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Surgical neuropathology of focal epilepsies : textbook and atlas / / Ingmar Blümcke, Harvey B. Sarnat, Roland Coras
| Surgical neuropathology of focal epilepsies : textbook and atlas / / Ingmar Blümcke, Harvey B. Sarnat, Roland Coras |
| Autore | Blümcke Ingmar |
| Pubbl/distr/stampa | Surrey : , : John Libbey Eurotext, , [2015] |
| Descrizione fisica | 1 online resource (166 p.) |
| Disciplina | 617.481 |
| Collana | Hors collection |
| Soggetto topico | Epilepsy - Surgery |
| ISBN |
2-7420-1451-9
2-7420-1456-X |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Surgical Neuropathology of Focal Epilepsies: Textbook and Atlas; Preface; CHAPTER 1. Introduction; CHAPTER 2. Hippocampal sclerosis (HS); CHAPTER 3. Malformations of cortical development; CHAPTER 4. Brain tumours associated with early epilepsy onset; CHAPTER 5. Encephalitis; CHAPTER 6. Vascular lesions associated with focal epilepsies; CHAPTER 7. Atlas of neuropathological lesions in epilepsy surgery; CHAPTER 8. Tables: Clinico-pathological findings in epilepsy surgery; CHAPTER 9. Recommendations for neuropathological work-up and microscopic evaluation of epilepsy surgery specimens |
| Record Nr. | UNINA-9910827881603321 |
Blümcke Ingmar
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| Surrey : , : John Libbey Eurotext, , [2015] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The treatment of epilepsy / / edited by Simon Shorvon, Emilio Perucca, Jerome Engel, Jr. ; contributors, Patrick Adjei [and one hundred thirty others]
| The treatment of epilepsy / / edited by Simon Shorvon, Emilio Perucca, Jerome Engel, Jr. ; contributors, Patrick Adjei [and one hundred thirty others] |
| Edizione | [Fourth edition.] |
| Pubbl/distr/stampa | Chichester, England : , : Wiley Blackwell, , 2016 |
| Descrizione fisica | 1 online resource (2765 p.) |
| Disciplina | 617.481 |
| Soggetto topico |
Epilepsy - Surgery
Anticonvulsants - Therapeutic use Epilepsy - Chemotherapy |
| ISBN |
1-118-93697-3
1-118-93699-X 1-118-93698-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Title page; Copyright; List of Contributors; Preface to the Fourth Edition; Preface to the First Edition; Historical Introduction The Drug Treatment of Epilepsy from 1857 to 2015; Commentary; Acknowledgement; References; Section I Introduction; 1 Definition (Terminology) and Classification in Epilepsy: A Historical Survey and Current Formulation, with Special Reference to the ILAE; Definition; Classification; The future of classification schemes of epilepsy; Definition; Definition and classification - status epilepticus; Afterthought; Acknowledgement; References
2 Differential Diagnosis of EpilepsyIntroduction; General approach to the diagnosis of episodic disturbances; Syncope; Non-epileptic seizures; Panic disorder; Migraine; Sleep disorders; Vertigo; Movement disorders; Cerebral ischaemia; Endocrine and metabolic abnormalities; Transient global amnesia; References; 3 Mechanisms of Epileptogenesis; Membrane ion channels; Membrane ion channels as targets for antibodies in acquired autoimmune disorders; Network and system involvement in epileptogenesis; Epileptogenesis as a process; New targets for antiepileptic and antiepileptogenic strategies ConclusionsReferences; 4 Antiepileptic Drug Discovery; Characteristics of the ideal model system; The current era of AED discovery; Anticonvulsant Screening Program; Early identification of antiepileptic activity; MES, scPTZ and 6-Hz tests; Differentiation of anticonvulsant activity; Pharmacological profile and potential clinical utility; Pharmacoresistant seizure models; Therapeutic index and toxicity assessment; Aetiologically relevant model systems; Beyond the seizure; Antiepileptogenesis and disease modification (see also Chapter 8); Conclusions; Acknowledgement; References 5 Antiepileptic Drug DevelopmentIntroduction; Overview on clinical studies and trials for drug development; Opportunities for developing better antiseizure AEDs; Development of epilepsy drugs beyond suppressing seizures; Conclusions; Acknowledgements; References; 6 Mechanisms of Antiepileptic Drug Action; Main targets; Other targets; References; 7 Mechanisms of Drug Resistance and Tolerance; Introduction; The concept of drug resistance in epilepsy; Disease-related mechanisms of drug resistance in epilepsy; Drug-related mechanisms of drug resistance in epilepsy Pharmacogenetic mechanisms of drug resistance in epilepsyProof-of-concept of drug resistance hypotheses; Conclusions; References; 8 Epilepsy Biomarkers; Introduction; Need for biomarkers; Mechanisms of epilepsy; Potential biomarkers; Research to identify biomarkers; Acknowledgements; References; Section II Principles of Medical Management; 9 General Principles of Medical Management; Aims of treatment; When should treatment be started?; Initiation of treatment and dose optimization; Assessing clinical response; What next when the initial treatment fails? - monotherapy and combination therapy How long should treatment be continued? |
| Record Nr. | UNINA-9910131471703321 |
| Chichester, England : , : Wiley Blackwell, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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