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MARC Lista (tabellare)
Restaurants and grocers reopening after hurricanes and flooding [[electronic resource]]
Restaurants and grocers reopening after hurricanes and flooding [[electronic resource]]
Edizione [Updated May 19, 2006 and Sept. 1, 2006.]
Pubbl/distr/stampa [College Park, Md.] : , : U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, , [2006]
Descrizione fisica 1 electronic text : HTML file
Soggetto topico Restaurants - Safety measures
Grocery trade - Safety measures
Food - Safety measures
Hurricanes - Safety measures
Floods - Safety measures
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910698039403321
[College Park, Md.] : , : U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, , [2006]
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Resumen de seguridad alimentaria [[electronic resource] ] : cómo protegerse a sí misma y a su bebé
Resumen de seguridad alimentaria [[electronic resource] ] : cómo protegerse a sí misma y a su bebé
Pubbl/distr/stampa [College Park, Md.] : , : [U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition], , [2005]
Descrizione fisica 2 unnumbered pages : digital, PDF file
Soggetto topico Pregnant women - Health and hygiene
Food - Safety measures
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione spa
Altri titoli varianti Cómo protegerse a sí misma y a su bebé
Record Nr. UNINA-9910695355803321
[College Park, Md.] : , : [U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition], , [2005]
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Risco alimentar
Risco alimentar
Autore Mafalda Miranda Barbosa
Pubbl/distr/stampa Coimbra University Press, 2017
Descrizione fisica 1 online resource (112 pages)
Disciplina 363.1926
Collana Instituto Jurídico
Soggetto topico Food - Safety measures
Food adulteration and inspection
ISBN 989-26-1407-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione por
Record Nr. UNINA-9910404228503321
Mafalda Miranda Barbosa  
Coimbra University Press, 2017
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Risk assessment of phytochemicals in food [[electronic resource] ] : novel approaches : symposium / / editors, DFG Senate Commission on Food Safety ; editorial committee, Gerhard Eisenbrand ... [et al.] ; scientists of the SKLM secretariat, Sabine Guth, Michael Habermeyer and Barbara Kochte-Clemens
Risk assessment of phytochemicals in food [[electronic resource] ] : novel approaches : symposium / / editors, DFG Senate Commission on Food Safety ; editorial committee, Gerhard Eisenbrand ... [et al.] ; scientists of the SKLM secretariat, Sabine Guth, Michael Habermeyer and Barbara Kochte-Clemens
Edizione [1st ed.]
Pubbl/distr/stampa Weinheim [Germany], : Wiley-VCH, 2010
Descrizione fisica 1 online resource (476 p. ) : ill. (some col.)
Disciplina 363.1922
Altri autori (Persone) EisenbrandGerhard
GuthSabine
HabermeyerMichael
Kochte-ClemensBarbara
Collana Forschungsberichte (DFG)
Soggetto topico Phytochemicals
Food - Safety measures
Soggetto genere / forma Electronic books.
ISBN 9786613302489
1-283-30248-9
3-527-63471-1
3-527-63470-3
3-527-63483-5
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Intro -- Title page -- copyright -- Vorwort -- Preface -- 1: Bericht und Schlussfolgerungen -- 1.1 Einleitung -- 1.2 Methodenübergreifende Aspekte -- 1.3 Methoden -- 1.4 Schlussfolgerungen und Empfehlungen -- 1.5 Fazit -- 2: Report and Conclusions -- 2.1 Preface -- 2.2 Transdisciplinary Aspects -- 2.3 Methodologies -- 2.4 Conclusions and Recommendations -- 2.5 Concluding Remarks -- 3: Contributions -- 3.1: Visions on Toxicity Testing in the 21st Century: Reflections on a Strategy Document of the US National Research Council -- 3.1.1 Introduction -- 3.1.2 A New Vision of Toxicity Testing -- 3.1.3 Testing the Vision -- 3.1.4 Steps toward a New Toxicology -- 3.1.5 The Precautionary Principle -- 3.1.6 The European Side -- 3.1.7 Tasks Ahead -- Acknowledgements -- Abbreviations and Glossary of Terms -- References -- 3.2: Safety Assessment of Botanicals and Botanical Preparations Used as Ingredients in Food Supplements: Testing an European Food Safety AuthorityTiered Approach -- 3.2.1 Introduction -- 3.2.2 Materials and Methods -- 3.2.3 Results -- 3.2.4 Discussion -- Acknowledgement -- References -- 3.3: In Silico Toxicology Screening of the Rodent Carcinogenic Potential of Phytochemicals Using Quantitative Structure-Activity Relationship Analysis -- 3.3.1 Introduction -- 3.3.2 Why Use In Silico Predictive Models at FDA? -- 3.3.3 What In Silico Predictive Models does the FDA Use? -- 3.3.4 What In Silico Predictive Software does the FDA Use? -- 3.3.5 Why Use In Silico Strategies as a Novel Approach to Assess Toxicity of Phytochemicals? -- 3.3.6 Prediction of Rodent Carcinogenicity of Phytochemicals in an External Validation Study -- 3.3.7 Conclusions -- Acknowledgements -- Conflict of Interest Statement -- References -- 3.4: Testing Computational Toxicology Models with Phytochemicals -- 3.4.1 Introduction -- 3.4.2 Materials and Methods -- 3.4.3 Results.
3.4.4 Discussion -- Acknowledgements -- Abbreviations -- Conflict of Interest Statement -- References -- 3.5: In Silico Models to Establish Level of Safety Concern in Absence of Sufficient Toxicological Data -- 3.5.1 Introduction -- 3.5.2 Computational Toxicology Models Relevant for the Food Sectors: Requirements -- 3.5.3 Available Computational Toxicology Models for Food Applications -- 3.5.4 Model Integration and Application -- 3.5.5 Computational Toxicology and Safety Assessment of Botanical Extracts -- 3.5.6 Discussion and Conclusion -- References -- 3.6: In Silico Methods for Physiologically Based Biokinetic (PBBK) Models Describing Bioactivation and Detoxification of Coumarin and Estragole: Implications for Risk Assessment -- 3.6.1 Introduction -- 3.6.2 Methods -- 3.6.3 Results -- 3.6.4 Discussion -- Acknowledgements -- Abbreviations -- Conflict of Interest Statement -- References -- 3.7: In Vitro Models for Carcinogenicity Testing Reality or Fantasy? -- 3.7.1 Introduction -- 3.7.2 BALB/c 3T3 Cell Transformation Assay -- 3.7.3 Automated Soft Agar Assay -- 3.7.4 Concluding Remarks -- Acknowledgments -- References -- 3.8: Carcinogen Specific Expression Profiling: Prediction of Carcinogenic Potential? -- 3.9: Safety and Biological Efficacy Testing of Phytochemicals: An Industry Approach -- 3.9.1 Introduction -- 3.9.2 Screening Process -- 3.9.3 Regulatory Pre-Clinical Safety -- 3.9.4 Overall Conclusion -- References -- 3.10: Metabolite Profiling in Rat Plasma as a Potential New Tool for the Assessment of Chemically Induced Toxicity -- 3.10.1 Introduction -- 3.10.2 Materials and Methods -- 3.10.3 Results and Discussion -- 3.10.4 Concluding Remarks -- Acknowledgements -- References -- 3.11: Profiling Techniques in Nutrition and Food Research -- Hannelore Daniel1 -- 3.11.1 Introduction.
3.11.2 Genomics Applications in Basic and Pre-Clinical Nutrition and Food Research -- 3.11.3 Profiling Technologies Applied in Human Studies -- 3.11.4 Evidence for a Significant Role of the Gut Microbiota in Human Responses to Dietary Interventions -- 3.11.5 Summary -- References -- 3.12: The Complex Links between Dietary Phytochemicals and Human Health Deciphered by Metabolomics -- 3.12.1 Introduction -- 3.12.2 Measuring Dietary Intake of Phytochemicals: Current Limitations -- 3.12.3 Biomarkers of Phytochemical Intake -- 3.12.4 Metabolomics and Biomarker Discovery -- 3.12.5 Metabolomics and Phytochemical Intake -- 3.12.6 Metabolomics and Biological Effects of Phytochemicals -- 3.12.7 Conclusion -- Acknowledgments -- Glossary4 -- Conflict of Interest Statement -- References -- 3.13: Anti-Oxidative and Antigenotoxic Properties of Vegetables and Dietary Phytochemicals: The Value of Genomics Biomarkers in Molecular Epidemiology -- 3.13.1 Introduction -- 3.13.2 Colorectal Cancer Risk Prevention by Vegetables -- 3.13.3 Gene Expression Modulation in the Colon by Vegetables and Phytochemicals -- 3.13.4 Genetic Polymorphisms and Anti-Oxidative Response -- 3.13.5 Risk-Benefit Analysis of Dietary Phytochemicals -- 3.13.6 Concluding Remarks -- References -- 3.14: The Japanese Toxicogenomics Project: Application of Toxicogenomics - Utilizing Toxicogenomics into Drug Safety Screening -- 3.14.1 Introduction -- 3.14.2 Current Status of Worldwide Toxicogenomics Database Creation -- 3.14.3 The Toxicogenomics Project in Japan -- 3.14.4 Application of Toxicogenomics -- 3.14.5 Future Perspectives -- Acknowledgements -- Conflict of Interest Statement -- References -- 3.15: Toxicology and Risk Assessment of Coumarin: Focus on Human Data -- 3.15.1 Introduction -- 3.15.2 Hazard of Coumarin -- 3.15.3 Human Exposure -- 3.15.4 Risk Assessment -- 3.15.5 Summary and Conclusion.
Abbreviations -- Conflict of Interest Statement -- References -- 3.16: Risk from Furocoumarins in Food? An Exposure Assessment -- 3.16.1 Introduction -- 3.16.2 Materials and Methods -- 3.16.3 Results and Discussion -- 3.16.4 Conclusions -- Acknowledgements -- References -- 3.17: Transcriptome Analysis in Benefit-Risk Assessment of Micronutrients and Bioactive Food Components -- 3.17.1 Introduction -- 3.17.2 Whole Genome Transcriptome Analysis as a Tool for Benefit-Risk Analysis -- 3.17.3 Data Confirmation by qRT-PCR -- 3.17.4 Magnitude of Micronutrient Effects -- 3.17.5 Data Interpretation -- 3.17.6 In Vivo and In Vitro Approaches -- 3.17.7 Animal Models and Diets -- 3.17.8 Sensitivity and Power -- 3.17.9 Conclusion -- Acknowledgements -- Conflict of Interest Statement -- References -- 3.18: Colorectal and Prostate Cancer: The Role of Candidate Genes in Nutritional Pathways -- 3.18.1 Selenium: Biologic Mechanisms of the Chemopreventive Effects of Selenium -- 3.18.3 Overall Evidence from Candidate-Gene Association Studies for Cancer -- References -- 3.19: Glucosinolates: DNA Adduct Formation In Vivo and Mutagenicity In Vitro -- 3.19.1 Introduction -- 3.19.2 Formation of DNA-Reactive Molecules in Plant Homogenates -- 3.19.3 Formation of DNA Adducts in Animals Fed with Broccoli -- 3.19.4 Elucidation of the Structure of Broccoli-Associated DNA Adducts and Identification of the Substances Involved -- 3.19.5 Mutagenicity of GLS-A -- 3.19.6 Conclusions and Perspectives -- Acknowledgements -- References -- 3.20: Defence Mechanisms against Toxic Phytochemicals in the Diet of Domestic Animals -- 3.20.1 Introduction -- 3.20.2 Polygastric Herbivory: Pre-Systemic Detoxification of Phytochemicals by the Rumen Microbiota -- 3.20.3 Monogastric Herbivory: Are Acquired Feeding Strategies Sufficiently Protective?.
3.20.4 Efflux Transporters: Functional Elements of the Intestinal Barrier -- 3.20.5 Pre-Systemic Elimination by Biotransformation -- 3.20.6 Transcriptional Regulation of Efflux Transporters and Biotransformation Enzymes -- 3.20.7 Carnivorous Species: When Plant Metabolites Become Lethal -- 3.20.8 Risk Assessment of Phytochemicals in Animal Feeds -- References -- 4: Posters -- 4.1: Coumarin Risk Assessment: Lessons from Human Data -- References -- 4.2: Coffee and Coffee Compounds are Effective Antioxidants in Human Cells and In Vivo -- 4.2.1 Introduction -- 4.2.2 Materials and Methods -- 4.2.3 Results and Discussion -- Acknowledgments -- References -- 4.3: Studying Absorption, Distribution, Metabolism, and Excretion of a Complex Extract -- 4.4: Polyphenolic Apple Extracts and their Constituents Modulate DNA Strand Breaks and Oxidation Damage in Human Colon Carcinoma Cells -- 4.4.1 Introduction -- 4.4.2 Methods -- 4.4.3 Results and Discussion -- 4.4.4 Conclusion -- Acknowledgements -- References -- 4.5: Comparative Evaluation of Experimental Data on α-Amylase Inhibition by Flavonoids Using Molecular Modelling -- 4.6: Potential Risk of Furan in Foods -- 4.7: Comparative Study on the Toxicity of Alternariol and Alternariol Monomethyl Ether in Human Tumour Cells of Different Origin -- References -- 4.8: A Role for Resveratrol and Curcumine in Sensitization of Glioblastoma Cells to Genotoxic Stress Induced by Alkylating Chemotherapeutics -- 4.9: BfR Risk Assessment of Alkaloids as Ingredients and Contaminants of Food: Quinine, Opium Alkaloids, and Senecio Pyrrolizidine Alkaloids -- 4.9.1 Quinine in Bitter Soft Drinks - Are there Special Risk Groups? -- 4.9.2 Opium Alkaloids as Contaminants of Poppy Seeds -- 4.9.3 Senecio vulgaris L. as Contaminant of Mixed Salad -- References.
4.10: Elucidation of the Genotoxic Activity of the Alkaloid Ellipticine in Human Cell Lines.
Record Nr. UNINA-9910265225503321
Weinheim [Germany], : Wiley-VCH, 2010
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Risk assessment of phytochemicals in food [[electronic resource] ] : novel approaches : symposium / / editors, DFG Senate Commission on Food Safety ; editorial committee, Gerhard Eisenbrand ... [et al.] ; scientists of the SKLM secretariat, Sabine Guth, Michael Habermeyer and Barbara Kochte-Clemens
Risk assessment of phytochemicals in food [[electronic resource] ] : novel approaches : symposium / / editors, DFG Senate Commission on Food Safety ; editorial committee, Gerhard Eisenbrand ... [et al.] ; scientists of the SKLM secretariat, Sabine Guth, Michael Habermeyer and Barbara Kochte-Clemens
Edizione [1st ed.]
Pubbl/distr/stampa Weinheim [Germany], : Wiley-VCH, 2010
Descrizione fisica 1 online resource (476 p. ) : ill. (some col.)
Disciplina 363.1922
Altri autori (Persone) EisenbrandGerhard
GuthSabine
HabermeyerMichael
Kochte-ClemensBarbara
Collana Forschungsberichte (DFG)
Soggetto topico Phytochemicals
Food - Safety measures
ISBN 9786613302489
1-283-30248-9
3-527-63471-1
3-527-63470-3
3-527-63483-5
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Intro -- Title page -- copyright -- Vorwort -- Preface -- 1: Bericht und Schlussfolgerungen -- 1.1 Einleitung -- 1.2 Methodenübergreifende Aspekte -- 1.3 Methoden -- 1.4 Schlussfolgerungen und Empfehlungen -- 1.5 Fazit -- 2: Report and Conclusions -- 2.1 Preface -- 2.2 Transdisciplinary Aspects -- 2.3 Methodologies -- 2.4 Conclusions and Recommendations -- 2.5 Concluding Remarks -- 3: Contributions -- 3.1: Visions on Toxicity Testing in the 21st Century: Reflections on a Strategy Document of the US National Research Council -- 3.1.1 Introduction -- 3.1.2 A New Vision of Toxicity Testing -- 3.1.3 Testing the Vision -- 3.1.4 Steps toward a New Toxicology -- 3.1.5 The Precautionary Principle -- 3.1.6 The European Side -- 3.1.7 Tasks Ahead -- Acknowledgements -- Abbreviations and Glossary of Terms -- References -- 3.2: Safety Assessment of Botanicals and Botanical Preparations Used as Ingredients in Food Supplements: Testing an European Food Safety AuthorityTiered Approach -- 3.2.1 Introduction -- 3.2.2 Materials and Methods -- 3.2.3 Results -- 3.2.4 Discussion -- Acknowledgement -- References -- 3.3: In Silico Toxicology Screening of the Rodent Carcinogenic Potential of Phytochemicals Using Quantitative Structure-Activity Relationship Analysis -- 3.3.1 Introduction -- 3.3.2 Why Use In Silico Predictive Models at FDA? -- 3.3.3 What In Silico Predictive Models does the FDA Use? -- 3.3.4 What In Silico Predictive Software does the FDA Use? -- 3.3.5 Why Use In Silico Strategies as a Novel Approach to Assess Toxicity of Phytochemicals? -- 3.3.6 Prediction of Rodent Carcinogenicity of Phytochemicals in an External Validation Study -- 3.3.7 Conclusions -- Acknowledgements -- Conflict of Interest Statement -- References -- 3.4: Testing Computational Toxicology Models with Phytochemicals -- 3.4.1 Introduction -- 3.4.2 Materials and Methods -- 3.4.3 Results.
3.4.4 Discussion -- Acknowledgements -- Abbreviations -- Conflict of Interest Statement -- References -- 3.5: In Silico Models to Establish Level of Safety Concern in Absence of Sufficient Toxicological Data -- 3.5.1 Introduction -- 3.5.2 Computational Toxicology Models Relevant for the Food Sectors: Requirements -- 3.5.3 Available Computational Toxicology Models for Food Applications -- 3.5.4 Model Integration and Application -- 3.5.5 Computational Toxicology and Safety Assessment of Botanical Extracts -- 3.5.6 Discussion and Conclusion -- References -- 3.6: In Silico Methods for Physiologically Based Biokinetic (PBBK) Models Describing Bioactivation and Detoxification of Coumarin and Estragole: Implications for Risk Assessment -- 3.6.1 Introduction -- 3.6.2 Methods -- 3.6.3 Results -- 3.6.4 Discussion -- Acknowledgements -- Abbreviations -- Conflict of Interest Statement -- References -- 3.7: In Vitro Models for Carcinogenicity Testing Reality or Fantasy? -- 3.7.1 Introduction -- 3.7.2 BALB/c 3T3 Cell Transformation Assay -- 3.7.3 Automated Soft Agar Assay -- 3.7.4 Concluding Remarks -- Acknowledgments -- References -- 3.8: Carcinogen Specific Expression Profiling: Prediction of Carcinogenic Potential? -- 3.9: Safety and Biological Efficacy Testing of Phytochemicals: An Industry Approach -- 3.9.1 Introduction -- 3.9.2 Screening Process -- 3.9.3 Regulatory Pre-Clinical Safety -- 3.9.4 Overall Conclusion -- References -- 3.10: Metabolite Profiling in Rat Plasma as a Potential New Tool for the Assessment of Chemically Induced Toxicity -- 3.10.1 Introduction -- 3.10.2 Materials and Methods -- 3.10.3 Results and Discussion -- 3.10.4 Concluding Remarks -- Acknowledgements -- References -- 3.11: Profiling Techniques in Nutrition and Food Research -- Hannelore Daniel1 -- 3.11.1 Introduction.
3.11.2 Genomics Applications in Basic and Pre-Clinical Nutrition and Food Research -- 3.11.3 Profiling Technologies Applied in Human Studies -- 3.11.4 Evidence for a Significant Role of the Gut Microbiota in Human Responses to Dietary Interventions -- 3.11.5 Summary -- References -- 3.12: The Complex Links between Dietary Phytochemicals and Human Health Deciphered by Metabolomics -- 3.12.1 Introduction -- 3.12.2 Measuring Dietary Intake of Phytochemicals: Current Limitations -- 3.12.3 Biomarkers of Phytochemical Intake -- 3.12.4 Metabolomics and Biomarker Discovery -- 3.12.5 Metabolomics and Phytochemical Intake -- 3.12.6 Metabolomics and Biological Effects of Phytochemicals -- 3.12.7 Conclusion -- Acknowledgments -- Glossary4 -- Conflict of Interest Statement -- References -- 3.13: Anti-Oxidative and Antigenotoxic Properties of Vegetables and Dietary Phytochemicals: The Value of Genomics Biomarkers in Molecular Epidemiology -- 3.13.1 Introduction -- 3.13.2 Colorectal Cancer Risk Prevention by Vegetables -- 3.13.3 Gene Expression Modulation in the Colon by Vegetables and Phytochemicals -- 3.13.4 Genetic Polymorphisms and Anti-Oxidative Response -- 3.13.5 Risk-Benefit Analysis of Dietary Phytochemicals -- 3.13.6 Concluding Remarks -- References -- 3.14: The Japanese Toxicogenomics Project: Application of Toxicogenomics - Utilizing Toxicogenomics into Drug Safety Screening -- 3.14.1 Introduction -- 3.14.2 Current Status of Worldwide Toxicogenomics Database Creation -- 3.14.3 The Toxicogenomics Project in Japan -- 3.14.4 Application of Toxicogenomics -- 3.14.5 Future Perspectives -- Acknowledgements -- Conflict of Interest Statement -- References -- 3.15: Toxicology and Risk Assessment of Coumarin: Focus on Human Data -- 3.15.1 Introduction -- 3.15.2 Hazard of Coumarin -- 3.15.3 Human Exposure -- 3.15.4 Risk Assessment -- 3.15.5 Summary and Conclusion.
Abbreviations -- Conflict of Interest Statement -- References -- 3.16: Risk from Furocoumarins in Food? An Exposure Assessment -- 3.16.1 Introduction -- 3.16.2 Materials and Methods -- 3.16.3 Results and Discussion -- 3.16.4 Conclusions -- Acknowledgements -- References -- 3.17: Transcriptome Analysis in Benefit-Risk Assessment of Micronutrients and Bioactive Food Components -- 3.17.1 Introduction -- 3.17.2 Whole Genome Transcriptome Analysis as a Tool for Benefit-Risk Analysis -- 3.17.3 Data Confirmation by qRT-PCR -- 3.17.4 Magnitude of Micronutrient Effects -- 3.17.5 Data Interpretation -- 3.17.6 In Vivo and In Vitro Approaches -- 3.17.7 Animal Models and Diets -- 3.17.8 Sensitivity and Power -- 3.17.9 Conclusion -- Acknowledgements -- Conflict of Interest Statement -- References -- 3.18: Colorectal and Prostate Cancer: The Role of Candidate Genes in Nutritional Pathways -- 3.18.1 Selenium: Biologic Mechanisms of the Chemopreventive Effects of Selenium -- 3.18.3 Overall Evidence from Candidate-Gene Association Studies for Cancer -- References -- 3.19: Glucosinolates: DNA Adduct Formation In Vivo and Mutagenicity In Vitro -- 3.19.1 Introduction -- 3.19.2 Formation of DNA-Reactive Molecules in Plant Homogenates -- 3.19.3 Formation of DNA Adducts in Animals Fed with Broccoli -- 3.19.4 Elucidation of the Structure of Broccoli-Associated DNA Adducts and Identification of the Substances Involved -- 3.19.5 Mutagenicity of GLS-A -- 3.19.6 Conclusions and Perspectives -- Acknowledgements -- References -- 3.20: Defence Mechanisms against Toxic Phytochemicals in the Diet of Domestic Animals -- 3.20.1 Introduction -- 3.20.2 Polygastric Herbivory: Pre-Systemic Detoxification of Phytochemicals by the Rumen Microbiota -- 3.20.3 Monogastric Herbivory: Are Acquired Feeding Strategies Sufficiently Protective?.
3.20.4 Efflux Transporters: Functional Elements of the Intestinal Barrier -- 3.20.5 Pre-Systemic Elimination by Biotransformation -- 3.20.6 Transcriptional Regulation of Efflux Transporters and Biotransformation Enzymes -- 3.20.7 Carnivorous Species: When Plant Metabolites Become Lethal -- 3.20.8 Risk Assessment of Phytochemicals in Animal Feeds -- References -- 4: Posters -- 4.1: Coumarin Risk Assessment: Lessons from Human Data -- References -- 4.2: Coffee and Coffee Compounds are Effective Antioxidants in Human Cells and In Vivo -- 4.2.1 Introduction -- 4.2.2 Materials and Methods -- 4.2.3 Results and Discussion -- Acknowledgments -- References -- 4.3: Studying Absorption, Distribution, Metabolism, and Excretion of a Complex Extract -- 4.4: Polyphenolic Apple Extracts and their Constituents Modulate DNA Strand Breaks and Oxidation Damage in Human Colon Carcinoma Cells -- 4.4.1 Introduction -- 4.4.2 Methods -- 4.4.3 Results and Discussion -- 4.4.4 Conclusion -- Acknowledgements -- References -- 4.5: Comparative Evaluation of Experimental Data on α-Amylase Inhibition by Flavonoids Using Molecular Modelling -- 4.6: Potential Risk of Furan in Foods -- 4.7: Comparative Study on the Toxicity of Alternariol and Alternariol Monomethyl Ether in Human Tumour Cells of Different Origin -- References -- 4.8: A Role for Resveratrol and Curcumine in Sensitization of Glioblastoma Cells to Genotoxic Stress Induced by Alkylating Chemotherapeutics -- 4.9: BfR Risk Assessment of Alkaloids as Ingredients and Contaminants of Food: Quinine, Opium Alkaloids, and Senecio Pyrrolizidine Alkaloids -- 4.9.1 Quinine in Bitter Soft Drinks - Are there Special Risk Groups? -- 4.9.2 Opium Alkaloids as Contaminants of Poppy Seeds -- 4.9.3 Senecio vulgaris L. as Contaminant of Mixed Salad -- References.
4.10: Elucidation of the Genotoxic Activity of the Alkaloid Ellipticine in Human Cell Lines.
Record Nr. UNINA-9910830691103321
Weinheim [Germany], : Wiley-VCH, 2010
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Risk assessment of phytochemicals in food [[electronic resource] ] : novel approaches : symposium / / editors, DFG Senate Commission on Food Safety ; editorial committee, Gerhard Eisenbrand ... [et al.] ; scientists of the SKLM secretariat, Sabine Guth, Michael Habermeyer and Barbara Kochte-Clemens
Risk assessment of phytochemicals in food [[electronic resource] ] : novel approaches : symposium / / editors, DFG Senate Commission on Food Safety ; editorial committee, Gerhard Eisenbrand ... [et al.] ; scientists of the SKLM secretariat, Sabine Guth, Michael Habermeyer and Barbara Kochte-Clemens
Edizione [1st ed.]
Pubbl/distr/stampa Weinheim [Germany], : Wiley-VCH, 2010
Descrizione fisica 1 online resource (476 p. ) : ill. (some col.)
Disciplina 363.1922
Altri autori (Persone) EisenbrandGerhard
GuthSabine
HabermeyerMichael
Kochte-ClemensBarbara
Collana Forschungsberichte (DFG)
Soggetto topico Phytochemicals
Food - Safety measures
ISBN 9786613302489
1-283-30248-9
3-527-63471-1
3-527-63470-3
3-527-63483-5
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Intro -- Title page -- copyright -- Vorwort -- Preface -- 1: Bericht und Schlussfolgerungen -- 1.1 Einleitung -- 1.2 Methodenübergreifende Aspekte -- 1.3 Methoden -- 1.4 Schlussfolgerungen und Empfehlungen -- 1.5 Fazit -- 2: Report and Conclusions -- 2.1 Preface -- 2.2 Transdisciplinary Aspects -- 2.3 Methodologies -- 2.4 Conclusions and Recommendations -- 2.5 Concluding Remarks -- 3: Contributions -- 3.1: Visions on Toxicity Testing in the 21st Century: Reflections on a Strategy Document of the US National Research Council -- 3.1.1 Introduction -- 3.1.2 A New Vision of Toxicity Testing -- 3.1.3 Testing the Vision -- 3.1.4 Steps toward a New Toxicology -- 3.1.5 The Precautionary Principle -- 3.1.6 The European Side -- 3.1.7 Tasks Ahead -- Acknowledgements -- Abbreviations and Glossary of Terms -- References -- 3.2: Safety Assessment of Botanicals and Botanical Preparations Used as Ingredients in Food Supplements: Testing an European Food Safety AuthorityTiered Approach -- 3.2.1 Introduction -- 3.2.2 Materials and Methods -- 3.2.3 Results -- 3.2.4 Discussion -- Acknowledgement -- References -- 3.3: In Silico Toxicology Screening of the Rodent Carcinogenic Potential of Phytochemicals Using Quantitative Structure-Activity Relationship Analysis -- 3.3.1 Introduction -- 3.3.2 Why Use In Silico Predictive Models at FDA? -- 3.3.3 What In Silico Predictive Models does the FDA Use? -- 3.3.4 What In Silico Predictive Software does the FDA Use? -- 3.3.5 Why Use In Silico Strategies as a Novel Approach to Assess Toxicity of Phytochemicals? -- 3.3.6 Prediction of Rodent Carcinogenicity of Phytochemicals in an External Validation Study -- 3.3.7 Conclusions -- Acknowledgements -- Conflict of Interest Statement -- References -- 3.4: Testing Computational Toxicology Models with Phytochemicals -- 3.4.1 Introduction -- 3.4.2 Materials and Methods -- 3.4.3 Results.
3.4.4 Discussion -- Acknowledgements -- Abbreviations -- Conflict of Interest Statement -- References -- 3.5: In Silico Models to Establish Level of Safety Concern in Absence of Sufficient Toxicological Data -- 3.5.1 Introduction -- 3.5.2 Computational Toxicology Models Relevant for the Food Sectors: Requirements -- 3.5.3 Available Computational Toxicology Models for Food Applications -- 3.5.4 Model Integration and Application -- 3.5.5 Computational Toxicology and Safety Assessment of Botanical Extracts -- 3.5.6 Discussion and Conclusion -- References -- 3.6: In Silico Methods for Physiologically Based Biokinetic (PBBK) Models Describing Bioactivation and Detoxification of Coumarin and Estragole: Implications for Risk Assessment -- 3.6.1 Introduction -- 3.6.2 Methods -- 3.6.3 Results -- 3.6.4 Discussion -- Acknowledgements -- Abbreviations -- Conflict of Interest Statement -- References -- 3.7: In Vitro Models for Carcinogenicity Testing Reality or Fantasy? -- 3.7.1 Introduction -- 3.7.2 BALB/c 3T3 Cell Transformation Assay -- 3.7.3 Automated Soft Agar Assay -- 3.7.4 Concluding Remarks -- Acknowledgments -- References -- 3.8: Carcinogen Specific Expression Profiling: Prediction of Carcinogenic Potential? -- 3.9: Safety and Biological Efficacy Testing of Phytochemicals: An Industry Approach -- 3.9.1 Introduction -- 3.9.2 Screening Process -- 3.9.3 Regulatory Pre-Clinical Safety -- 3.9.4 Overall Conclusion -- References -- 3.10: Metabolite Profiling in Rat Plasma as a Potential New Tool for the Assessment of Chemically Induced Toxicity -- 3.10.1 Introduction -- 3.10.2 Materials and Methods -- 3.10.3 Results and Discussion -- 3.10.4 Concluding Remarks -- Acknowledgements -- References -- 3.11: Profiling Techniques in Nutrition and Food Research -- Hannelore Daniel1 -- 3.11.1 Introduction.
3.11.2 Genomics Applications in Basic and Pre-Clinical Nutrition and Food Research -- 3.11.3 Profiling Technologies Applied in Human Studies -- 3.11.4 Evidence for a Significant Role of the Gut Microbiota in Human Responses to Dietary Interventions -- 3.11.5 Summary -- References -- 3.12: The Complex Links between Dietary Phytochemicals and Human Health Deciphered by Metabolomics -- 3.12.1 Introduction -- 3.12.2 Measuring Dietary Intake of Phytochemicals: Current Limitations -- 3.12.3 Biomarkers of Phytochemical Intake -- 3.12.4 Metabolomics and Biomarker Discovery -- 3.12.5 Metabolomics and Phytochemical Intake -- 3.12.6 Metabolomics and Biological Effects of Phytochemicals -- 3.12.7 Conclusion -- Acknowledgments -- Glossary4 -- Conflict of Interest Statement -- References -- 3.13: Anti-Oxidative and Antigenotoxic Properties of Vegetables and Dietary Phytochemicals: The Value of Genomics Biomarkers in Molecular Epidemiology -- 3.13.1 Introduction -- 3.13.2 Colorectal Cancer Risk Prevention by Vegetables -- 3.13.3 Gene Expression Modulation in the Colon by Vegetables and Phytochemicals -- 3.13.4 Genetic Polymorphisms and Anti-Oxidative Response -- 3.13.5 Risk-Benefit Analysis of Dietary Phytochemicals -- 3.13.6 Concluding Remarks -- References -- 3.14: The Japanese Toxicogenomics Project: Application of Toxicogenomics - Utilizing Toxicogenomics into Drug Safety Screening -- 3.14.1 Introduction -- 3.14.2 Current Status of Worldwide Toxicogenomics Database Creation -- 3.14.3 The Toxicogenomics Project in Japan -- 3.14.4 Application of Toxicogenomics -- 3.14.5 Future Perspectives -- Acknowledgements -- Conflict of Interest Statement -- References -- 3.15: Toxicology and Risk Assessment of Coumarin: Focus on Human Data -- 3.15.1 Introduction -- 3.15.2 Hazard of Coumarin -- 3.15.3 Human Exposure -- 3.15.4 Risk Assessment -- 3.15.5 Summary and Conclusion.
Abbreviations -- Conflict of Interest Statement -- References -- 3.16: Risk from Furocoumarins in Food? An Exposure Assessment -- 3.16.1 Introduction -- 3.16.2 Materials and Methods -- 3.16.3 Results and Discussion -- 3.16.4 Conclusions -- Acknowledgements -- References -- 3.17: Transcriptome Analysis in Benefit-Risk Assessment of Micronutrients and Bioactive Food Components -- 3.17.1 Introduction -- 3.17.2 Whole Genome Transcriptome Analysis as a Tool for Benefit-Risk Analysis -- 3.17.3 Data Confirmation by qRT-PCR -- 3.17.4 Magnitude of Micronutrient Effects -- 3.17.5 Data Interpretation -- 3.17.6 In Vivo and In Vitro Approaches -- 3.17.7 Animal Models and Diets -- 3.17.8 Sensitivity and Power -- 3.17.9 Conclusion -- Acknowledgements -- Conflict of Interest Statement -- References -- 3.18: Colorectal and Prostate Cancer: The Role of Candidate Genes in Nutritional Pathways -- 3.18.1 Selenium: Biologic Mechanisms of the Chemopreventive Effects of Selenium -- 3.18.3 Overall Evidence from Candidate-Gene Association Studies for Cancer -- References -- 3.19: Glucosinolates: DNA Adduct Formation In Vivo and Mutagenicity In Vitro -- 3.19.1 Introduction -- 3.19.2 Formation of DNA-Reactive Molecules in Plant Homogenates -- 3.19.3 Formation of DNA Adducts in Animals Fed with Broccoli -- 3.19.4 Elucidation of the Structure of Broccoli-Associated DNA Adducts and Identification of the Substances Involved -- 3.19.5 Mutagenicity of GLS-A -- 3.19.6 Conclusions and Perspectives -- Acknowledgements -- References -- 3.20: Defence Mechanisms against Toxic Phytochemicals in the Diet of Domestic Animals -- 3.20.1 Introduction -- 3.20.2 Polygastric Herbivory: Pre-Systemic Detoxification of Phytochemicals by the Rumen Microbiota -- 3.20.3 Monogastric Herbivory: Are Acquired Feeding Strategies Sufficiently Protective?.
3.20.4 Efflux Transporters: Functional Elements of the Intestinal Barrier -- 3.20.5 Pre-Systemic Elimination by Biotransformation -- 3.20.6 Transcriptional Regulation of Efflux Transporters and Biotransformation Enzymes -- 3.20.7 Carnivorous Species: When Plant Metabolites Become Lethal -- 3.20.8 Risk Assessment of Phytochemicals in Animal Feeds -- References -- 4: Posters -- 4.1: Coumarin Risk Assessment: Lessons from Human Data -- References -- 4.2: Coffee and Coffee Compounds are Effective Antioxidants in Human Cells and In Vivo -- 4.2.1 Introduction -- 4.2.2 Materials and Methods -- 4.2.3 Results and Discussion -- Acknowledgments -- References -- 4.3: Studying Absorption, Distribution, Metabolism, and Excretion of a Complex Extract -- 4.4: Polyphenolic Apple Extracts and their Constituents Modulate DNA Strand Breaks and Oxidation Damage in Human Colon Carcinoma Cells -- 4.4.1 Introduction -- 4.4.2 Methods -- 4.4.3 Results and Discussion -- 4.4.4 Conclusion -- Acknowledgements -- References -- 4.5: Comparative Evaluation of Experimental Data on α-Amylase Inhibition by Flavonoids Using Molecular Modelling -- 4.6: Potential Risk of Furan in Foods -- 4.7: Comparative Study on the Toxicity of Alternariol and Alternariol Monomethyl Ether in Human Tumour Cells of Different Origin -- References -- 4.8: A Role for Resveratrol and Curcumine in Sensitization of Glioblastoma Cells to Genotoxic Stress Induced by Alkylating Chemotherapeutics -- 4.9: BfR Risk Assessment of Alkaloids as Ingredients and Contaminants of Food: Quinine, Opium Alkaloids, and Senecio Pyrrolizidine Alkaloids -- 4.9.1 Quinine in Bitter Soft Drinks - Are there Special Risk Groups? -- 4.9.2 Opium Alkaloids as Contaminants of Poppy Seeds -- 4.9.3 Senecio vulgaris L. as Contaminant of Mixed Salad -- References.
4.10: Elucidation of the Genotoxic Activity of the Alkaloid Ellipticine in Human Cell Lines.
Record Nr. UNINA-9910840986003321
Weinheim [Germany], : Wiley-VCH, 2010
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Safe food [[electronic resource] ] : the politics of food safety / / Marion Nestle
Safe food [[electronic resource] ] : the politics of food safety / / Marion Nestle
Autore Nestle Marion
Edizione [Updated and expanded [ed.].]
Pubbl/distr/stampa Berkeley, Calif., : University of California Press, c2010
Descrizione fisica 1 online resource (406 p.)
Disciplina 363.19260973
Collana California studies in food and culture
Soggetto topico Bioterrorism
Food - Biotechnology
Food - Safety measures
Soggetto genere / forma Electronic books.
ISBN 1-282-69774-9
9786612697746
0-520-94630-8
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Frontmatter -- CONTENTS -- PREFACE TO THE 2010 EDITION -- PREFACE TO THE FIRST EDITION -- ACKNOWLEDGMENTS -- LIST OF ABBREVIATIONS -- INTRODUCTION. FOOD SAFETY IS POLITICAL -- PART ONE. RESISTING FOOD SAFETY -- PART TWO. SAFETY AS A SURROGATE -- CONCLUSION. THE FUTURE OF FOOD SAFETY -- EPILOGUE -- APPENDIX. THE SCIENCE OF PLANT BIOTECHNOLOGY -- NOTES -- LIST OF TABLES -- LIST OF FIGURES -- INDEX
Record Nr. UNINA-9910459276703321
Nestle Marion  
Berkeley, Calif., : University of California Press, c2010
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Safe food [[electronic resource] ] : the politics of food safety / / Marion Nestle
Safe food [[electronic resource] ] : the politics of food safety / / Marion Nestle
Autore Nestle Marion
Edizione [Updated and expanded [ed.].]
Pubbl/distr/stampa Berkeley, Calif., : University of California Press, c2010
Descrizione fisica 1 online resource (406 p.)
Disciplina 363.19260973
Collana California studies in food and culture
Soggetto topico Bioterrorism
Food - Biotechnology
Food - Safety measures
ISBN 1-282-69774-9
9786612697746
0-520-94630-8
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Frontmatter -- CONTENTS -- PREFACE TO THE 2010 EDITION -- PREFACE TO THE FIRST EDITION -- ACKNOWLEDGMENTS -- LIST OF ABBREVIATIONS -- INTRODUCTION. FOOD SAFETY IS POLITICAL -- PART ONE. RESISTING FOOD SAFETY -- PART TWO. SAFETY AS A SURROGATE -- CONCLUSION. THE FUTURE OF FOOD SAFETY -- EPILOGUE -- APPENDIX. THE SCIENCE OF PLANT BIOTECHNOLOGY -- NOTES -- LIST OF TABLES -- LIST OF FIGURES -- INDEX
Record Nr. UNINA-9910784923203321
Nestle Marion  
Berkeley, Calif., : University of California Press, c2010
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Safe food [[electronic resource] ] : the politics of food safety / / Marion Nestle
Safe food [[electronic resource] ] : the politics of food safety / / Marion Nestle
Autore Nestle Marion
Edizione [Updated and expanded [ed.].]
Pubbl/distr/stampa Berkeley, Calif., : University of California Press, c2010
Descrizione fisica 1 online resource (406 p.)
Disciplina 363.19260973
Collana California studies in food and culture
Soggetto topico Bioterrorism
Food - Biotechnology
Food - Safety measures
ISBN 1-282-69774-9
9786612697746
0-520-94630-8
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Frontmatter -- CONTENTS -- PREFACE TO THE 2010 EDITION -- PREFACE TO THE FIRST EDITION -- ACKNOWLEDGMENTS -- LIST OF ABBREVIATIONS -- INTRODUCTION. FOOD SAFETY IS POLITICAL -- PART ONE. RESISTING FOOD SAFETY -- PART TWO. SAFETY AS A SURROGATE -- CONCLUSION. THE FUTURE OF FOOD SAFETY -- EPILOGUE -- APPENDIX. THE SCIENCE OF PLANT BIOTECHNOLOGY -- NOTES -- LIST OF TABLES -- LIST OF FIGURES -- INDEX
Record Nr. UNINA-9910821148503321
Nestle Marion  
Berkeley, Calif., : University of California Press, c2010
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
The safe food imperative : accelerating progress in low- and middle-income countries / / Steven Jaffee [and four others]
The safe food imperative : accelerating progress in low- and middle-income countries / / Steven Jaffee [and four others]
Autore Jaffee Steven
Pubbl/distr/stampa Washington, D. C. : , : World Bank Group, , [2019]
Descrizione fisica 1 online resource (211 pages)
Disciplina 363.1926
Soggetto topico Food - Safety measures
Soggetto genere / forma Electronic books.
ISBN 1-4648-1346-9
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910480256803321
Jaffee Steven  
Washington, D. C. : , : World Bank Group, , [2019]
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui