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Anthony Cerami : a life in translational medicine / / Conrad Keating
| Anthony Cerami : a life in translational medicine / / Conrad Keating |
| Autore | Keating Conrad |
| Pubbl/distr/stampa | New Brunswick : , : Rutgers University Press, , [2021] |
| Descrizione fisica | 1 online resource (219 pages) |
| Disciplina | 610.72 |
| Soggetto topico |
Medicine - Research
Medical scientists Drugs - Design Biochemists |
| Soggetto non controllato | Anthony Cerami, Translational Medicine, Medicine, therapeutics, Rockefeller University, biochemistry, malaria vaccine, tropical diseases, Africa, immunology, metabolic diseases, diabetes, medical research, Ph.D., pathogenesis, Harvard, Crohn's disease |
| ISBN |
1-9788-0142-4
1-9788-0144-0 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Introduction -- Hard work -- The Rockefeller effect -- The shaping of a scientific mind -- The Rockefeller University and the broad horizon -- Diabetes: The creation of the hemoglobin arc test -- Glucose, aging, the cross-linking of biology and business -- The conceptual breakthrough -- Cachectin -- Tumor necrosis factor -- Leaving the Rockefeller University: The end of the dream -- Philanthropy goes awry -- Translation in transition -- Anti-TNF therapy: Changing the pharmaceutical landscape -- Taking on big pharma. |
| Record Nr. | UNINA-9910794539803321 |
Keating Conrad
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| New Brunswick : , : Rutgers University Press, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Anthony Cerami : a life in translational medicine / / Conrad Keating
| Anthony Cerami : a life in translational medicine / / Conrad Keating |
| Autore | Keating Conrad |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | New Brunswick : , : Rutgers University Press, , [2021] |
| Descrizione fisica | 1 online resource (219 pages) |
| Disciplina | 610.72 |
| Soggetto topico |
Medicine - Research
Medical scientists Drugs - Design Biochemists |
| Soggetto non controllato | Anthony Cerami, Translational Medicine, Medicine, therapeutics, Rockefeller University, biochemistry, malaria vaccine, tropical diseases, Africa, immunology, metabolic diseases, diabetes, medical research, Ph.D., pathogenesis, Harvard, Crohn's disease |
| ISBN |
1-9788-0142-4
1-9788-0144-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Introduction -- Hard work -- The Rockefeller effect -- The shaping of a scientific mind -- The Rockefeller University and the broad horizon -- Diabetes: The creation of the hemoglobin arc test -- Glucose, aging, the cross-linking of biology and business -- The conceptual breakthrough -- Cachectin -- Tumor necrosis factor -- Leaving the Rockefeller University: The end of the dream -- Philanthropy goes awry -- Translation in transition -- Anti-TNF therapy: Changing the pharmaceutical landscape -- Taking on big pharma. |
| Record Nr. | UNINA-9910813351403321 |
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Keating Conrad
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| New Brunswick : , : Rutgers University Press, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Anticancer drugs : design, delivery and pharmacology / / Peter Spencer and Walter Holt, editors
| Anticancer drugs : design, delivery and pharmacology / / Peter Spencer and Walter Holt, editors |
| Pubbl/distr/stampa | New York : , : Nova Biomedical Books, , 2009 |
| Descrizione fisica | 1 online resource (xi, 271 pages) : illustrations |
| Disciplina | 615/.798 |
| Altri autori (Persone) |
HoltWalter
SpencerPeter <1964-> |
| Collana | Cancer etiology, diagnosis and treatments |
| Soggetto topico |
Antineoplastic agents
Antimitotic agents Cancer - Chemotherapy Drugs - Design |
| ISBN | 1-60876-629-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Micro- and nano-particulate drug delivery systems for cancer treatment / José L. Arias -- Geldanamycin derivatives as promising anticancer drugs : therapy via Hsp90 inhibition / Alexander E. Kabakov -- Synergistic antitumor activity of metronomic dosing chemotherapy in combination with liposomal anticancer drug / Tatsuhiro Ishida, Hiroshi Kiwada -- Organotin polyethers as anticancer drugs / Charles E. Carraher, Michael R. Roner, Girish Barot -- Studies on anti-cancer agents : phenolic compounds and their pharmacological activity / Maria Dolors Pujol, Isabel Sánchez -- Design of novel anticancer drugs utilizing busulfan for optimizing pharmacological properties and pattern recognition techniques for elucidation of clinical efficacy / Ronald Bartzatt -- Analysis of associations among novel property descriptors and their capacity in determining clinical efficacy by utilizing pattern recognition technigues / Ronald Bartzatt -- Insights into the mode of action of bioreductive ruthenium cytotoxins / Erwin Reisner -- Marina crystal minerals(MCM) induce apoptosis of human metastatic breast cancer MDA-MB-231 cells in vitro / Mamdooh Ghoneum, Takeshi Ogura, Sastry Gollapudi. |
| Record Nr. | UNINA-9910779518403321 |
| New York : , : Nova Biomedical Books, , 2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Anticancer drugs : design, delivery and pharmacology / / Peter Spencer and Walter Holt, editors
| Anticancer drugs : design, delivery and pharmacology / / Peter Spencer and Walter Holt, editors |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | New York : , : Nova Biomedical Books, , 2009 |
| Descrizione fisica | 1 online resource (xi, 271 pages) : illustrations |
| Disciplina | 615/.798 |
| Altri autori (Persone) |
HoltWalter
SpencerPeter <1964-> |
| Collana | Cancer etiology, diagnosis and treatments |
| Soggetto topico |
Antineoplastic agents
Antimitotic agents Cancer - Chemotherapy Drugs - Design |
| ISBN | 1-60876-629-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Micro- and nano-particulate drug delivery systems for cancer treatment / José L. Arias -- Geldanamycin derivatives as promising anticancer drugs : therapy via Hsp90 inhibition / Alexander E. Kabakov -- Synergistic antitumor activity of metronomic dosing chemotherapy in combination with liposomal anticancer drug / Tatsuhiro Ishida, Hiroshi Kiwada -- Organotin polyethers as anticancer drugs / Charles E. Carraher, Michael R. Roner, Girish Barot -- Studies on anti-cancer agents : phenolic compounds and their pharmacological activity / Maria Dolors Pujol, Isabel Sánchez -- Design of novel anticancer drugs utilizing busulfan for optimizing pharmacological properties and pattern recognition techniques for elucidation of clinical efficacy / Ronald Bartzatt -- Analysis of associations among novel property descriptors and their capacity in determining clinical efficacy by utilizing pattern recognition technigues / Ronald Bartzatt -- Insights into the mode of action of bioreductive ruthenium cytotoxins / Erwin Reisner -- Marina crystal minerals(MCM) induce apoptosis of human metastatic breast cancer MDA-MB-231 cells in vitro / Mamdooh Ghoneum, Takeshi Ogura, Sastry Gollapudi. |
| Record Nr. | UNINA-9910824158703321 |
| New York : , : Nova Biomedical Books, , 2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Antimicrobial drug discovery [[electronic resource] ] : emerging strategies / / edited by George Tegos and Eleftherios Mylonakis
| Antimicrobial drug discovery [[electronic resource] ] : emerging strategies / / edited by George Tegos and Eleftherios Mylonakis |
| Pubbl/distr/stampa | Wallingford, Oxfordshire, U.K., : CABI, 2012 |
| Descrizione fisica | 1 online resource (369 p.) |
| Disciplina | 615.792 |
| Altri autori (Persone) |
TegosGeorge
MylonakisEleftherios |
| Collana |
Advances in Molecular and Cellular Microbiology
Advances in molecular and cellular microbiology |
| Soggetto topico |
Anti-infective agents
Drugs - Design Diseases - Animal models High throughput screening - Methodology Photosensitizing compounds Pharmacology |
| ISBN |
1-283-67084-4
1-78064-031-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Emerging discovery strategies : an evolving necessity / Anthony R. Ball and George P. Tegos -- The antibiotic crisis / Arnold L. Demain and Jaroslav Spizek -- Structure, genetic regulation, physiology and function of the AcrAB-TolC efflux pump of escerichia coli and salmonella / Leonard Amaral ... [et al.] -- Small molecule efflux pump inhibitors from natural products as a potential source of antimicrobial agents / Sanjay M. Jachak ... [et al.] -- Fungal efflux-mediated resistance : from targets to inhibitors / Brian C. Monk ... [et al.] -- Vacuolar ATPase (V-ATPase) : a model proton pump for antifungal drug discovery -- Karlett J Parra -- Drug tolerance, persister cells and drug discovery / Kim Lewis -- Inhibition of quorum sensing as a novel antimicrobial strategy -- Gilles Brackman, Hans J. Nelis and Tom Coenye -- Filamentous temperature-sensitive mutant Z (FtsZ) protein as an antibacterial target / Jaroslaw M. Boberek ... [et al.] -- Lysostaphin : a silver bullet for staph / John F. Kokai-Kun -- Strategies to identify modified ribosomally synthesized antimicrobials -- Alan J. Marsh ... [et al.] -- QSAR based discovery of antimicrobial peptides active against multidrug resistant bacteria / Christopher D. Fjell ... [et al.] -- Acetyl-CoA carboxylase as a target for antibacterial development / Grover L. Waldrop -- Underexploited targets in LPS biogenenesis for the design of antibacterials / Laura Cipolla ... [et al.] -- Predicting and dissecting biomolecular interactions by information-driven docking / Panagiotis Kastritsis & Alexandre M.J.J Bonvin -- Anti-fungals and anti-fungal drug discovery / Richard Calderone ... [et al.] -- Pathosystematic studies and the rational design of antifungal interventions / Elaine M Bignell and Darius Armstrong-James -- In vivo high-throughput antimicrobial discovery screens utilizing caenorhabditis elegans as an alternative host / Jeffrey J. Coleman and Eleftherios Mylonakis -- Drosophila melanogaster as a versatile model for discovery of drugs effective against human microbe-induced infection and pathology / Yiorgos Apidianakis and Dimitrios P. Kontoyiannis -- Antimicrobial photosensitizers - harnessing the power of light to treat infections / Sulbha K Sharma, Tianhong Dai and Michael R Hamblin -- Nanoparticle platforms for antimicrobial therapy / David Trofa, Joshua D. Nosanchuk -- Antimicrobial activity of carbon nanotubes / Shaobin Liu, Yuan Chen. |
| Record Nr. | UNINA-9910626114203321 |
| Wallingford, Oxfordshire, U.K., : CABI, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Antimicrobial peptides : discovery, design and novel therapeutic strategies / / edited by Guangshun Wang
| Antimicrobial peptides : discovery, design and novel therapeutic strategies / / edited by Guangshun Wang |
| Edizione | [Second edition.] |
| Pubbl/distr/stampa | Oxfordshire, England ; ; Boston, Massachusetts : , : CABI, , [2017] |
| Descrizione fisica | 1 online resource (xvii, 268 pages) : illustrations |
| Disciplina | 612.015 |
| Soggetto topico |
Peptide antibiotics
Drugs - Design |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-78639-041-8
1-78639-040-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910480831003321 |
| Oxfordshire, England ; ; Boston, Massachusetts : , : CABI, , [2017] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Antimicrobial peptides : discovery, design and novel therapeutic strategies / / edited by Guangshun Wang
| Antimicrobial peptides : discovery, design and novel therapeutic strategies / / edited by Guangshun Wang |
| Edizione | [Second edition.] |
| Pubbl/distr/stampa | Oxfordshire, England ; ; Boston, Massachusetts : , : CABI, , [2017] |
| Descrizione fisica | 1 online resource (xvii, 268 pages) : illustrations |
| Disciplina | 612.015 |
| Soggetto topico |
Peptide antibiotics
Drugs - Design |
| ISBN |
1-78639-041-8
1-78639-040-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Discovery, classification and functional diversity of antimicrobial peptides / Guangshun Wang -- Structural and functional diversity of cathelicidins / Alessandro Tossi, Barbara Skerlavaj, Francesca D'Este and Renato Gennaro -- Disulfide-linked defensins and their therapeutic potential -- Monique von Hoek -- Lantibiotics : bioengineering and applications / Brian Healy and Paul Cotter -- Discovery of novel antimicrobial peptides using combinatorial chemistry and high-throughput screening / Charles G. Starr and William C. Wimley -- Prediction and design of antimicrobial peptides: methods and applications to genomes and proteomes / Guangshun Wang -- Antimicrobial peptides, multiple mechanisms against a variety of targets / Li-av Segev-Zarko, Maria Luisa Mangoni and Yechiel Shai -- Microbial membranes and the action of antimicrobial peptides / José Carlos Bozelli Junior, Shirley Schreier and Richard Epand -- Non-membrane-targeting amps, novel therapeutic opportunities? / Marco Scocchi, Mario Mardirossian, Giulia Runti and Monica Benincasa -- Structural insight into the mechanism of action of antimicrobial peptides and structure-based design / Guangshun Wang -- Synergy of antimicrobial peptides / Moswabar H. Chowdhury, Gill Diamond and Lisa Kathleen Ryan -- Surface immobilization of antimicrobial peptides to prevent biofilm formation / Biswajit Mishra, Scott Reiling and Guangshun Wang -- Sustained delivery of cathelicidin antimicrobial peptide-inducing compounds to minimize infection and enhance wound healing / Jingwei Xie, Gitali Ganguli-Indra,, Arup K. Indra and Adrian Gombart -- Immunomodulatory activities of cationic host defense peptides and novel therapeutic strategies / Kelli C. Wuerth and Robert Hancock. |
| Record Nr. | UNINA-9910529502403321 |
| Oxfordshire, England ; ; Boston, Massachusetts : , : CABI, , [2017] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Applied biophysics for drug discovery / / edited by Donald Huddler, Edward R. Zartler
| Applied biophysics for drug discovery / / edited by Donald Huddler, Edward R. Zartler |
| Pubbl/distr/stampa | Hoboken, New Jersey ; ; Chichester, West Sussex, England : , : Wiley, , 2017 |
| Descrizione fisica | 1 online resource (292 pages) : illustrations, graphs |
| Disciplina | 615.19 |
| Soggetto topico |
Drug development
Drugs - Design Biophysics |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-119-09950-1
1-119-09949-8 1-119-09951-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910270886603321 |
| Hoboken, New Jersey ; ; Chichester, West Sussex, England : , : Wiley, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Applied biophysics for drug discovery / / edited by Donald Huddler, Edward R. Zartler
| Applied biophysics for drug discovery / / edited by Donald Huddler, Edward R. Zartler |
| Pubbl/distr/stampa | Hoboken, New Jersey ; ; Chichester, West Sussex, England : , : Wiley, , 2017 |
| Descrizione fisica | 1 online resource (292 pages) : illustrations, graphs |
| Disciplina | 615.19 |
| Soggetto topico |
Drug development
Drugs - Design Biophysics |
| ISBN |
1-119-09950-1
1-119-09949-8 1-119-09951-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910831078103321 |
| Hoboken, New Jersey ; ; Chichester, West Sussex, England : , : Wiley, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The art of drug synthesis / / edited by Douglas S. Johnson, Jie Jack Li
| The art of drug synthesis / / edited by Douglas S. Johnson, Jie Jack Li |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, N.J. : , : Wiley-Interscience, , 2007 |
| Descrizione fisica | 1 online resource (xv, 276 pages) : illustrations |
| Disciplina |
615.19
615/.19 |
| Altri autori (Persone) |
JohnsonDouglas S <1968-> (Douglas Scott)
LiJie Jack |
| Collana | Wiley Series on Drug Synthesis |
| Soggetto topico |
Drugs - Design
Pharmaceutical chemistry |
| ISBN |
1-118-67846-X
1-280-91677-X 9786610916771 0-470-13497-6 0-470-13496-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
THE ART OF DRUG SYNTHESIS; CONTENTS; Foreword; Preface; Contributors; 1 THE ROLE OF MEDICINAL CHEMISTRY IN DRUG DISCOVERY; 1.1 Introduction; 1.2 Hurdles in the Drug Discovery Process; 1.3 The Tools of Medicinal Chemistry; 1.3.1 In Silico Modeling; 1.3.2 Structure-Based Drug Design (SBDD); 1.4 The Role of Synthetic Chemistry in Drug Discovery; References; 2 PROCESS RESEARCH: HOW MUCH? HOW SOON?; 2.1 Introduction; 2.2 Considerations for Successful Scale-up to Tox Batches and Phase I Material; 2.3 Considerations for Phase 2 Material and Beyond; 2.3.1 Reagent Selection; 2.3.2 Solvent Selection
2.3.3 Unit Operations; 2.3.4 Developing Simple, Effective, Efficient Work-ups and Isolations; 2.3.5 The Importance of Physical States; 2.3.6 Route Design and Process Optimization to Minimize COG; 2.4 Summary; References; I CANCER AND INFECTIOUS DISEASES; 3 AROMATASE INHIBITORS FOR BREAST CANCER: EXEMESTANE (AROMASIN®), ANASTROZOLE (ARIMIDEX®), AND LETROZOLE (FEMARA®); 3.1 Introduction; 3.2 Synthesis of Exemestane; 3.3 Synthesis of Anastrozole; 3.4 Synthesis of Letrozole; References 4 QUINOLONE ANTIBIOTICS: LEVOFLOXACIN (LEVAQUIN®), MOXIFLOXACIN (AVELOX®), GEMIFLOXACIN (FACTIVE®), AND GARENOXACIN (T-3811)4.1 Introduction; 4.1.1 Mechanism of Action; 4.1.2 Modes of Resistance; 4.1.3 Structure-Activity Relationship (SAR) and Structure-Toxicity Relationship (STR); 4.1.4 Pharmacokinetics; 4.1.5 Synthetic Approaches; 4.2 Levofloxacin; 4.3 Moxifloxacin; 4.4 Gemifloxacin; 4.5 Garenoxacin (T-3811): A Promising Clinical Candidate; References; 5 TRIAZOLE ANTIFUNGALS: ITRACONAZOLE (SPORANOX®), FLUCONAZOLE (DIFLUCAN®), VORICONAZOLE (VFEND®), AND FOSFLUCONAZOLE (PRODIF®) 5.1 Introduction; 5.2 Synthesis of Itraconazole; 5.3 Synthesis of Fluconazole; 5.4 Synthesis of Voriconazole; 5.5 Synthesis of Fosfluconazole; References; 6 NON-NUCLEOSIDE HIV REVERSE TRANSCRIPTASE INHIBITORS; 6.1 Introduction; 6.2 Synthesis of Nevirapine; 6.3 Synthesis of Efavirenz; 6.4 Synthesis of Delavirdine Mesylate; References; 7 NEURAMINIDASE INHIBITORS FOR INFLUENZA: OSELTAMIVIR PHOSPHATE (TAMIFLU®) AND ZANAMIVIR (RELENZA®); 7.1 Introduction; 7.1.1 Relenza; 7.1.2 Tamiflu; 7.2 Synthesis of Oseltamivir Phosphate (Tamiflu®); 7.3 Synthesis of Zanamivir (Relenza®); References II CARDIOVASCULAR AND METABOLIC DISEASES; 8 PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) AGONISTS FOR TYPE 2 DIABETES; 8.1 Introduction; 8.1.1 Insulin; 8.1.2 Sulfonylurea Drugs; 8.1.3 Meglitinides; 8.1.4 Biguanides; 8.1.5 Alpha-Glucosidase Inhibitors; 8.1.6 Thiazolidinediones; 8.2 Synthesis of Rosiglitazone; 8.3 Synthesis of Pioglitazone; 8.4 Synthesis of Muraglitazar; References; 9 ANGIOTENSIN AT(1) ANTAGONISTS FOR HYPERTENSION; 9.1 Introduction; 9.2 Losartan Potassium; 9.2.1 Introduction to Losartan Potassium; 9.2.2 Synthesis of Losartan Potassium; 9.3 Valsartan; 9.3.1 Introduction to Valsartan |
| Record Nr. | UNINA-9910143402603321 |
| Hoboken, N.J. : , : Wiley-Interscience, , 2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Soggetto topico
-
Drugs - Design
(283)
- Pharmaceutical chemistry (86)
- Drug development (61)
- Drug Design (35)
- Drug delivery systems (16)