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Clinical Epigenetics [[electronic resource] /] / edited by Luke B. Hesson, Antonia L. Pritchard
| Clinical Epigenetics [[electronic resource] /] / edited by Luke B. Hesson, Antonia L. Pritchard |
| Edizione | [1st ed. 2019.] |
| Pubbl/distr/stampa | Singapore : , : Springer Singapore : , : Imprint : Springer, , 2019 |
| Descrizione fisica | 1 online resource (XI, 265 p. 34 illus., 8 illus. in color.) |
| Disciplina | 611.01816 |
| Soggetto topico |
Gene expression
Medical genetics Gene therapy Cytogenetics Molecular biology Gene Expression Gene Function Gene Therapy Molecular Medicine |
| ISBN | 981-13-8958-6 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Genetics and epigenetics: a Historical Overview -- The DNA methylation machinery -- Methylcytosine and its oxidised derivatives -- The role of nucleosomes in epigenetic gene regulation -- Circular RNAs in human health and disease -- The role of histone variants in cancer -- DNA methylation and carcinogenesis: Current and future perspectives -- Dysregulation of cis-regulatory elements in cancer -- Germline epigenetic testing of imprinting disorders in a diagnostic setting -- Cancer methylation biomarkers in circulating cell-free DNA -- The clinical utility of epigenetics. |
| Record Nr. | UNINA-9910350350303321 |
| Singapore : , : Springer Singapore : , : Imprint : Springer, , 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Concepts in genetic medicine [[electronic resource] /] / edited by Boro Dropulic, Barrie Carter
| Concepts in genetic medicine [[electronic resource] /] / edited by Boro Dropulic, Barrie Carter |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley-Liss, c2008 |
| Descrizione fisica | 1 online resource (393 p.) |
| Disciplina | 616/.042 |
| Altri autori (Persone) |
DropulicBoro
CarterBarrie |
| Soggetto topico |
Medical genetics
Gene therapy |
| ISBN |
1-281-28442-4
9786611284428 0-470-18458-2 0-470-18457-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
CONCEPTS IN GENETIC MEDICINE; CONTENTS; CONTRIBUTORS; PREFACE; INTRODUCTION; 1 The Evolution of Human Gene Therapy: A Journey from Excessive Hype to Excessive Diffidence to Reality; VECTOR SYSTEMS; 2 Murine Leukemia Virus-Based Retroviral Vectors; 3 Lentivirus Vectors; 4 Adenoviral Vectors: History and Perspective; 5 Adeno-Associated Virus Vectors; 6 SV40 Virus-Derived Vectors; 7 Herpes Simplex Virus Vectors; 8 Nonviral Gene Delivery Systems; APPLICATIONS; 9 Therapeutic Gene Transfer to Skeletal Muscle; 10 Gene Therapy for Cardiovascular Disease
11 Intra-articular Vector Delivery for Inflammatory Joint Disease 12 The Respiratory System as a Platform for Gene Delivery; 13 The Brain as a Target for Gene Therapy; 14 Immune Responses to Viral Vectors Injected Systemically or into the CNS; 15 Cancer Vaccines; 16 Genetically Modified T Cells for Human Gene Therapy; 17 Lentiviral Vector Delivery of RNAi for the Treatment of HIV-1 Infection; 18 Vector Targeting; THE MANUFACTURE OF GENE THERAPY PRODUCTS; 19 The Manufacture of Genetic Viral Vector Products; 20 The Manufacture of Adeno-Associated Viral Vectors; 21 Lentivirus Vector Manufacturing SAFETY AND REGULATORY CONSIDERATIONS 22 Assays for the Release of Viral Vector Gene Therapy Products for Human Clinical Trials; 23 Safety of Retroviral Vectors: Regulatory and Technical Considerations; 24 Assays for the Quality Control of Lentiviral Vectors; 25 Assays for Nonviral Vectors; 26 Assays for the Release of Cellular Gene Therapy Products; 27 Toxicology for Gene Therapy Products: Concepts and Challenges; 28 Regulatory Aspects of Gene Therapy Medicinal Products in the European Union; FINANCE AND REIMBURSEMENT; 29 Venture Capital and Biotechnology Startups 30 The Role of Investment Banking in the Growth of Biotechnology Companies 31 Managing Reimbursement for Gene Therapy Products; INDEX |
| Record Nr. | UNINA-9910145265303321 |
| Hoboken, N.J., : Wiley-Liss, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Concepts in genetic medicine [[electronic resource] /] / edited by Boro Dropulic, Barrie Carter
| Concepts in genetic medicine [[electronic resource] /] / edited by Boro Dropulic, Barrie Carter |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley-Liss, c2008 |
| Descrizione fisica | 1 online resource (393 p.) |
| Disciplina | 616/.042 |
| Altri autori (Persone) |
DropulicBoro
CarterBarrie |
| Soggetto topico |
Medical genetics
Gene therapy |
| ISBN |
1-281-28442-4
9786611284428 0-470-18458-2 0-470-18457-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
CONCEPTS IN GENETIC MEDICINE; CONTENTS; CONTRIBUTORS; PREFACE; INTRODUCTION; 1 The Evolution of Human Gene Therapy: A Journey from Excessive Hype to Excessive Diffidence to Reality; VECTOR SYSTEMS; 2 Murine Leukemia Virus-Based Retroviral Vectors; 3 Lentivirus Vectors; 4 Adenoviral Vectors: History and Perspective; 5 Adeno-Associated Virus Vectors; 6 SV40 Virus-Derived Vectors; 7 Herpes Simplex Virus Vectors; 8 Nonviral Gene Delivery Systems; APPLICATIONS; 9 Therapeutic Gene Transfer to Skeletal Muscle; 10 Gene Therapy for Cardiovascular Disease
11 Intra-articular Vector Delivery for Inflammatory Joint Disease 12 The Respiratory System as a Platform for Gene Delivery; 13 The Brain as a Target for Gene Therapy; 14 Immune Responses to Viral Vectors Injected Systemically or into the CNS; 15 Cancer Vaccines; 16 Genetically Modified T Cells for Human Gene Therapy; 17 Lentiviral Vector Delivery of RNAi for the Treatment of HIV-1 Infection; 18 Vector Targeting; THE MANUFACTURE OF GENE THERAPY PRODUCTS; 19 The Manufacture of Genetic Viral Vector Products; 20 The Manufacture of Adeno-Associated Viral Vectors; 21 Lentivirus Vector Manufacturing SAFETY AND REGULATORY CONSIDERATIONS 22 Assays for the Release of Viral Vector Gene Therapy Products for Human Clinical Trials; 23 Safety of Retroviral Vectors: Regulatory and Technical Considerations; 24 Assays for the Quality Control of Lentiviral Vectors; 25 Assays for Nonviral Vectors; 26 Assays for the Release of Cellular Gene Therapy Products; 27 Toxicology for Gene Therapy Products: Concepts and Challenges; 28 Regulatory Aspects of Gene Therapy Medicinal Products in the European Union; FINANCE AND REIMBURSEMENT; 29 Venture Capital and Biotechnology Startups 30 The Role of Investment Banking in the Growth of Biotechnology Companies 31 Managing Reimbursement for Gene Therapy Products; INDEX |
| Record Nr. | UNINA-9910823323803321 |
| Hoboken, N.J., : Wiley-Liss, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The CRISPR/Cas system : emerging technology and application / / edited by Muhammad Jamal
| The CRISPR/Cas system : emerging technology and application / / edited by Muhammad Jamal |
| Pubbl/distr/stampa | Norfolk, UK : , : Caister Academic Press, , [2017] |
| Descrizione fisica | 1 online resource (122 pages) |
| Disciplina | 660.65 |
| Soggetto topico |
Genetic engineering
Gene therapy Molecular genetics |
| Soggetto genere / forma | Electronic books. |
| ISBN | 1-910190-64-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910465921803321 |
| Norfolk, UK : , : Caister Academic Press, , [2017] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The CRISPR/Cas system : emerging technology and application / / edited by Muhammad Jamal
| The CRISPR/Cas system : emerging technology and application / / edited by Muhammad Jamal |
| Pubbl/distr/stampa | Norfolk, UK : , : Caister Academic Press, , [2017] |
| Descrizione fisica | 1 online resource (122 pages) |
| Disciplina | 660.65 |
| Soggetto topico |
Genetic engineering
Gene therapy Molecular genetics |
| ISBN | 1-910190-64-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910792843903321 |
| Norfolk, UK : , : Caister Academic Press, , [2017] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The CRISPR/Cas system : emerging technology and application / / edited by Muhammad Jamal
| The CRISPR/Cas system : emerging technology and application / / edited by Muhammad Jamal |
| Pubbl/distr/stampa | Norfolk, UK : , : Caister Academic Press, , [2017] |
| Descrizione fisica | 1 online resource (122 pages) |
| Disciplina | 660.65 |
| Soggetto topico |
Genetic engineering
Gene therapy Molecular genetics |
| ISBN | 1-910190-64-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910825767103321 |
| Norfolk, UK : , : Caister Academic Press, , [2017] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Current Strategies in Cancer Gene Therapy [[electronic resource] /] / edited by Wolfgang Walther
| Current Strategies in Cancer Gene Therapy [[electronic resource] /] / edited by Wolfgang Walther |
| Edizione | [1st ed. 2016.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 |
| Descrizione fisica | 1 online resource (124 pages) : color illustrations |
| Disciplina | 610 |
| Collana | Recent Results in Cancer Research |
| Soggetto topico |
Oncology
Cancer research Gene therapy Oncology Cancer Research Gene Therapy |
| ISBN | 3-319-42934-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Cancer Gene therapy trials worldwide -- Viral vectors for cancer gene therapy -- Nonviral vectors for cancer gene therapy -- Delivery systems for cancer gene therapy -- Targeted vectors for cancer gene therapy -- Current strategies for cancer suicide gene therapy -- Stem cell guided gene therapy for cancer -- Gene replacement therapy to treat cancer -- miRNA for cancer gene therapy -- Gene suppression gene therapy for cancer -- Recent developments in oncolytic virus therapy -- DNA vaccination for cancer therapy -- mRNA based cancer vaccines -- Engineered T-cells to treat cancer -- Gene therapy for overcoming drug resistance. |
| Record Nr. | UNINA-9910160262403321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cytokines, cellular & molecular therapy
| Cytokines, cellular & molecular therapy |
| Pubbl/distr/stampa | [London], : Martin Dunitz Ltd |
| Disciplina | 616.079 |
| Soggetto topico |
Cytokines - Therapeutic use
Gene therapy Genetic Therapy |
| Soggetto genere / forma |
Periodical
Fulltext Internet Resources. Periodicals. |
| ISSN | 1471-177X |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Cytokines, cellular, and molecular therapy |
| Record Nr. | UNINA-9910154528503321 |
| [London], : Martin Dunitz Ltd | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Digestive System Diseases [[electronic resource] ] : Stem Cell Mechanisms and Therapies / / edited by Maria Gazouli, George E. Theodoropoulos
| Digestive System Diseases [[electronic resource] ] : Stem Cell Mechanisms and Therapies / / edited by Maria Gazouli, George E. Theodoropoulos |
| Edizione | [1st ed. 2019.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Humana, , 2019 |
| Descrizione fisica | 1 online resource (194 pages) |
| Disciplina | 616.3 |
| Collana | Stem Cell Biology and Regenerative Medicine |
| Soggetto topico |
Stem cells
Gene therapy Cancer research Gastroenterology Stem Cells Gene Therapy Cancer Research Gastroenterology |
| ISBN | 3-030-11965-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1. Introduction -- 2. Stem cells principles and biology -- 3. The truth behind esophagus: the stem cells significance -- 4. Pancreatic Diseases: The Role of Stem Cells -- 5. Stem cells therapy for liver diseases -- 6. The role of stem cells in colorectal cancer carcinogenesis and treatment -- 7. THE ROLE OF STEM CELLS IN THE TREATMENT OF ANAL FISTULAS -- 8. Stem cells in inflammatory bowel disease: From pathogenesis to clinical practice -- 9. Paneth Cells Physiology and Pathophysiology in Inflammatory Bowel Disease. |
| Record Nr. | UNINA-9910337956503321 |
| Cham : , : Springer International Publishing : , : Imprint : Humana, , 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
DNA pharmaceuticals [[electronic resource] ] : formulation and delivery in gene therapy, DNA vaccination and immunotherapy / / edited by Martin Schleef
| DNA pharmaceuticals [[electronic resource] ] : formulation and delivery in gene therapy, DNA vaccination and immunotherapy / / edited by Martin Schleef |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2005 |
| Descrizione fisica | 1 online resource (277 p.) |
| Disciplina |
615.372
616.0796 |
| Altri autori (Persone) | SchleefM (Martin) |
| Soggetto topico |
DNA vaccines
Gene therapy Immunotherapy |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-85409-X
9786610854097 3-527-60753-6 3-527-60700-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
DNA Pharmaceuticals; Preface; Contents; List of Contributors; Abbreviations; 1 DNA Vaccines - An Overview; 1.1 Rationale for DNA Vaccines; 1.2 Preclinical Proof of Concept; 1.3 Clinical Trials; 1.4 Second-Generation Vaccines; 1.5 Conclusions; References; 2 DNA as a Pharmaceutical - Regulatory Aspects; 2.1 Introduction; 2.2 Quality Requirements for DNA used as a Gene Therapy Product; 2.2.1 Introduction; 2.2.2 Production and Purification; 2.2.2.1 Raw Materials; 2.2.2.2 Antibiotics; 2.2.2.3 Solvents; 2.2.2.4 Fermentation; 2.2.2.5 Purification; 2.2.3 Cell Banking System Procedures
2.2.3.1 Generation and Characterization of Master and Working Cell Banks2.2.4 Product Characterization and Quality Criteria; 2.2.4.1 Identity; 2.2.4.2 Purity; 2.2.4.3 Adventitious Agents; 2.2.4.4 Potency; 2.3 Safety Studies for Clinical Trials; 2.3.1 General Considerations; 2.3.2 Conduct of Preclinical Safety Studies; 2.3.2.1 Regulations; 2.3.2.2 Design of an Appropriate Toxicology Program; 2.3.2.3 Single- and Repeat-Dose Toxicity Studies; 2.3.2.4 Safety of the Formulated Plasmid DNA; 2.3.2.5 Specific Safety Considerations; 2.3.2.6 Choice of Animal Model; 2.4 Special Issues 2.4.1 Comparability of Plasmid Gene Therapy Products2.4.2 Mixed Plasmid Preparations; 2.4.3 Plasmid Molecular Structure; 2.5 Biosafety Issues and Environmental Risk Assessment; References; 3 From Bulk to Delivery: Plasmid Manufacturing and Storage; 3.1 Introduction; 3.1.1 Gene Therapy; 3.1.2 DNA Vaccination; 3.2 Manufacturing of Plasmid DNA; 3.2.1 Bacterial Cultivation; 3.2.2 Plasmid DNA Purification; 3.2.3 Innovative Aspects in Plasmid Manufacturing; 3.3 Quality Control of Plasmid DNA Vectors; 3.3.1 Proteins, Ribonucleic Acid, and Lipopolysaccharides; 3.3.2 Chromosomal DNA 3.3.3 Plasmid Identity3.3.4 Plasmid Topology (Structural Homogeneity); 3.4 Plasmid Stability during Storage and Application; 3.4.1 Long-Term Stability of Plasmid DNA; 3.4.2 Lyophilization for Long-Term Storage; 3.4.3 Stability during Application; 3.5 Future Developments; References; 4 Minimized, CpG-Depleted, and Methylated DNA Vectors: Towards Perfection in Nonviral Gene Therapy; 4.1 Introduction; 4.2 The Mammalian Immune System as a Barrier to Nonviral Gene Delivery; 4.3 Strategies to Minimize DNA Vectors 4.3.1 Excision of a DNA Fragment Containing a Transgene Expression Cassette from Plasmid DNA4.3.2 Intramolecular Site-Specific Recombination Within a Bacterial Plasmid; 4.3.3 Synthesis of Minimized DNA Vectors by PCR; 4.3.4 Improvement of Minimized DNA Vector Yield and Purity; 4.4 Depletion of CpG Dinucleotides in the Bacterial Vector Backbone; 4.5 Methylation of CpG Dinucleotides in Plasmid DNA; 4.6 Towards an Ideal Nonviral Vector; 4.7 Conclusion; References; 5 Localized Nucleic Acid Delivery: A Discussion of Selected Methods; 5.1 Foreword; 5.2 Nucleic Acid Delivery - What For? 5.3 Nucleic Acid Delivery - How? |
| Record Nr. | UNINA-9910144557003321 |
| Weinheim, : Wiley-VCH, c2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Soggetto topico
-
Gene therapy
(140)
- Gene Therapy (53)
- Genetic Therapy (22)
- Regenerative Medicine/Tissue Engineering (14)
- Regenerative medicine (14)