surgical Patient -- Introduction -- Cardiovascular monitors -- Electrocardiogram (ECG) -- Intermittent noninvasive blood pressure (BP) monitors -- Physics and technical aspects for accurate intravascular pressure measurements -- Arterial catheterization -- Central venous pressure (CVP) -- Pulmonary artery catheter (PAC) -- Cardiac output (CO) -- Echocardiography -- Temperature. Indications: Cardiopulmonary bypass (CPB) and hypothermia -- Sites of measurement -- Risks of temperature monitoring -- Recommendations for temperature monitoring -- Renal function -- Indications for monitoring -- Urinary catheter -- Electrolytes -- Acute kidney injury (AKI) -- Neurologic function -- General considerations -- Indications for monitoring neurologic function -- Physiologic and metabolic monitoring -- Monitors of central nervous system (CNS) electrical activity -- Monitors of regional cerebral metabolic function -- Near-infrared spectroscopy (NIRS) and cerebral oximetry -- Monitors of CNS embolic events -- Monitors of splanchnic perfusion and venous function -- Cardiac surgical procedures with special monitoring considerations -- Off-pump coronary artery bypass (OPCAB) -- OPCAB monitoring -- Deep hypothermic circulatory arrest (DHCA) -- Thoracoabdominal aortic aneurysm (TAAA) -- Additional resources -- 5. Transesophageal Echocardiography -- Basic principles of ultrasound imaging -- Basic principles of Doppler echocardiography -- Doppler echocardiography -- The Bernoulli equation -- Modes of cardiac ultrasound imaging -- M-mode echocardiography -- Two-dimensional (2D) echocardiography -- Pulsed-wave Doppler (PWD) -- Continuous-wave Doppler (CWD) -- Color-flow Doppler (CFD) -- Tissue Doppler -- Indications for transesophageal echocardiography (TEE) during cardiac surgery -- Safety, contraindications, and risk of TEE -- Preoperative screening -- TEE probe insertion and manipulation -- Complications of TEE -- Intraoperative TEE examination -- Probe insertion -- Probe manipulation -- Machine settings -- TEE views -- Examination of specific structures -- Monitoring applications of TEE -- Assessing preload -- Measuring intracardiac pressures -- Measuring cardiac output -- Detecting myocardial ischemia -- Intracardiac air. TEE for specific types of surgery -- Coronary artery bypass grafting (CABG) -- Valve repair surgery -- Valve replacement surgery -- Surgery for congenital heart disease -- Surgery for infective endocarditis -- Surgery for hypertrophic obstructive cardiomyopathy -- Thoracic aortic surgery -- Transplantation surgery -- Ventricular assist device implantation -- Minimally invasive cardiac surgery -- Transcatheter valve interventions -- Three-dimensional (3D) echocardiography -- Fundamental limitations of ultrasound imaging -- Computed rendering of 2D images into 3D -- Real-time insonation of a volume of tissue -- 3D image display and manipulation -- 6. Induction of Anesthesia and Precardiopulmonary Bypass Management -- Introduction -- Premedication -- Preinduction period -- Basic monitors -- Invasive monitors -- Clinical tips -- Last-minute checks -- Induction -- Attenuation of hemodynamic responses -- Guiding principles -- Anticipated difficult intubation -- Drugs and pharmacology for induction of anesthesia -- Opioids -- Other intravenous (IV) anesthetic agents -- Inhalational agents -- Muscle relaxants -- Applications of old drugs in sick patients -- Inhalational induction in very sick patients -- Immediate postinduction period -- Management of events between anesthetic induction and cardiopulmonary bypass (CPB) -- General principles -- Preincision -- Incision -- Opening the sternum -- During and after sternal spreading -- Concerns with cardiac reoperation ("redo heart") -- Concerns with urgent or emergent cardiac operation -- Internal mammary artery (IMA) and radial artery dissection -- Sympathetic nerve dissection -- Perioperative stress response -- Treatment of hemodynamic changes -- Preparation for cardiopulmonary bypass -- 7. Management of Cardiopulmonary Bypass -- Preparations for cardiopulmonary bypass (CPB). Assembling and checking the CPB circuit -- Anesthesiologist's pre-CPB checklist -- Management of arterial and venous cannulation -- Commencement of CPB -- Establishing "full flow" -- Initial CPB checklist -- Cessation of ventilation and lung management -- Monitoring -- Adequacy of perfusion -- Typical CPB sequence -- Typical coronary artery bypass graft (CABG) operation -- Typical aortic valve replacement (or repair) operation -- Typical mitral valve replacement (or repair) operation -- Typical combined procedures -- Maintenance of CPB -- Anesthesia -- Hemodynamic management -- Fluid management and hemodilution -- Management of anticoagulation -- Temperature management -- ECG management -- Myocardial protection -- Arterial blood gas and acid-base management -- Management of serum electrolytes -- Management of blood glucose -- Rewarming, aortic cross-clamp release, and preparation for weaning -- Rewarming -- Release of aortic cross-clamp -- Preparation for weaning from CPB -- Organ protection during CPB -- Renal protection -- Brain protection -- Myocardial protection -- Inflammatory response to CPB -- Lung protection -- Splanchnic and gastrointestinal protection -- Prevention and management of adverse events, complications, and catastrophes associated with CPB -- Malposition of arterial cannula -- Reversed cannulation -- Obstruction to venous return -- High pressure in the arterial pump line -- Massive gas embolism -- Failure of oxygen supply -- Pump or oxygenator failure -- Clotted oxygenator or circuit -- Dislodgement of cannula or tubing rupture -- Heater-cooler malfunction -- Minimally invasive surgical techniques requiring CPB -- Port-access surgery -- Minithoracotomy -- Minimally invasive mitral valve surgery -- Minimally invasive aortic valve surgery -- Choice of cardioplegia -- Management of unusual or rare conditions affecting bypass. Sickle cell trait and disease. |
| Altri titoli varianti | Practical approach to cardiac anesthesia |
| Record Nr. | UNINA-9910793143903321 |
| Philadelphia : , : Wolters Kluwer, , [2019] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Hensley's practical approach to cardiothoracic anesthesia / / editors, Glenn P. Gravlee, MD (Professor and Vice Chair for Faculty Affairs, Department of Anesthesiology, University of Colorado School of Medicine, Aurora, Colorado), Andrew D. Shaw, MB, FRCA (Professor and Chair, Department of Anesthesiology and Pain Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada), Karsten Bartels, MD, MS (Assistant Professor of Anesthesiology, Medicine and Surgery, Department of Anesthesiology, University of Colorado School of Medicine, Aurora, Colorado)
| Hensley's practical approach to cardiothoracic anesthesia / / editors, Glenn P. Gravlee, MD (Professor and Vice Chair for Faculty Affairs, Department of Anesthesiology, University of Colorado School of Medicine, Aurora, Colorado), Andrew D. Shaw, MB, FRCA (Professor and Chair, Department of Anesthesiology and Pain Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada), Karsten Bartels, MD, MS (Assistant Professor of Anesthesiology, Medicine and Surgery, Department of Anesthesiology, University of Colorado School of Medicine, Aurora, Colorado) |
| Edizione | [Sixth edition.] |
| Pubbl/distr/stampa | Philadelphia : , : Wolters Kluwer, , [2019] |
| Descrizione fisica | 1 online resource (1022 pages) |
| Disciplina | 617.9/67412 |
| Soggetto topico |
Anesthesia, Cardiac Procedures
Heart - drug effects Heart - Effect of drugs on Anesthesia |
| ISBN | 1-4963-7268-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover -- Title Page -- Copyright -- Dedication -- Contributors -- Preface -- Acknowledgments -- Contents -- SECTION I: CARDIOVASCULAR PHYSIOLOGY AND PHARMACOLOGY -- 1. Cardiovascular Physiology: A Primer -- Introduction -- Embryologic development of the heart -- Electrical conduction -- Cardiac myocyte -- Sarcomere -- Organization of myocytes -- Length-tension relationship -- A heart chamber and external work -- The chamber wall -- Atria -- Ventricle -- Preload and compliance -- Ventricular work -- Starling curve -- Myocardial oxygen consumption -- Control systems -- The cardiovascular control system -- Stretch receptors: Pressure sensors -- Atrial baroreceptors -- Arterial baroreceptors -- Effectors and physiologic reserves for the healthy individual -- The cardiovascular system integration -- Effect of anesthesia providers and our pharmacology on the cardiovascular system -- The surgical patient -- The anesthetic choice -- Treating the cause: Goal-directed therapy -- 2. Cardiovascular Drugs -- Introduction -- Drug dosage calculations -- Vasoactive inotrope scoring -- Drug receptor interactions -- Receptor activation -- Pharmacogenetics and genomics -- Guidelines for prevention and treatment of cardiovascular disease -- CAD -- CHF -- Hypertension -- Atrial fibrillation prophylaxis -- Resuscitation of patients in cardiac arrest after cardiac surgery -- Resuscitation after cardiopulmonary arrest -- Vasopressors -- α-Adrenergic receptor pharmacology -- Vasopressin pharmacology and agonists -- Angiotensin II -- Positive inotropic drugs -- Treatment of low CO -- cAMP-dependent agents -- cAMP-independent agents -- β-Adrenergic receptor-blocking drugs -- Actions -- Advantages of β-adrenergic-blocking drugs -- Disadvantages -- Distinguishing features of β-blockers -- Clinical use -- Vasodilator drugs -- Comparison -- Specific agents.
Calcium channel blockers -- General considerations -- Clinical effects common to all CCBs -- Specific intravenous agents -- Pharmacologic control of HR and rhythm -- Overview of antiarrhythmic medications -- Supraventricular arrhythmias -- Diuretics -- Actions -- Adverse effects -- Specific drugs -- Pulmonary hypertension -- SECTION II: GENERAL APPROACH TO CARDIOTHORACIC ANESTHESIA -- 3. The Cardiac Surgical Patient -- Introduction -- Patient presentation -- Clinical perioperative risk assessment-multifactorial risk indices -- Functional status -- Genomic contributions to cardiac risk assessment -- Risk associated with surgical problems and procedures -- Preoperative medical management of cardiovascular disease -- Myocardial ischemia -- Congestive heart failure -- Dysrhythmias -- Hypertension -- Cerebrovascular disease -- Noninvasive cardiac imaging -- Echocardiography -- Preoperative testing for myocardial ischemia -- Cardiac catheterization -- Overview -- Assessment of coronary anatomy -- Assessment of left ventricular function -- Assessment of valvular function -- Interventional cardiac catheterization -- Percutaneous coronary intervention (PCI) -- Preoperative management of patients with prior interventional procedures -- Management of preoperative medications -- β-Adrenergic blockers -- Statins (HMG-CoA inhibitors) -- Anticoagulant and antithrombotic medication -- Antihypertensives -- Antidysrhythmics -- 4. Monitoring the Cardiac Surgical Patient -- Introduction -- Cardiovascular monitors -- Electrocardiogram (ECG) -- Intermittent noninvasive blood pressure (BP) monitors -- Physics and technical aspects for accurate intravascular pressure measurements -- Arterial catheterization -- Central venous pressure (CVP) -- Pulmonary artery catheter (PAC) -- Cardiac output (CO) -- Echocardiography -- Temperature. Indications: Cardiopulmonary bypass (CPB) and hypothermia -- Sites of measurement -- Risks of temperature monitoring -- Recommendations for temperature monitoring -- Renal function -- Indications for monitoring -- Urinary catheter -- Electrolytes -- Acute kidney injury (AKI) -- Neurologic function -- General considerations -- Indications for monitoring neurologic function -- Physiologic and metabolic monitoring -- Monitors of central nervous system (CNS) electrical activity -- Monitors of regional cerebral metabolic function -- Near-infrared spectroscopy (NIRS) and cerebral oximetry -- Monitors of CNS embolic events -- Monitors of splanchnic perfusion and venous function -- Cardiac surgical procedures with special monitoring considerations -- Off-pump coronary artery bypass (OPCAB) -- OPCAB monitoring -- Deep hypothermic circulatory arrest (DHCA) -- Thoracoabdominal aortic aneurysm (TAAA) -- Additional resources -- 5. Transesophageal Echocardiography -- Basic principles of ultrasound imaging -- Basic principles of Doppler echocardiography -- Doppler echocardiography -- The Bernoulli equation -- Modes of cardiac ultrasound imaging -- M-mode echocardiography -- Two-dimensional (2D) echocardiography -- Pulsed-wave Doppler (PWD) -- Continuous-wave Doppler (CWD) -- Color-flow Doppler (CFD) -- Tissue Doppler -- Indications for transesophageal echocardiography (TEE) during cardiac surgery -- Safety, contraindications, and risk of TEE -- Preoperative screening -- TEE probe insertion and manipulation -- Complications of TEE -- Intraoperative TEE examination -- Probe insertion -- Probe manipulation -- Machine settings -- TEE views -- Examination of specific structures -- Monitoring applications of TEE -- Assessing preload -- Measuring intracardiac pressures -- Measuring cardiac output -- Detecting myocardial ischemia -- Intracardiac air. TEE for specific types of surgery -- Coronary artery bypass grafting (CABG) -- Valve repair surgery -- Valve replacement surgery -- Surgery for congenital heart disease -- Surgery for infective endocarditis -- Surgery for hypertrophic obstructive cardiomyopathy -- Thoracic aortic surgery -- Transplantation surgery -- Ventricular assist device implantation -- Minimally invasive cardiac surgery -- Transcatheter valve interventions -- Three-dimensional (3D) echocardiography -- Fundamental limitations of ultrasound imaging -- Computed rendering of 2D images into 3D -- Real-time insonation of a volume of tissue -- 3D image display and manipulation -- 6. Induction of Anesthesia and Precardiopulmonary Bypass Management -- Introduction -- Premedication -- Preinduction period -- Basic monitors -- Invasive monitors -- Clinical tips -- Last-minute checks -- Induction -- Attenuation of hemodynamic responses -- Guiding principles -- Anticipated difficult intubation -- Drugs and pharmacology for induction of anesthesia -- Opioids -- Other intravenous (IV) anesthetic agents -- Inhalational agents -- Muscle relaxants -- Applications of old drugs in sick patients -- Inhalational induction in very sick patients -- Immediate postinduction period -- Management of events between anesthetic induction and cardiopulmonary bypass (CPB) -- General principles -- Preincision -- Incision -- Opening the sternum -- During and after sternal spreading -- Concerns with cardiac reoperation ("redo heart") -- Concerns with urgent or emergent cardiac operation -- Internal mammary artery (IMA) and radial artery dissection -- Sympathetic nerve dissection -- Perioperative stress response -- Treatment of hemodynamic changes -- Preparation for cardiopulmonary bypass -- 7. Management of Cardiopulmonary Bypass -- Preparations for cardiopulmonary bypass (CPB). Assembling and checking the CPB circuit -- Anesthesiologist's pre-CPB checklist -- Management of arterial and venous cannulation -- Commencement of CPB -- Establishing "full flow" -- Initial CPB checklist -- Cessation of ventilation and lung management -- Monitoring -- Adequacy of perfusion -- Typical CPB sequence -- Typical coronary artery bypass graft (CABG) operation -- Typical aortic valve replacement (or repair) operation -- Typical mitral valve replacement (or repair) operation -- Typical combined procedures -- Maintenance of CPB -- Anesthesia -- Hemodynamic management -- Fluid management and hemodilution -- Management of anticoagulation -- Temperature management -- ECG management -- Myocardial protection -- Arterial blood gas and acid-base management -- Management of serum electrolytes -- Management of blood glucose -- Rewarming, aortic cross-clamp release, and preparation for weaning -- Rewarming -- Release of aortic cross-clamp -- Preparation for weaning from CPB -- Organ protection during CPB -- Renal protection -- Brain protection -- Myocardial protection -- Inflammatory response to CPB -- Lung protection -- Splanchnic and gastrointestinal protection -- Prevention and management of adverse events, complications, and catastrophes associated with CPB -- Malposition of arterial cannula -- Reversed cannulation -- Obstruction to venous return -- High pressure in the arterial pump line -- Massive gas embolism -- Failure of oxygen supply -- Pump or oxygenator failure -- Clotted oxygenator or circuit -- Dislodgement of cannula or tubing rupture -- Heater-cooler malfunction -- Minimally invasive surgical techniques requiring CPB -- Port-access surgery -- Minithoracotomy -- Minimally invasive mitral valve surgery -- Minimally invasive aortic valve surgery -- Choice of cardioplegia -- Management of unusual or rare conditions affecting bypass. Sickle cell trait and disease. |
| Altri titoli varianti | Practical approach to cardiac anesthesia |
| Record Nr. | UNINA-9910806239803321 |
| Philadelphia : , : Wolters Kluwer, , [2019] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Integrated cardiac safety [[electronic resource] ] : assessment methodologies for noncardiac drugs in discovery, development, and postmarketing surveillance / / J. Rick Turner, Todd A. Durham
| Integrated cardiac safety [[electronic resource] ] : assessment methodologies for noncardiac drugs in discovery, development, and postmarketing surveillance / / J. Rick Turner, Todd A. Durham |
| Autore | Turner J. Rick |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, N.J., : John Wiley & Sons, c2009 |
| Descrizione fisica | 1 online resource (500 p.) |
| Disciplina | 616.1/23061 |
| Altri autori (Persone) | DurhamTodd A |
| Soggetto topico |
Cardiovascular toxicology
Heart - Effect of drugs on Drugs - Side effects - Testing Drugs - Safety measures |
| ISBN |
1-282-00206-6
9786612002069 0-470-41129-5 0-470-41128-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | The importance of cardiac safety assessments -- The biological basis of adverse drug reactions -- Cardiac structure and function -- Cardiac pathophysiology and disease -- Drug discovery and drug design -- Nonclinical development -- The thorough QT/QTc trial -- General safety assessments -- Therapeutic use trials and meta-analyses -- Assessment methodologies in nonexperimental postmarketing surveillance -- Postmarketing proarrhythmic cardiac safety assessments -- Generalized cardiac safety -- Medication errors, adherence, and concordance -- Future directions in drug safety. |
| Record Nr. | UNINA-9910144409203321 |
Turner J. Rick
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| Hoboken, N.J., : John Wiley & Sons, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
