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Basic principles of drug discovery and development / / Benjamin E. Blass
| Basic principles of drug discovery and development / / Benjamin E. Blass |
| Autore | Benjamin Blass |
| Pubbl/distr/stampa | Amsterdam, [Netherlands] : , : Academic Press, , 2015 |
| Descrizione fisica | 1 online resource (591 p.) |
| Disciplina | 615.19 |
| Soggetto topico |
Drug development
Drugs - Design |
| ISBN | 1-78539-787-7 |
| Classificazione | 44.38 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Basic Principles of Drug Discovery and Development; Copyright; Dedication; Contents; Foreword; Chapter 1 - Drug Discovery and Development: An Overview of Modern Methods and Principles; DRUG DISCOVERY AND DEVELOPMENT FROM 20,000FEET (FIGURE 1.7); TARGET SELECTION: THE FIRST STEP FORWARD; HIT IDENTIFICATION: FINDING A STARTING POINT; IDENTIFY A CLINICAL CANDIDATE: JUGGLING THE PROPERTIES; QUESTIONS; References; Chapter 2 - The Drug Discovery Process: From Ancient Times to the Present Day; THE AGE OF BOTANICALS: PREINDUSTRIAL DRUG DISCOVERY
PAUL EHRLICH: THE FATHER OF MODERN DRUG DISCOVERY10MILESTONES IN DRUG DISCOVERY; THE RISE OF BIOLOGICS AND MACROMOLECULAR THERAPEUTICS; SOCIETAL AND GOVERNMENTAL IMPACTS; REGULATORY MILESTONES; FUTURE DEVELOPMENTS IN DRUG DISCOVERY; QUESTIONS; References; Chapter 3 - Classical Targets in Drug Discovery; PROTEIN STRUCTURE; ENZYMES; INHIBITION OF ENZYMES; G-PROTEIN-COUPLED RECEPTORS (GPCRS); ION CHANNELS; MEMBRANE TRANSPORT PROTEINS (TRANSPORTERS); EMERGING TARGETS; QUESTIONS; References; Chapter 4 - In vitro Screening Systems; THE LANGUAGE OF SCREENING: BASIC TERMS; STREPTAVIDIN AND BIOTIN BIOCHEMICAL VERSUS CELLULAR ASSAYSASSAY SYSTEMS AND METHODS OF DETECTION; RADIOLIGAND ASSAY SYSTEMS; ENZYME-LINKED IMMUNOSORBENT ASSAY (ELISA); FLUORESCENCE-BASED ASSAY SYSTEMS; REPORTER GENE ASSAYS; KINETIC FLUORESCENT MEASUREMENT SYSTEMS; LABEL-FREE ASSAY SYSTEMS; ELECTROPHYSIOLOGICAL PATCH CLAMP; GENERAL CONSIDERATION FOR ALL SCREENING METHODS; QUESTIONS; References; Chapter 5 - Medicinal Chemistry; STRUCTURE-ACTIVITY RELATIONSHIPS AND STRUCTURE-PROPERTY RELATIONSHIPS; THE ROLE OF CHIRALITY; PUSH AND PULL IN STRUCTURE-ACTIVITY RELATIONSHIPS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS EXEMPLARY ANIMAL MODELS BY DISEASE CATEGORYANIMAL MODELS OF INFECTIOUS DISEASE; ANIMAL MODELS OF ONCOLOGY; QUESTIONS; References; Chapter 8 - Safety and Toxicology; SOURCES OF TOXICITY; ACUTE VERSUS CHRONIC TOXICITY; CYTOTOXICITY; CARCINOGENICITY, GENOTOXICITY, AND MUTAGENICITY; DRUG-DRUG INTERACTIONS; CARDIOVASCULAR SAFETY AND TOXICOLOGY STUDIES; CENTRAL NERVOUS SYSTEM SAFETY AND TOXICOLOGY STUDIES; IMMUNE SYSTEM MEDIATED SAFETY ISSUES; TERATOGENICITY; IN VIVO TOXICITY AND SAFETY STUDIES; QUESTIONS; References; Chapter 9 - Basics of Clinical Trials; BEFORE THE CLINIC; DRUG SUPPLY DELIVERY METHODS |
| Record Nr. | UNINA-9910788115403321 |
Benjamin Blass
|
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| Amsterdam, [Netherlands] : , : Academic Press, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Basic principles of drug discovery and development / / Benjamin E. Blass
| Basic principles of drug discovery and development / / Benjamin E. Blass |
| Autore | Benjamin Blass |
| Pubbl/distr/stampa | Amsterdam, [Netherlands] : , : Academic Press, , 2015 |
| Descrizione fisica | 1 online resource (591 p.) |
| Disciplina | 615.19 |
| Soggetto topico |
Drug development
Drugs - Design |
| ISBN | 1-78539-787-7 |
| Classificazione | 44.38 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Basic Principles of Drug Discovery and Development; Copyright; Dedication; Contents; Foreword; Chapter 1 - Drug Discovery and Development: An Overview of Modern Methods and Principles; DRUG DISCOVERY AND DEVELOPMENT FROM 20,000FEET (FIGURE 1.7); TARGET SELECTION: THE FIRST STEP FORWARD; HIT IDENTIFICATION: FINDING A STARTING POINT; IDENTIFY A CLINICAL CANDIDATE: JUGGLING THE PROPERTIES; QUESTIONS; References; Chapter 2 - The Drug Discovery Process: From Ancient Times to the Present Day; THE AGE OF BOTANICALS: PREINDUSTRIAL DRUG DISCOVERY
PAUL EHRLICH: THE FATHER OF MODERN DRUG DISCOVERY10MILESTONES IN DRUG DISCOVERY; THE RISE OF BIOLOGICS AND MACROMOLECULAR THERAPEUTICS; SOCIETAL AND GOVERNMENTAL IMPACTS; REGULATORY MILESTONES; FUTURE DEVELOPMENTS IN DRUG DISCOVERY; QUESTIONS; References; Chapter 3 - Classical Targets in Drug Discovery; PROTEIN STRUCTURE; ENZYMES; INHIBITION OF ENZYMES; G-PROTEIN-COUPLED RECEPTORS (GPCRS); ION CHANNELS; MEMBRANE TRANSPORT PROTEINS (TRANSPORTERS); EMERGING TARGETS; QUESTIONS; References; Chapter 4 - In vitro Screening Systems; THE LANGUAGE OF SCREENING: BASIC TERMS; STREPTAVIDIN AND BIOTIN BIOCHEMICAL VERSUS CELLULAR ASSAYSASSAY SYSTEMS AND METHODS OF DETECTION; RADIOLIGAND ASSAY SYSTEMS; ENZYME-LINKED IMMUNOSORBENT ASSAY (ELISA); FLUORESCENCE-BASED ASSAY SYSTEMS; REPORTER GENE ASSAYS; KINETIC FLUORESCENT MEASUREMENT SYSTEMS; LABEL-FREE ASSAY SYSTEMS; ELECTROPHYSIOLOGICAL PATCH CLAMP; GENERAL CONSIDERATION FOR ALL SCREENING METHODS; QUESTIONS; References; Chapter 5 - Medicinal Chemistry; STRUCTURE-ACTIVITY RELATIONSHIPS AND STRUCTURE-PROPERTY RELATIONSHIPS; THE ROLE OF CHIRALITY; PUSH AND PULL IN STRUCTURE-ACTIVITY RELATIONSHIPS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS EXEMPLARY ANIMAL MODELS BY DISEASE CATEGORYANIMAL MODELS OF INFECTIOUS DISEASE; ANIMAL MODELS OF ONCOLOGY; QUESTIONS; References; Chapter 8 - Safety and Toxicology; SOURCES OF TOXICITY; ACUTE VERSUS CHRONIC TOXICITY; CYTOTOXICITY; CARCINOGENICITY, GENOTOXICITY, AND MUTAGENICITY; DRUG-DRUG INTERACTIONS; CARDIOVASCULAR SAFETY AND TOXICOLOGY STUDIES; CENTRAL NERVOUS SYSTEM SAFETY AND TOXICOLOGY STUDIES; IMMUNE SYSTEM MEDIATED SAFETY ISSUES; TERATOGENICITY; IN VIVO TOXICITY AND SAFETY STUDIES; QUESTIONS; References; Chapter 9 - Basics of Clinical Trials; BEFORE THE CLINIC; DRUG SUPPLY DELIVERY METHODS |
| Record Nr. | UNINA-9910811820003321 |
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Benjamin Blass
|
||
| Amsterdam, [Netherlands] : , : Academic Press, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biomarkers in drug discovery and development : a handbook of practice, application, and strategy / / edited by Ramin Rahbari, Jonathan Van Niewaal, Michael R. Bleavins
| Biomarkers in drug discovery and development : a handbook of practice, application, and strategy / / edited by Ramin Rahbari, Jonathan Van Niewaal, Michael R. Bleavins |
| Edizione | [Second edition.] |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , 2020 |
| Descrizione fisica | 1 online resource (611 pages) |
| Disciplina | 615.19 |
| Soggetto topico |
Biochemical markers
Drugs - Design Drug development |
| ISBN |
1-119-18752-4
1-119-18751-6 1-119-18754-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Biomarkers Are Not New / Ian Dews -- Biomarkers : Facing the Challenges at the Crossroads of Research and Health Care / Gregory J. Downing -- Enabling Go/No Go Decisions / J. Fred Pritchard and M. Lynn Pritchard -- Developing a Clinical Biomarker Method with External Resources : A Case Study / Ross A. Fredenburg -- Imaging as a Localized Biomarker : Opportunities and Challenges / Jonathan B. Moody, Philip S. Murphy, and Edward P. Ficaro -- Imaging for Early Clinical Drug Development : Integrating Imaging Science With Drug Research / Philip S. Murphy, Mats Bergstrom, Jonathan B. Moody, and Edward P. Ficaro -- Circulating microRNAs as Biomarkers in Cardiovascular and Pulmonary Vascular Disease : Promises and Challenges / Miranda K. Culley and Stephen Y. Chan -- Characterization and Validation Biomarkers in Drug Development : Regulatory Perspective / Federico Goodsaid -- Fit-for-Purpose Method Validation and Assays of Protein Biomarkers During Drug Development / Jean W. Lee, Yuling Wu, and Jin Wang -- Applying Statistics Appropriately for Your Biomarker Application / Mary Zacour -- Qualification of Safety Biomarkers for Application to Early Drug Development / William B. Mattes and Frank D. Sistare -- A Pathologist's View of Drug and Biomarker Development / Robert W. Dunstan -- Development of Serum Calcium and Phosphorus as Clinical Biomarkers for Drug-Induced Systemic Mineralization : Case Study with a MEK Inhibitor / Alan P. Brown -- New Markers of Kidney Injury / Sven A. Beushausen -- Biomarkers from Bench to Bedside and Back -- Back Translation of Clinical Studies to Pre-clinical Models / Damian O'Connell, Zaki Shaikhibrahim, Frank Kramer, and Matthias Ocker -- Translational Medicine -- A Paradigm Shift in Modern Drug Discovery and Development : The Role of Biomarkers / Giora Z. Feuerstein, Salvatore Alesci, Frank L. Walsh, J. Lynn Rutkowski, and Robert R. Ruffolo, Jr. --.
Clinical Validation and Biomarker Translation / Ji-Young V. Kim, Raymond T. Ng, Robert Balshaw, Paul Keown, Robert McMaster, Bruce McManus, Karen Lam, and Scott J. Tebbutt -- Predicting and Assessing an Inflammatory Disease and Its Complications : Example from Rheumatoid Arthritis / Christina Trollmo and Lars Klareskog -- Validating In Vitro Toxicity Biomarkers Against Clinical Endpoints / Calvert Louden and Ruth A. Roberts -- Opportunities and Pitfalls Associated with Early Utilization of Biomarkers : Case Study in Anticoagulant Development / Kay A. Criswell -- Integrating Molecular Testing into Clinical Applications / Anthony A. Killeen -- IT Supporting Biomarker Enabled Drug Development / Michael Hehenberger -- Identifying Biomarker Profiles Through the Epidemiologic Analysis of Big Healthcare Data Implications for Clinical Management and Clinical Trial Design : A Case Study in Anemia of Chronic Kidney Disease / Gregory P. Fusco -- Computational Biology Approaches to Support Biomarker Discovery and Development / Bin Li, Hyunjin Shin, William L. Trepiccho, and Andrew Dorner -- Biomarkers in Pharmaceutical Development : The Essential Role of Project Management and Teamwork / Lena King, Malle Jurima-Romet, and Nita Ichhpurani -- Novel and Traditional Nonclinical Biomarker Utilization in the Estimation of Pharmaceutical Therapeutic Indices / Bruce D. Car, Brian Gemzik, and William R. Foster -- Ethics of Biomarkers : The Borders of Investigative Research, Informed Consent, and Patient Protection / Sara Assadian, Michael Burgess, Breanne Crouch, Karen Lam, and Bruce McManus -- Anti-Unicorn Principle : Appropriate Biomarkers Don't Need to Be Rare or Hard to Find / Michael R. Bleavins and Ramin Rahbari -- Translational Biomarker Imaging : Applications, Trends and Successes Today and Tomorrow / Patrick McConville and Deanne Lister --. |
| Record Nr. | UNINA-9910554843603321 |
| Hoboken, New Jersey : , : Wiley, , 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biomarkers in drug discovery and development : a handbook of practice, application, and strategy / / edited by Ramin Rahbari, Jonathan Van Niewaal, Michael R. Bleavins
| Biomarkers in drug discovery and development : a handbook of practice, application, and strategy / / edited by Ramin Rahbari, Jonathan Van Niewaal, Michael R. Bleavins |
| Edizione | [Second edition.] |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , 2020 |
| Descrizione fisica | 1 online resource (611 pages) |
| Disciplina | 615.19 |
| Soggetto topico |
Biochemical markers
Drugs - Design Drug development |
| ISBN |
1-119-18752-4
1-119-18751-6 1-119-18754-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Biomarkers Are Not New / Ian Dews -- Biomarkers : Facing the Challenges at the Crossroads of Research and Health Care / Gregory J. Downing -- Enabling Go/No Go Decisions / J. Fred Pritchard and M. Lynn Pritchard -- Developing a Clinical Biomarker Method with External Resources : A Case Study / Ross A. Fredenburg -- Imaging as a Localized Biomarker : Opportunities and Challenges / Jonathan B. Moody, Philip S. Murphy, and Edward P. Ficaro -- Imaging for Early Clinical Drug Development : Integrating Imaging Science With Drug Research / Philip S. Murphy, Mats Bergstrom, Jonathan B. Moody, and Edward P. Ficaro -- Circulating microRNAs as Biomarkers in Cardiovascular and Pulmonary Vascular Disease : Promises and Challenges / Miranda K. Culley and Stephen Y. Chan -- Characterization and Validation Biomarkers in Drug Development : Regulatory Perspective / Federico Goodsaid -- Fit-for-Purpose Method Validation and Assays of Protein Biomarkers During Drug Development / Jean W. Lee, Yuling Wu, and Jin Wang -- Applying Statistics Appropriately for Your Biomarker Application / Mary Zacour -- Qualification of Safety Biomarkers for Application to Early Drug Development / William B. Mattes and Frank D. Sistare -- A Pathologist's View of Drug and Biomarker Development / Robert W. Dunstan -- Development of Serum Calcium and Phosphorus as Clinical Biomarkers for Drug-Induced Systemic Mineralization : Case Study with a MEK Inhibitor / Alan P. Brown -- New Markers of Kidney Injury / Sven A. Beushausen -- Biomarkers from Bench to Bedside and Back -- Back Translation of Clinical Studies to Pre-clinical Models / Damian O'Connell, Zaki Shaikhibrahim, Frank Kramer, and Matthias Ocker -- Translational Medicine -- A Paradigm Shift in Modern Drug Discovery and Development : The Role of Biomarkers / Giora Z. Feuerstein, Salvatore Alesci, Frank L. Walsh, J. Lynn Rutkowski, and Robert R. Ruffolo, Jr. --.
Clinical Validation and Biomarker Translation / Ji-Young V. Kim, Raymond T. Ng, Robert Balshaw, Paul Keown, Robert McMaster, Bruce McManus, Karen Lam, and Scott J. Tebbutt -- Predicting and Assessing an Inflammatory Disease and Its Complications : Example from Rheumatoid Arthritis / Christina Trollmo and Lars Klareskog -- Validating In Vitro Toxicity Biomarkers Against Clinical Endpoints / Calvert Louden and Ruth A. Roberts -- Opportunities and Pitfalls Associated with Early Utilization of Biomarkers : Case Study in Anticoagulant Development / Kay A. Criswell -- Integrating Molecular Testing into Clinical Applications / Anthony A. Killeen -- IT Supporting Biomarker Enabled Drug Development / Michael Hehenberger -- Identifying Biomarker Profiles Through the Epidemiologic Analysis of Big Healthcare Data Implications for Clinical Management and Clinical Trial Design : A Case Study in Anemia of Chronic Kidney Disease / Gregory P. Fusco -- Computational Biology Approaches to Support Biomarker Discovery and Development / Bin Li, Hyunjin Shin, William L. Trepiccho, and Andrew Dorner -- Biomarkers in Pharmaceutical Development : The Essential Role of Project Management and Teamwork / Lena King, Malle Jurima-Romet, and Nita Ichhpurani -- Novel and Traditional Nonclinical Biomarker Utilization in the Estimation of Pharmaceutical Therapeutic Indices / Bruce D. Car, Brian Gemzik, and William R. Foster -- Ethics of Biomarkers : The Borders of Investigative Research, Informed Consent, and Patient Protection / Sara Assadian, Michael Burgess, Breanne Crouch, Karen Lam, and Bruce McManus -- Anti-Unicorn Principle : Appropriate Biomarkers Don't Need to Be Rare or Hard to Find / Michael R. Bleavins and Ramin Rahbari -- Translational Biomarker Imaging : Applications, Trends and Successes Today and Tomorrow / Patrick McConville and Deanne Lister --. |
| Record Nr. | UNINA-9910810893903321 |
| Hoboken, New Jersey : , : Wiley, , 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biomedical Translational Research [[electronic resource] ] : Drug Design and Discovery / / edited by R.C. Sobti, Naranjan S. Dhalla
| Biomedical Translational Research [[electronic resource] ] : Drug Design and Discovery / / edited by R.C. Sobti, Naranjan S. Dhalla |
| Edizione | [1st ed. 2022.] |
| Pubbl/distr/stampa | Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2022 |
| Descrizione fisica | 1 online resource (597 pages) |
| Disciplina | 610.28 |
| Soggetto topico |
Medicine - Research
Biology - Research Drugs - Design Pharmaceutical chemistry Genomics Bioinformatics Biomedical Research Structure-Based Drug Design Pharmaceutics Disseny de medicaments Enginyeria biomèdica |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 981-16-9232-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Chapter 1. Emerging Technologies : Gateway to Understand Molecular Insight of Diseases, Newer Drugs, Their Design and Targeting -- Chapter 2. Polypharmacology: New Paradigms in Drug Development -- Chapter 3. Drug Repurposing in Biomedical Research : Benefits and Challenges -- Chapter 4. Computational Methods for Drug Repurposing -- Chapter 5. Genomic Approaches for Drug Repositioning -- Chapter 6. Organ-On-A- Chip: Novel in-Vitro Model For Drug Discovery -- Chapter 7. Precision Radiomolecular Oncology: Challenging the Classical Statistical Evidence Based Medicine -- Chapter 8. Drug Repositioning of the Phenylpiperazine Derivative Naftopidil in Prostate Cancer Treatment -- Chapter 9. Biomarker Based Drug Discovery and Reverse Translational Approach -- Chapter 10. Nanotechnology in Dentistry -- Chapter 11. Nanoparticles a Potential Breakthrough in Counteracting Multidrug-Resistant Bacterial Infections: A Holistic View on Underlying Mechanisms and Antibacterial Properties -- Chapter 12. Emerging Role of Cannabinoid System Modulators in Treatment of Cancer -- Chapter 13. Nanodrugs : A Futuristic Approach for Treating Nephrolithiasis -- Chapter 14. Lipo Dermaceuticals : Technological Transformation -- Chapter 15. The Importance of Drug Dose Adjustment in Elderly Patients with Special Considerations for Patients on Diverse Co-Medications and Antidepressants -- Chapter 16. Role of Microfluidics and Nano Fluidics in Managing CAD -- Chapter 17. Targeted Gene Delivery Through Magnetofection: The New Face of Medicine -- Chapter 18. Qbd-Steered Systematic Development of Drug Delivery Nanoconstructs : Vital Precepts, Retrospect and Prospects -- Chapter 19. Nanoemulsions: A Potential Advanced Nanocarrier Platform for Herbal Drug Delivery -- Chapter 20. Sirna Encapsulated Nanoparticles for Targeting Dorsal Root Ganglion (Drg) in Diabetic Neuropathic Pain -- Chapter 21. EGFR Targeted Quinazoline Clubbed Heterocycles as Anti-Cancer Agents. Chapter 22. Therapeutic Human Monoclonal Antibodies -- Chapter 23. Hydroxyapatites and Their Biomedical Applications -- Chapter 24. Recent Progress in Applications of Magnetic Nanoparticles in Medicine: A Review -- Chapter 25. Chimeric Antigen Receptor T-Cell Therapy: A Cutting Edge Therapy for Multiple Myeloma -- Chapter 26. Nanoparticles-Associated Lipopeptides: A New Class of Antimicrobials -- Chapter 27. Antimicrobial Applications of Engineered Metal-Based Nanomaterials -- Chapter 28. Strengthening Immunity-Ayurveda & Medicinal Plants -- Chapter 29. The Pathophysiology of Liver Disorders and Pharmacotherapy Options with Special Reference to Traditional Herbal Medicines: A Comprehensive Review -- Chapter 30. Polymeric Vehicles for Controlled Delivery of Ayurvedic Drugs for Wound Management. |
| Record Nr. | UNINA-9910585974703321 |
| Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biosilico
| Biosilico |
| Pubbl/distr/stampa | London, : Elsevier Science, ©2003 |
| Descrizione fisica | 1 online resource |
| Collana | Drug discovery today publications |
| Soggetto topico |
Drugs - Design
Drugs - Design - Data processing Biochemistry - Data processing Drugs - Computer simulation Drug development - Data processing Drug Design Medical Informatics |
| Soggetto genere / forma |
Periodicals
Periodicals. |
| ISSN | 1478-5282 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-996198118503316 |
| London, : Elsevier Science, ©2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Biosilico
| Biosilico |
| Pubbl/distr/stampa | London, : Elsevier Science, ©2003 |
| Descrizione fisica | 1 online resource |
| Collana | Drug discovery today publications |
| Soggetto topico |
Drugs - Design
Drugs - Design - Data processing Biochemistry - Data processing Drugs - Computer simulation Drug development - Data processing Drug Design Medical Informatics |
| Soggetto genere / forma |
Periodicals
Periodicals. |
| ISSN | 1478-5282 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910143062803321 |
| London, : Elsevier Science, ©2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Case studies in modern drug discovery and development [[electronic resource] /] / edited by Xianhai Huang, Robert G. Aslanian
| Case studies in modern drug discovery and development [[electronic resource] /] / edited by Xianhai Huang, Robert G. Aslanian |
| Pubbl/distr/stampa | Hoboken, NJ, : John Wiley & Sons, c2012 |
| Descrizione fisica | 1 online resource (451 p.) |
| Disciplina | 615.19 |
| Altri autori (Persone) |
HuangXianhai
AslanianRobert G |
| Soggetto topico |
Drugs - Design
Pharmaceutical chemistry |
| ISBN |
1-280-59100-5
9786613620835 1-118-21967-8 1-118-21968-6 1-118-21970-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Introduction: drug discovery in difficult times / Malcom MacCoss -- Discovery and development of the DPP-4 inhibitor JANUVIA? (Sitagliptin) / Emma R. Parmee ... [et al.] -- Olmesartan medoxiomil, an angiotensin II receptor blocker / Hiroaki Yanagisawa, Hiroyuki Koike, and Shinichiro Miura -- Discovery of heterocyclic phosphonic acids as novel AMP mimics that are potent and selective fructose-1,6-bisphosphatase inhibitors and elicit potent glucose-lowering effects in diabetic animals and human / Qun Dang, and Mark D. Erion -- Setting the paradigm of targeted drugs for the treatment of cancer : Imatinib and Nilotinib therapies for chronic myelogenous leukaemia / Paul W. Manley and Jürg Zimmermann -- Amrubicin, a completely synthetic 9-aminoanthracycline, for extensive-disease small-cell lung cancer / Mitsuharu Hanada -- The discovery of dual IGF-1R and IR inhibitor FQIT for the treatment of cancer / Meizhong Jin, Elizabeth Buck, and Mark J. Mulvihill -- Discovery and development of Montelukast (Singulair?) / Robert N. Young -- Discovery and development of Maraviroc, a CCR5 antagonist for the treatment of HIV Infection / Patrick Dorr, Blanda Stammen, Elna van der Ryst -- Discovery of antimalarial drug Artemisinin and beyond / Ao Zhang, Weiwei Mao, Yu Zhang -- Discovery and process development of MK-4965, a potent non-nucleoside reverse transcriptase inhibitor / Yong-Li Zhong, Thomas J. Tucker, and Jingjun Yin -- Discovery of Boceprevir and Narlaprevir : the first and second generation of HCV NS3 protease inhibitors / Kevin X. Chen, F. George Njoroge -- The discovery of Samsca (Tolvaptan) : the first oral nonpeptide vasopressin receptor antagonist / Kazumi Kondo, Yoshitaka Yamamura -- SILODOSIN (Urief?, Rapaflo?, Thrupas?, Urorec?, SilodixTM) : a selective à1A adrenoceptor antagonist for the treatment of benign prostatic hyperplasia / Masaki Yoshida ... [et al.] -- Raloxifene : a selective estrogen receptor modulator (SERM) / Jeffrey A. Dodge and Henry U. Bryant. |
| Record Nr. | UNINA-9910141253903321 |
| Hoboken, NJ, : John Wiley & Sons, c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Challenges and Solutions Against Visceral Leishmaniasis [[electronic resource] /] / edited by Angamuthu Selvapandiyan, Ruchi Singh, Niti Puri, Nirmal K. Ganguly
| Challenges and Solutions Against Visceral Leishmaniasis [[electronic resource] /] / edited by Angamuthu Selvapandiyan, Ruchi Singh, Niti Puri, Nirmal K. Ganguly |
| Edizione | [1st ed. 2023.] |
| Pubbl/distr/stampa | Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2023 |
| Descrizione fisica | 1 online resource (XXI, 449 p. 36 illus., 34 illus. in color.) |
| Disciplina | 571.999 |
| Soggetto topico |
Parasitology
Drugs - Design Pharmaceutical chemistry Epidemiology Structure-Based Drug Design Pharmaceutics |
| ISBN | 981-9969-99-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Module 1_Epidemiology and Surveillances -- Module 2_Omics and Advancement in Diagnosis -- Module 3_Genetics -- Module 4_New Drug Discovery Opportunity -- Module 5_Immunity and Vaccine Development. |
| Record Nr. | UNINA-9910806194803321 |
| Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2023 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Chemical biology & drug design
| Chemical biology & drug design |
| Pubbl/distr/stampa | [Oxford], : Blackwell Munksgaard |
| Descrizione fisica | 1 online resource |
| Soggetto topico |
Peptides
Proteins Drugs - Design Biochemistry Pharmaceutical chemistry Chemistry, Pharmaceutical Drug Design biochemistry Protéines Médicaments - Conception Biochimie Chimie pharmaceutique |
| Soggetto genere / forma |
Internet resource
Computer network resources. Periodicals. |
| ISSN | 1747-0285 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti |
Chemical biology and drug design
Chem Biol Drug Des |
| Record Nr. | UNISA-996207300103316 |
| [Oxford], : Blackwell Munksgaard | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Soggetto topico
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Drugs - Design
(307)
- Pharmaceutical chemistry (91)
- Drug development (68)
- Drug Design (35)
- Biopharmaceutics (16)