Info
- Utilizzare la checkbox di selezione a fianco di ciascun documento per attivare le funzionalità di stampa, invio email, download nei formati disponibili del (i) record.
DNA pharmaceuticals [[electronic resource] ] : formulation and delivery in gene therapy, DNA vaccination and immunotherapy / / edited by Martin Schleef
| DNA pharmaceuticals [[electronic resource] ] : formulation and delivery in gene therapy, DNA vaccination and immunotherapy / / edited by Martin Schleef |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2005 |
| Descrizione fisica | 1 online resource (277 p.) |
| Disciplina |
615.372
616.0796 |
| Altri autori (Persone) | SchleefM (Martin) |
| Soggetto topico |
DNA vaccines
Gene therapy Immunotherapy |
| ISBN |
1-280-85409-X
9786610854097 3-527-60753-6 3-527-60700-5 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
DNA Pharmaceuticals; Preface; Contents; List of Contributors; Abbreviations; 1 DNA Vaccines - An Overview; 1.1 Rationale for DNA Vaccines; 1.2 Preclinical Proof of Concept; 1.3 Clinical Trials; 1.4 Second-Generation Vaccines; 1.5 Conclusions; References; 2 DNA as a Pharmaceutical - Regulatory Aspects; 2.1 Introduction; 2.2 Quality Requirements for DNA used as a Gene Therapy Product; 2.2.1 Introduction; 2.2.2 Production and Purification; 2.2.2.1 Raw Materials; 2.2.2.2 Antibiotics; 2.2.2.3 Solvents; 2.2.2.4 Fermentation; 2.2.2.5 Purification; 2.2.3 Cell Banking System Procedures
2.2.3.1 Generation and Characterization of Master and Working Cell Banks2.2.4 Product Characterization and Quality Criteria; 2.2.4.1 Identity; 2.2.4.2 Purity; 2.2.4.3 Adventitious Agents; 2.2.4.4 Potency; 2.3 Safety Studies for Clinical Trials; 2.3.1 General Considerations; 2.3.2 Conduct of Preclinical Safety Studies; 2.3.2.1 Regulations; 2.3.2.2 Design of an Appropriate Toxicology Program; 2.3.2.3 Single- and Repeat-Dose Toxicity Studies; 2.3.2.4 Safety of the Formulated Plasmid DNA; 2.3.2.5 Specific Safety Considerations; 2.3.2.6 Choice of Animal Model; 2.4 Special Issues 2.4.1 Comparability of Plasmid Gene Therapy Products2.4.2 Mixed Plasmid Preparations; 2.4.3 Plasmid Molecular Structure; 2.5 Biosafety Issues and Environmental Risk Assessment; References; 3 From Bulk to Delivery: Plasmid Manufacturing and Storage; 3.1 Introduction; 3.1.1 Gene Therapy; 3.1.2 DNA Vaccination; 3.2 Manufacturing of Plasmid DNA; 3.2.1 Bacterial Cultivation; 3.2.2 Plasmid DNA Purification; 3.2.3 Innovative Aspects in Plasmid Manufacturing; 3.3 Quality Control of Plasmid DNA Vectors; 3.3.1 Proteins, Ribonucleic Acid, and Lipopolysaccharides; 3.3.2 Chromosomal DNA 3.3.3 Plasmid Identity3.3.4 Plasmid Topology (Structural Homogeneity); 3.4 Plasmid Stability during Storage and Application; 3.4.1 Long-Term Stability of Plasmid DNA; 3.4.2 Lyophilization for Long-Term Storage; 3.4.3 Stability during Application; 3.5 Future Developments; References; 4 Minimized, CpG-Depleted, and Methylated DNA Vectors: Towards Perfection in Nonviral Gene Therapy; 4.1 Introduction; 4.2 The Mammalian Immune System as a Barrier to Nonviral Gene Delivery; 4.3 Strategies to Minimize DNA Vectors 4.3.1 Excision of a DNA Fragment Containing a Transgene Expression Cassette from Plasmid DNA4.3.2 Intramolecular Site-Specific Recombination Within a Bacterial Plasmid; 4.3.3 Synthesis of Minimized DNA Vectors by PCR; 4.3.4 Improvement of Minimized DNA Vector Yield and Purity; 4.4 Depletion of CpG Dinucleotides in the Bacterial Vector Backbone; 4.5 Methylation of CpG Dinucleotides in Plasmid DNA; 4.6 Towards an Ideal Nonviral Vector; 4.7 Conclusion; References; 5 Localized Nucleic Acid Delivery: A Discussion of Selected Methods; 5.1 Foreword; 5.2 Nucleic Acid Delivery - What For? 5.3 Nucleic Acid Delivery - How? |
| Record Nr. | UNINA-9910829843803321 |
| Weinheim, : Wiley-VCH, c2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
DNA pharmaceuticals [[electronic resource] ] : formulation and delivery in gene therapy, DNA vaccination and immunotherapy / / edited by Martin Schleef
| DNA pharmaceuticals [[electronic resource] ] : formulation and delivery in gene therapy, DNA vaccination and immunotherapy / / edited by Martin Schleef |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2005 |
| Descrizione fisica | 1 online resource (277 p.) |
| Disciplina |
615.372
616.0796 |
| Altri autori (Persone) | SchleefM (Martin) |
| Soggetto topico |
DNA vaccines
Gene therapy Immunotherapy |
| ISBN |
1-280-85409-X
9786610854097 3-527-60753-6 3-527-60700-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
DNA Pharmaceuticals; Preface; Contents; List of Contributors; Abbreviations; 1 DNA Vaccines - An Overview; 1.1 Rationale for DNA Vaccines; 1.2 Preclinical Proof of Concept; 1.3 Clinical Trials; 1.4 Second-Generation Vaccines; 1.5 Conclusions; References; 2 DNA as a Pharmaceutical - Regulatory Aspects; 2.1 Introduction; 2.2 Quality Requirements for DNA used as a Gene Therapy Product; 2.2.1 Introduction; 2.2.2 Production and Purification; 2.2.2.1 Raw Materials; 2.2.2.2 Antibiotics; 2.2.2.3 Solvents; 2.2.2.4 Fermentation; 2.2.2.5 Purification; 2.2.3 Cell Banking System Procedures
2.2.3.1 Generation and Characterization of Master and Working Cell Banks2.2.4 Product Characterization and Quality Criteria; 2.2.4.1 Identity; 2.2.4.2 Purity; 2.2.4.3 Adventitious Agents; 2.2.4.4 Potency; 2.3 Safety Studies for Clinical Trials; 2.3.1 General Considerations; 2.3.2 Conduct of Preclinical Safety Studies; 2.3.2.1 Regulations; 2.3.2.2 Design of an Appropriate Toxicology Program; 2.3.2.3 Single- and Repeat-Dose Toxicity Studies; 2.3.2.4 Safety of the Formulated Plasmid DNA; 2.3.2.5 Specific Safety Considerations; 2.3.2.6 Choice of Animal Model; 2.4 Special Issues 2.4.1 Comparability of Plasmid Gene Therapy Products2.4.2 Mixed Plasmid Preparations; 2.4.3 Plasmid Molecular Structure; 2.5 Biosafety Issues and Environmental Risk Assessment; References; 3 From Bulk to Delivery: Plasmid Manufacturing and Storage; 3.1 Introduction; 3.1.1 Gene Therapy; 3.1.2 DNA Vaccination; 3.2 Manufacturing of Plasmid DNA; 3.2.1 Bacterial Cultivation; 3.2.2 Plasmid DNA Purification; 3.2.3 Innovative Aspects in Plasmid Manufacturing; 3.3 Quality Control of Plasmid DNA Vectors; 3.3.1 Proteins, Ribonucleic Acid, and Lipopolysaccharides; 3.3.2 Chromosomal DNA 3.3.3 Plasmid Identity3.3.4 Plasmid Topology (Structural Homogeneity); 3.4 Plasmid Stability during Storage and Application; 3.4.1 Long-Term Stability of Plasmid DNA; 3.4.2 Lyophilization for Long-Term Storage; 3.4.3 Stability during Application; 3.5 Future Developments; References; 4 Minimized, CpG-Depleted, and Methylated DNA Vectors: Towards Perfection in Nonviral Gene Therapy; 4.1 Introduction; 4.2 The Mammalian Immune System as a Barrier to Nonviral Gene Delivery; 4.3 Strategies to Minimize DNA Vectors 4.3.1 Excision of a DNA Fragment Containing a Transgene Expression Cassette from Plasmid DNA4.3.2 Intramolecular Site-Specific Recombination Within a Bacterial Plasmid; 4.3.3 Synthesis of Minimized DNA Vectors by PCR; 4.3.4 Improvement of Minimized DNA Vector Yield and Purity; 4.4 Depletion of CpG Dinucleotides in the Bacterial Vector Backbone; 4.5 Methylation of CpG Dinucleotides in Plasmid DNA; 4.6 Towards an Ideal Nonviral Vector; 4.7 Conclusion; References; 5 Localized Nucleic Acid Delivery: A Discussion of Selected Methods; 5.1 Foreword; 5.2 Nucleic Acid Delivery - What For? 5.3 Nucleic Acid Delivery - How? |
| Record Nr. | UNINA-9910841418403321 |
| Weinheim, : Wiley-VCH, c2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
DNA Replication - Epigenetic Mechanisms and Gene Therapy Applications / / Ziyad S. Haidar, editor
| DNA Replication - Epigenetic Mechanisms and Gene Therapy Applications / / Ziyad S. Haidar, editor |
| Pubbl/distr/stampa | London : , : IntechOpen, , 2023 |
| Descrizione fisica | 1 online resource (94 pages) |
| Disciplina | 572.8645 |
| Soggetto topico |
DNA replication
Epigenetics Gene therapy |
| ISBN | 1-80356-876-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Introductory Chapter: Unraveling the Complexities of DNA Replication, Epigenetics, and Gene Therapy Applications -- Anti-Tumor Drug Resistance and Modern Oncologic Pharmaco-Therapy: RNA and DNA Methylation, Mechanisms and Histone Modification, Epigenetic Regulation and Targeting Epigenetic Modifiers in Contemporary Cancer Therapy -- Perspective Chapter: Epigenetic Therapy - The Future Treatment for Cancer -- Perspective Chapter: Topoisomerase 1 and Colo Rectal Carcinoma -- Marker Assisted Selection in Groundnut. |
| Record Nr. | UNINA-9910765548203321 |
| London : , : IntechOpen, , 2023 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drug discovery today Targets
| Drug discovery today Targets |
| Pubbl/distr/stampa | [Amsterdam] ; ; [New York], : Elsevier Science, -2004 |
| Disciplina | 572.86 |
| Soggetto topico |
Drugs - Design
Gene therapy Medical genetics Drug Design Genomics Proteomics Médicament Thérapie génique Génétique médicale |
| Soggetto genere / forma |
Periodical
Periodicals. Périodique électronique (Descripteur de forme) Ressource Internet (Descripteur de forme) |
| Soggetto non controllato | Pharmacy, Therapeutics, & Pharmacology |
| ISSN | 1878-7363 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti |
Targets
DDT. |
| Record Nr. | UNINA-9910143062503321 |
| [Amsterdam] ; ; [New York], : Elsevier Science, -2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drug discovery today Targets
| Drug discovery today Targets |
| Pubbl/distr/stampa | [Amsterdam] ; ; [New York], : Elsevier Science, -2004 |
| Disciplina | 572.86 |
| Soggetto topico |
Drugs - Design
Gene therapy Medical genetics Drug Design Genomics Proteomics Médicament Thérapie génique Génétique médicale |
| Soggetto genere / forma |
Periodical
Periodicals. Périodique électronique (Descripteur de forme) Ressource Internet (Descripteur de forme) |
| Soggetto non controllato | Pharmacy, Therapeutics, & Pharmacology |
| ISSN | 1878-7363 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti |
Targets
DDT. |
| Record Nr. | UNISA-996198117603316 |
| [Amsterdam] ; ; [New York], : Elsevier Science, -2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Emerging Trends in Cell and Gene Therapy [[electronic resource] /] / edited by Michael K. Danquah, Ram I. Mahato
| Emerging Trends in Cell and Gene Therapy [[electronic resource] /] / edited by Michael K. Danquah, Ram I. Mahato |
| Edizione | [1st ed. 2013.] |
| Pubbl/distr/stampa | Totowa, NJ : , : Humana Press : , : Imprint : Humana, , 2013 |
| Descrizione fisica | 1 online resource (712 p.) |
| Disciplina |
615.3
615.89 |
| Soggetto topico |
Cell biology
Gene therapy Biotechnology Pharmaceutical technology Cell Biology Gene Therapy Pharmaceutical Sciences/Technology |
| ISBN | 1-62703-417-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | The Mechanism of Stem Cell Differentiation into Smooth Muscle Cells -- Recent Advances in Embryonic Stem Cell Engineering Towards Tailored “Lineage Differentiation -- Human Amniotic Membrane: A Potential Tissue and Cell Source for Cell Therapy and Regenerative Medicine -- Novel Strategies Applied to Provide Multiple Sources of Stem Cells as a Regenerative Therapy for Parkinson’s Disease -- Hair Follicle: A Novel Source of Stem Cells for Cell and Gene Therapy -- Genetically Modified Stem Cells for Transplantation -- Induced Pluripotent Stem Cells: Basics, and the Application in Disease Model and Regenerative Medicine -- Gene Transfer to the Heart. Emerging Strategies for the Selection of Vectors, Delivery Techniques and Therapeutic Targets -- Cell-Based Therapy for Cardiovascular Injury -- Induced Pluripotent Stem Cells: New Advances in Cardiac Regenerative Medicine -- Dendritic Cells for Cancer Immunotherapy -- Mesenchymal stem cells: prospects for cancer therapy -- RNA Interference for Oncology: Clinical Prospects Beyond the Hype -- Cell Therapy using Adult Stem Cells in Osteonecrosis and Nonunion Fractures -- Stem Cell Therapies for the Treatment of Spinal Cord Injuries: Current Progress in Basic Science and Clinical Research -- Pluripotent Stem Cells for Neural Regeneration -- Synovial Mesenchymal Stem Cells and their Applications in Musculoskeletal Regeneration -- Stem Cell Therapy Aided liver Regeneration -- Application of Microfluidics of Study Stem Cell Dynamics -- Stem Cell Therapy Aided liver Regeneration -- Application of Microfluidics of Study Stem Cell Dynamics -- Stem Cell Therapy Aided liver Regeneration -- Application of Microfluidics of Study Stem Cell Dynamics -- Biomimetic Multiscale Topography for Cell Alignment -- Spinal Cord Repair by Means of Tissue Engineered Scaffolds -- Stem Cells in Ligament Tissue Engineering -- Biomaterials for Bone Tissue Engineering -- Gene Therapy for the Inner Ear: Progress and Prospects -- Preclinical Studies on Growth Plate Cartilage Regeneration Using Chondrocytes or Mesenchymal Stem Cells -- Cell and Gene Transfer Strategies for Vascularization During Skin Would Healing. |
| Record Nr. | UNINA-9910437604903321 |
| Totowa, NJ : , : Humana Press : , : Imprint : Humana, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Entwicklung der gentherapie : Stellungnahme der Senatskommission für Grundsatzfragen der genforschung / / Memorandum by the Senate Commission on Genetic Research
| Entwicklung der gentherapie : Stellungnahme der Senatskommission für Grundsatzfragen der genforschung / / Memorandum by the Senate Commission on Genetic Research |
| Pubbl/distr/stampa | Weinheim, Germany : , : WILEY-VCH Verlag GmbH & Co. KGaA, , 2007 |
| Descrizione fisica | 1 online resource (91 p.) |
| Disciplina | 615.895 |
| Collana | Deutsche Forschungsgemeinschaft |
| Soggetto topico | Gene therapy |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-85470-7
9786610854707 3-527-61052-9 3-527-61053-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | ger |
| Nota di contenuto | 3 Clinical application: successes and setbacks4 Present situation and further research needs; 5 Legal and ethical considerations; 6 Conclusions and recommendations; 7 References; 8 Glossary; 9 Members of the Working Group on "Gene Therapy", who prepared the present statement; 10 Members of the Senate Commission on Genetic Research |
| Record Nr. | UNINA-9910144559703321 |
| Weinheim, Germany : , : WILEY-VCH Verlag GmbH & Co. KGaA, , 2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Entwicklung der gentherapie : Stellungnahme der Senatskommission für Grundsatzfragen der genforschung / / Memorandum by the Senate Commission on Genetic Research
| Entwicklung der gentherapie : Stellungnahme der Senatskommission für Grundsatzfragen der genforschung / / Memorandum by the Senate Commission on Genetic Research |
| Pubbl/distr/stampa | Weinheim, Germany : , : WILEY-VCH Verlag GmbH & Co. KGaA, , 2007 |
| Descrizione fisica | 1 online resource (91 p.) |
| Disciplina | 615.895 |
| Collana | Deutsche Forschungsgemeinschaft |
| Soggetto topico | Gene therapy |
| ISBN |
1-280-85470-7
9786610854707 3-527-61052-9 3-527-61053-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | ger |
| Nota di contenuto | 3 Clinical application: successes and setbacks4 Present situation and further research needs; 5 Legal and ethical considerations; 6 Conclusions and recommendations; 7 References; 8 Glossary; 9 Members of the Working Group on "Gene Therapy", who prepared the present statement; 10 Members of the Senate Commission on Genetic Research |
| Record Nr. | UNINA-9910831048803321 |
| Weinheim, Germany : , : WILEY-VCH Verlag GmbH & Co. KGaA, , 2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Epigenetic Therapy of Cancer [[electronic resource] ] : Preclinical Models and Treatment Approaches / / edited by Michael Lübbert, Peter A. Jones
| Epigenetic Therapy of Cancer [[electronic resource] ] : Preclinical Models and Treatment Approaches / / edited by Michael Lübbert, Peter A. Jones |
| Edizione | [1st ed. 2014.] |
| Pubbl/distr/stampa | Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2014 |
| Descrizione fisica | 1 online resource (332 p.) |
| Disciplina | 616.994042695 |
| Soggetto topico |
Oncology
Hematology Gene therapy Oncology Gene Therapy |
| ISBN | 3-642-38404-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | The fundamental role of epigenetic regulation for normal and disturbed all growth and differentiation -- Mouse models to study DNA methylation in cancer research -- Epigenetic regulation of normal hematopoietic development -- Epigenetic regulation of globin genes and disturbances in hemoglobinopathies -- DNA methylation abnormalities in hematopoietic disorders: biological significance and methodological approaches -- Epigenetic modifications mediated by the AML1/ETO and MLL leukemia fusion proteins -- Epigenetic abnormalities in lung cancer -- Pharmacodynamic Responses to DNA Methyltransferase Inhibition -- Histone Methyltransferases: Opportunities in Cancer Drug Discovery -- Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy -- Clinical Implications of Epigenetic Alterations in Lung Cancer -- Epigenetic disturbances in colorectal cancer -- Epigenetic Therapies in Solid Tumours: from preclinical models to clinical trial results. |
| Record Nr. | UNINA-9910300095803321 |
| Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Fetal morph functional diagnosis / / Hideaki Masuzaki, editor
| Fetal morph functional diagnosis / / Hideaki Masuzaki, editor |
| Edizione | [1st ed. 2021.] |
| Pubbl/distr/stampa | Singapore : , : Springer, , [2021] |
| Descrizione fisica | 1 online resource (IX, 354 p. 108 illus., 60 illus. in color.) |
| Disciplina | 618.1 |
| Collana | Comprehensive gynecology and obstetrics |
| Soggetto topico |
Radiology
Gynecology Gene therapy |
| ISBN | 981-15-8171-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Part I Ultrasound examination -- 1.Ultrasonic Screenin -- 2.Abnormal findings in Ultrasound examination -- Part II_ Genetic tests -- 3.Screening tests -- 4.Diagnostic test -- Part III_Genetic Disorders -- 5.Mendelian Diseases -- 6.Abnormalities in fetal brain(congenital hydrocephalus etc) -- 7.Muscular Dystrophy -- 8.Skeletal dysplasia -- 9.Genito-urinary tract abnormality -- 10.Genomic imprinting disorders ( including mesenchymal placental dysplasia) -- 11.Genetics in Multiple gestation -- 12.Fetal Therapy -- Part IV_Chromosoma disease -- 13.Autosomal disease -- 14.Sex chromosome-linked diseases -- Part V_Genetic counseling -- 15.fetal anomaly and genetic counseling -- 16.Soft marker test (NT, Nasal bone etc) and genetic counseling -- 17.NIPT and genetic counseling -- 18.Trisomy and genetic counseling -- 19.Sex chromosomel abnormality and genetic counseling -- 20.Chromosome structural abnormalities and genetic counseling -- 21.Chromosome Mosaic and Genetic Counseling -- 22.Gene disorders and genetic counseling -- Part VI_Technical -- 23. G-banding -- 24. FISH -- 25. PCR -- 26. Microarray and Next generation sequencing -- 27. How to get the licenses for prenatal diagnosis. |
| Record Nr. | UNINA-9910483936903321 |
| Singapore : , : Springer, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Soggetto topico
-
Gene therapy
(140)
- Gene Therapy (53)
- Genetic Therapy (22)
- Regenerative Medicine/Tissue Engineering (14)
- Regenerative medicine (14)