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Plasmids for therapy and vaccination [[electronic resource] /] / edited by M. Schleef
| Plasmids for therapy and vaccination [[electronic resource] /] / edited by M. Schleef |
| Pubbl/distr/stampa | Weinheim ; ; New York, : Wiley-VCH, c2001 |
| Descrizione fisica | 1 online resource (308 p.) |
| Disciplina |
615.32
615.372 |
| Altri autori (Persone) | SchleefM (Martin) |
| Soggetto topico |
DNA vaccines
Gene therapy Plasmids |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-76398-5
9786611763985 3-527-61283-1 3-527-61284-X |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Plasmids for Therapy and Vaccination; Preface; Contents; List of Contributors; 1 The Biology of Plasmids; 1 Introduction: What are plasmids?; 2 General properties of plasmids; 2.1 Plasmid replication and its control; 2.2 The molecular basis of incompatibility; 2.3 Plasmid inheritance; 2.4 Mechanisms of plasmid spread; 2.4.1 Conjugation in gram-negative bacteria; 2.4.2 Conjugation in gram-positive bacteria; 3 Plasmid-encoded phenotypes; 3.1 Bacteriocin production and resistance; 3.2 The Ti plasmids; 3.3 Heavy metal resistance; 3.4 Other phenotypical traits
4 The clinical importance of plasmids4.1 The spread of antibiotic resistance and the evolution of multiple antibiotic resistance; 4.2 Transfer of antibiotic resistance genes; 4.3 Mechanisms of antibiotic resistance; 4.4 Bacterial virulence genes; 5 Plasmid cloning vectors; 6 Perspectives; References; 2 Structures of Plasmid DNA; 1 Introduction; 2 Topological structures of plasmids; 3 Supercoiling of DNA; 4 DNA intercalating dyes; 5 Analysis of plasmid structures; 5.1 Electron microscopy (EM); 5.2 Agarose gel electrophoresis (AGE); 5.3 Capillary gel electrophoresis (CGE) 5.4 Analytical chromatography6 Conclusion; References; 3 Genetic Vaccination with Plasmid Vectors; 1 Introduction; 2 Vector design; 2.1 Plasmid DNA; 2.2 Construction of simple transcription units; 2.3 Construction of complex transcription units; 3 Strategies for DNA delivery; 4 Priming humoral and cellular immune responses by DNA vaccines; 5 Experimental strategies facilitated by DNA vaccination; 6 Unique advantages of DNA vaccination; 7 DNA vaccines in preclinical animal models; 7.1 DNA vaccines to control infectious diseases; 7.2 Therapeutic tumor vaccines; 7.3 Autoimmune disease 7.4 Treatment of allergy by therapeutic DNA vaccination8 Proposed clinical applications of DNA vaccines; 9 Risks of nucleic acid vaccination; 10 Future perspectives; References; 4 A Liposomal iNOS-Gene Therapy Approach to Prevent Neointimal Lesion Formation in Porcine Femoral Arteries; 1 Introduction; 2 Results and discussion; 2.1 Therapeutic plasmid; 2.2 The gene therapy product has a clinically acceptable format; 2.3 Efficient gene transfer was established in a minipig femoral artery injury model; 2.4 Transfection efficiency is dose dependent 2.5 Non-viral iNOS gene transfer efficiently inhibits neointimal lesion formation3 Summary and perspectives; References; 5 lmmunotherapy of Chronic Hepatitis B by pCMV-S2.S DNA Vaccine; 1 Introduction; 1.1 Hepatitis B: the disease; 1.2 Hepatitis B: treatments; 1.3 Hepatitis B: immune response to infection; 1.4 What are DNA vaccines?; 1.5 Which DNA vaccines for hepatitis B?; 2 DNA vaccines for the prevention of hepatitis B; 2.1 The mouse model; 2.1.1 Humoral response; 2.1.2 Cell-mediated response; 2.1.3 Mechanisms of DNA-induced immune response to HBsAg; 2.1.4 The primate model 2.1.5 DNA-based vaccination of chimpanzees against HBV |
| Record Nr. | UNINA-9910144561703321 |
| Weinheim ; ; New York, : Wiley-VCH, c2001 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Plasmids for therapy and vaccination [[electronic resource] /] / edited by M. Schleef
| Plasmids for therapy and vaccination [[electronic resource] /] / edited by M. Schleef |
| Pubbl/distr/stampa | Weinheim ; ; New York, : Wiley-VCH, c2001 |
| Descrizione fisica | 1 online resource (308 p.) |
| Disciplina |
615.32
615.372 |
| Altri autori (Persone) | SchleefM (Martin) |
| Soggetto topico |
DNA vaccines
Gene therapy Plasmids |
| ISBN |
1-281-76398-5
9786611763985 3-527-61283-1 3-527-61284-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Plasmids for Therapy and Vaccination; Preface; Contents; List of Contributors; 1 The Biology of Plasmids; 1 Introduction: What are plasmids?; 2 General properties of plasmids; 2.1 Plasmid replication and its control; 2.2 The molecular basis of incompatibility; 2.3 Plasmid inheritance; 2.4 Mechanisms of plasmid spread; 2.4.1 Conjugation in gram-negative bacteria; 2.4.2 Conjugation in gram-positive bacteria; 3 Plasmid-encoded phenotypes; 3.1 Bacteriocin production and resistance; 3.2 The Ti plasmids; 3.3 Heavy metal resistance; 3.4 Other phenotypical traits
4 The clinical importance of plasmids4.1 The spread of antibiotic resistance and the evolution of multiple antibiotic resistance; 4.2 Transfer of antibiotic resistance genes; 4.3 Mechanisms of antibiotic resistance; 4.4 Bacterial virulence genes; 5 Plasmid cloning vectors; 6 Perspectives; References; 2 Structures of Plasmid DNA; 1 Introduction; 2 Topological structures of plasmids; 3 Supercoiling of DNA; 4 DNA intercalating dyes; 5 Analysis of plasmid structures; 5.1 Electron microscopy (EM); 5.2 Agarose gel electrophoresis (AGE); 5.3 Capillary gel electrophoresis (CGE) 5.4 Analytical chromatography6 Conclusion; References; 3 Genetic Vaccination with Plasmid Vectors; 1 Introduction; 2 Vector design; 2.1 Plasmid DNA; 2.2 Construction of simple transcription units; 2.3 Construction of complex transcription units; 3 Strategies for DNA delivery; 4 Priming humoral and cellular immune responses by DNA vaccines; 5 Experimental strategies facilitated by DNA vaccination; 6 Unique advantages of DNA vaccination; 7 DNA vaccines in preclinical animal models; 7.1 DNA vaccines to control infectious diseases; 7.2 Therapeutic tumor vaccines; 7.3 Autoimmune disease 7.4 Treatment of allergy by therapeutic DNA vaccination8 Proposed clinical applications of DNA vaccines; 9 Risks of nucleic acid vaccination; 10 Future perspectives; References; 4 A Liposomal iNOS-Gene Therapy Approach to Prevent Neointimal Lesion Formation in Porcine Femoral Arteries; 1 Introduction; 2 Results and discussion; 2.1 Therapeutic plasmid; 2.2 The gene therapy product has a clinically acceptable format; 2.3 Efficient gene transfer was established in a minipig femoral artery injury model; 2.4 Transfection efficiency is dose dependent 2.5 Non-viral iNOS gene transfer efficiently inhibits neointimal lesion formation3 Summary and perspectives; References; 5 lmmunotherapy of Chronic Hepatitis B by pCMV-S2.S DNA Vaccine; 1 Introduction; 1.1 Hepatitis B: the disease; 1.2 Hepatitis B: treatments; 1.3 Hepatitis B: immune response to infection; 1.4 What are DNA vaccines?; 1.5 Which DNA vaccines for hepatitis B?; 2 DNA vaccines for the prevention of hepatitis B; 2.1 The mouse model; 2.1.1 Humoral response; 2.1.2 Cell-mediated response; 2.1.3 Mechanisms of DNA-induced immune response to HBsAg; 2.1.4 The primate model 2.1.5 DNA-based vaccination of chimpanzees against HBV |
| Record Nr. | UNINA-9910830465703321 |
| Weinheim ; ; New York, : Wiley-VCH, c2001 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Plasmids for therapy and vaccination [[electronic resource] /] / edited by M. Schleef
| Plasmids for therapy and vaccination [[electronic resource] /] / edited by M. Schleef |
| Pubbl/distr/stampa | Weinheim ; ; New York, : Wiley-VCH, c2001 |
| Descrizione fisica | 1 online resource (308 p.) |
| Disciplina |
615.32
615.372 |
| Altri autori (Persone) | SchleefM (Martin) |
| Soggetto topico |
DNA vaccines
Gene therapy Plasmids |
| ISBN |
1-281-76398-5
9786611763985 3-527-61283-1 3-527-61284-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Plasmids for Therapy and Vaccination; Preface; Contents; List of Contributors; 1 The Biology of Plasmids; 1 Introduction: What are plasmids?; 2 General properties of plasmids; 2.1 Plasmid replication and its control; 2.2 The molecular basis of incompatibility; 2.3 Plasmid inheritance; 2.4 Mechanisms of plasmid spread; 2.4.1 Conjugation in gram-negative bacteria; 2.4.2 Conjugation in gram-positive bacteria; 3 Plasmid-encoded phenotypes; 3.1 Bacteriocin production and resistance; 3.2 The Ti plasmids; 3.3 Heavy metal resistance; 3.4 Other phenotypical traits
4 The clinical importance of plasmids4.1 The spread of antibiotic resistance and the evolution of multiple antibiotic resistance; 4.2 Transfer of antibiotic resistance genes; 4.3 Mechanisms of antibiotic resistance; 4.4 Bacterial virulence genes; 5 Plasmid cloning vectors; 6 Perspectives; References; 2 Structures of Plasmid DNA; 1 Introduction; 2 Topological structures of plasmids; 3 Supercoiling of DNA; 4 DNA intercalating dyes; 5 Analysis of plasmid structures; 5.1 Electron microscopy (EM); 5.2 Agarose gel electrophoresis (AGE); 5.3 Capillary gel electrophoresis (CGE) 5.4 Analytical chromatography6 Conclusion; References; 3 Genetic Vaccination with Plasmid Vectors; 1 Introduction; 2 Vector design; 2.1 Plasmid DNA; 2.2 Construction of simple transcription units; 2.3 Construction of complex transcription units; 3 Strategies for DNA delivery; 4 Priming humoral and cellular immune responses by DNA vaccines; 5 Experimental strategies facilitated by DNA vaccination; 6 Unique advantages of DNA vaccination; 7 DNA vaccines in preclinical animal models; 7.1 DNA vaccines to control infectious diseases; 7.2 Therapeutic tumor vaccines; 7.3 Autoimmune disease 7.4 Treatment of allergy by therapeutic DNA vaccination8 Proposed clinical applications of DNA vaccines; 9 Risks of nucleic acid vaccination; 10 Future perspectives; References; 4 A Liposomal iNOS-Gene Therapy Approach to Prevent Neointimal Lesion Formation in Porcine Femoral Arteries; 1 Introduction; 2 Results and discussion; 2.1 Therapeutic plasmid; 2.2 The gene therapy product has a clinically acceptable format; 2.3 Efficient gene transfer was established in a minipig femoral artery injury model; 2.4 Transfection efficiency is dose dependent 2.5 Non-viral iNOS gene transfer efficiently inhibits neointimal lesion formation3 Summary and perspectives; References; 5 lmmunotherapy of Chronic Hepatitis B by pCMV-S2.S DNA Vaccine; 1 Introduction; 1.1 Hepatitis B: the disease; 1.2 Hepatitis B: treatments; 1.3 Hepatitis B: immune response to infection; 1.4 What are DNA vaccines?; 1.5 Which DNA vaccines for hepatitis B?; 2 DNA vaccines for the prevention of hepatitis B; 2.1 The mouse model; 2.1.1 Humoral response; 2.1.2 Cell-mediated response; 2.1.3 Mechanisms of DNA-induced immune response to HBsAg; 2.1.4 The primate model 2.1.5 DNA-based vaccination of chimpanzees against HBV |
| Record Nr. | UNINA-9910840769403321 |
| Weinheim ; ; New York, : Wiley-VCH, c2001 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Proteomic Methods in Neuropsychiatric Research [[electronic resource] /] / edited by Paul C. Guest
| Proteomic Methods in Neuropsychiatric Research [[electronic resource] /] / edited by Paul C. Guest |
| Edizione | [1st ed. 2017.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017 |
| Descrizione fisica | 1 online resource (XII, 370 p. 55 illus., 45 illus. in color.) |
| Disciplina | 572.6 |
| Collana | Proteomics, Metabolomics, Interactomics and Systems Biology |
| Soggetto topico |
Proteomics
Gene expression Gene therapy Gene Expression Gene Therapy |
| ISBN | 3-319-52479-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Preface – Proteomic studies in psychiatric disease and neurological disorders -- Part 1: REVIEWS -- Application of proteomic techniques for improved stratification and treatment of schizophrenia patients -- Multiplexing biomarker methods, proteomics and considerations for Alzheimer’s disease -- What have proteomic studies taught us about novel drug targets in autism? -- Application of proteomic approaches to accelerate drug development for psychiatric disorders -- Proteomic biomarker identification in cerebrospinal fluid for leptomeningeal metastases with neurological complications -- Connecting brain proteomics with behavioural neuroscience in translational animal models of neuropsychiatric disorders -- LC-MSE for qualitative and quantitative proteomicstudies of psychiatric disorders -- The utility of multiplex assays for identification of proteomic signatures in psychiatry -- Part 2: PROTOCOLS -- Blood sampling and preparation procedures for proteomic biomarker studies of psychiatric disorders -- Multiplex immunoassay profiling of serum in psychiatric disorders -- Sequential immunopreciptation of secretory vesicle proteins from biosynthetically-labelled cells -- 2d gel electrophoresis of insulin secretory granule proteins from biosynthetically-labelled pancreatic islets -- Two-dimensional gel electrophoresis: a reference protocol -- A two-dimensional difference gel electrophoresis (2D-DIGE) protocol for studies of neural precursor cells -- Identifying biomarker candidates in the blood plasma or serum proteome -- Selective reaction monitoring mass spectrometry for quantitation of glycolytic enzymes in post-mortem brain samples -- A selected reaction monitoring mass spectrometry protocol for validation of proteomic biomarker candidates in studies of psychiatric disorders -- Application of iTRAQ shotgun proteomics for measurement of brain proteins in studies of psychiatric disorders -- Co-immunoprecipitation for deciphering protein interactomes -- Sequential co-immunopreciptation and immunoblot approach to determine oligomerisation of G-protein coupled receptors -- A protocol for producing the maternal low protein rat model: a tool for pre-clinical proteomic studies -- A clinical study protocol to identify serum biomarkers predictive of response to antipsychotics in schizophrenia patients -- Generation of the acute phencyclidine rat model for proteomic studies of schizophrenia A protocol for generation of a corticosterone model of psychiatric disorders -- MK-801-treated oligodendrocytes as a cellular model to study schizophrenia -- Combining patient-reprogrammed neural cells and proteomics as a model to study psychiatric disorders -- SILAC mass spectrometry profiling: a psychiatric disorder perspective -- Preparation of peripheral blood mononuclear cells (PBMCs) as a model for proteomic studies psychiatric disorders -- Proteomic profiling of skin fibroblasts as a model of schizophrenia Proteomic profiling of the pituitary gland in studies of psychiatric disorders -- Development of an assay for measuring proprotein-conversion activity on a multiplex magnetic bead-based array platform -- Phenotyping multiple subsets of immune cells in situ in formalin-fixed, paraffin-embedded tissue sections -- Lab-on-a-chip proteomic assays for psychiatric disorders -- Development of a user-friendly app for testing blood coagulation status in schizophrenia patients -- Part 3:FUTURE PERSPECTIVES -- Proteomic approaches to enable point-of-care testing and personalized medicine for psychiatric disorders. |
| Record Nr. | UNINA-9910253912303321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Regenerative Medicine for the Inner Ear [[electronic resource] /] / edited by Juichi Ito
| Regenerative Medicine for the Inner Ear [[electronic resource] /] / edited by Juichi Ito |
| Edizione | [1st ed. 2014.] |
| Pubbl/distr/stampa | Tokyo : , : Springer Japan : , : Imprint : Springer, , 2014 |
| Descrizione fisica | 1 online resource (311 p.) |
| Disciplina | 617.882 |
| Soggetto topico |
Otorhinolaryngology
Regenerative medicine Tissue engineering Otolaryngologic surgery Gene therapy Neurosciences Regenerative Medicine/Tissue Engineering Head and Neck Surgery Gene Therapy |
| ISBN | 4-431-54862-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Part I Targets of Regenerative Medicine for the Inner Ear -- 1 Anatomy of the Inner Ear -- 2 Therapeutic Targets and Possible Strategies for Regenerative Medicine for the Inner Ear -- 3 Hair cell -- 4 Stereocilia -- 5 Cochlear Lateral Wall -- 6 Spiral Ganglion Cell and Auditory Neuron -- 7 Synaptic Contacts between Hair Cells and Primary Neurons -- 8 Otolith -- 9 Tectorial membrane -- Part II Development of the Inner Ear -- 10 Development and regeneration -- 11 Otic Induction -- 12 Cochlear Development -- 13 Vestibular Development -- Part III Cochlear Implants -- 14 Cochlear Implant: Past, Present and Future.- 15 Recent Progress in Cochlear Implant -- 16 Regenerative medicine in cochlear implantation -- 17 Artificial cochlear epithelium -- 18 Auditory Brainstem Implant -- Part IV Hair Cell Regeneration -- 19 Hair Cell Regeneration in the Avian -- 20 Self Repair -- 21 Transdifferentiation -- 22 Dedifferentiation‐mediated Regeneration -- 23 Gene Therapy -- 24 Cell Therapy -- Part V Spiral Ganglion Neuron Regeneration -- 25 Clinical Background -- 26 SGN development -- 27 Gene Therapy for Regeneration and Preservation of Spinal Ganglion Neurons -- 28 Cell therapy -- 29 Afferent dendrite and axon -- Part VI Stem Cells -- 30 Inner ear stem cells -- 31 Pluripotent Stem Cells -- 32 Somatic Stem Cells -- Part VII Future Perspective -- 33 Regenerative Medicine for the Inner Ear ‐ Summary. |
| Record Nr. | UNINA-9910300342503321 |
| Tokyo : , : Springer Japan : , : Imprint : Springer, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Regulatory Aspects of Gene Therapy and Cell Therapy Products [[electronic resource] ] : A Global Perspective / / edited by Maria Cristina Galli, Mercedes Serabian
| Regulatory Aspects of Gene Therapy and Cell Therapy Products [[electronic resource] ] : A Global Perspective / / edited by Maria Cristina Galli, Mercedes Serabian |
| Edizione | [1st ed. 2015.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015 |
| Descrizione fisica | 1 online resource (235 p.) |
| Disciplina | 616.042 |
| Collana | American Society of Gene & Cell Therapy |
| Soggetto topico |
Gene therapy
Gene Therapy |
| ISBN | 3-319-18618-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1. Regulatory Oversight of Gene Therapy and Cell Therapy Products in the US - FDA/CBER -- 2. US Oversight of Gene Therapy Products – NIH RAC -- 3. Regulatory Oversight of Gene Therapy and Cell Therapy Products in Canada - Health Canada -- 4. Overview of the Regulatory Oversight Implemented by the French Regulatory Authorities for the Clinical Investigation of Gene Therapy and Cell Therapy Products -- 5. Regulation of Clinical Trials with Advanced Therapy Medicinal Products (ATMP) in Germany -- 6. EU Clinical Trials Regulatory Oversight of Advanced Therapy Medicinal Products (ATMP): Perspectives from Various Member States -- 7. Regulatory Oversight of Gene Therapy and Cell Therapy Products in Switzerland - Swissmedic -- 8. Regulatory Oversight of Gene Therapy and Cell Therapy Products in Japan - Japan Ministry of Health, Labour and Welfare (MHLW) and Pharmaceutical and Medical Device Agency (PMDA) -- 9. Regulatory Oversight of Gene Therapy and Cell Therapy Products in Korea - Korean Ministry of Food and Drug Safety (MFDS) -- 10. Regulatory Oversight of Gene Therapy and Cell Therapy Products in Taiwan - Taiwan Food and Drug Administration (TFDA) -- 11. Regulatory Oversight of Gene Therapy and Cell Therapy Products in Singapore - Singapore Health Science Authorities (HSA) -- 12. Regulatory Oversight of Gene Therapy and Cell Therapy Products in Brazil - National Health Surveillance Agency (ANVISA). |
| Record Nr. | UNINA-9910298453303321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Retinal Degenerative Diseases [[electronic resource] ] : Mechanisms and Experimental Therapy / / edited by John D. Ash, Christian Grimm, Joe G. Hollyfield, Robert E. Anderson, Matthew M. LaVail, Catherine Bowes Rickman
| Retinal Degenerative Diseases [[electronic resource] ] : Mechanisms and Experimental Therapy / / edited by John D. Ash, Christian Grimm, Joe G. Hollyfield, Robert E. Anderson, Matthew M. LaVail, Catherine Bowes Rickman |
| Edizione | [1st ed. 2014.] |
| Pubbl/distr/stampa | New York, NY : , : Springer New York : , : Imprint : Springer, , 2014 |
| Descrizione fisica | 1 online resource (841 p.) |
| Disciplina | 617.7/35 |
| Collana | Advances in Experimental Medicine and Biology |
| Soggetto topico |
Ophthalmology
Neurosciences Geriatrics Human genetics Gene therapy Geriatrics/Gerontology Human Genetics Gene Therapy |
| ISBN | 1-4614-3209-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
""Preface""; ""Travel Awards""; ""Contents""; ""Contributors""; ""About the Editors""; ""Part I""; ""Basic Processes: Development, Physiology and Function""; ""Chapter-1""; ""Cell Type-Specific Epigenetic Signatures Accompany Late Stages of Mouse Retina Development""; ""References""; ""Chapter-2""; ""Programmed Cell Death During Retinal Development of the Mouse Eye""; ""2.1 Introduction""; ""2.2 Programmed Cell Death in the Mouse Retina""; ""2.3 Neurotrophins""; ""2.4 Signaling Mechanisms During Programmed Cell Death of the Mouse Retina""; ""References ""; ""Chapter-3""
""4.2 Materials and Methods""""4.2.1 Experiment with Animals""; ""4.2.2 Light Exposure""; ""4.2.3 Immunohistochemistry""; ""4.2.4 Western Blot Analysis""; ""4.3 Results""; ""4.3.1 GSTP1 Expression in Retina Accompanied Murine Retinal Maturation""; ""4.3.2 GSTP1 Levels in Murine Retina Increased with Developmental Age and with Light Exposure""; ""4.4 Discussion""; ""References""; ""Chapter-5""; ""RETINA-Specific Expression of Kcnv2 Is Controlled by Cone-Rod Homeobox (Crx) and Neural Retina Leucine Zipper (Nrl)""; ""5.1 Introduction""; ""5.2 Materials and Methods""; ""5.2.1 Mouse Husbandry"" ""5.2.2 DNA Constructs""""5.2.3 RNA-Isolation, RT-PCR and qRT-PCR""; ""5.2.4 Bioinformatic Analysis""; ""5.2.5 Chromatin Immunoprecipitation""; ""5.2.6 Electroporation of Mouse Retinas""; ""5.3 Results""; ""5.3.1 Kcnv2 is Highly Expressed in the Murine Retina""; ""5.3.2 Kcnv2 Localizes to Inner Segment Membranes of Photoreceptors""; ""5.3.3 Retinal Kcnv2 Expression Is Regulated by Crx and Nrl""; ""5.4 Discussion""; ""References""; ""Chapter-6""; ""AIPL1 Protein and its Indispensable Role in Cone Photoreceptor Function and Survival""; ""6.1 Introduction"" ""6.2 Animal Models of AIPL1 Deficiency""""6.3 Link Between AIPL1 and Rod PDE6""; ""6.4 AIPL1 in Mouse Cones""; ""6.5 AIPL1 in Primate Cones""; ""6.6 Conclusions and Future Directions""; ""References""; ""Chapter-7 ""; ""Primate Short-Wavelength Cones Share Molecular Markers with Rods""; ""7.1 Introduction""; ""7.2 Materials and Methods""; ""7.2.1 Tissue""; ""7.2.2 Immunohistochemical (IHC) Staining""; ""7.3 Results""; ""7.3.1 Cone Arr4 (Pab LUMIf; Mab 7G6)""; ""7.3.2 Rod Arr1 (S-Antigen; Mab D9F2; Pab C10C10)""; ""7.3.3 Cone Alpha Transducin (CTr; Mab A1.1)"" ""7.3.4 Rod Transducin (RTr |
| Record Nr. | UNINA-9910300337203321 |
| New York, NY : , : Springer New York : , : Imprint : Springer, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Safety and Efficacy of Gene-Based Therapeutics for Inherited Disorders [[electronic resource] /] / edited by Nicola Brunetti-Pierri
| Safety and Efficacy of Gene-Based Therapeutics for Inherited Disorders [[electronic resource] /] / edited by Nicola Brunetti-Pierri |
| Edizione | [1st ed. 2017.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017 |
| Descrizione fisica | 1 online resource (IX, 220 p. 32 illus., 19 illus. in color.) |
| Disciplina | 615 |
| Soggetto topico |
Pharmacology
Gene therapy Molecular biology Pharmacology/Toxicology Gene Therapy Molecular Medicine |
| ISBN | 3-319-53457-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Overview: gene transfer strategies, principles, applications -- Manufacturing viral gene therapy vectors: general approaches and challenges -- Retrovirus- and lentivirus-based vectors -- Preclinical and clinical applications of retroviral vectors -- Preclinical and clinical applications of lentiviral vectors -- Retrovirus and lentivirus integration -- Adenovirus-based vectors for gene therapy -- Adenoviral vector-host interactions -- Helper-dependent adenoviral vectors -- Gene therapy for cancer treatment -- Oncolytic adenoviruses for cancer treatment -- Vaccination by gene transfer vectors -- AAV vectors: general features and applications -- Adaptive immune response to viral vector delivery -- Herpes viruses: general features and applications -- RNA interference-based strategy for treatment of human diseases -- Antisense oligonucleotide based therapeutics -- Gene editing strategies -- Nonviral vectors. |
| Record Nr. | UNINA-9910253914203321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Seeking cures [[electronic resource] ] : design of therapies for genetically determined diseases / / Moyra Smith
| Seeking cures [[electronic resource] ] : design of therapies for genetically determined diseases / / Moyra Smith |
| Autore | Smith Moyra |
| Pubbl/distr/stampa | Oxford ; ; New York, : Oxford University Press, c2014 |
| Descrizione fisica | 1 online resource (311 p.) |
| Disciplina | 616/.042 |
| Soggetto topico |
Genetic disorders
Gene therapy |
| Soggetto genere / forma | Electronic books. |
| ISBN |
0-19-021309-4
0-19-991587-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Contents; Preface; Acknowledgments; 1. Introduction and History; 2. Therapy: Design and General Approaches; 3. Inborn Errors of Metabolism: Progress in Diagnosis and Treatment; 4. Lysosomal Storage Diseases and Therapies; 5. Mitochondrial Function, Defects, and Approaches to Treatment; 6. Protein Misfolding, Endoplasmic Reticulum Stress, and Pathogenesis of Disease; 7. Transporters and Solute Carriers: Proteins That Transport Molecules Across Membranes; 8. Advances in Therapy for Specific Monogenic Diseases; 9. Identifying Therapeutic Targets in Complex, Multifactorial Diseases
10. Approaches to Cancer Treatment11. Gene-Based Molecular Therapies; 12. Stem Cells and Induced Pluripotent Stem Cells; Epilogue (Envoi); References; Index; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; Q; R; S; T; U; V; W; X; Y; Z |
| Record Nr. | UNINA-9910452945503321 |
Smith Moyra
|
||
| Oxford ; ; New York, : Oxford University Press, c2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Seeking cures [[electronic resource] ] : design of therapies for genetically determined diseases / / Moyra Smith
| Seeking cures [[electronic resource] ] : design of therapies for genetically determined diseases / / Moyra Smith |
| Autore | Smith Moyra |
| Pubbl/distr/stampa | Oxford ; ; New York, : Oxford University Press, c2014 |
| Descrizione fisica | 1 online resource (311 p.) |
| Disciplina | 616/.042 |
| Soggetto topico |
Genetic disorders
Gene therapy |
| ISBN |
0-19-021309-4
0-19-991587-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Contents; Preface; Acknowledgments; 1. Introduction and History; 2. Therapy: Design and General Approaches; 3. Inborn Errors of Metabolism: Progress in Diagnosis and Treatment; 4. Lysosomal Storage Diseases and Therapies; 5. Mitochondrial Function, Defects, and Approaches to Treatment; 6. Protein Misfolding, Endoplasmic Reticulum Stress, and Pathogenesis of Disease; 7. Transporters and Solute Carriers: Proteins That Transport Molecules Across Membranes; 8. Advances in Therapy for Specific Monogenic Diseases; 9. Identifying Therapeutic Targets in Complex, Multifactorial Diseases
10. Approaches to Cancer Treatment11. Gene-Based Molecular Therapies; 12. Stem Cells and Induced Pluripotent Stem Cells; Epilogue (Envoi); References; Index; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; Q; R; S; T; U; V; W; X; Y; Z |
| Record Nr. | UNINA-9910779856903321 |
|
Smith Moyra
|
||
| Oxford ; ; New York, : Oxford University Press, c2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Soggetto topico
-
Gene therapy
(140)
- Gene Therapy (53)
- Genetic Therapy (22)
- Regenerative Medicine/Tissue Engineering (14)
- Regenerative medicine (14)