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Clinical Approaches to Hospital Medicine [[electronic resource] ] : Advances, Updates and Controversies / / edited by Kevin Conrad
Clinical Approaches to Hospital Medicine [[electronic resource] ] : Advances, Updates and Controversies / / edited by Kevin Conrad
Edizione [1st ed. 2018.]
Pubbl/distr/stampa Cham : , : Springer International Publishing : , : Imprint : Springer, , 2018
Descrizione fisica 1 online resource (XV, 314 p. 32 illus., 18 illus. in color.)
Disciplina 610.6
Soggetto topico Practice of medicine
Internal medicine
Pharmacy
Practice and Hospital Management
Internal Medicine
Drug Safety and Pharmacovigilance
ISBN 3-319-64774-1
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Section I – A Clinical Update in Hospital Medicine -- Chapter 1: Diagnosis and Treatment of Heart Failure for Inpatient Providers -- Chapter 2: Hospital Management of Migraine -- Chapter 3: Candidemia: New directions for Management and Treatment -- Chapter 4: Adjunct Corticosteroid Therapy for Patients with Community Acquired Pneumonia -- Chapter 5: Procalcitonin and New Biomarkers -- Chapter 6: New Developments and Treatment Options for Cellulitis in the Hospital -- Chapter 7: An In Depth Look into the Management and Treatment of Delirium -- Chapter 8: Update in the Treatment of Sepsis and Septic Shock; Transitioning from SIRS to SOFA -- Section II - Extended Topics in Hospital Medicine -- Chapter 9: Palliative Medicine -- Chapter 10: Stroke Units and Their Effect on Patient Outcomes -- Chapter 11: An Update in Perioperative Medicine -- Chapter 12: Obstetrics: The Hospitalist’s Approach to the Pregnant Patient -- Section III – The Opiod Epidemic – Tools for the Hospitalist -- Chapter 13: Solving America’s Opiod Epidemic – Pathophysiology and Ethics -- Chapter 14: Solving America’s Opiod Epiedmic – Treatment and Systems Approach -- Chapter 15:The Opioid Risk Tool: Assessing Opioid Risk: Why Is the Sensitive Question Important? -- Chapter 16:Nonopioid and Adjuvant Analgesics for Acute Pain Management -- Chapter 17:Hospitalist Management of Injectable Drugs of Abuse -- Section IV – Perspectives in Hospital Medicine -- Chapter 18:The State of Hospitalist Medicine: Trends in Compensation, Practice Patterns, Advanced Practice Providers, Malpractice and Career Satisfaction -- Chapter 19:The Background and Development of Hospital Medicine Globally: The Challenges of International Hospital Medicine -- Chapter 20: Philosophical Tools for Applying Medical Knowledge.
Record Nr. UNINA-9910300306203321
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2018
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Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials [[electronic resource] /] / by Tony K.L. Kiang, Kyle John Wilby, Mary H.H. Ensom
Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials [[electronic resource] /] / by Tony K.L. Kiang, Kyle John Wilby, Mary H.H. Ensom
Autore Kiang Tony K.L
Edizione [1st ed. 2015.]
Pubbl/distr/stampa Cham : , : Springer International Publishing : , : Imprint : Adis, , 2015
Descrizione fisica 1 online resource (149 p.)
Disciplina 353998
610
613
614.44
Soggetto topico Tropical medicine
Health promotion
Pharmacy
Tropical Medicine
Health Promotion and Disease Prevention
Drug Safety and Pharmacovigilance
ISBN 3-319-10527-2
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Introduction -- Pharmacology of Recommended Antimalarial Agents -- Drug Interaction Potential of Antimalarial Drugs Based on Known Metabolic Properties of Antimalarials -- Pharmacokinetic Drug Interactions Affecting Antimalarials -- Effects of Antimalarials on the Pharmacokinetics of Co-Administered Drugs -- Effects of Antimalarials on the Pharmacokinetics of Co-Administered Antimalarials -- Pharmacodynamic Interactions: Clinical Evidence for Combination Therapy, In Vitro Interactions, and In Vivo Interactions -- Limitations, Future Directions, and Conclusions.
Record Nr. UNINA-9910300188803321
Kiang Tony K.L  
Cham : , : Springer International Publishing : , : Imprint : Adis, , 2015
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Cognitive Errors and Diagnostic Mistakes [[electronic resource] ] : A Case-Based Guide to Critical Thinking in Medicine / / by Jonathan Howard
Cognitive Errors and Diagnostic Mistakes [[electronic resource] ] : A Case-Based Guide to Critical Thinking in Medicine / / by Jonathan Howard
Autore Howard Jonathan
Edizione [1st ed. 2019.]
Pubbl/distr/stampa Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019
Descrizione fisica 1 online resource (589 pages)
Disciplina 616.075
Soggetto topico General practice (Medicine)
Health promotion
Pharmacy
Neurology 
Diagnostic Errors - prevention & control
Medical Errors - prevention & control
Clinical Decision-Making
Clinical Competence
Attitude of Health Personnel
General Practice / Family Medicine
Health Promotion and Disease Prevention
Drug Safety and Pharmacovigilance
Neurology
Soggetto genere / forma Case Reports.
ISBN 3-319-93224-1
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto An introduction to cognitive biases and how they led to errors and impact medical diagnoses -- Aggregate bias -- Anchoring -- Availability -- Base-rate neglect -- Commission bias -- Diagnosis momentum -- Feedback sanction -- Framing effect -- Fundamental attribution error -- Gambler’s fallacy -- Gender bias -- Hindsight bias -- Multiple alternatives bias -- Omission bias -- Order effects -- Outcome bias -- Overconfidence bias -- Playing the odds -- Posterior probability error -- Premature closure -- Psych-out error -- Representativeness restraint -- Search satisfying -- Sutton’s slip -- Triage cueing -- Unpacking principle -- Vertical line failure -- Visceral bias -- Yin Yang -- Strategies to improve critical thinking and minimize cognitive biases/diagnostic errors. .
Record Nr. UNINA-9910337477403321
Howard Jonathan  
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019
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Communicating about Risks and Safe Use of Medicines [[electronic resource] ] : Real Life and Applied Research / / edited by Priya Bahri
Communicating about Risks and Safe Use of Medicines [[electronic resource] ] : Real Life and Applied Research / / edited by Priya Bahri
Edizione [1st ed. 2020.]
Pubbl/distr/stampa Singapore : , : Springer Singapore : , : Imprint : Adis, , 2020
Descrizione fisica 1 online resource (523 pages)
Disciplina 615.1
Soggetto topico Pharmacy
Drug Safety and Pharmacovigilance
Medicaments
Avaluació del risc per la salut
Comunicació en farmàcia
Soggetto genere / forma Llibres electrònics
ISBN 981-15-3013-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Foreword (Baruch Fischhoff) -- Preface: Guide for readers (Priya Bahri) -- Authors’ biographical notes -- Overview of contents in chapters -- 1. A multilayered research framework for humanities and epidemiology of medicinal product risk communication (Priya Bahri) -- Part I: Medicines in real life as communication challenges. 2. Hormonal contraceptives - Communication for risk awareness and informed choice, or a public scare? (Barbara Mintzes, Teresa Alves, with a contribution from Priya Bahri) -- 3. COX-2 inhibitors - Communication of accumulating risk evidence and a product withdrawal (Amy Rogers, Kerr Grieve, Thomas M MacDonald, with a contribution from Sérgio Nishioka) -- 4. Isotretinoin - Communication for preventing birth defects and alerting of an uncertain risk of suicide (Ineke (HJMJ) Crijns) -- 5. Pandemic influenza vaccines - Communication of benefits, risks and uncertainties (Glen J Nowak, Emilie Karafillakis, Heidi Larson) -- Part II: Tackling the challenges – Methods for medicinal product risk communication research. 6. Ethical frameworks (Ghislaine van Thiel) -- 7. The cognitive and behavioural sciences (Sara Rubinelli, Nicola Diviani, Maddalena Fiordelli) -- 8. The social sciences (Brian Taylor, Anne Moorhead) -- 9. Rhetoric and science & technology studies (Mathias Møllebæk) -- 10. Media science and practice (Glen J Nowak, Michael A Cacciatore) -- 11. Social media research (Nabarun Dasgupta, Carly Winokur, Carrie E Pierce) -- 12. Design science with a focus on user-centred evaluation of written information (Jörg Fuchs) -- 13. Dissemination & implementation science (Elaine Morrato, Meredith Smith) -- 14. Pharmacoepidemiology (Bert (HGM) Leufkens) -- 15. Legal frameworks (Burkhard Sträter) -- 16. From passive to active - Patients as contributors to medicinal product risk communication research (François Houÿez) -- Afterword: The dimension of communicating medicine risks in low- and middle-income countries (Nilima A Kshirsagar).
Record Nr. UNINA-9910407725603321
Singapore : , : Springer Singapore : , : Imprint : Adis, , 2020
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Comprehensive Healthcare Simulation: Pharmacy Education, Practice and Research [[electronic resource] /] / edited by Yaser Mohammed Al-Worafi
Comprehensive Healthcare Simulation: Pharmacy Education, Practice and Research [[electronic resource] /] / edited by Yaser Mohammed Al-Worafi
Autore Al-Worafi Yaser Mohammed
Edizione [1st ed. 2023.]
Pubbl/distr/stampa Cham : , : Springer International Publishing : , : Imprint : Springer, , 2023
Descrizione fisica 1 online resource (278 pages)
Disciplina 615.10711
Collana Comprehensive Healthcare Simulation
Soggetto topico Pharmacy
Pharmacology
Pharmacovigilance
Public health administration
Drug Safety and Pharmacovigilance
Health Administration
ISBN 3-031-33761-1
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Part I. Simulation in Pharmacy Education -- Overview of Simulation in Pharmacy Education -- Patient simulation in Pharmacy Education -- Fidelity simulation in Pharmacy Education -- Computer-based Simulation in Pharmacy Education -- Simulation for Introductory Pharmacy Practice Experience (IPPE) -- Simulation for Advanced Pharmacy Practice Experience (APPE) -- Simulation for Pharmacotherapy -- Simulation for Clinical Pharmacokinetics -- Simulation for Medication Safety -- Simulation for Pharmacology -- Simulation for Pharmaceutical Chemistry -- Simulation for Pharmaceutics and Pharmaceutical Industry -- Simulation for Drug Information and Poisons Services -- Simulation for Complementary and Alternative Medicines and Nutraceuticals -- Simulation for personalized medicine -- Simulation for Clinical Toxicology and Forensic Medicine -- In situ and mobile simulation in pharmacy education -- Facilitators of Simulation in Pharmacy Education -- Barriers of Simulation in Pharmacy Education -- Assessment, Evaluation and Feedback of Simulation in Pharmacy Education -- Effectiveness of simulation in pharmacy education -- Quality standards and recommendations of the simulation in pharmacy education -- Simulation training -- Part II. Simulation for Pharmacy Practice -- Overview of Simulation in Pharmacy Practice -- Simulation in Community Pharmacy Practice -- Simulation in Hospital Pharmacy Practice -- Simulation for communication skills assessment -- Simulation in patient care -- Simulation in the distance and online pharmacy practice: telepharmacy and telehealth -- Simulation for medication safety and patient safety practice -- Assessment, Evaluation and Feedback of Simulation in Pharmacy Practice -- Facilitators of Simulation in Pharmacy Practice -- Barriers of Simulation in Pharmacy Practice -- Quality standards and recommendations of Simulation in Pharmacy Practice -- Part III. Simulation for Pharmacy Research -- Overview of Simulation in Pharmacy Research -- Simulation for Drug Development -- Design simulation-based research in pharmacy -- Recruiting and train the simulated patients/persons -- Data analysis -- Ethics in simulation research -- Simulation research reports and publication -- Facilitators of simulation research -- Barriers of simulation research.
Record Nr. UNINA-9910736020703321
Al-Worafi Yaser Mohammed  
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2023
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Cutaneous Drug Hypersensitivity [[electronic resource] ] : Clinical Features, Mechanisms, Diagnosis, and Management / / edited by Andreas J. Bircher, Howard I. Maibach, Knut Brockow, Annick Barbaud
Cutaneous Drug Hypersensitivity [[electronic resource] ] : Clinical Features, Mechanisms, Diagnosis, and Management / / edited by Andreas J. Bircher, Howard I. Maibach, Knut Brockow, Annick Barbaud
Edizione [1st ed. 2022.]
Pubbl/distr/stampa Cham : , : Springer International Publishing : , : Imprint : Springer, , 2022
Descrizione fisica 1 online resource (346 pages)
Disciplina 615.778
Soggetto topico Dermatology
Allergy
Internal medicine
Pharmacovigilance
Primary care (Medicine)
Family medicine
Allergology
Internal Medicine
Drug Safety and Pharmacovigilance
Primary Care Medicine
General Practice and Family Medicine
ISBN 3-030-82743-7
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Part I. General aspects of drug hypersensitivity -- Chapter 1. Terminology, classifications, chronology -- Chapter 2. Epidemiology -- Chapter 3. Clinical manifestations: Cutaneous signs and syndromes -- Chapter 4. Clinical manifestations: Other organs (kidney, gut, heart, brain etc.) -- Chapter 5. Danger signs in drug hypersensitivity and severity SCORES -- Chapter 6. Pathomechanisms in Drug Hypersensitivities -- Part II. Diagnostic methods -- Chapter 7. Skin tests -- Chapter 8. Serological tests -- Chapter 9. T cell tests -- Chapter 10. Basophil activation tests -- Chapter 11. Histopathology of drug induced exanthemas -- Part III. Management -- Chapter 12. Drug desensitization in immediate-type hypersensitivity -- Chapter 13. Documentation allergy card/pass -- Part IV. Drug hypersensitivity in specific populations -- Chapter 14. Children and Adolescents -- Chapter 15. HIV-Infection and AIDS -- Chapter 16. Oncology. immune checkpoint Inhibitors -- Chapter 17. MC releasing syndromes in drug hypersensitivity -- Part V. Eliciting Drugs -- Chapter 18. Penicillins -- Chapter 19. Cephalosporin Allergy -- Chapter 20. Other Antibiotics -- Chapter 21. Other Antiinfectious drugs -- Chapter 22. Analgesics and non-steroidal antiphlogistic drugs -- Chapter 23. Periinterventional hypersensitivity: Anesthetic drugs and materials -- Chapter 24. Muscle relaxants -- Chapter 25. Anticoagulants -- Chapter 26. Biological drugs -- Chapter 27. Hormones (delayed) -- Chapter 28. Vaccines -- Chapter 29. Antiepileptic and psychotropic drugs -- Chapter 30. PROTON PUMP INHIBITORS -- Chapter 31. Diagnostic agents -- Chapter 32. Hypersensitivity to blood pressure agents -- Chapter 33. Iron preparations -- Chapter 34. Vitamins and supplements -- Chapter 35. Anti-tumor drugs / Cytostatics -- Chapter 36. Photosensitizing drugs -- Chapter 37. Topically applied drugs -- Chapter 38. Additives: Preservatives, Antioxidants (sulfites), Colors, dyes and other.
Record Nr. UNINA-9910768200103321
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2022
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Drug Discovery and Evaluation: Pharmacological Assays [[electronic resource] /] / edited by Franz J. Hock
Drug Discovery and Evaluation: Pharmacological Assays [[electronic resource] /] / edited by Franz J. Hock
Edizione [4th ed. 2016.]
Pubbl/distr/stampa Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016
Descrizione fisica 1 online resource (32 illus., 20 illus. in color. eReference.)
Disciplina 610
Collana Springer Reference
Soggetto topico Medicine
Pharmacology
Pharmacy
Biomedicine, general
Pharmacology/Toxicology
Drug Safety and Pharmacovigilance
ISBN 3-319-05392-2
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Intro -- Preface to the Fourth Edition -- Contents -- About the Editor -- Contributors -- Part I: Cardiovascular Activity -- Studies in Isolated Organs -- α-Sympatholytic Activity in Isolated Vascular Smooth Muscle -- Purpose and Rationale -- Procedure -- Experimental Course -- Evaluation -- Modifications of the Method -- α-Sympatholytic Activity in the Isolated Guinea Pig Seminal Vesicle -- Purpose and Rationale -- Procedure -- Evaluation -- Modification of the Method -- α-Sympatholytic Activity in the Isolated Vas Deferens of the Rat -- Purpose and Rationale -- Procedure -- Evaluation -- Modifications of the Method -- α-Sympatholytic Activity in the Isolated Rat Spleen -- Purpose and Rationale -- Procedure -- Evaluation -- Modifications of the Method -- α-Sympatholytic Activity in the Isolated Rat Anococcygeus Muscle -- Purpose and Rationale -- Procedure -- Evaluation -- Modifications of the Method -- beta1-Sympatholytic Activity in Isolated Guinea Pig Atria -- Purpose and Rationale -- Procedure -- Right Atrium -- Left Atrium -- Evaluation -- Modifications of the Method -- beta2-Sympatholytic Activity in the Isolated Tracheal Chain -- Purpose and Rationale -- Procedure -- Experimental Course -- Evaluation -- Modifications of the Method -- Angiotensin-Converting Enzyme Inhibition in the Isolated Guinea Pig Ileum -- Purpose and Rationale -- Procedure -- Angiotensin I Antagonism -- Bradykinin Potentiation -- Evaluation -- Angiotensin I Antagonism -- Bradykinin Potentiation -- Modification of the Method -- Contractile and Relaxing Activity on Isolated Blood Vessels Including Effects of Potassium-Channel Openers -- Purpose and Rationale -- Procedure -- Evaluation -- Modifications of the Method -- Isolated Guinea Pig Ureter -- Purpose and Rationale -- Procedure -- Evaluation -- Critical Assessment of the Method -- Modifications of the Method.
Isolated Corpus Cavernosum -- Purpose and Rationale -- Procedure -- Evaluation -- Modifications of the Method -- References and Further Reading -- α-Sympatholytic Activity in Isolated Vascular Smooth Muscle -- α-Sympatholytic Activity in the Isolated Guinea Pig Seminal Vesicle -- α-Sympatholytic Activity in the Isolated Vas Deferens of the Rat -- α-Sympatholytic Activity in the Isolated Rat Spleen -- α-Sympatholytic Activity in the Isolated Rat Anococcygeus Muscle -- beta1-Sympatholytic Activity in Isolated Guinea Pig Atria -- beta2-Sympatholytic Activity in the Isolated Tracheal Chain -- Angiotensin Converting Enzyme Inhibition in the Isolated Guinea Pig Ileum -- Contractile and Relaxing Activity on Isolated Blood Vessels Including Effects of Potassium-Channel Openers -- Isolated Guinea Pig Ureter -- Isolated Corpus Cavernosum -- Cardiovascular Analysis In Vivo -- Hemodynamic Screening in Anesthetized Rats -- Purpose and Rationale -- Procedure -- Evaluation -- Critical Assessment of the Method -- Modifications of the Method -- Blood Pressure in Pithed Rats -- Purpose and Rationale -- Procedure -- Evaluation -- Modifications of the Method -- Antihypertensive Vasodilator Activity in Ganglion-Blocked, Angiotensin II-Supported Rats -- Purpose and Rationale -- Procedure -- Evaluation -- Critical Assessment of the Method -- Modifications of the Method -- Blood Pressure in Conscious Hypertensive Rats (Tail-Cuff Method) -- Purpose and Rationale -- Procedure -- Surgical Procedure to Induce Renal Hypertension -- Test Procedure -- Evaluation -- Critical Assessment of the Method -- Modifications of the Method -- Direct Measurement of Blood Pressure in Conscious Rats with Indwelling Catheter -- Purpose and Rationale -- Procedure -- Preparation of Cannulae -- Implantation of Cannulae -- Measurement of Blood Pressure -- Evaluation.
Critical Assessment of the Method -- Modifications of the Method -- Cannulation Techniques in Rodents -- Purpose and Rationale -- Permanent Cannulation of the Jugular Vein in Rats -- Purpose and Rationale -- Procedure -- Modifications of the Method -- Permanent Cannulation of the Renal Vein in Rats -- Purpose and Rationale -- Procedure -- Permanent Cannulation of the Portal Vein in Rats -- Purpose and Rationale -- Procedure -- Permanent Cannulation of the Thoracic Duct in Rats -- Purpose and Rationale -- Procedure -- Portacaval Anastomosis in Rats -- Purpose and Rationale -- Procedure -- Cardiovascular Analysis in Anesthetized Mice -- Purpose and Rationale -- Procedure -- Evaluation -- Modifications of the Method -- Blood Pressure in Anesthetized Cats -- Purpose and Rationale -- Procedure -- Evaluation -- Critical Assessment of the Method -- Modifications of the Method -- Cardiovascular Drug Challenging Experiments in Anesthetized Dogs -- Purpose and Rationale -- Procedure -- Evaluation -- Hemodynamic Analysis in Anesthetized Dogs -- Purpose and Rationale -- Procedure -- Preparation for Hemodynamic Measurements -- Experimental Course -- Calculation of Results and Evaluation -- Modifications of the Method -- Hemodynamic Measurements in Conscious Dogs -- Purpose and Rationale -- Procedure -- Experimental Protocol -- Evaluation -- Modifications of the Method -- Hemodynamic Studies in Monkeys -- Purpose and Rationale -- Procedure -- Evaluation -- Modifications of the Method -- Measurement of Cardiac Output and Regional Blood Flow with Microspheres -- Purpose and Rationale -- Procedure -- Evaluation -- Critical Assessment of the Method -- Modifications of the Method -- Carotid Artery Loop Technique -- Purpose and Rationale -- Procedure -- Critical Assessment of the Method -- Modifications of the Method.
Measurement of Heart Dimensions in Anesthetized Dogs -- Purpose and Rationale -- Procedure -- Implantation of Ultrasonic Transducers -- Preparation for Hemodynamic Measurements -- Experimental Course -- Evaluation -- Modifications of the Method -- Telemetric Monitoring of Cardiovascular Parameters in Rats -- Purpose and Rationale -- Procedure -- Evaluation -- Modifications of the Method -- Cardiovascular Effects After Intracerebroventricular Administration -- Purpose and Rationale -- Procedure -- Evaluation -- Modifications of the Method -- Influence on Orthostatic Hypotension -- Purpose and Rationale -- Procedure -- Evaluation -- Modifications of the Method -- Bezold-Jarisch Reflex -- Purpose and Rationale -- Procedure -- Evaluation -- Modifications of the Method -- Endotoxin-Induced Shock -- Purpose and Rationale -- Procedure -- Evaluation -- Modifications of the Method -- Hemorrhagic Shock -- Purpose and Rationale -- Procedure -- Evaluation -- Critical Assessment of the Method -- Modifications of the Method -- Tourniquet Shock -- Purpose and Rationale -- Procedure -- Evaluation -- Critical Evaluation of the Method -- Modifications of the Method -- Heatstroke -- Purpose and Rationale -- Procedure -- Evaluation -- Modifications of the Method -- α- and beta-Adrenoreceptors in the Mouse Iris -- Purpose and Rationale -- Procedure -- Evaluation -- Modifications of the Method -- α2-Adrenoreceptor Blockade Measured In Vivo by Clonidine-Induced Sleep in Chicks -- Purpose and Rationale -- Procedure -- Evaluation -- Critical Assessment of the Method -- Activity at beta1- and beta2-Adrenoreceptors in the Rat -- Purpose and Rationale -- Procedure -- Evaluation of Agonists -- Evaluation of Antagonists -- Critical Assessment of the Method -- Modifications of the Method -- beta1- and beta2-Sympatholytic Activity in Dogs -- Purpose and Rationale -- Procedure.
Preparation for Hemodynamic Measurements -- Screening for beta-Blocking Effects in Anesthetized Dogs -- Testing for beta1- and beta2-Blocking Effects: Determination of ED50 -- Evaluation -- Intrinsic beta-Sympathomimetic Activity in Reserpine-Pretreated Dogs -- Purpose and Rationale -- Procedure -- Preparation for Hemodynamic Measurements -- Experimental Course -- Evaluation -- Cat Nictitating Membrane Preparation (Ganglion-Blocking Activity) -- Purpose and Rationale -- Procedure -- Evaluation -- Critical Assessment of the Method -- Modifications of the Method -- Assessment of Ganglion-Blocking Activity in the Isolated Bovine Retractor Penis Muscle -- Purpose and Rationale -- Procedure -- Evaluation -- Critical Assessment of the Method -- Modifications of the Method -- Angiotensin II Antagonism -- Purpose and Rationale -- Procedure -- Intrinsic Agonistic Activity -- Antagonistic Activity -- Duration of Activity -- Evaluation -- Intrinsic Agonistic Activity -- Antagonistic Activity -- Critical Assessment of the Method -- Modifications of the Method -- ACE Inhibition Measured In Vivo in the Rat -- Purpose and Rationale -- Procedure -- Inhibition of Angiotensin I Cleavage -- Potentiation of Bradykinin-Induced Vasodepression -- Evaluation -- Inhibition of Angiotensin I Cleavage -- Potentiation of Bradykinin-Induced Vasodepression -- Critical Assessment of the Method -- Modifications of the Method -- Evaluation of Renin Inhibitors in Dogs -- Purpose and Rationale -- Procedure -- Animal Experiment -- Analytical Procedures -- Evaluation -- Critical Assessment of the Method -- Modifications of the Method -- Evaluation of Renin Inhibitors in Monkeys -- Purpose and Rationale -- Procedure -- Evaluation -- Modifications of the Method -- Critical Assessment of the Method -- Penile Erection in Rabbits -- Purpose and Rationale -- Procedure -- Evaluation.
Modifications of the Method.
Record Nr. UNINA-9910253870903321
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016
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Drug Therapy and Interactions in Pediatric Oncology [[electronic resource] ] : A Pocket Guide / / by Carolina Witchmichen Penteado Schmidt, Fabiana Gatti de Menezes
Drug Therapy and Interactions in Pediatric Oncology [[electronic resource] ] : A Pocket Guide / / by Carolina Witchmichen Penteado Schmidt, Fabiana Gatti de Menezes
Autore Penteado Schmidt Carolina Witchmichen
Edizione [1st ed. 2017.]
Pubbl/distr/stampa Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017
Descrizione fisica 1 online resource (XXI, 212 p. 15 illus. in color.)
Disciplina 618.92
Soggetto topico Pediatrics
Oncology  
Hematology
Pharmacy
Cancer research
Oncology
Drug Safety and Pharmacovigilance
Cancer Research
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto 1. Introduction -- 2. The main diseases in pediatric oncohematology -- 3. The main protocols in pediatric oncohematology -- 4. Background on drug interactions -- 5. Food - drug interactions -- 6. Body surface -- 7. Carboplatin dosage calculation -- 8. Creatinine clearance estimate.
Record Nr. UNINA-9910135952103321
Penteado Schmidt Carolina Witchmichen  
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017
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Drug Transporters in Drug Disposition, Effects and Toxicity [[electronic resource] /] / edited by Xiaodong Liu, Guoyu Pan
Drug Transporters in Drug Disposition, Effects and Toxicity [[electronic resource] /] / edited by Xiaodong Liu, Guoyu Pan
Edizione [1st ed. 2019.]
Pubbl/distr/stampa Singapore : , : Springer Singapore : , : Imprint : Springer, , 2019
Descrizione fisica 1 online resource (588 pages)
Disciplina 615.1
Collana Advances in Experimental Medicine and Biology
Soggetto topico Pharmacology
Pharmacy
Medicinal chemistry
Pharmacology/Toxicology
Drug Safety and Pharmacovigilance
Medicinal Chemistry
ISBN 981-13-7647-6
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Overview: role of drug transporters in drug disposition and its clinical significance -- ABC family transporters -- SLC family transporters -- Current research method in transporter study -- Transporter-mediated drug–drug interactions and their significance -- Roles of hepatic drug transporters in drug disposition and liver toxicity -- Roles of renal drug transporter in drug disposition and renal toxicity -- Intestinal transporter associated toxicity and absorption -- Contributions of drug transporters to blood-brain barriers -- Contributions of drug transporters to blood-retinal barrier(BRB) -- Contributions of drug transporters to blood-placental barrier -- ABC transporter-mediated multidrug-resistant cancer.
Record Nr. UNINA-9910350349703321
Singapore : , : Springer Singapore : , : Imprint : Springer, , 2019
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Ethical Innovation for Global Health [[electronic resource] ] : Pandemic, Democracy and Ethics in Research / / edited by Chieko Kurihara, Dirceu Greco, Ames Dhai
Ethical Innovation for Global Health [[electronic resource] ] : Pandemic, Democracy and Ethics in Research / / edited by Chieko Kurihara, Dirceu Greco, Ames Dhai
Autore Kurihara Chieko
Edizione [1st ed. 2023.]
Pubbl/distr/stampa Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2023
Descrizione fisica 1 online resource (331 pages)
Disciplina 174.2
Altri autori (Persone) GrecoDirceu
DhaiAmes
Soggetto topico Medical Ethics
Bioethics
Pharmacovigilance
Medical policy
Pharmaceutical chemistry
Drug Safety and Pharmacovigilance
Health Policy
Pharmaceutics
ISBN 981-9961-63-7
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto 1 Introduction to Ethical innovation for global health: pandemic, democracy and ethics in research. Part 1 Relevant constructions from a middle-income country (MIC) and/or non-Western paradigms: Brazil, South Africa, Taiwan, South Korea, and Japan -- 2 Democracy restoration in Brazil, the constitutional guarantee of health as a right for all, giving rise to a universal health system (SUS) and of a National Research Ethics Commission -- 3 Equitable access to COVID-19 vaccines, vaccine research and Vaccine Apartheid on the African continent: challenges and recommendations -- 4 Response to Covid-19 pandemic and Ethical Innovations in Taiwan -- 5 Between truth and profit: Scientific misconduct case of human cloned embryonic stem cell and revisiting cases during COVID-19 pandemic -- 6 Therapeutic misconception as the basis for vaccine nationalism of Japan: a historical reflection and perspectives for global public health -- Part 2 Historical and international perspectives on the development of ethical principles in research involving humans -- 7 The Declaration of Helsinki as a living document: Revisiting its principles in a global pandemic -- 8 Hidden Medical War Crimes and the Emergence of Bioethics in Japan -- 9 From Nuremberg to Helsinki: Historicizing the Codification of Post-War Research Ethics -- 10 CIOMS research guidelines: Considering the needs of developing countries -- 11 Ethics of placebo-controlled trial: historical analysis including the experience of COVID-19 pandemic -- 12 Post-trial access: historical analysis considering the experience of COVID-19 pandemic -- 13 Our “WMA Declaration of Helsinki”: opinions and pro-posals from patient and public for research ethics -- Part 3 Alternative frameworks for innovation and drug development strategies -- 14 Medicines development for global health: Learning from COVID-19 vaccines R&D -- 15 Development of portfolios and pipelines of drugs for the treatment, prevention and control of neglected tropical diseases -- 16 Patient and Public Involvement (PPI) and pharmaceutical development through Open Innovation Processes ~ recent activities.
Record Nr. UNINA-9910765490203321
Kurihara Chieko  
Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2023
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