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Drug interactions in psychiatry / / edited by Domenic A. Ciraulo [and three others]
| Drug interactions in psychiatry / / edited by Domenic A. Ciraulo [and three others] |
| Edizione | [Third edition.] |
| Pubbl/distr/stampa | Philadelphia : , : Lippincott Williams & Wilkins, , [2006] |
| Descrizione fisica | 1 online resource (454 pages) : illustrations |
| Disciplina | 615/.788 |
| Altri autori (Persone) | CirauloDomenic A |
| Soggetto topico |
Psychotropic drugs - Side effects
Drug interactions |
| ISBN | 1-4511-6635-4 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Concepts and mechanisms of drug disposition and drug interactions -- Antidepressants -- Antipsychotics -- Lithium -- Anticonvulsants -- Electroconvulsive therapy -- Drug ineractions of importance in substance abuse -- Interactions of psychotropics with herbals -- Drugs (including metabolites) that are substrates of cytochrome P450. |
| Record Nr. | UNINA-9910813011803321 |
| Philadelphia : , : Lippincott Williams & Wilkins, , [2006] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Drug metabolism and drug interactions
| Drug metabolism and drug interactions |
| Pubbl/distr/stampa | [Berlin, Germany] : , : De Gruyter |
| Descrizione fisica | 1 online resource |
| Disciplina | 615.7045 |
| Soggetto topico |
Drug interactions
Drugs - Metabolism Pharmacology Drug Interactions Pharmaceutical Preparations - metabolism Médicaments - Interactions Médicaments - Métabolisme Pharmacologie Interactions médicamenteuses |
| Soggetto genere / forma |
Periodical
Periodicals. |
| ISSN | 2191-0162 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Reviews on drug metabolism and drug interactions |
| Record Nr. | UNISA-996336713603316 |
| [Berlin, Germany] : , : De Gruyter | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
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Drug safety newsletter
| Drug safety newsletter |
| Pubbl/distr/stampa | [Bethesda, Md.], : Food and Drug Administration, Center for Drug Evaluation and Research |
| Descrizione fisica | 1 online resource (7 volumes) |
| Disciplina | 363 |
| Soggetto topico |
Drug interactions - United States
Drugs - Toxicology - United States Drug interactions Drugs - Toxicology Drug-Related Side Effects and Adverse Reactions Drug Interactions |
| Soggetto genere / forma |
Periodicals.
Periodical |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | FDA drug safety newsletter |
| Record Nr. | UNINA-9910693437603321 |
| [Bethesda, Md.], : Food and Drug Administration, Center for Drug Evaluation and Research | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Drug-Acceptor Interactions : Modeling Theoretical Tools to Test and Evaluate Experimental Equilibrium Effects
| Drug-Acceptor Interactions : Modeling Theoretical Tools to Test and Evaluate Experimental Equilibrium Effects |
| Autore | Bindslev Niels |
| Edizione | [First edition.] |
| Pubbl/distr/stampa | Co-Action Publishing |
| Descrizione fisica | 1 online resource (798 pages) : illustrations |
| Disciplina | 615.7045 |
| Soggetto topico |
Drug interactions
Chemotherapy |
| Soggetto non controllato |
Drugs
therapy |
| ISBN |
1-351-66057-8
1-315-15978-3 1-351-66058-6 91-977071-1-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910139090703321 |
Bindslev Niels
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| Co-Action Publishing | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Drug-Acceptor Interactions : Modeling Theoretical Tools to Test and Evaluate Experimental Equilibrium Effects
| Drug-Acceptor Interactions : Modeling Theoretical Tools to Test and Evaluate Experimental Equilibrium Effects |
| Autore | Bindslev Niels |
| Edizione | [First edition.] |
| Pubbl/distr/stampa | Co-Action Publishing |
| Descrizione fisica | 1 online resource (798 pages) : illustrations |
| Disciplina | 615.7045 |
| Soggetto topico |
Drug interactions
Chemotherapy |
| Soggetto non controllato |
Drugs
therapy |
| ISBN |
1-351-66057-8
1-315-15978-3 1-351-66058-6 91-977071-1-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-996205888003316 |
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Bindslev Niels
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| Co-Action Publishing | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
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Drug-drug interactions for therapeutic biologics [[electronic resource] /] / edited by Honghui Zhou, Bernd Meibohm
| Drug-drug interactions for therapeutic biologics [[electronic resource] /] / edited by Honghui Zhou, Bernd Meibohm |
| Pubbl/distr/stampa | Hoboken, N.J., : John Wiley & Sons, c2013 |
| Descrizione fisica | 1 online resource (379 p.) |
| Disciplina | 615.7/045 |
| Altri autori (Persone) |
ZhouHonghui
MeibohmBernd |
| Soggetto topico | Drug interactions |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-118-63014-9
1-118-63021-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Drug interactions for therapeutic proteins : a journey just beginning / Honghui Zhou, Bernd Meibohm -- Pharmacokinetic and pharmacodynamic-based drug interactions for therapeutic proteins / Dan Lu ... [et al.] -- Drug interaction assessment strategies : small molecules versus therapeutic proteins / Shannon Dallas ... [et al.] -- Model-independent and modeling-based methods to assess drug-drug interactions for therapeutic proteins / Di Wu, Jeffrey Barrett -- Utility of in vitro methods in drug-drug interaction assessment and prediction for therapeutic biologics / Theresa Nguyen, Narendra Kishnani, Raymond Evers -- Use of animal models for projection of clinical drug-drug interactions for therapeutic proteins / Eugenia Kraynov, Martin E. Dowty -- The "cocktail" approach and its utility in drug-drug interaction assessments for therapeutic proteins / Alexander Jetter, Uwe Fuhr -- Logistic considerations in study design for biologic drug-drug interaction assessments / Min Zhu and Yu-Nien (Tom) Sun -- Statistical considerations in assessing drug-drug interactions for therapeutic proteins / Chuanpu Hu and Honghui Zhou -- FDA perspectives on therapeutic protein drug-drug interaction assessments / Hong Zhao ... [et al.] -- Disease-drug-drug interaction assessments for tocilizumab : a monoclonal antibody against interleukin-6 receptor to treat patients with rheumatoid arthritis / Xuapang Zhang and Barbara J. Brennan -- -- Drug-drug interactions for etamercept : a fusion protein / Joan Korth-Bradley -- Drug interactions of cytokines and anti-cytokine therapeutic proteins / J. Greg Slatter L.C. Wienkers and Leslie J. Dickmann -- Drug interactions for growth factors and hormones / Yow-Ming Wang, Tarundeep Kakkar -- Drug-drug interactions for nucleic acid-based derivatires / Jan Wang and Hong Zhao. |
| Record Nr. | UNINA-9910463252803321 |
| Hoboken, N.J., : John Wiley & Sons, c2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drug-drug interactions for therapeutic biologics [[electronic resource] /] / edited by Honghui Zhou, Bernd Meibohm
| Drug-drug interactions for therapeutic biologics [[electronic resource] /] / edited by Honghui Zhou, Bernd Meibohm |
| Pubbl/distr/stampa | Hoboken, N.J., : John Wiley & Sons, c2013 |
| Descrizione fisica | 1 online resource (379 p.) |
| Disciplina | 615.7/045 |
| Altri autori (Persone) |
ZhouHonghui
MeibohmBernd |
| Soggetto topico | Drug interactions |
| ISBN |
1-118-63014-9
1-118-63021-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Drug interactions for therapeutic proteins : a journey just beginning / Honghui Zhou, Bernd Meibohm -- Pharmacokinetic and pharmacodynamic-based drug interactions for therapeutic proteins / Dan Lu ... [et al.] -- Drug interaction assessment strategies : small molecules versus therapeutic proteins / Shannon Dallas ... [et al.] -- Model-independent and modeling-based methods to assess drug-drug interactions for therapeutic proteins / Di Wu, Jeffrey Barrett -- Utility of in vitro methods in drug-drug interaction assessment and prediction for therapeutic biologics / Theresa Nguyen, Narendra Kishnani, Raymond Evers -- Use of animal models for projection of clinical drug-drug interactions for therapeutic proteins / Eugenia Kraynov, Martin E. Dowty -- The "cocktail" approach and its utility in drug-drug interaction assessments for therapeutic proteins / Alexander Jetter, Uwe Fuhr -- Logistic considerations in study design for biologic drug-drug interaction assessments / Min Zhu and Yu-Nien (Tom) Sun -- Statistical considerations in assessing drug-drug interactions for therapeutic proteins / Chuanpu Hu and Honghui Zhou -- FDA perspectives on therapeutic protein drug-drug interaction assessments / Hong Zhao ... [et al.] -- Disease-drug-drug interaction assessments for tocilizumab : a monoclonal antibody against interleukin-6 receptor to treat patients with rheumatoid arthritis / Xuapang Zhang and Barbara J. Brennan -- -- Drug-drug interactions for etamercept : a fusion protein / Joan Korth-Bradley -- Drug interactions of cytokines and anti-cytokine therapeutic proteins / J. Greg Slatter L.C. Wienkers and Leslie J. Dickmann -- Drug interactions for growth factors and hormones / Yow-Ming Wang, Tarundeep Kakkar -- Drug-drug interactions for nucleic acid-based derivatires / Jan Wang and Hong Zhao. |
| Record Nr. | UNINA-9910786956303321 |
| Hoboken, N.J., : John Wiley & Sons, c2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drug-drug interactions for therapeutic biologics / / edited by Honghui Zhou, Bernd Meibohm
| Drug-drug interactions for therapeutic biologics / / edited by Honghui Zhou, Bernd Meibohm |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, N.J., : John Wiley & Sons, c2013 |
| Descrizione fisica | 1 online resource (379 p.) |
| Disciplina | 615.7/045 |
| Altri autori (Persone) |
ZhouHonghui
MeibohmBernd |
| Soggetto topico | Drug interactions |
| ISBN |
1-118-63014-9
1-118-63021-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Drug interactions for therapeutic proteins : a journey just beginning / Honghui Zhou, Bernd Meibohm -- Pharmacokinetic and pharmacodynamic-based drug interactions for therapeutic proteins / Dan Lu ... [et al.] -- Drug interaction assessment strategies : small molecules versus therapeutic proteins / Shannon Dallas ... [et al.] -- Model-independent and modeling-based methods to assess drug-drug interactions for therapeutic proteins / Di Wu, Jeffrey Barrett -- Utility of in vitro methods in drug-drug interaction assessment and prediction for therapeutic biologics / Theresa Nguyen, Narendra Kishnani, Raymond Evers -- Use of animal models for projection of clinical drug-drug interactions for therapeutic proteins / Eugenia Kraynov, Martin E. Dowty -- The "cocktail" approach and its utility in drug-drug interaction assessments for therapeutic proteins / Alexander Jetter, Uwe Fuhr -- Logistic considerations in study design for biologic drug-drug interaction assessments / Min Zhu and Yu-Nien (Tom) Sun -- Statistical considerations in assessing drug-drug interactions for therapeutic proteins / Chuanpu Hu and Honghui Zhou -- FDA perspectives on therapeutic protein drug-drug interaction assessments / Hong Zhao ... [et al.] -- Disease-drug-drug interaction assessments for tocilizumab : a monoclonal antibody against interleukin-6 receptor to treat patients with rheumatoid arthritis / Xuapang Zhang and Barbara J. Brennan -- -- Drug-drug interactions for etamercept : a fusion protein / Joan Korth-Bradley -- Drug interactions of cytokines and anti-cytokine therapeutic proteins / J. Greg Slatter L.C. Wienkers and Leslie J. Dickmann -- Drug interactions for growth factors and hormones / Yow-Ming Wang, Tarundeep Kakkar -- Drug-drug interactions for nucleic acid-based derivatires / Jan Wang and Hong Zhao. |
| Record Nr. | UNINA-9910817661603321 |
| Hoboken, N.J., : John Wiley & Sons, c2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drug-drug interactions in pharmaceutical development [[electronic resource] /] / edited by Albert P. Li
| Drug-drug interactions in pharmaceutical development [[electronic resource] /] / edited by Albert P. Li |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley-interscience, c2008 |
| Descrizione fisica | 1 online resource (261 p.) |
| Disciplina |
615.7045
615/.7045 |
| Altri autori (Persone) | LiA. P |
| Collana | Wiley series in drug discovery and development |
| Soggetto topico |
Drug interactions
Drug development |
| ISBN |
1-282-02206-7
9786612022067 0-470-18792-1 0-470-18791-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
DRUG-DRUG INTERACTIONS IN PHARMACEUTICAL DEVELOPMENT; CONTENTS; Preface; Contributors; 1 In Vitro Evaluation of Metabolic Drug-Drug Interactions: Concepts and Practice; 1.1 Introduction; 1.2 Mechanisms of Adverse Drug-Drug Interactions; 1.2.1 Pharmacological Interactions; 1.2.2 Pharmacokinetic Interactions; 1.3 Drug Metabolism; 1.3.1 Phase I Oxidation; 1.3.2 Phase II Conjugation; 1.4 CYP Isoforms; 1.5 Human In Vitro Experimental Systems for Drug Metabolism; 1.5.1 Hepatocytes; 1.5.2 Liver Postmitochondrial Supernatant (PMS); 1.5.3 Human Liver Microsomes; 1.5.4 Recombinant P450 Isoforms (rCYP)
1.5.5 Cytosol1.6 Mechanisms of Metabolic Drug-Drug Interactions; 1.7 Mechanism-Based Approach for Evaluation of Drug-Drug Interaction Potential; 1.7.1 Metabolic Phenotyping; 1.7.2 Evaluation of Inhibitory Potential for Drug-Metabolizing Enzymes; 1.7.3 Induction Potential for Drug-Metabolizing Enzymes; 1.8 Experimental Approaches for In Vitro Evaluation of Drug-Drug Interaction Potential; 1.8.1 Study 1: Metabolic Phenotyping 1-Metabolite Identification; 1.8.2 Study 2: Metabolic Phenotyping 2-Identification of Major Metabolic Pathways 1.8.3 Study 3: Metabolic Phenotyping 3-Identification of P450 Isoform Pathways (P450 Phenotyping)1.8.4 Study 4: CYP Inhibitory Potential; 1.8.5 Study 5: Enzyme Induction Potential; 1.8.6 Study 6: In Vitro Empirical Drug-Drug Interactions; 1.9 Data Interpretation; 1.9.1 Pathway Evaluation; 1.9.2 P450 Inhibition; 1.9.3 P450 Induction; 1.10 Conclusion; References; 2 In Vitro Approaches to Anticipating Clinical Drug Interactions; 2.1 In Vitro Systems for Human CYP450 Metabolism; 2.1.1 Incubation Buffer (pH and Ionic Strength); 2.1.2 MgCl(2) and Cytochrome b(5); 2.1.3 Nonspecific Binding 2.1.4 Organic Solvents and Excipients2.2 Analysis of Data from In Vitro Systems; 2.2.1 Linear Transformation of Michaelis-Menten Equation (Lineweaver-Burk and Eadie-Hofstee); 2.2.2 Nonlinear Regression Analysis of Hyperbolic Kinetic Data; 2.2.3 Consideration of Non-Michaelis-Menten Kinetics; 2.3 Use of In Vitro Kinetic Data to Predict In Vivo Clearance; 2.3.1 Calculation of In Vitro (Predicted) Hepatic Clearance; 2.3.2 Comparison of In Vitro (Predicted) with In Vivo Hepatic Clearance; 2.4 Use of In Vitro Kinetic Data to Predict Drug-Drug Interactions 2.4.1 Choice of Probe Substrates for Inhibition Studies2.4.2 Determining the Mechanism of CYP450 Inhibition; 2.4.3 Prediction of In Vivo Drug-Drug Inhibition Interactions from In Vitro Data; 2.5 Consideration of Non-CYP Enzymatic Systems; 2.5.1 Flavin-Containing Monooxygenase (FMO); 2.5.2 UDP-glucuronosyltransferase (UGT); 2.5.3 Sulfotransferase (SULT); 2.5.4 N-Acetyltransferase (NAT); 2.5.5 Methyltransferase; 2.5.6 Epoxidase Hydrolase; 2.5.7 Aldehyde Oxidase and Dehydrogenase; 2.5.8 Glutathione-S-transferase (GST); 2.6 Summary; 2.7 Acknowledgments; References 3 Inhibition of Drug-Metabolizing Enzymes and Drug-Drug Interactions in Drug Discovery and Development |
| Record Nr. | UNINA-9910143982103321 |
| Hoboken, N.J., : Wiley-interscience, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drug-drug interactions in pharmaceutical development / / edited by Albert P. Li
| Drug-drug interactions in pharmaceutical development / / edited by Albert P. Li |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley-interscience, c2008 |
| Descrizione fisica | 1 online resource (261 p.) |
| Disciplina |
615.7045
615/.7045 |
| Altri autori (Persone) | LiA. P |
| Collana | Wiley series in drug discovery and development |
| Soggetto topico |
Drug interactions
Drug development |
| ISBN |
1-282-02206-7
9786612022067 0-470-18792-1 0-470-18791-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
DRUG-DRUG INTERACTIONS IN PHARMACEUTICAL DEVELOPMENT; CONTENTS; Preface; Contributors; 1 In Vitro Evaluation of Metabolic Drug-Drug Interactions: Concepts and Practice; 1.1 Introduction; 1.2 Mechanisms of Adverse Drug-Drug Interactions; 1.2.1 Pharmacological Interactions; 1.2.2 Pharmacokinetic Interactions; 1.3 Drug Metabolism; 1.3.1 Phase I Oxidation; 1.3.2 Phase II Conjugation; 1.4 CYP Isoforms; 1.5 Human In Vitro Experimental Systems for Drug Metabolism; 1.5.1 Hepatocytes; 1.5.2 Liver Postmitochondrial Supernatant (PMS); 1.5.3 Human Liver Microsomes; 1.5.4 Recombinant P450 Isoforms (rCYP)
1.5.5 Cytosol1.6 Mechanisms of Metabolic Drug-Drug Interactions; 1.7 Mechanism-Based Approach for Evaluation of Drug-Drug Interaction Potential; 1.7.1 Metabolic Phenotyping; 1.7.2 Evaluation of Inhibitory Potential for Drug-Metabolizing Enzymes; 1.7.3 Induction Potential for Drug-Metabolizing Enzymes; 1.8 Experimental Approaches for In Vitro Evaluation of Drug-Drug Interaction Potential; 1.8.1 Study 1: Metabolic Phenotyping 1-Metabolite Identification; 1.8.2 Study 2: Metabolic Phenotyping 2-Identification of Major Metabolic Pathways 1.8.3 Study 3: Metabolic Phenotyping 3-Identification of P450 Isoform Pathways (P450 Phenotyping)1.8.4 Study 4: CYP Inhibitory Potential; 1.8.5 Study 5: Enzyme Induction Potential; 1.8.6 Study 6: In Vitro Empirical Drug-Drug Interactions; 1.9 Data Interpretation; 1.9.1 Pathway Evaluation; 1.9.2 P450 Inhibition; 1.9.3 P450 Induction; 1.10 Conclusion; References; 2 In Vitro Approaches to Anticipating Clinical Drug Interactions; 2.1 In Vitro Systems for Human CYP450 Metabolism; 2.1.1 Incubation Buffer (pH and Ionic Strength); 2.1.2 MgCl(2) and Cytochrome b(5); 2.1.3 Nonspecific Binding 2.1.4 Organic Solvents and Excipients2.2 Analysis of Data from In Vitro Systems; 2.2.1 Linear Transformation of Michaelis-Menten Equation (Lineweaver-Burk and Eadie-Hofstee); 2.2.2 Nonlinear Regression Analysis of Hyperbolic Kinetic Data; 2.2.3 Consideration of Non-Michaelis-Menten Kinetics; 2.3 Use of In Vitro Kinetic Data to Predict In Vivo Clearance; 2.3.1 Calculation of In Vitro (Predicted) Hepatic Clearance; 2.3.2 Comparison of In Vitro (Predicted) with In Vivo Hepatic Clearance; 2.4 Use of In Vitro Kinetic Data to Predict Drug-Drug Interactions 2.4.1 Choice of Probe Substrates for Inhibition Studies2.4.2 Determining the Mechanism of CYP450 Inhibition; 2.4.3 Prediction of In Vivo Drug-Drug Inhibition Interactions from In Vitro Data; 2.5 Consideration of Non-CYP Enzymatic Systems; 2.5.1 Flavin-Containing Monooxygenase (FMO); 2.5.2 UDP-glucuronosyltransferase (UGT); 2.5.3 Sulfotransferase (SULT); 2.5.4 N-Acetyltransferase (NAT); 2.5.5 Methyltransferase; 2.5.6 Epoxidase Hydrolase; 2.5.7 Aldehyde Oxidase and Dehydrogenase; 2.5.8 Glutathione-S-transferase (GST); 2.6 Summary; 2.7 Acknowledgments; References 3 Inhibition of Drug-Metabolizing Enzymes and Drug-Drug Interactions in Drug Discovery and Development |
| Record Nr. | UNINA-9910818381003321 |
| Hoboken, N.J., : Wiley-interscience, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
