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Hit and lead profiling : identification and optimization of drug-like molecules
| Hit and lead profiling : identification and optimization of drug-like molecules |
| Pubbl/distr/stampa | [Place of publication not identified], : Wiley VCH, 2009 |
| Collana | Methods and principles in medicinal chemistry Hit and lead profiling |
| Soggetto topico |
Drugs - Design
Drugs - Structure-activity relationships Pharmaceutical chemistry Pharmacological Phenomena Biochemical Phenomena Pharmacological Processes Chemistry, Pharmaceutical Investigative Techniques Physiological Phenomena Analytical, Diagnostic and Therapeutic Techniques and Equipment Chemical Phenomena Pharmacology Chemistry Physiological Processes Phenomena and Processes Natural Science Disciplines Biological Science Disciplines Disciplines and Occupations Drug Discovery Drug Interactions Structure-Activity Relationship Health & Biological Sciences Pharmacy, Therapeutics, & Pharmacology |
| ISBN | 3-527-62744-8 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910877109303321 |
| [Place of publication not identified], : Wiley VCH, 2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Host-guest molecular interactions [[electronic resource] ] : from chemistry to biology
| Host-guest molecular interactions [[electronic resource] ] : from chemistry to biology |
| Pubbl/distr/stampa | Chichester ; ; New York, : Wiley, 1991 |
| Descrizione fisica | 1 online resource (290 p.) |
| Disciplina |
574.19
574.19245 574.88 |
| Collana | Ciba Foundation symposium |
| Soggetto topico |
Ligand binding (Biochemistry)
Drugs - Design Protein engineering Protein binding |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-282-34771-3
9786612347719 0-470-51408-6 0-470-51409-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
HOST-GUEST MOLECULAR INTERACTIONS: FROM CHEMISTRY TO BIOLOGY; Contents; Introduction; Molecular self-assembly processes; Self-assembly in supramolecular systems; General discussion I : Flexibility or rigidity?; Host-guest interactions in thin membranes: selective ion transport and transduction into electronic signals; Molecular recognition and molecular sensors; The natural design of vancomycin family antibiotics to bind to their target peptides; General discussion II : Crystals as supramolecules; Molecular devices and sensors; Clefts as receptor and enzyme analogues; Enzyme mimics
Binding of antibiotics to DNADesign of sequence-specific bifunctional nucleic acid ligands; Synthesis and biochemical studies of dithioate DNA; Conformational flexibility and protein specificity; Protein design: template-assembled synthetic proteins; General discussion III Transition state theory and energy requirements for reaction; Binding of peptides to proteins: an exercise in molecular design; Involvement of water in host-guest interactions; Molecular modelling approaches to host-guest complexes; Summing-up; Index of contributors; Subject index |
| Record Nr. | UNINA-9910144297703321 |
| Chichester ; ; New York, : Wiley, 1991 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Host-guest molecular interactions [[electronic resource] ] : from chemistry to biology
| Host-guest molecular interactions [[electronic resource] ] : from chemistry to biology |
| Pubbl/distr/stampa | Chichester ; ; New York, : Wiley, 1991 |
| Descrizione fisica | 1 online resource (290 p.) |
| Disciplina |
574.19
574.19245 574.88 |
| Collana | Ciba Foundation symposium |
| Soggetto topico |
Ligand binding (Biochemistry)
Drugs - Design Protein engineering Protein binding |
| ISBN |
1-282-34771-3
9786612347719 0-470-51408-6 0-470-51409-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
HOST-GUEST MOLECULAR INTERACTIONS: FROM CHEMISTRY TO BIOLOGY; Contents; Introduction; Molecular self-assembly processes; Self-assembly in supramolecular systems; General discussion I : Flexibility or rigidity?; Host-guest interactions in thin membranes: selective ion transport and transduction into electronic signals; Molecular recognition and molecular sensors; The natural design of vancomycin family antibiotics to bind to their target peptides; General discussion II : Crystals as supramolecules; Molecular devices and sensors; Clefts as receptor and enzyme analogues; Enzyme mimics
Binding of antibiotics to DNADesign of sequence-specific bifunctional nucleic acid ligands; Synthesis and biochemical studies of dithioate DNA; Conformational flexibility and protein specificity; Protein design: template-assembled synthetic proteins; General discussion III Transition state theory and energy requirements for reaction; Binding of peptides to proteins: an exercise in molecular design; Involvement of water in host-guest interactions; Molecular modelling approaches to host-guest complexes; Summing-up; Index of contributors; Subject index |
| Record Nr. | UNINA-9910830060703321 |
| Chichester ; ; New York, : Wiley, 1991 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Host-guest molecular interactions : from chemistry to biology
| Host-guest molecular interactions : from chemistry to biology |
| Pubbl/distr/stampa | Chichester ; ; New York, : Wiley, 1991 |
| Descrizione fisica | 1 online resource (290 p.) |
| Disciplina | 574.19/245 |
| Collana | Ciba Foundation symposium |
| Soggetto topico |
Ligand binding (Biochemistry)
Drugs - Design Protein engineering Protein binding |
| ISBN |
1-282-34771-3
9786612347719 0-470-51408-6 0-470-51409-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
HOST-GUEST MOLECULAR INTERACTIONS: FROM CHEMISTRY TO BIOLOGY; Contents; Introduction; Molecular self-assembly processes; Self-assembly in supramolecular systems; General discussion I : Flexibility or rigidity?; Host-guest interactions in thin membranes: selective ion transport and transduction into electronic signals; Molecular recognition and molecular sensors; The natural design of vancomycin family antibiotics to bind to their target peptides; General discussion II : Crystals as supramolecules; Molecular devices and sensors; Clefts as receptor and enzyme analogues; Enzyme mimics
Binding of antibiotics to DNADesign of sequence-specific bifunctional nucleic acid ligands; Synthesis and biochemical studies of dithioate DNA; Conformational flexibility and protein specificity; Protein design: template-assembled synthetic proteins; General discussion III Transition state theory and energy requirements for reaction; Binding of peptides to proteins: an exercise in molecular design; Involvement of water in host-guest interactions; Molecular modelling approaches to host-guest complexes; Summing-up; Index of contributors; Subject index |
| Record Nr. | UNINA-9910877290203321 |
| Chichester ; ; New York, : Wiley, 1991 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Inflammation and Allergy Drug Design
| Inflammation and Allergy Drug Design |
| Autore | Izuhara K |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Chicester, : Wiley, 2011 |
| Descrizione fisica | 1 online resource (346 p.) |
| Disciplina |
615.7
615.794 615/.7 |
| Altri autori (Persone) |
HolgateStephen T
Wills-KarpMarsha |
| Soggetto topico |
Allergy - Treatment
Allergy -- Treatment Antiallergic agents Anti-Allergic Agents Anti-Inflammatory Agents Anti-inflammatory agents Drug Design Drugs - Design Drugs -- Design Hypersensitivity - drug therapy Hypersensitivity -- drug therapy Antiallergic agents - Treatment Allergy - Design Drugs Drug Discovery Therapeutics Immune System Diseases Therapeutic Uses Diseases Pharmacologic Actions Investigative Techniques Chemistry, Pharmaceutical Chemical Actions and Uses Pharmacology Chemistry Biological Science Disciplines Natural Science Disciplines Drug Therapy Hypersensitivity Health & Biological Sciences Pharmacy, Therapeutics, & Pharmacology |
| ISBN |
1-283-20493-2
9786613204936 1-4443-4668-7 1-4443-4666-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Inflammation and Allergy Drug Design; Contents; Contributors; Preface; Part I: Cells contributing to the pathogenesis of allergic diseases in the respiratory tract; 1: Novel anti-inflammatory drugs based on targeting lung dendritic cells and airway epithelial cells; 2: Role of Th2 cells in the allergic diathesis; 3: Importance of Th17-and Th1-associated responses for the development of asthma; 4: Regulatory T cells; 5: A role for natural killer T-cell subsets in the pathogenesis of various allergic disorders; 6: Regulatory roles of B cells in allergy and inflammation; 7: Mast cells
8: Eosinophils9: Basophils in inflammation and allergy drug design; 10: Epithelial cells; 11: Fibroblasts; 12: Airway smooth muscle cells; Part II: Cytokines contributing to the pathogenesis of allergic diseases in the respiratory tract; 13: Interleukin 4, interleukin 13, and interleukin 9; 14: Interleukin 3, interleukin 5, and granulocyte-macrophage colony-stimulating factor; 15: Interleukin 15, interleukin 17, and interleukin 25; 16: Thymic stromal lymphopoietin; 17: Interleukin 10; 18: Tumor necrosis factor alpha; 19: Profibrotic and angiogenic factors in asthma; 20: Chemokines 21: Epithelial growth factorsPart III: Other mediators contributing to the pathogenesis of allergic diseases in the respiratory tract; 22: Prostanoids; 23: Leukotrienes; 24: Proteases in allergy; 25: Toll-like receptors; Index |
| Record Nr. | UNINA-9910139614403321 |
Izuhara K
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| Chicester, : Wiley, 2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Innovative drug synthesis / / edited by Jie Jack Li, University of San Francisco and Douglas S. Johnson, Pfizer Worldwide Research and Development
| Innovative drug synthesis / / edited by Jie Jack Li, University of San Francisco and Douglas S. Johnson, Pfizer Worldwide Research and Development |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , 2016 |
| Descrizione fisica | 1 online resource (439 p.) |
| Disciplina | 615.1/9 |
| Collana | Drug synthesis series |
| Soggetto topico |
Drugs - Design
Pharmaceutical chemistry |
| ISBN |
1-118-82008-8
1-118-82002-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910137230203321 |
| Hoboken, New Jersey : , : Wiley, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Innovative drug synthesis / / edited by Jie Jack Li, University of San Francisco and Douglas S. Johnson, Pfizer Worldwide Research and Development
| Innovative drug synthesis / / edited by Jie Jack Li, University of San Francisco and Douglas S. Johnson, Pfizer Worldwide Research and Development |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , 2016 |
| Descrizione fisica | 1 online resource (439 p.) |
| Disciplina | 615.1/9 |
| Collana | Drug synthesis series |
| Soggetto topico |
Drugs - Design
Pharmaceutical chemistry |
| ISBN |
1-118-82008-8
1-118-82002-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910830144903321 |
| Hoboken, New Jersey : , : Wiley, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Integrated pharmaceutics : applied preformulation, product design, and regulatory science / / Antoine Al-Achi, Mali Ram Gupta, William C. Stagner
| Integrated pharmaceutics : applied preformulation, product design, and regulatory science / / Antoine Al-Achi, Mali Ram Gupta, William C. Stagner |
| Autore | Al-Achi Antoine <1955-> |
| Edizione | [Second edition.] |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , [2022] |
| Descrizione fisica | 1 online resource (819 pages) |
| Disciplina | 615.19 |
| Soggetto topico |
Drugs - Design
Pharmaceutical chemistry Drugs - Dosage forms |
| ISBN |
1-5231-5665-1
1-394-15612-X 1-119-57472-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910678197303321 |
|
Al-Achi Antoine <1955->
|
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| Hoboken, New Jersey : , : Wiley, , [2022] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Integrated pharmaceutics [[electronic resource] ] : applied preformulation, product design, and regulatory science / / Antoine Al-Achi, Mali Ram Gupta, William Craig Stagner
| Integrated pharmaceutics [[electronic resource] ] : applied preformulation, product design, and regulatory science / / Antoine Al-Achi, Mali Ram Gupta, William Craig Stagner |
| Autore | Al-Achi Antoine <1955-> |
| Pubbl/distr/stampa | Hoboken, N.J., : John Wiley & Sons, c2013 |
| Descrizione fisica | 1 online resource (1013 p.) |
| Disciplina | 615.7 |
| Altri autori (Persone) |
GuptaMali Ram
StagnerWilliam Craig |
| Soggetto topico |
Pharmaceutical chemistry
Biopharmaceutics Drugs - Dosage forms Drugs - Design |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-283-99374-0
1-118-35671-3 1-118-35672-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | pt. I. Preformulation -- pt. II. Product design -- pt. III. Regulatory science. |
| Record Nr. | UNINA-9910463141803321 |
|
Al-Achi Antoine <1955->
|
||
| Hoboken, N.J., : John Wiley & Sons, c2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Integrated pharmaceutics [[electronic resource] ] : applied preformulation, product design, and regulatory science / / Antoine Al-Achi, Mali Ram Gupta, William Craig Stagner
| Integrated pharmaceutics [[electronic resource] ] : applied preformulation, product design, and regulatory science / / Antoine Al-Achi, Mali Ram Gupta, William Craig Stagner |
| Autore | Al-Achi Antoine <1955-> |
| Pubbl/distr/stampa | Hoboken, N.J., : John Wiley & Sons, c2013 |
| Descrizione fisica | xix, 991 p. : ill. (some col.) |
| Disciplina | 615.7 |
| Altri autori (Persone) |
GuptaMali Ram
StagnerWilliam Craig |
| Soggetto topico |
Pharmaceutical chemistry
Biopharmaceutics Drugs - Dosage forms Drugs - Design |
| ISBN |
1-118-35672-1
1-283-99374-0 1-118-35671-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | pt. I. Preformulation -- pt. II. Product design -- pt. III. Regulatory science. |
| Record Nr. | UNINA-9910795944003321 |
|
Al-Achi Antoine <1955->
|
||
| Hoboken, N.J., : John Wiley & Sons, c2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Soggetto topico
-
Drugs - Design
(310)
- Pharmaceutical chemistry (91)
- Drug development (68)
- Drug Design (35)
- Biopharmaceutics (16)