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Chemical biology & drug design
| Chemical biology & drug design |
| Pubbl/distr/stampa | [Oxford], : Blackwell Munksgaard |
| Descrizione fisica | 1 online resource |
| Soggetto topico |
Peptides
Proteins Drugs - Design Biochemistry Pharmaceutical chemistry Chemistry, Pharmaceutical Drug Design biochemistry Protéines Médicaments - Conception Biochimie Chimie pharmaceutique |
| Soggetto genere / forma |
Internet resource
Computer network resources. Periodicals. |
| ISSN | 1747-0285 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti |
Chemical biology and drug design
Chem Biol Drug Des |
| Record Nr. | UNINA-9910146933303321 |
| [Oxford], : Blackwell Munksgaard | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Chemical drug design / / edited by Girish Kumar Gupta, Vinod Kumar
| Chemical drug design / / edited by Girish Kumar Gupta, Vinod Kumar |
| Pubbl/distr/stampa | Berlin, [Germany] : , : De Gruyter, , 2016 |
| Descrizione fisica | 1 online resource (298 p.) |
| Disciplina | 615.1/9 |
| Soggetto topico |
Drugs - Design
Pharmaceutical chemistry |
| ISBN | 3-11-036882-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910796553103321 |
| Berlin, [Germany] : , : De Gruyter, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Chemical drug design / / edited by Girish Kumar Gupta, Vinod Kumar
| Chemical drug design / / edited by Girish Kumar Gupta, Vinod Kumar |
| Pubbl/distr/stampa | Berlin, [Germany] : , : De Gruyter, , 2016 |
| Descrizione fisica | 1 online resource (298 p.) |
| Disciplina | 615.1/9 |
| Soggetto topico |
Drugs - Design
Pharmaceutical chemistry |
| ISBN | 3-11-036882-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910819214303321 |
| Berlin, [Germany] : , : De Gruyter, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Chemoinformatics in drug discovery [[electronic resource] /] / edited by Tudor I. Oprea
| Chemoinformatics in drug discovery [[electronic resource] /] / edited by Tudor I. Oprea |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2005 |
| Descrizione fisica | 1 online resource (517 p.) |
| Disciplina | 615.19 |
| Altri autori (Persone) | OpreaTudor I |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Drugs - Design
Cheminformatics |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-51960-6
9786610519606 3-527-60374-3 3-527-60420-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Chemoinformatics in Drug Discovery; Contents; A Personal Foreword; Preface; List of Contributors; 1 Introduction to Chemoinformatics in Drug Discovery - A Personal View; 1.1 Introduction; 1.2 Historical Evolution; 1.3 Known versus Unknown Targets; 1.4 Graph Theory and Molecular Numerology; 1.5 Pharmacophore; 1.6 Active-Analog Approach; 1.7 Active-Site Modeling; 1.8 Validation of the Active-Analog Approach and Active-Site Modeling; 1.9 PLS/CoMFA; 1.10 Prediction of Affinity; 1.11 Protein Structure Prediction; 1.12 Structure-Based Drug Design; 1.13 Real World Pharmaceutical Issues
1.14 Combinatorial Chemistry and High-throughput Screens1.15 Diversity and Similarity; 1.16 Prediction of ADME; 1.17 Failures to Accurately Predict; 1.18 Summary; References; Part I Virtual Screening; 2 Chemoinformatics in Lead Discovery; 2.1 Chemoinformatics in the Context of Pharmaceutical Research; 2.2 Leads in the Drug Discovery Paradigm; 2.3 Is There a Trend for High Activity Molecules?; 2.4 The Concept of Leadlikeness; 2.5 Conclusions; References; 3 Computational Chemistry, Molecular Complexity and Screening Set Design; 3.1 Introduction 3.2 Background Concepts: the Virtual, Tangible and Real Worlds of Compounds, the ""Knowledge Plot"" and Target Tractability3.3 The Construction of High Throughput Screening Sets; 3.4 Compound Filters; 3.5 ""Leadlike"" Screening Sets; 3.6 Focused and Biased Set Design; 3.7 Conclusion; References; 4 Algorithmic Engines in Virtual Screening; 4.1 Introduction; 4.2 Software Tools for Virtual Screening; 4.3 Physicochemical Models in Virtual Screening; 4.3.1 Intermolecular Forces in Protein-Ligand Interactions; 4.3.2 Scoring Functions for Protein-Ligand Recognition 4.3.3 Covering Conformational Space4.3.4 Scoring Structural Alignments; 4.4 Algorithmic Engines in Virtual Screening; 4.4.1 Mathematical Concepts; 4.4.2 Algorithmic Concepts; 4.4.3 Descriptor Technology; 4.4.4 Global Search Algorithms; 4.5 Entering the Real World: Virtual Screening Applications; 4.5.1 Practical Considerations on Virtual Screening; 4.5.2 Successful Applications of Virtual Screening; 4.6 Practical Virtual Screening: Some Final Remarks; References; 5 Strengths and Limitations of Pharmacophore-Based Virtual Screening; 5.1 Introduction 5.2 The ""Pharmacophore"" Concept: Pharmacophore Features5.3 Pharmacophore Models: Managing Pharmacophore-related Information; 5.4 The Main Topic of This Paper; 5.5 The Cox2 Data Set; 5.6 Pharmacophore Fingerprints and Similarity Searches; 5.7 Molecular Field Analysis (MFA)-Based Pharmacophore Information; 5.8 QSAR Models; 5.9 Hypothesis Models; 5.10 The Minimalist Overlay-Independent QSAR Model; 5.11 Minimalist and Consensus Overlay-Based QSAR Models; 5.12 Diversity Analysis of the Cox2 Compound Set 5.13 Do Hypothesis Models Actually Tell Us More Than Similarity Models About the Structural Reasons of Activity? |
| Record Nr. | UNINA-9910144276303321 |
| Weinheim, : Wiley-VCH, c2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Chemoinformatics in drug discovery [[electronic resource] /] / edited by Tudor I. Oprea
| Chemoinformatics in drug discovery [[electronic resource] /] / edited by Tudor I. Oprea |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2005 |
| Descrizione fisica | 1 online resource (517 p.) |
| Disciplina | 615.19 |
| Altri autori (Persone) | OpreaTudor I |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Drugs - Design
Cheminformatics |
| ISBN |
1-280-51960-6
9786610519606 3-527-60374-3 3-527-60420-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Chemoinformatics in Drug Discovery; Contents; A Personal Foreword; Preface; List of Contributors; 1 Introduction to Chemoinformatics in Drug Discovery - A Personal View; 1.1 Introduction; 1.2 Historical Evolution; 1.3 Known versus Unknown Targets; 1.4 Graph Theory and Molecular Numerology; 1.5 Pharmacophore; 1.6 Active-Analog Approach; 1.7 Active-Site Modeling; 1.8 Validation of the Active-Analog Approach and Active-Site Modeling; 1.9 PLS/CoMFA; 1.10 Prediction of Affinity; 1.11 Protein Structure Prediction; 1.12 Structure-Based Drug Design; 1.13 Real World Pharmaceutical Issues
1.14 Combinatorial Chemistry and High-throughput Screens1.15 Diversity and Similarity; 1.16 Prediction of ADME; 1.17 Failures to Accurately Predict; 1.18 Summary; References; Part I Virtual Screening; 2 Chemoinformatics in Lead Discovery; 2.1 Chemoinformatics in the Context of Pharmaceutical Research; 2.2 Leads in the Drug Discovery Paradigm; 2.3 Is There a Trend for High Activity Molecules?; 2.4 The Concept of Leadlikeness; 2.5 Conclusions; References; 3 Computational Chemistry, Molecular Complexity and Screening Set Design; 3.1 Introduction 3.2 Background Concepts: the Virtual, Tangible and Real Worlds of Compounds, the ""Knowledge Plot"" and Target Tractability3.3 The Construction of High Throughput Screening Sets; 3.4 Compound Filters; 3.5 ""Leadlike"" Screening Sets; 3.6 Focused and Biased Set Design; 3.7 Conclusion; References; 4 Algorithmic Engines in Virtual Screening; 4.1 Introduction; 4.2 Software Tools for Virtual Screening; 4.3 Physicochemical Models in Virtual Screening; 4.3.1 Intermolecular Forces in Protein-Ligand Interactions; 4.3.2 Scoring Functions for Protein-Ligand Recognition 4.3.3 Covering Conformational Space4.3.4 Scoring Structural Alignments; 4.4 Algorithmic Engines in Virtual Screening; 4.4.1 Mathematical Concepts; 4.4.2 Algorithmic Concepts; 4.4.3 Descriptor Technology; 4.4.4 Global Search Algorithms; 4.5 Entering the Real World: Virtual Screening Applications; 4.5.1 Practical Considerations on Virtual Screening; 4.5.2 Successful Applications of Virtual Screening; 4.6 Practical Virtual Screening: Some Final Remarks; References; 5 Strengths and Limitations of Pharmacophore-Based Virtual Screening; 5.1 Introduction 5.2 The ""Pharmacophore"" Concept: Pharmacophore Features5.3 Pharmacophore Models: Managing Pharmacophore-related Information; 5.4 The Main Topic of This Paper; 5.5 The Cox2 Data Set; 5.6 Pharmacophore Fingerprints and Similarity Searches; 5.7 Molecular Field Analysis (MFA)-Based Pharmacophore Information; 5.8 QSAR Models; 5.9 Hypothesis Models; 5.10 The Minimalist Overlay-Independent QSAR Model; 5.11 Minimalist and Consensus Overlay-Based QSAR Models; 5.12 Diversity Analysis of the Cox2 Compound Set 5.13 Do Hypothesis Models Actually Tell Us More Than Similarity Models About the Structural Reasons of Activity? |
| Record Nr. | UNINA-9910830617803321 |
| Weinheim, : Wiley-VCH, c2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Chemometric methods in molecular design [[electronic resource] /] / edited by Han van de Waterbeemd
| Chemometric methods in molecular design [[electronic resource] /] / edited by Han van de Waterbeemd |
| Pubbl/distr/stampa | Weinheim, Ger. ; ; New York, : VCH, c1995 |
| Descrizione fisica | 1 online resource (380 p.) |
| Disciplina |
547.13
615/.1901 |
| Altri autori (Persone) | WaterbeemdHan van de |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
QSAR (Biochemistry)
Drugs - Design |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-75866-3
9786611758660 3-527-61545-8 3-527-61544-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Chernornetric Methods in Molecular Design; Preface; A Personal Foreword; Contents; 1 Introduction; 1.1 Quantitative Molecular Design; 1.2 Chemometrics; 1.3 The Hansch Approach; 1.4 Modern Chemometric Approaches in Molecular Design; 1.5 Software; 1.5.1 General Statistical Packages; 1.5.2 Specialized Software for SPC Studies; References; 2 Molecular Concepts; 2.1 Representations of Molecules; 2.1.1 Introduction; 2.1.2 Substituent Constants; 2.1.2.1 Electronic Substituent Constants; 2.1.2.2 The Hydrophobic Substituent Constant,p; 2.1.2.3 Partition Coefficient - Log P
2.1.2.4 Steric Substituent Constants2.1.3 Whole Molecule Representations; 2.1.3.1 Topological Descriptions; 2.1.3.2 Electronic Whole Molecule Descriptors; 2.1.3.3 Geometric Descriptors; References; 2.2 Atom-Level Descriptors for QSAR Analyzes; 2.2.1 Introduction; 2.2.2 An Atom-Level Description of Structure; 2.2.2.1 The Field; 2.2.2.2 The Intrinsic State of an Atom; 2.2.2.3 The Field Effect on Each Atom; 2.2.3 Strategies for Use of E-State Indices; 2.2.4 Examples of E-State QSAR; 2.2.4.1 MAO Inhibition with Hydrazides; 2.2.4.2 Adenosine A, Inhibitors 2.2.4.3 Anesthetic Concentration of Haloalkanes2.2.4.4 Odor Sensitivity of Pyrazines; 2.2.5 Conclusions; References; 3 Experimental Design in Synthesis Planning and Structure-Property Correlations; 3.1 Experimental Design; 3.1.1 The Importance of Experimental Design in Medicinal Chemistry; 3.1.2 Strategy in Experimental Design; 3.1.3 Selected Methods for Experimental Design; 3.1.3.1 Methods for the Direct Optimization of Lead Compounds; 3.1.3.2 Methods for the Systematic Investigation of Parameter Space; 3.1.3.3 Choice of Molecular Descriptors; 3.1.4 Summary and Conclusion; References 3.2 Applications of Statistical Experimental Design and PLS Modeling in QSAR3.2.1 Introduction; 3.2.2 A Strategy for QSAR Development in Drug Design; 3.2.2.1 Formulation of Classes of Similar Compounds (Step 1); 3.2.2.2 Structural Description and Definition of Design Variables (Step 2); 3.2.2.3 Selection of the Training Set of Compounds (Step 3); 3.2.2.4 Biological Testing (Step 4); 3.2.2.5 QSAR Development (Step 5; 3.2.2.6 Validation and Predictions for Non-Tested Compounds (Step; 3.2.3 Examples of Design and PLS Modeling; 3.2.3.1 Bradykinin Potentiating Pentapeptides 3.2.3.2 Dipeptides (Inhibiting the Angiotensin Converting Enzyme)3.2.3.3 Dipeptides (Bitter Tasting); 3.2.3.4 Mimetics; 3.2.3.5 Haloalkanes; 3.2.3.6 Dibenzofurans; 3.2.3.7 Monosubstituted Benzenes; 3.2.3.8 Corrosive Carboxylic Acids; 3.2.4 Discussion and Conclusions; Software Used; Acknowledgements; References; 3.3 Total Response Surface Optimization; 3.3.1 Background; 3.3.2 Representation of a Response Surface; 3.3.3 Structure Descriptors from Chemical Graph Theory; 3.3.4 Examples; 3.3.4.1 Neurotoxicity of Fluorophosphorous Compounds 3.3.4.2 Bioconcentration of Chlorinated Phenyls and Biphenyls |
| Record Nr. | UNINA-9910144132703321 |
| Weinheim, Ger. ; ; New York, : VCH, c1995 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Chemometric methods in molecular design [[electronic resource] /] / edited by Han van de Waterbeemd
| Chemometric methods in molecular design [[electronic resource] /] / edited by Han van de Waterbeemd |
| Pubbl/distr/stampa | Weinheim, Ger. ; ; New York, : VCH, c1995 |
| Descrizione fisica | 1 online resource (380 p.) |
| Disciplina |
547.13
615/.1901 |
| Altri autori (Persone) | WaterbeemdHan van de |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
QSAR (Biochemistry)
Drugs - Design |
| ISBN |
1-281-75866-3
9786611758660 3-527-61545-8 3-527-61544-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Chernornetric Methods in Molecular Design; Preface; A Personal Foreword; Contents; 1 Introduction; 1.1 Quantitative Molecular Design; 1.2 Chemometrics; 1.3 The Hansch Approach; 1.4 Modern Chemometric Approaches in Molecular Design; 1.5 Software; 1.5.1 General Statistical Packages; 1.5.2 Specialized Software for SPC Studies; References; 2 Molecular Concepts; 2.1 Representations of Molecules; 2.1.1 Introduction; 2.1.2 Substituent Constants; 2.1.2.1 Electronic Substituent Constants; 2.1.2.2 The Hydrophobic Substituent Constant,p; 2.1.2.3 Partition Coefficient - Log P
2.1.2.4 Steric Substituent Constants2.1.3 Whole Molecule Representations; 2.1.3.1 Topological Descriptions; 2.1.3.2 Electronic Whole Molecule Descriptors; 2.1.3.3 Geometric Descriptors; References; 2.2 Atom-Level Descriptors for QSAR Analyzes; 2.2.1 Introduction; 2.2.2 An Atom-Level Description of Structure; 2.2.2.1 The Field; 2.2.2.2 The Intrinsic State of an Atom; 2.2.2.3 The Field Effect on Each Atom; 2.2.3 Strategies for Use of E-State Indices; 2.2.4 Examples of E-State QSAR; 2.2.4.1 MAO Inhibition with Hydrazides; 2.2.4.2 Adenosine A, Inhibitors 2.2.4.3 Anesthetic Concentration of Haloalkanes2.2.4.4 Odor Sensitivity of Pyrazines; 2.2.5 Conclusions; References; 3 Experimental Design in Synthesis Planning and Structure-Property Correlations; 3.1 Experimental Design; 3.1.1 The Importance of Experimental Design in Medicinal Chemistry; 3.1.2 Strategy in Experimental Design; 3.1.3 Selected Methods for Experimental Design; 3.1.3.1 Methods for the Direct Optimization of Lead Compounds; 3.1.3.2 Methods for the Systematic Investigation of Parameter Space; 3.1.3.3 Choice of Molecular Descriptors; 3.1.4 Summary and Conclusion; References 3.2 Applications of Statistical Experimental Design and PLS Modeling in QSAR3.2.1 Introduction; 3.2.2 A Strategy for QSAR Development in Drug Design; 3.2.2.1 Formulation of Classes of Similar Compounds (Step 1); 3.2.2.2 Structural Description and Definition of Design Variables (Step 2); 3.2.2.3 Selection of the Training Set of Compounds (Step 3); 3.2.2.4 Biological Testing (Step 4); 3.2.2.5 QSAR Development (Step 5; 3.2.2.6 Validation and Predictions for Non-Tested Compounds (Step; 3.2.3 Examples of Design and PLS Modeling; 3.2.3.1 Bradykinin Potentiating Pentapeptides 3.2.3.2 Dipeptides (Inhibiting the Angiotensin Converting Enzyme)3.2.3.3 Dipeptides (Bitter Tasting); 3.2.3.4 Mimetics; 3.2.3.5 Haloalkanes; 3.2.3.6 Dibenzofurans; 3.2.3.7 Monosubstituted Benzenes; 3.2.3.8 Corrosive Carboxylic Acids; 3.2.4 Discussion and Conclusions; Software Used; Acknowledgements; References; 3.3 Total Response Surface Optimization; 3.3.1 Background; 3.3.2 Representation of a Response Surface; 3.3.3 Structure Descriptors from Chemical Graph Theory; 3.3.4 Examples; 3.3.4.1 Neurotoxicity of Fluorophosphorous Compounds 3.3.4.2 Bioconcentration of Chlorinated Phenyls and Biphenyls |
| Record Nr. | UNISA-996218390503316 |
| Weinheim, Ger. ; ; New York, : VCH, c1995 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Chemometric methods in molecular design [[electronic resource] /] / edited by Han van de Waterbeemd
| Chemometric methods in molecular design [[electronic resource] /] / edited by Han van de Waterbeemd |
| Pubbl/distr/stampa | Weinheim, Ger. ; ; New York, : VCH, c1995 |
| Descrizione fisica | 1 online resource (380 p.) |
| Disciplina |
547.13
615/.1901 |
| Altri autori (Persone) | WaterbeemdHan van de |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
QSAR (Biochemistry)
Drugs - Design |
| ISBN |
1-281-75866-3
9786611758660 3-527-61545-8 3-527-61544-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Chernornetric Methods in Molecular Design; Preface; A Personal Foreword; Contents; 1 Introduction; 1.1 Quantitative Molecular Design; 1.2 Chemometrics; 1.3 The Hansch Approach; 1.4 Modern Chemometric Approaches in Molecular Design; 1.5 Software; 1.5.1 General Statistical Packages; 1.5.2 Specialized Software for SPC Studies; References; 2 Molecular Concepts; 2.1 Representations of Molecules; 2.1.1 Introduction; 2.1.2 Substituent Constants; 2.1.2.1 Electronic Substituent Constants; 2.1.2.2 The Hydrophobic Substituent Constant,p; 2.1.2.3 Partition Coefficient - Log P
2.1.2.4 Steric Substituent Constants2.1.3 Whole Molecule Representations; 2.1.3.1 Topological Descriptions; 2.1.3.2 Electronic Whole Molecule Descriptors; 2.1.3.3 Geometric Descriptors; References; 2.2 Atom-Level Descriptors for QSAR Analyzes; 2.2.1 Introduction; 2.2.2 An Atom-Level Description of Structure; 2.2.2.1 The Field; 2.2.2.2 The Intrinsic State of an Atom; 2.2.2.3 The Field Effect on Each Atom; 2.2.3 Strategies for Use of E-State Indices; 2.2.4 Examples of E-State QSAR; 2.2.4.1 MAO Inhibition with Hydrazides; 2.2.4.2 Adenosine A, Inhibitors 2.2.4.3 Anesthetic Concentration of Haloalkanes2.2.4.4 Odor Sensitivity of Pyrazines; 2.2.5 Conclusions; References; 3 Experimental Design in Synthesis Planning and Structure-Property Correlations; 3.1 Experimental Design; 3.1.1 The Importance of Experimental Design in Medicinal Chemistry; 3.1.2 Strategy in Experimental Design; 3.1.3 Selected Methods for Experimental Design; 3.1.3.1 Methods for the Direct Optimization of Lead Compounds; 3.1.3.2 Methods for the Systematic Investigation of Parameter Space; 3.1.3.3 Choice of Molecular Descriptors; 3.1.4 Summary and Conclusion; References 3.2 Applications of Statistical Experimental Design and PLS Modeling in QSAR3.2.1 Introduction; 3.2.2 A Strategy for QSAR Development in Drug Design; 3.2.2.1 Formulation of Classes of Similar Compounds (Step 1); 3.2.2.2 Structural Description and Definition of Design Variables (Step 2); 3.2.2.3 Selection of the Training Set of Compounds (Step 3); 3.2.2.4 Biological Testing (Step 4); 3.2.2.5 QSAR Development (Step 5; 3.2.2.6 Validation and Predictions for Non-Tested Compounds (Step; 3.2.3 Examples of Design and PLS Modeling; 3.2.3.1 Bradykinin Potentiating Pentapeptides 3.2.3.2 Dipeptides (Inhibiting the Angiotensin Converting Enzyme)3.2.3.3 Dipeptides (Bitter Tasting); 3.2.3.4 Mimetics; 3.2.3.5 Haloalkanes; 3.2.3.6 Dibenzofurans; 3.2.3.7 Monosubstituted Benzenes; 3.2.3.8 Corrosive Carboxylic Acids; 3.2.4 Discussion and Conclusions; Software Used; Acknowledgements; References; 3.3 Total Response Surface Optimization; 3.3.1 Background; 3.3.2 Representation of a Response Surface; 3.3.3 Structure Descriptors from Chemical Graph Theory; 3.3.4 Examples; 3.3.4.1 Neurotoxicity of Fluorophosphorous Compounds 3.3.4.2 Bioconcentration of Chlorinated Phenyls and Biphenyls |
| Record Nr. | UNINA-9910830975303321 |
| Weinheim, Ger. ; ; New York, : VCH, c1995 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
CNS & neurological disorders drug targets
| CNS & neurological disorders drug targets |
| Pubbl/distr/stampa | Saif Zone, Sharjah, U.A.E. ; ; San Francisco, CA, : Bentham Science Publishers, ©2006- |
| Descrizione fisica | 1 online resource |
| Soggetto topico |
Neuropharmacology
Nervous system - Diseases - Effect of drugs on Drug delivery systems Drugs - Design Central Nervous System Diseases - drug therapy Nervous System Diseases - drug therapy Drug Delivery Systems Drug Design |
| Soggetto genere / forma | Periodicals. |
| ISSN | 1996-3181 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti |
CNS & neurological disorders. Drug targets
CNS and neurological disorders drug targets |
| Record Nr. | UNISA-996207246403316 |
| Saif Zone, Sharjah, U.A.E. ; ; San Francisco, CA, : Bentham Science Publishers, ©2006- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Comprehensive quality by design for pharmaceutical product development and manufacture / / edited by Gintaras V. Reklaitis, Salvador Garcia-Munoz, Christine Seymour
| Comprehensive quality by design for pharmaceutical product development and manufacture / / edited by Gintaras V. Reklaitis, Salvador Garcia-Munoz, Christine Seymour |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , 2017 |
| Descrizione fisica | 1 online resource (397 pages) |
| Disciplina | 615.1/9 |
| Soggetto topico |
Drugs - Design
Pharmaceutical technology - Quality control |
| ISBN |
1-119-35617-2
1-119-35616-4 1-119-35618-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910270939003321 |
| Hoboken, New Jersey : , : Wiley, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Soggetto topico
-
Drugs - Design
(283)
- Pharmaceutical chemistry (86)
- Drug development (61)
- Drug Design (35)
- Drug delivery systems (16)