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Biyokimya dergisi
| Biyokimya dergisi |
| Pubbl/distr/stampa | Ankara, : Türk Biyokimya Derneği, [1976-1999] |
| Soggetto topico |
Clinical biochemistry
Biochemistry Molecular biology |
| Soggetto genere / forma | Periodical |
| ISSN | 1303-829X |
| Formato | Materiale a stampa  |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | tur |
| Record Nr. | UNINA-9910397058203321 |
| Ankara, : Türk Biyokimya Derneği, [1976-1999] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The carbonic anhydrases : current and emerging therapeutic targets / / W. Richard Chegwidden, Nicholas D. Carter, editors
| The carbonic anhydrases : current and emerging therapeutic targets / / W. Richard Chegwidden, Nicholas D. Carter, editors |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2021] |
| Descrizione fisica | 1 online resource (296 pages) |
| Disciplina | 615.1 |
| Collana | Progress in Drug Research |
| Soggetto topico |
Genètica mèdica
Pharmacology Clinical biochemistry Pharmacy |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-79511-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Dedication to Richard Tashian -- Preface -- Contents -- 1 The Carbonic Anhydrases in Health and Disease -- References -- 2 Carbonic Anhydrase Isozymes as Diagnostic Biomarkers and Therapeutic Targets -- 2.1 Short Introduction of Mammalian Carbonic Anhydrases -- 2.2 CA II as a Biomarker -- 2.3 CA IX as a Biomarker -- 2.4 CA IX Immunoassay Data -- 2.5 CA XII in Cancer -- 2.6 Carbonic Anhydrases as Therapeutic Targets -- 2.7 Concluding Remarks -- References -- 3 Targeting Carbonic Anhydrases in Cardiovascular and Pulmonary Disease -- 3.1 Introduction -- 3.2 Carbonic Anhydrase Isozymes and Activity in the Cardiopulmonary System -- 3.3 Effects of CA Inhibitors Independent of CA Inhibition -- 3.4 CA Functions in the Normal Heart -- 3.4.1 CO2 Elimination -- 3.4.2 Cardiac pH Homeostasis -- 3.4.3 Metabolism-Perfusion Matching -- 3.4.4 Fatty Acid/Lactate Uptake -- 3.4.5 Myocardial Contractility and Calcium Mobilization -- 3.5 CA Functions in the Normal Lung -- 3.5.1 Alveolar Carbon Dioxide Elimination -- 3.5.2 Lung Fluid Exchange and pH Regulation -- 3.5.3 Ventilation-Perfusion Matching -- 3.5.4 Pleural Fluid Composition and Turnover -- 3.6 Carbonic Anhydrase Inhibitors and Cardiovascular Disease -- 3.6.1 Systemic Hypertension -- 3.6.2 Cardiac Hypertrophy and Heart Failure -- 3.6.3 Coronary Artery Disease and Myocardial Infarction -- 3.7 Carbonic Anhydrase Inhibitors in Pulmonary Disease -- 3.7.1 Chronic Obstructive Pulmonary Disease (COPD) -- 3.7.2 Chronic Cough -- 3.7.3 Pulmonary Hypertension (PH) -- 3.7.4 Lung Ischemia-Reperfusion Injury -- 3.8 Conclusions -- References -- 4 Carbonic Anhydrase Inhibitors in Ophthalmology: Glaucoma and Macular Oedema -- 4.1 Introduction -- 4.2 Carbonic Anhydrase Inhibitors in Glaucoma -- 4.2.1 Systemic Carbonic Anhydrase Inhibitors -- 4.2.2 Topical Carbonic Anhydrase Inhibitors.
4.2.3 Carbonic Anhydrase Inhibitors in Ocular Perfusion -- 4.3 Carbonic Anhydrase Inhibitors in Macular Oedema -- 4.3.1 Systemic Carbonic Anhydrase Inhibitors -- 4.3.2 Topical Carbonic Anhydrase Inhibitors -- References -- 5 Targeting Carbonic Anhydrase Isozymes in the Treatment of Neurological Disorders -- 5.1 Expression and Function of Enzymatically Active Carbonic Anhydrases in the Nervous System -- 5.2 CA Inhibitors in the Treatment of Neurological Diseases -- 5.3 CA Inhibitors in the Treatment of Acute High-Altitude Illness -- 5.4 CA Inhibitors in the Treatment of Pseudotumor Cerebri -- 5.5 CA Inhibitors in the Treatment of Brain Edema -- 5.6 CA Inhibitors in the Treatment of Epilepsy -- 5.7 Carbonic Anhydrase-Related Proteins (CARPs) -- 5.8 Localization and Role of CARP VIII -- 5.9 Distribution and Role of CARP X -- 5.10 Distribution and Role of CARP XI -- 5.11 Concluding Remarks -- References -- 6 Potential of Carbonic Anhydrase Inhibitors in the Treatment of Oxidative Stress and Diabetes -- 6.1 Introduction -- 6.2 Oxidative Stress and Diabetes -- 6.3 Retinal Pericytes and Metabolic Activity -- 6.4 Metabolic Activity, Oxidative Stress, and Diabetic Retinopathy -- 6.5 Carbonic Anhydrases -- 6.6 Mitochondrial Carbonic Anhydrases and Oxidative Stress -- 6.7 Carbonic Anhydrase Inhibitors and Prevention of Diabetic Retinopathy -- 6.8 Conclusions -- References -- 7 An Overview of Carbonic Anhydrase-Related Neoplasms -- 7.1 Introduction -- 7.2 Expression of Cytoplasmic CA Isoforms in Neoplasms -- 7.3 Expression of Mitochondrial CA Isoforms in Cancer -- 7.4 Expression of Membrane-Bound and Secreted CA Isoforms in Cancer -- 7.5 Expression of Inactive CA Isoforms in Cancer -- 7.6 Carbonic Anhydrase-Related Neoplasms -- 7.7 Conclusions -- References -- 8 Carbonic Anhydrase IX Interactome and the Regulation of Cancer Progression. 8.1 Tumour Microenvironment and Hypoxia -- 8.2 CAIX-regulation, Protein and Function -- 8.3 Overview of the CAIX Interactome -- 8.4 CAIX in Metastasis -- 8.4.1 CAIX and Cell-cell De-Adhesion -- 8.4.2 CAIX and Cell Migration -- 8.4.3 Invadopodia-Mediated Cell Invasion -- 8.5 Amino Acid Transporters and CAIX -- 8.6 CAIX and Unfolded Protein Response -- 8.7 Summary and Therapeutic Implications -- References -- 9 Carbonic Anhydrase IX: Current and Emerging Therapies -- 9.1 Introduction -- 9.2 Carbonic Anhydrase IX Imaging -- 9.2.1 CAIX Imaging in RCC -- 9.2.2 CAIX Imaging in Non-RCC -- 9.3 Intraoperative Imaging -- 9.4 CAIX-Directed Radioimmunotherapy -- 9.5 Carbonic Anhydrase IX Immunotherapy -- 9.6 Conclusion and Future Perspectives -- References -- 10 Carbonic Anhydrase Inhibitors: Designing Isozyme-Specific Inhibitors as Therapeutic Agents -- 10.1 Introduction: Classical CA Inhibitors (CAIs) -- 10.2 CA Inhibition Mechanisms and the Drug Design -- 10.3 Strategies for Obtaining Isoform-Selective CAIs -- 10.4 Conclusions -- References -- 11 Carbonic Anhydrase Inhibitors: Identifying Therapeutic Cancer Agents Through Virtual Screening -- 11.1 Virtual Screening in Drug Discovery -- 11.2 Virtual Screening Studies Identifying Novel Carbonic Anhydrase Inhibitors -- 11.3 Retrospective Virtual Screening Studies Using Carbonic Anhydrases as Target Receptors -- References -- 12 Targeting Carbonic Anhydrase IX in Tumor Imaging and Theranostic Cancer Therapy -- 12.1 Introduction -- 12.2 Targeting CA-IX as a Biomarker of Tumor Hypoxia -- 12.3 Methods for Detecting Tumor Hypoxia -- 12.4 CA-IX Expression in Clear Cell Renal Cell Carcinoma -- 12.5 Monoclonal Antibodies -- 12.5.1 Imaging with G250/cG250 -- 12.5.2 Radioimmunotherapy with G250/cG250 -- 12.5.3 Dual Modality Imaging with cG250 -- 12.6 Peptides and Affibodies -- 12.7 Small Molecule Inhibitors. 12.7.1 Net Charge -- 12.7.2 Multivalence and Size -- 12.7.3 Radiometal Chelator Complex -- 12.8 Perspectives and Conclusion -- References -- Index. |
| Record Nr. | UNINA-9910508477203321 |
| Cham, Switzerland : , : Springer, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cardiac remodeling : molecular mechanisms / / Bodh I. Jugdutt, Naranjan S. Dhalla, editors
| Cardiac remodeling : molecular mechanisms / / Bodh I. Jugdutt, Naranjan S. Dhalla, editors |
| Edizione | [1st ed. 2013.] |
| Pubbl/distr/stampa | New York : , : Springer, , 2013 |
| Descrizione fisica | 1 online resource (xi, 569 pages) : illustrations (some color) |
| Disciplina | 616.12 |
| Collana | Advances in Biochemistry in Health and Disease |
| Soggetto topico |
Ventricular remodeling
Clinical biochemistry |
| ISBN |
1-299-33562-4
1-4614-5930-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Part I: Molecular mechanisms of remodeling in pressure and volume overload hypertrophy and ehart failure -- β-adrenergic receptor signaling pathway in heart failure -- Remodeling of potassium channels in cardiac hypertrophy -- Role of gender in Ca2+ cycling and cardiac remodeling due to heart failure -- The failing heart: is it an inefficient engine or an engine out of fuel? -- Regulation of cardiac hypertrophic remodeling by the USP15/SLIM1 pathway -- Role of galectin-3 pathways in the pathogenesis of cardiac remodeling and heart failure -- A mitochondriocentric pathway to cardiomyocyte necrosis: an upstream molecular mechanism in myocardial fibrosis -- The ACE2/Ang (1-7) pathway in cardiac remodeling due to pressure-overload -- Local actions of natriuretic peptides and nitric oxide in cardiac remodelling: Implications for therapy -- Modulating G protein-coupled receptors to effect reverse cardiac remodeling -- Role of inflammation and matrix proteinases in cardiac remodeling following stress and injury -- Role of chymase in matrix and myocardial remodeling due to mitral regurgitation. Implications for therapy -- Cardiac remodeling due to aortic regurgitation and mitral regurgitation -- Reducing oxidative stress and manipulating molecular signaling events using resveratrol as a therapy for pathological cardiac hypertrophy -- Angiogenesis, arteriogenesis, and mitochondrial dysfunction -- Part II: Molecular mechanisms of remodeling after myocardial injury and infarction -- Subcellular remodeling and cardiac dysfunction due to ischemia-reperfusion injury -- Role of microRNAs in cardiac hypertrophy and post-infarction remodeling -- Negative regulators of inflammation as endogenous protective mechanisms in post-infarction remodeling -- TLR-dependent pathways and Akt/mTOR/P70S6K pathways in cardiac remodeling after myocardial infarction -- The STAT3 pathway and downstream mechanisms in cardiac remodeling: Friend or foe -- The role of growth differentiation factor 5 in cardiac repair post myocardial infarction -- Extracellular matrix biomarkers of adverse remodeling after myocardial infarction -- Oxidative stress in cardiac repair and remodeling: Molecular pathways and therapeutic strategies -- Role of SPARC in cardiac extracellular matrix remodeling after myocardial infarction -- Tissue inhibitor of matrix metalloproteinases in the pathogenesis of heart failure syndromes -- Intracellular matrix remodeling and cardiac function in ischemia-reperfusion injury -- Aging and markers of adverse remodeling after myocardial infarction -- Optimizing stem cell therapy for cardiac repair following a myocardial infarction -- Regulation of fibrosis after myocardial infarction. Implications for ventricular remodeling -- The ACE2/Ang-(1-7) pathway in cardiac fibroblasts as a potential target for cardiac remodeling. |
| Record Nr. | UNINA-9910437848303321 |
| New York : , : Springer, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The Clinical biochemist Reviews / / Australian Association of Clinical Biochemists Inc
| The Clinical biochemist Reviews / / Australian Association of Clinical Biochemists Inc |
| Pubbl/distr/stampa | Chippendale, NSW, : Associated Business Publications, 1980- |
| Soggetto topico |
Clinical biochemistry
Biochemistry Chemistry, Clinical Medicine. Biochemistry. Serials |
| Soggetto genere / forma |
Periodical
Periodicals. |
| Soggetto non controllato | Australian |
| ISSN | 1838-0212 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-996204734903316 |
| Chippendale, NSW, : Associated Business Publications, 1980- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
The Clinical biochemist Reviews / / Australian Association of Clinical Biochemists Inc
| The Clinical biochemist Reviews / / Australian Association of Clinical Biochemists Inc |
| Pubbl/distr/stampa | Chippendale, NSW, : Associated Business Publications, 1980- |
| Soggetto topico |
Clinical biochemistry
Biochemistry Chemistry, Clinical Medicine. Biochemistry. Serials |
| Soggetto genere / forma |
Periodical
Periodicals. |
| Soggetto non controllato | Australian |
| ISSN | 1838-0212 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910131173303321 |
| Chippendale, NSW, : Associated Business Publications, 1980- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Clinical biochemistry
| Clinical biochemistry |
| Pubbl/distr/stampa | New York, NY, : Elsevier Science |
| Soggetto topico |
Clinical biochemistry
Clinical biochemistry - Periodicals Biochemistry - periodicals Chemistry, Clinical - periodicals Biochimie clinique - Périodiques Biochimie clinique |
| Soggetto genere / forma | Periodicals. |
| ISSN | 1873-2933 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-996214088303316 |
| New York, NY, : Elsevier Science | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Clinical biochemistry
| Clinical biochemistry |
| Pubbl/distr/stampa | New York, NY, : Elsevier Science |
| Soggetto topico |
Clinical biochemistry
Clinical biochemistry - Periodicals Biochemistry - periodicals Chemistry, Clinical - periodicals Biochimie clinique - Périodiques Biochimie clinique |
| Soggetto genere / forma | Periodicals. |
| ISSN | 1873-2933 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910333132703321 |
| New York, NY, : Elsevier Science | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Clinical biochemistry and metabolic medicine / / by Martin Andrew Crook
| Clinical biochemistry and metabolic medicine / / by Martin Andrew Crook |
| Autore | Crook Martin Andrew |
| Edizione | [Eight edition.] |
| Pubbl/distr/stampa | Boca Raton, FL : , : CRC Press, an imprint of Taylor and Francis, , 2013 |
| Descrizione fisica | 1 online resource (441 p.) |
| Disciplina | 612.3/9 |
| Soggetto topico |
Clinical biochemistry
Metabolism |
| Soggetto genere / forma | Electronic books. |
| ISBN |
0-429-16757-1
9786613688026 1-4441-4415-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Book title; Contents; Preface; List of abbreviations; 1 Requesting laboratory tests and interpreting the results; 2 Water and sodium; 3 The kidneys; 4 Acid-base disturbances; 5 Potassium; 6 Calcium, phosphate and magnesium; 7 The hypothalamus and pituitary gland; 8 The adrenal cortex; 9 The reproductive system; 10 Pregnancy and infertility; 11 Thyroid function; 12 Carbohydrate metabolism; 13 Plasma lipids and lipoproteins; 14 Nutrition; 15 Vitamins, trace elements and metals; 16 The gastrointestinal tract; 17 Liver disorders and gallstones
18 Plasma enzymes in diagnosis (clinical enzymology)19 Proteins in plasma and urine; 20 Purine and urate metabolism; 21 Disorders of haem metabolism: iron and the porphyrias; 22 Cardiovascular disease; 23 Cerebrospinal, pleural and ascitic fluids; 24 Metabolic effects of tumours; 25 Therapeutic drug monitoring and poisoning; 26 Clinical biochemistry at the extremes of age; 27 Inborn errors of metabolism; 28 Genetics and deoxyribonucleic acid-based technology in clinical biochemistry; 29 Patient sample collection and use of the laboratory; 30 Point-of-care testing Appendix 1: Units in clinical chemistryIndex; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; R; S; T; U; V; W; X; Y; Z |
| Record Nr. | UNINA-9910462361703321 |
Crook Martin Andrew
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| Boca Raton, FL : , : CRC Press, an imprint of Taylor and Francis, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Clinical biochemistry and metabolic medicine / / by Martin A. Crook
| Clinical biochemistry and metabolic medicine / / by Martin A. Crook |
| Autore | Crook Martin |
| Edizione | [8th edition.] |
| Pubbl/distr/stampa | Boca Raton, FL : , : CRC Press, , 2013 |
| Descrizione fisica | 1 online resource (441 p.) |
| Disciplina | 612.3/9 |
| Soggetto topico |
Clinical biochemistry
Metabolism |
| ISBN |
9781444144154
9781444144147 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Book title; Contents; Preface; List of abbreviations; 1 Requesting laboratory tests and interpreting the results; 2 Water and sodium; 3 The kidneys; 4 Acid-base disturbances; 5 Potassium; 6 Calcium, phosphate and magnesium; 7 The hypothalamus and pituitary gland; 8 The adrenal cortex; 9 The reproductive system; 10 Pregnancy and infertility; 11 Thyroid function; 12 Carbohydrate metabolism; 13 Plasma lipids and lipoproteins; 14 Nutrition; 15 Vitamins, trace elements and metals; 16 The gastrointestinal tract; 17 Liver disorders and gallstones
18 Plasma enzymes in diagnosis (clinical enzymology)19 Proteins in plasma and urine; 20 Purine and urate metabolism; 21 Disorders of haem metabolism: iron and the porphyrias; 22 Cardiovascular disease; 23 Cerebrospinal, pleural and ascitic fluids; 24 Metabolic effects of tumours; 25 Therapeutic drug monitoring and poisoning; 26 Clinical biochemistry at the extremes of age; 27 Inborn errors of metabolism; 28 Genetics and deoxyribonucleic acid-based technology in clinical biochemistry; 29 Patient sample collection and use of the laboratory; 30 Point-of-care testing |
| Record Nr. | UNINA-9910790357303321 |
|
Crook Martin
|
||
| Boca Raton, FL : , : CRC Press, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Clinical biochemistry and metabolic medicine / / by Martin A. Crook
| Clinical biochemistry and metabolic medicine / / by Martin A. Crook |
| Autore | Crook Martin |
| Edizione | [8th edition.] |
| Pubbl/distr/stampa | Boca Raton, FL : , : CRC Press, , 2013 |
| Descrizione fisica | 1 online resource (441 p.) |
| Disciplina | 612.3/9 |
| Soggetto topico |
Clinical biochemistry
Metabolism |
| ISBN |
9781444144154
9781444144147 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Book title; Contents; Preface; List of abbreviations; 1 Requesting laboratory tests and interpreting the results; 2 Water and sodium; 3 The kidneys; 4 Acid-base disturbances; 5 Potassium; 6 Calcium, phosphate and magnesium; 7 The hypothalamus and pituitary gland; 8 The adrenal cortex; 9 The reproductive system; 10 Pregnancy and infertility; 11 Thyroid function; 12 Carbohydrate metabolism; 13 Plasma lipids and lipoproteins; 14 Nutrition; 15 Vitamins, trace elements and metals; 16 The gastrointestinal tract; 17 Liver disorders and gallstones
18 Plasma enzymes in diagnosis (clinical enzymology)19 Proteins in plasma and urine; 20 Purine and urate metabolism; 21 Disorders of haem metabolism: iron and the porphyrias; 22 Cardiovascular disease; 23 Cerebrospinal, pleural and ascitic fluids; 24 Metabolic effects of tumours; 25 Therapeutic drug monitoring and poisoning; 26 Clinical biochemistry at the extremes of age; 27 Inborn errors of metabolism; 28 Genetics and deoxyribonucleic acid-based technology in clinical biochemistry; 29 Patient sample collection and use of the laboratory; 30 Point-of-care testing |
| Record Nr. | UNINA-9910821776503321 |
|
Crook Martin
|
||
| Boca Raton, FL : , : CRC Press, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Soggetto topico
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Clinical biochemistry
(82)
- Biochemistry (43)
- Medical Biochemistry (11)
- Biochimie clinique (10)
- Chemistry, Clinical (10)