New drug discovery and development [[electronic resource] /] / Daniel Lednicer |
Autore | Lednicer Daniel <1929-> |
Pubbl/distr/stampa | Hoboken, N.J., : Wiley-Interscience, c2007 |
Descrizione fisica | 1 online resource (204 p.) |
Disciplina |
615.19
615/.19 |
Soggetto topico |
Pharmaceutical chemistry
Drugs - Design Drug development |
Soggetto genere / forma | Electronic books. |
ISBN |
1-280-72148-0
9786610721481 0-470-06827-2 0-470-06826-4 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Antibiotics -- Antiviral drugs -- Antihypertensive agents -- Lipid lowering drugs -- Centrally acting analgesics -- Nonopiate analgesic agents -- Steroids -- Histamine -- From lab bench to pharmacy shelf. |
Record Nr. | UNINA-9910143680403321 |
Lednicer Daniel <1929->
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Hoboken, N.J., : Wiley-Interscience, c2007 | ||
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Lo trovi qui: Univ. Federico II | ||
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New drug discovery and development [[electronic resource] /] / Daniel Lednicer |
Autore | Lednicer Daniel <1929-> |
Pubbl/distr/stampa | Hoboken, N.J., : Wiley-Interscience, c2007 |
Descrizione fisica | 1 online resource (204 p.) |
Disciplina |
615.19
615/.19 |
Soggetto topico |
Pharmaceutical chemistry
Drugs - Design Drug development |
ISBN |
1-280-72148-0
9786610721481 0-470-06827-2 0-470-06826-4 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Antibiotics -- Antiviral drugs -- Antihypertensive agents -- Lipid lowering drugs -- Centrally acting analgesics -- Nonopiate analgesic agents -- Steroids -- Histamine -- From lab bench to pharmacy shelf. |
Record Nr. | UNINA-9910830715503321 |
Lednicer Daniel <1929->
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||
Hoboken, N.J., : Wiley-Interscience, c2007 | ||
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Lo trovi qui: Univ. Federico II | ||
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New medicine |
Pubbl/distr/stampa | Warszawa, : Borgis, [1996]- |
Soggetto topico |
Drugs - Design
Pharmaceutical Preparations Dietary Supplements Nutritional Physiological Phenomena |
Soggetto genere / forma |
Periodical
Periodicals. |
ISSN | 1731-2507 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Periodico |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910208359503321 |
Warszawa, : Borgis, [1996]- | ||
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Lo trovi qui: Univ. Federico II | ||
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New medicine |
Pubbl/distr/stampa | Warszawa, : Borgis, [1996]- |
Soggetto topico |
Drugs - Design
Pharmaceutical Preparations Dietary Supplements Nutritional Physiological Phenomena |
Soggetto genere / forma |
Periodical
Periodicals. |
ISSN | 1731-2507 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Periodico |
Lingua di pubblicazione | eng |
Record Nr. | UNISA-996321366003316 |
Warszawa, : Borgis, [1996]- | ||
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Lo trovi qui: Univ. di Salerno | ||
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Nitric oxide donors [[electronic resource] ] : for pharmaceutical and biological applications / / edited by Peng George Wang, Tingwei Bill Cai, Naoyuki Taniguchi |
Pubbl/distr/stampa | Weinheim ; ; [Great Britain], : Wiley-VCH, c2005 |
Descrizione fisica | 1 online resource (414 p.) |
Disciplina | 572.54 |
Altri autori (Persone) |
WangPeng George
CaiTingwai Bill TaniguchiNaoyuki <1942-> |
Soggetto topico |
Nitric oxide
Nitric oxide - Physiological effect Drugs - Design Pharmaceutical chemistry |
Soggetto genere / forma | Electronic books. |
ISBN |
1-280-51948-7
9786610519484 3-527-60375-1 3-527-60384-0 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Nitric Oxide Donors; Contents; Preface; List of Contributors; Part 1 Chemistry of NO Donors; 1 NO and NO Donors; 1.1 Introduction to NO Biosynthesis and NO donors; 1.1.1 Nitric Oxide Synthases; 1.1.2 Chemistry of Reactive Nitrogen Species; 1.2 Classification of NO Donors; 1.3 New Classes of NO Donors under Development; 1.3.1 Nitroarene; 1.3.2 Hydroxamic Acids; 1.4 Development of NO-Drug Hybrid Molecules; 1.4.1 Nitrate Hybrid Molecules; 1.4.2 Furoxan Hybrid Molecules; 1.5 New Therapeutic Applications of NO Donors; 1.5.1 NO Donors against Cancer
1.5.1.1 Diazeniumdiolates (NONOates) as Promising Anticancer Drugs1.5.1.2 The Synergistic Effect of NO and Anticancer Drugs; 1.5.1.3 NO-NSAIDs as a New Generation of Anti-tumoral Agents; 1.5.1.4 Other NO Donors with Anticancer Activity; 1.5.2 NO against Virus; 1.5.2.1 HIV-1 Induces NO Production; 1.5.2.2 Antiviral and Proviral Activity of NO; 1.5.3 Inhibition of Bone Resorption; 1.5.4 Treatment of Diabetes; 1.5.5 Thromboresistant Polymeric Films; 1.5.6 Inhibition of Cysteine Proteases; 1.6 Conclusion; References; 2 Organic Nitrates and Nitrites; 2.1 Organic Nitrates 2.1.1 Direct Chemical Reaction between Organic Nitrates and Thiols2.1.2 Glutathione-S-transferase; 2.1.3 Cytochrome P-450-dependent Systems; 2.1.4 Membrane-bound Enzyme of Vascular Smooth Muscle Cells; 2.1.5 Xanthine Oxidoreductase; 2.1.6 Mitochondrial Aldehyde Dehydrogenase; 2.1.7 Tolerance; 2.2 Organic Nitrites; 2.3 Conclusions; References; 3 N-Nitroso Compounds; 3.1 Introduction; 3.2 N-Nitrosamines; 3.2.1 Synthesis of Nitrosamines; 3.2.2 Physical Properties and Reactions of N-Nitrosamines; 3.2.3 Structure-Activity Relationship of N-Nitrosamines; 3.2.4 Application of N-Nitrosamines 3.3 N-Hydroxy-N-nitrosoamines3.3.1 Biologically Active N-Hydroxy-N-nitrosamine Compounds; 3.3.2 Synthesis of N-Hydroxy-N-nitrosamines; 3.3.3 Properties of N-Hydroxy-N-nitrosamines; 3.3.4 Reactivity of N-Hydroxo-N-nitrosamines; 3.4 N-Nitrosimines; 3.4.1 Mechanism of Thermal Reaction of N-Nitrosoimine; 3.4.2 Properties of N-Nitrosoimines; 3.4.3 Synthesis of N-Nitrosoimines; 3.5 N-Diazeniumdiolates; 3.5.1 Mechanism of NO Release; 3.5.2 Synthesis of N-Diazeniumdiolates; 3.5.2.1 Ionic Diazeniumdiolates; 3.5.2.2 O-derivatized Diazeniumdiolates; 3.5.3 Reactions of N-Diazeniumdiolates 3.5.4 Clinical Applications3.5.4.1 Reversal of Cerebral Vasospasm; 3.5.4.2 Treatment of Impotency; 3.5.4.3 Nonthrombogenic Blood-contact Surfaces; 3.5.5 Future Directions; References; 4 The Role of S-Nitrosothiols in the Biological Milieu; 4.1 Structure and Cellular Reactivity of RSNOs; 4.1.1 RSNO Structure; 4.1.1.1 Enzymatic Consumption of RSNOs; 4.1.2 Formation of RSNOs in the Biological Milieu; 4.1.2.1 Nitrite Mediated; 4.1.2.2 NO Mediated; 4.1.2.3 NO Oxidation Products Mediated; 4.1.2.4 Metalloprotein Mediated; 4.1.2.5 Transnitrosation; 4.2 Postulated Physiological roles of RSNOs 4.2.1 Regulation of Blood Flow by HbSNO |
Record Nr. | UNINA-9910144298603321 |
Weinheim ; ; [Great Britain], : Wiley-VCH, c2005 | ||
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Lo trovi qui: Univ. Federico II | ||
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Nitric oxide donors [[electronic resource] ] : for pharmaceutical and biological applications / / edited by Peng George Wang, Tingwei Bill Cai, Naoyuki Taniguchi |
Pubbl/distr/stampa | Weinheim ; ; [Great Britain], : Wiley-VCH, c2005 |
Descrizione fisica | 1 online resource (414 p.) |
Disciplina | 572.54 |
Altri autori (Persone) |
WangPeng George
CaiTingwai Bill TaniguchiNaoyuki <1942-> |
Soggetto topico |
Nitric oxide
Nitric oxide - Physiological effect Drugs - Design Pharmaceutical chemistry |
ISBN |
1-280-51948-7
9786610519484 3-527-60375-1 3-527-60384-0 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Nitric Oxide Donors; Contents; Preface; List of Contributors; Part 1 Chemistry of NO Donors; 1 NO and NO Donors; 1.1 Introduction to NO Biosynthesis and NO donors; 1.1.1 Nitric Oxide Synthases; 1.1.2 Chemistry of Reactive Nitrogen Species; 1.2 Classification of NO Donors; 1.3 New Classes of NO Donors under Development; 1.3.1 Nitroarene; 1.3.2 Hydroxamic Acids; 1.4 Development of NO-Drug Hybrid Molecules; 1.4.1 Nitrate Hybrid Molecules; 1.4.2 Furoxan Hybrid Molecules; 1.5 New Therapeutic Applications of NO Donors; 1.5.1 NO Donors against Cancer
1.5.1.1 Diazeniumdiolates (NONOates) as Promising Anticancer Drugs1.5.1.2 The Synergistic Effect of NO and Anticancer Drugs; 1.5.1.3 NO-NSAIDs as a New Generation of Anti-tumoral Agents; 1.5.1.4 Other NO Donors with Anticancer Activity; 1.5.2 NO against Virus; 1.5.2.1 HIV-1 Induces NO Production; 1.5.2.2 Antiviral and Proviral Activity of NO; 1.5.3 Inhibition of Bone Resorption; 1.5.4 Treatment of Diabetes; 1.5.5 Thromboresistant Polymeric Films; 1.5.6 Inhibition of Cysteine Proteases; 1.6 Conclusion; References; 2 Organic Nitrates and Nitrites; 2.1 Organic Nitrates 2.1.1 Direct Chemical Reaction between Organic Nitrates and Thiols2.1.2 Glutathione-S-transferase; 2.1.3 Cytochrome P-450-dependent Systems; 2.1.4 Membrane-bound Enzyme of Vascular Smooth Muscle Cells; 2.1.5 Xanthine Oxidoreductase; 2.1.6 Mitochondrial Aldehyde Dehydrogenase; 2.1.7 Tolerance; 2.2 Organic Nitrites; 2.3 Conclusions; References; 3 N-Nitroso Compounds; 3.1 Introduction; 3.2 N-Nitrosamines; 3.2.1 Synthesis of Nitrosamines; 3.2.2 Physical Properties and Reactions of N-Nitrosamines; 3.2.3 Structure-Activity Relationship of N-Nitrosamines; 3.2.4 Application of N-Nitrosamines 3.3 N-Hydroxy-N-nitrosoamines3.3.1 Biologically Active N-Hydroxy-N-nitrosamine Compounds; 3.3.2 Synthesis of N-Hydroxy-N-nitrosamines; 3.3.3 Properties of N-Hydroxy-N-nitrosamines; 3.3.4 Reactivity of N-Hydroxo-N-nitrosamines; 3.4 N-Nitrosimines; 3.4.1 Mechanism of Thermal Reaction of N-Nitrosoimine; 3.4.2 Properties of N-Nitrosoimines; 3.4.3 Synthesis of N-Nitrosoimines; 3.5 N-Diazeniumdiolates; 3.5.1 Mechanism of NO Release; 3.5.2 Synthesis of N-Diazeniumdiolates; 3.5.2.1 Ionic Diazeniumdiolates; 3.5.2.2 O-derivatized Diazeniumdiolates; 3.5.3 Reactions of N-Diazeniumdiolates 3.5.4 Clinical Applications3.5.4.1 Reversal of Cerebral Vasospasm; 3.5.4.2 Treatment of Impotency; 3.5.4.3 Nonthrombogenic Blood-contact Surfaces; 3.5.5 Future Directions; References; 4 The Role of S-Nitrosothiols in the Biological Milieu; 4.1 Structure and Cellular Reactivity of RSNOs; 4.1.1 RSNO Structure; 4.1.1.1 Enzymatic Consumption of RSNOs; 4.1.2 Formation of RSNOs in the Biological Milieu; 4.1.2.1 Nitrite Mediated; 4.1.2.2 NO Mediated; 4.1.2.3 NO Oxidation Products Mediated; 4.1.2.4 Metalloprotein Mediated; 4.1.2.5 Transnitrosation; 4.2 Postulated Physiological roles of RSNOs 4.2.1 Regulation of Blood Flow by HbSNO |
Record Nr. | UNINA-9910830161903321 |
Weinheim ; ; [Great Britain], : Wiley-VCH, c2005 | ||
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Lo trovi qui: Univ. Federico II | ||
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Novel frontiers in the production of compounds for biomedical use [[electronic resource] /] / edited by Annie Van Broeckhoven, Fred Shapiro and Jozef Anné |
Edizione | [1st ed. 2002.] |
Pubbl/distr/stampa | London ; ; Dordrecht, : Kluwer Academic, c2002 |
Descrizione fisica | 1 online resource (460 p.) |
Disciplina | 615.19 |
Altri autori (Persone) |
Van BroekhovenAnnie
ShapiroFred AnnéJozef |
Collana | Focus on biotechnology |
Soggetto topico |
Pharmaceutical biotechnology
Drugs - Design |
Soggetto genere / forma | Electronic books. |
ISBN |
1-280-04347-4
9786610043477 0-306-46885-9 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Genomics: the New Approach to the Discovery of New Compounds -- The Genomics Approach: Is it Really the Solution? -- The Contribution of Genomics to the Discovery of New Antibiotics -- Antibiotics -- The Antibiotic Gallidermin-Evolution of a Production Process -- Resistance to ?-Lactams, a Self-Regenerating Problem -- Resistance to aminoglycoside Antibiotics: Function meets structure -- The Genetics and Biochemistry of Resistance to Glycopeptide Antibiotics -- ?-Lactamases, an Old but Ever Renascent Problem -- Metabolic Flux Analysis in Streptomyces Coelicolor: Effect of nitrogen source -- Metabolic Engineering of the Lysine Pathway for ?-Lactam Overproduction in Penicillium Chrysogenum -- Glycosylation of Antibiotics and Other Agents from Actinomycetes -- Enzymatic Synthesis of Amoxicillin -- Production of Therapeutic Antibodies -- New Recombinant Bi- and Trispecific Antibody Derivatives -- Advantages of Single-Domain Antigen-Binding Fragments Derived from Functional Camel Heavy-Chain Antibodied -- Heterologous Protein Production: New Production Strategies -- Furin as a Tool for the Endoproteolytic Maturation of Susceptible Recombinant Biopharmaceuticals -- Development of Bioprocesses for the Generation of Anti-Inflammatory, Anti-Viral and Anti-Leukaemic Agents -- Apoptosis and Bioprocess Technology -- Gram-Positive Bacteria as Host Cells for Heterologous Production of Biopharmaceuticals -- Multiple Pathways of Exoprotein Secretion in Gram-Negative Bacteria -- Alteration of Metabolic Flux Distributions in Recombinant Escherichia Coli in Response to Heterologous Protein Production -- Dynamics of Proteolysis and its Influence on the Accumulation of Intracellular Recombinant Protein -- Artificial Organs and Xenografting -- The Impact of Transgenesis and Cloning on Cell and Organ Xenotransplantation to Humans -- Reinforced Bioartificial Skin in the Form of Collagen Sponge and Threads -- Antitumour Compounds -- Towards the Generation of Novel Antitumour Agents from Actinomycetes by Combinational Biosynthesis -- Cell Immobilisation of Taxus Media -- Pre and Probiotics -- The Role of Prebiotics in Human Gut Microbiology -- The Influence of Intestinal Microflora on Mucosal and Systemic Immune Responses. |
Record Nr. | UNINA-9910454831003321 |
London ; ; Dordrecht, : Kluwer Academic, c2002 | ||
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Lo trovi qui: Univ. Federico II | ||
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Novel frontiers in the production of compounds for biomedical use . Vol. 1 / / editors, Annie Van Broeckhoven, Fred Shapiro, Jozef Anné |
Edizione | [First edition 2002.] |
Pubbl/distr/stampa | London ; ; Dordrecht : , : Kluwer Academic, , 2002 |
Descrizione fisica | 1 online resource (v, 453 pages) : illustrations |
Disciplina | 615.19 |
Altri autori (Persone) |
Van BroekhovenAnnie
ShapiroFred AnnéJozef |
Collana | Focus on biotechnology |
Soggetto topico |
Pharmaceutical biotechnology
Drugs - Design |
ISBN |
1-280-04347-4
9786610043477 0-306-46885-9 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Genomics: the New Approach to the Discovery of New Compounds -- The Genomics Approach: Is it Really the Solution? -- The Contribution of Genomics to the Discovery of New Antibiotics -- Antibiotics -- The Antibiotic Gallidermin-Evolution of a Production Process -- Resistance to ?-Lactams, a Self-Regenerating Problem -- Resistance to aminoglycoside Antibiotics: Function meets structure -- The Genetics and Biochemistry of Resistance to Glycopeptide Antibiotics -- ?-Lactamases, an Old but Ever Renascent Problem -- Metabolic Flux Analysis in Streptomyces Coelicolor: Effect of nitrogen source -- Metabolic Engineering of the Lysine Pathway for ?-Lactam Overproduction in Penicillium Chrysogenum -- Glycosylation of Antibiotics and Other Agents from Actinomycetes -- Enzymatic Synthesis of Amoxicillin -- Production of Therapeutic Antibodies -- New Recombinant Bi- and Trispecific Antibody Derivatives -- Advantages of Single-Domain Antigen-Binding Fragments Derived from Functional Camel Heavy-Chain Antibodied -- Heterologous Protein Production: New Production Strategies -- Furin as a Tool for the Endoproteolytic Maturation of Susceptible Recombinant Biopharmaceuticals -- Development of Bioprocesses for the Generation of Anti-Inflammatory, Anti-Viral and Anti-Leukaemic Agents -- Apoptosis and Bioprocess Technology -- Gram-Positive Bacteria as Host Cells for Heterologous Production of Biopharmaceuticals -- Multiple Pathways of Exoprotein Secretion in Gram-Negative Bacteria -- Alteration of Metabolic Flux Distributions in Recombinant Escherichia Coli in Response to Heterologous Protein Production -- Dynamics of Proteolysis and its Influence on the Accumulation of Intracellular Recombinant Protein -- Artificial Organs and Xenografting -- The Impact of Transgenesis and Cloning on Cell and Organ Xenotransplantation to Humans -- Reinforced Bioartificial Skin in the Form of Collagen Sponge and Threads -- Antitumour Compounds -- Towards the Generation of Novel Antitumour Agents from Actinomycetes by Combinational Biosynthesis -- Cell Immobilisation of Taxus Media -- Pre and Probiotics -- The Role of Prebiotics in Human Gut Microbiology -- The Influence of Intestinal Microflora on Mucosal and Systemic Immune Responses. |
Record Nr. | UNINA-9910780046703321 |
London ; ; Dordrecht : , : Kluwer Academic, , 2002 | ||
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Lo trovi qui: Univ. Federico II | ||
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Novel frontiers in the production of compounds for biomedical use . Vol. 1 / / editors, Annie Van Broeckhoven, Fred Shapiro, Jozef Anné |
Edizione | [First edition 2002.] |
Pubbl/distr/stampa | London ; ; Dordrecht : , : Kluwer Academic, , 2002 |
Descrizione fisica | 1 online resource (v, 453 pages) : illustrations |
Disciplina | 615.19 |
Altri autori (Persone) |
Van BroekhovenAnnie
ShapiroFred AnnéJozef |
Collana | Focus on biotechnology |
Soggetto topico |
Pharmaceutical biotechnology
Drugs - Design |
ISBN |
1-280-04347-4
9786610043477 0-306-46885-9 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Genomics: the New Approach to the Discovery of New Compounds -- The Genomics Approach: Is it Really the Solution? -- The Contribution of Genomics to the Discovery of New Antibiotics -- Antibiotics -- The Antibiotic Gallidermin-Evolution of a Production Process -- Resistance to ?-Lactams, a Self-Regenerating Problem -- Resistance to aminoglycoside Antibiotics: Function meets structure -- The Genetics and Biochemistry of Resistance to Glycopeptide Antibiotics -- ?-Lactamases, an Old but Ever Renascent Problem -- Metabolic Flux Analysis in Streptomyces Coelicolor: Effect of nitrogen source -- Metabolic Engineering of the Lysine Pathway for ?-Lactam Overproduction in Penicillium Chrysogenum -- Glycosylation of Antibiotics and Other Agents from Actinomycetes -- Enzymatic Synthesis of Amoxicillin -- Production of Therapeutic Antibodies -- New Recombinant Bi- and Trispecific Antibody Derivatives -- Advantages of Single-Domain Antigen-Binding Fragments Derived from Functional Camel Heavy-Chain Antibodied -- Heterologous Protein Production: New Production Strategies -- Furin as a Tool for the Endoproteolytic Maturation of Susceptible Recombinant Biopharmaceuticals -- Development of Bioprocesses for the Generation of Anti-Inflammatory, Anti-Viral and Anti-Leukaemic Agents -- Apoptosis and Bioprocess Technology -- Gram-Positive Bacteria as Host Cells for Heterologous Production of Biopharmaceuticals -- Multiple Pathways of Exoprotein Secretion in Gram-Negative Bacteria -- Alteration of Metabolic Flux Distributions in Recombinant Escherichia Coli in Response to Heterologous Protein Production -- Dynamics of Proteolysis and its Influence on the Accumulation of Intracellular Recombinant Protein -- Artificial Organs and Xenografting -- The Impact of Transgenesis and Cloning on Cell and Organ Xenotransplantation to Humans -- Reinforced Bioartificial Skin in the Form of Collagen Sponge and Threads -- Antitumour Compounds -- Towards the Generation of Novel Antitumour Agents from Actinomycetes by Combinational Biosynthesis -- Cell Immobilisation of Taxus Media -- Pre and Probiotics -- The Role of Prebiotics in Human Gut Microbiology -- The Influence of Intestinal Microflora on Mucosal and Systemic Immune Responses. |
Record Nr. | UNINA-9910827244803321 |
London ; ; Dordrecht : , : Kluwer Academic, , 2002 | ||
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Lo trovi qui: Univ. Federico II | ||
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Nutraceuticals and natural product derivatives : disease prevention & drug discovery / / edited by Mohammad Fahad Ullah, Aamir Ahmad |
Pubbl/distr/stampa | Hoboken, NJ : , : Wiley Blackwell, , 2019 |
Descrizione fisica | 1 online resource (453 pages) |
Disciplina | 615.19 |
Soggetto topico |
Drugs - Design
Natural products |
Soggetto genere / forma | Electronic books. |
ISBN |
1-119-43671-0
1-119-43669-9 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910467623503321 |
Hoboken, NJ : , : Wiley Blackwell, , 2019 | ||
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Lo trovi qui: Univ. Federico II | ||
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