Autore	Ali Imran
Pubbl/distr/stampa	Hoboken, N.J., : John Wiley & Sons, c2009
Descrizione fisica	1 online resource (288 p.)
Disciplina	543/.8
Altri autori (Persone)	Aboul-EneinHassan Y GuptaVinod K. <1953->
Soggetto topico	Chromatographic analysis Capillary electrophoresis Drugs - Analysis Pollutants - Analysis Nanoparticles - Analysis
ISBN	1-282-11320-8 9786612113208 0-470-43492-9 1-61583-174-6 0-470-43491-0
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	NANOCHROMATOGRAPHY AND NANOCAPILLARY ELECTROPHORESIS; CONTENTS; PREFACE; ACKNOWLEDGMENTS; 1 Introduction; 1.1. Nanoanalyses; 1.2. Definition of Nanochromatography and Nanocapillary Electrophoresis; 1.3. Nanochromatography and Nanocapillary Electrophoresis; 1.4. Fabrication of Microdevices; 1.5. Developments in Nanoanalyses; 1.6. Data Integration; 1.7. Protocol of Nanoanalyses; 1.8. Scope of the Book; 1.9. Conclusion; References; 2 Fabrication of Microchips; 2.1. Introduction; 2.2. Substrates; 2.3. Techniques of Fabrication; 2.3.1. Glass Chips; 2.3.2. Quartz Chips; 2.3.3. Silica Chips 2.3.4. Polymer Chips2.3.5. Plastic Chips; 2.3.6. Chips and the Polymerase Chain Reaction; 2.4. Surface Modification; 2.4.1. Modification by Polymers; 2.4.2. Modification by Silica Gel; 2.4.3. Modification by Monolithics; 2.4.4. Modification by Sulfonation; 2.5. Designs of Chips; 2.6. Bindings in Chips; 2.7. Conclusion; References; 3 Instrumentation of Nanochromatography and Nanocapillary Electrophoresis; 3.1. Introduction; 3.2. Nanoliquid Chromatography (NLC); 3.2.1. Mobile Phase Reservoirs; 3.2.2. Mobile Phases and Flow Calibration; 3.2.3. Mobile Phase Tubings; 3.2.4. Solvent Delivery Pump 3.2.5. Sample Injector3.2.6. Separation Chips; 3.2.7. Detectors; 3.2.8. Recorder; 3.2.9. Sample Preparation Units; 3.3. Nanocapillary Electrophoresis; 3.3.1. Separation Chip; 3.3.2. Background Electrolyte and Its Reservoirs; 3.3.3. Sample Injection Port; 3.3.4. Detectors; 3.3.5. Recorder; 3.3.6. Sample Preparation Units; 3.4. Conclusion; References; 4 Detection in Nanochromatography and Nanocapillary Electrophoresis; 4.1. Introduction; 4.2. Mass Spectrometer Detectors; 4.3. Fluorescence Detectors; 4.4. Electrochemical Detectors; 4.5. Element Specific Detectors; 4.6. Miscellaneous Detectors 4.7. ConclusionReferences; 5 Sample Preparation in Nanochromatography and Nanocapillary Electrophoresis; 5.1. Introduction; 5.2. Sample Preparation; 5.3. Sampling; 5.3.1. Biological Samples; 5.3.1.1. Blood; 5.3.1.2. Urine; 5.3.1.3. Tissues; 5.3.1.4. Plants; 5.3.1.5. Food Stuffs; 5.3.2. Environmental Samples; 5.3.2.1. Air; 5.3.2.2. Water; 5.3.2.3. Sediment and Soils; 5.4. Preservation; 5.5. Filtration; 5.6. Digestion/Homogenization; 5.7. Extractions; 5.8. Clean Up; 5.9. Preconcentration; 5.10. Off-Line Nanosample Preparation Methods; 5.10.1. Nano Solid Phase Extractions 5.10.2. Nano Membrane Extractions5.10.3. Nano Miscellaneous Extractions; 5.11. Online Nanosample Preparation Methods; 5.12. Conclusion; References; 6 Nano-High Performance Liquid Chromatography; 6.1. Introduction; 6.2. Nano-HPLC; 6.3. Applications; 6.3.1. Nano-HPLC of Biological Matrices; 6.3.1.1. Proteomics; 6.3.1.2. Drugs Development and Design; 6.3.1.3. Environmental Analysis; 6.4. Optimization of Separations in Nano-HPLC; 6.5. Troubleshooting in Nano-HPLC; 6.6. Conclusion; References; 7 Nanocapillary Electrochromatography and Nanomicellar Electrokinetic Chromatography; 7.1. Introduction 7.2. Nanocapillary Electrochromatography
Record Nr.	UNINA-9910877725603321

Autore	Holzgrabe U (Ulrike)
Pubbl/distr/stampa	Weinheim ; ; New York ; ; Chichester, : Wiley-VCH, c1999
Descrizione fisica	1 online resource (313 p.)
Disciplina	615.19
Altri autori (Persone)	DiehlB (Bernd) WawerI (Iwona)
Soggetto topico	Drug development Drugs - Analysis Nuclear magnetic resonance spectroscopy
Soggetto genere / forma	Electronic books.
ISBN	1-281-76421-3 9786611764210 3-527-61364-1 3-527-61365-X
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	NMR Spectroscopy in Drug Development and Analysis; Preface; Contributors; Contents; Chapter 1 Introduction; 1.1 The Instrument; 1.2 Principles; 1.2.1 Spectra; 1.2.2 Response; 1.2.3 Reproducibility; 1.2.4 Calibration; 1.3 Experimental; Chapter 2 NMR Spectroscopy in the European Regulatory Dossier; 2.1 Directives, Rules and Guidelines; 2.2 Information Required to Establish Quality; 2.3 Control of Starting Materials; 2.3.1 Specifications and Routine Tests; 2.3.2 Scientific Data; 2.4 Control of the Finished Product; 2.5 Stability Studies; 2.6 Concluding Remarks; Chapter 3 Analysis of Drugs 3.1 NMR Spectroscopy in International Pharmacopoeias and Related Applications3.1.1 Polymers; 3.1.2 Biomolecules; 3.2 Identification and Quantification of Impurities in Drugs; 3.2.1 Impurities Resulting from the Synthesis Pathway; 3.2.2 Decomposition Reactions; 3.3 Quantification of Drugs in Dosage Forms; 3.3.1 Analysis of Single Drugs in Dosage Forms; 3.3.2 Analysis of Drug Mixtures in Dosage Forms; 3.3.3 Analysis of Drugs and Decomposition or Isomer Traces in Dosage Forms; 3.4 Analysis of Complex Mixtures, e. g. Excipients; 3.4.1 Phospholipids; 3.4.2 Silicones 3.4.3 Fluorine Containing Substances3.5 Concluding Remarks; Chapter 4 pH-Dependent NMR Measurements; 4.1 Introduction; 4.2 Determination of the Site of Protonation; 4.3 Determination of Dissociation Constants and Stability Constants by NMR-Controlled Titrations; 4.4 Applications in Pharmacy; 4.4.1 Macroscopic Dissociation Equilibria; 4.4.2 Microscopic Dissociation Equilibria; Chapter 5 Complexation Behaviour of Drugs Studied by NMR; 5.1 Selfassociation of Drugs and Association with Other Components of a Formulation; 5.2 Complexation with Cations Chapter 6 Determination of the Isomeric Composition of Drugs6.1 Determination of the Enantiomeric Excess; 6.2 Comparison of Different CSAs; Chapter 7 On-line Coupling of HPLC or SFC; 7.1 Introduction; 7.2 HPLC-NMR Coupling; 7.2.1 Continuous-flow Measurements; 7.2.2 Stopped-flow Measurements; 7.3 SPE-HPLC-NMR Coupling; 7.4 SFE-NMR and SFC-NMR Coupling; Chapter 8 NMR of Body Fluids; 8.1 NMR of Urine - Studies of Metabolism; 8.1.1 1H NMR Spectroscopy; 8.1.2 19F NMR Spectroscopy; 8.1.3 15N NMR Spectroscopy; 8.1.4 31P NMR Spectroscopy 8.2 NMR of Bile, Blood Plasma, Cerebrospinal and Seminal Fluids8.3 LC NMR Hyphenation; Chapter 9 NMR as a Tool in Drug Research; 9.1 Introduction; 9.2 Protein Structures from NMR; 9.3 Protein-Ligand Interactions; 9.3.1 NMR of Molecular Complexes; 9.3.2 Aspects of Binding Affinity; 9.3.3 Exchange Time Scales for NMR Parameters; 9.3.4 Transfer NOE; 9.3.5 Isotope Filters; 9.3.6 Measuring Binding Affinities by NMR; 9.3.7 Binding Site Localization; 9.3.8 Solvent-Accessible Surfaces; 9.3.9 Screening Protein-Ligand Interactions; 9.3.10 Conclusion; Chapter 10 Ligand-Cyclodextrin complexes 10.1 Introduction
Record Nr.	UNINA-9910144728003321

Pubbl/distr/stampa	Oxford, : Elsevier, 2008
Descrizione fisica	1 online resource (525 p.)
Disciplina	615.19 615.1901
Altri autori (Persone)	HolzgrabeU (Ulrike) WawerI (Iwona) DiehlB (Bernd)
Soggetto topico	Nuclear magnetic resonance spectroscopy Drugs - Analysis
Soggetto genere / forma	Electronic books.
ISBN	1-281-76266-0 9786611762667 0-08-095152-X 0-08-055819-4
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	Front Cover; NMR Spectroscopy in Pharmaceutical Analysis; Copyright Page; Table of Contents; Preface; List of Contributors; List of Editors; Part I FUNDAMENTALS AND TECHNIQUES; Chapter 1 Principles in NMR Spectroscopy; 1 Short History; 2 The NMR Experiment; 2.1 Excitation, relaxation and sensitivity; 2.2 Relaxation; 3 Chemical Shift; 3.1 Electronic density; 3.2 Anisotropy; 3.3 Mesomerism; 3.4 Steric effects; 4 Calibration and Relative Scale ppm; 5 Spin-Spin Coupling; 5.1 The coupling constant; 5.2 Multiplicity; 5.3 Roof effect; 5.4 Angular dependence of the coupling constant 5.5 Heteronuclear coupling5.6 13C NMR satellites in 1H NMR spectra; 6 Heteronuclear Spectra; 6.1 Decoupling; 6.2 Quantitative heteronuclear NMR; 7 Molecular Dynamics; 7.1 Deuterium exchange and solvent effects; 8 Chemical Derivatisation; 9 Stereochemistry; 9.1 Diastereomerism; 9.2 Atrop or axial chirality; 9.3 Enantiomeric excess; 9.4 Diastereotopy; 10 Two-dimensional Methods for Structure Elucidation; 11 Experimental Data; Chapter 2 Quantitative NMR in the Solution State NMR; 1 Introduction; 2 Basics; 3 Quantitative NMR Spectroscopy; 3.1 Relative method; 3.2 Absolute method; 4 Validation 4.1 Linearity4.2 Robustness; 4.3 Specificity and selectivity; 4.4 Accuracy; 4.5 Precision; 4.6 Measurement uncertainty; 4.7 Round robin tests; 5 Sensitivity; 6 Conclusion; Chapter 3 qNMR in Solid State; 1 Introduction to Solid-state NMR; 2 Quantitative Aspects of Solid-state NMR, Protocol for Quantitation; 3 An Example: Quantitation of Pseudoephedrine in Dosage Form; 4 Quantitation of Polymorphs and Formulated Drugs; Chapter 4 Microcoil Nuclear Magnetic Resonance Spectroscopy; 1 Introduction; 2 Intrinsic NMR Sensitivity; 3 Development of Small Coils for High-Resolution NMR 3.1 Saddle/Helmholtz coils3.2 Solenoidal coils; 3.3 Planar RF coils; 3.4 Novel microcoil designs; 3.5 High-temperature superconducting microprobes; 4 Sensitivity Comparisons; 5 Nanoliter Volume Applications of RF Microcoils - Hyphenated cITP-NMR; 6 Microliter Volume Applications of RF Microcoils; 6.1 Helmholtz/saddle coils; 6.2 Solenoidal coils; 6.3 Superconducting microcoils; 7 Hyphenation of Microseparation Techniques with Microliter NMR Detection; 8 Multiple Coil Probeheads; 9 Solid-State Applications of Small Coils; 10 Conclusion Chapter 5 qNMR Spectroscopy in Drug Analysis - A General View1 Introduction; 2 NMR Spectroscopy in International Pharmacopoeias; 2.1 Identification of drugs; 2.2 Tests; 2.3 Assay; 3 Validation; 4 Conclusions; Part II GENERAL APPLICATIONS; Chapter 1 Investigation of Multi-Component Drugs by NMR Spectroscopy; 1 Introduction; 1.1 Solvent; 1.2 pH value; 1.3 Temperature; 1.4 Auxiliary reagents; 1.5 Limitations; 2 Codergocrine Mesylate; 2.1 1H NMR spectroscopy; 2.2 13C NMR spectroscopy; 2.3 High-performance liquid chromatography; 2.4 HPLC versus NMR spectroscopy Chapter 2 NMR Applications for Polymer Characterisation
Record Nr.	UNINA-9910511424103321

Pubbl/distr/stampa	Burlington : , : Elsevier, , 2008
Descrizione fisica	1 online resource (525 pages)
Disciplina	615.19 615.1901
Altri autori (Persone)	HolzgrabeU (Ulrike) WawerI (Iwona) DiehlB (Bernd)
Soggetto topico	Nuclear magnetic resonance spectroscopy Drugs - Analysis
ISBN	1-281-76266-0 9786611762667 0-08-095152-X 0-08-055819-4
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	Front Cover; NMR Spectroscopy in Pharmaceutical Analysis; Copyright Page; Table of Contents; Preface; List of Contributors; List of Editors; Part I FUNDAMENTALS AND TECHNIQUES; Chapter 1 Principles in NMR Spectroscopy; 1 Short History; 2 The NMR Experiment; 2.1 Excitation, relaxation and sensitivity; 2.2 Relaxation; 3 Chemical Shift; 3.1 Electronic density; 3.2 Anisotropy; 3.3 Mesomerism; 3.4 Steric effects; 4 Calibration and Relative Scale ppm; 5 Spin-Spin Coupling; 5.1 The coupling constant; 5.2 Multiplicity; 5.3 Roof effect; 5.4 Angular dependence of the coupling constant 5.5 Heteronuclear coupling; 5.6 13C NMR satellites in 1H NMR spectra; 6 Heteronuclear Spectra; 6.1 Decoupling; 6.2 Quantitative heteronuclear NMR; 7 Molecular Dynamics; 7.1 Deuterium exchange and solvent effects; 8 Chemical Derivatisation; 9 Stereochemistry; 9.1 Diastereomerism; 9.2 Atrop or axial chirality; 9.3 Enantiomeric excess; 9.4 Diastereotopy; 10 Two-dimensional Methods for Structure Elucidation; 11 Experimental Data; Chapter 2 Quantitative NMR in the Solution State NMR; 1 Introduction; 2 Basics; 3 Quantitative NMR Spectroscopy; 3.1 Relative method; 3.2 Absolute method; 4 Validation 4.1 Linearity; 4.2 Robustness; 4.3 Specificity and selectivity; 4.4 Accuracy; 4.5 Precision; 4.6 Measurement uncertainty; 4.7 Round robin tests; 5 Sensitivity; 6 Conclusion; Chapter 3 qNMR in Solid State; 1 Introduction to Solid-state NMR; 2 Quantitative Aspects of Solid-state NMR, Protocol for Quantitation; 3 An Example: Quantitation of Pseudoephedrine in Dosage Form; 4 Quantitation of Polymorphs and Formulated Drugs; Chapter 4 Microcoil Nuclear Magnetic Resonance Spectroscopy; 1 Introduction; 2 Intrinsic NMR Sensitivity; 3 Development of Small Coils for High-Resolution NMR 3.1 Saddle/Helmholtz coils; 3.2 Solenoidal coils; 3.3 Planar RF coils; 3.4 Novel microcoil designs; 3.5 High-temperature superconducting microprobes; 4 Sensitivity Comparisons; 5 Nanoliter Volume Applications of RF Microcoils - Hyphenated cITP-NMR; 6 Microliter Volume Applications of RF Microcoils; 6.1 Helmholtz/saddle coils; 6.2 Solenoidal coils; 6.3 Superconducting microcoils; 7 Hyphenation of Microseparation Techniques with Microliter NMR Detection; 8 Multiple Coil Probeheads; 9 Solid-State Applications of Small Coils; 10 Conclusion Chapter 5 qNMR Spectroscopy in Drug Analysis - A General View; 1 Introduction; 2 NMR Spectroscopy in International Pharmacopoeias; 2.1 Identification of drugs; 2.2 Tests; 2.3 Assay; 3 Validation; 4 Conclusions; Part II GENERAL APPLICATIONS; Chapter 1 Investigation of Multi-Component Drugs by NMR Spectroscopy; 1 Introduction; 1.1 Solvent; 1.2 pH value; 1.3 Temperature; 1.4 Auxiliary reagents; 1.5 Limitations; 2 Codergocrine Mesylate; 2.1 1H NMR spectroscopy; 2.2 13C NMR spectroscopy; 2.3 High-performance liquid chromatography; 2.4 HPLC versus NMR spectroscopy; Chapter 2 NMR Applications for Polymer Characterisation
Record Nr.	UNINA-9910782367303321

Pubbl/distr/stampa	Hoboken, N.J., : Wiley-Interscience, c2008
Descrizione fisica	1 online resource (285 p.)
Disciplina	615.1901 615/.1901
Altri autori (Persone)	ŠašićSlobodan
Collana	Wiley series on technologies for the pharmaceutical industry
Soggetto topico	Raman spectroscopy Drugs - Analysis Pharmacy - Technique Pharmaceutical technology
ISBN	1-281-10029-3 9786611100292 0-470-22588-2 0-470-22587-4
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	Introduction to Raman spectroscopy / Yukihiro Ozaki and Slobodan Šašić -- Quantitative analysis of solid dosage formulations by Raman spectroscopy / Steven J.E. Bell -- Surface enhanced resonance Raman scattering / W. Ewen Smith -- Raman spectroscopy for identifying polymorphs / Fred Laplant and Anne De Paepe -- Raman spectroscopy for monitoring real-time processes in the pharmaceutical industry / Kevin L. Davis, Mark S. Kemper and Ian R. Lewis -- Raman chemical imaging of solid dosage formulations / Slobodan Šašić -- In vivo Raman confocal microspectroscopy of skin / Andre van der Pol, William M. Riggs and Peter J. Caspers -- Raman microspectroscopy and imaging of active pharmaceutical ingredients in cells / Jian Ling.
Record Nr.	UNINA-9910143981203321