Info
- Utilizzare la checkbox di selezione a fianco di ciascun documento per attivare le funzionalità di stampa, invio email, download nei formati disponibili del (i) record.
Post-translational modification of protein biopharmaceuticals
| Post-translational modification of protein biopharmaceuticals |
| Pubbl/distr/stampa | [Place of publication not identified], : Wiley VCH, 2009 |
| Soggetto topico |
Protein Processing, Post-Translational
Glycosylation Protein Engineering - methods Proteins - analysis Biopharmaceutics Biotechnology - methods Pharmacy, Therapeutics, & Pharmacology Health & Biological Sciences |
| ISBN | 3-527-62660-3 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910829984903321 |
| [Place of publication not identified], : Wiley VCH, 2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Post-translational modification of protein biopharmaceuticals
| Post-translational modification of protein biopharmaceuticals |
| Pubbl/distr/stampa | [Place of publication not identified], : Wiley VCH, 2009 |
| Soggetto topico |
Protein Processing, Post-Translational
Glycosylation Protein Engineering - methods Proteins - analysis Biopharmaceutics Biotechnology - methods Pharmacy, Therapeutics, & Pharmacology Health & Biological Sciences |
| ISBN | 3-527-62660-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910841434703321 |
| [Place of publication not identified], : Wiley VCH, 2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Respiratory Delivery of Biologics, Nucleic Acids, and Vaccines [[electronic resource] /] / edited by Jenny Lam, Philip Chi Lip Kwok
| Respiratory Delivery of Biologics, Nucleic Acids, and Vaccines [[electronic resource] /] / edited by Jenny Lam, Philip Chi Lip Kwok |
| Autore | Lam Jenny |
| Edizione | [1st ed. 2023.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2023 |
| Descrizione fisica | 1 online resource (224 pages) |
| Disciplina | 615.19 |
| Altri autori (Persone) | KwokPhilip Chi Lip |
| Collana | AAPS Introductions in the Pharmaceutical Sciences |
| Soggetto topico |
Pharmaceutical chemistry
Drug delivery systems Biologicals Biopharmaceutics Vaccines - Biotechnology Biomaterials Drugs - Design Pharmacology Drug Delivery Systems Chemistry, Pharmaceutical Drug Design Pharmaceutics Drug Delivery Biologics Biomaterials-Vaccines Structure-Based Drug Design |
| ISBN | 3-031-47567-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Chapter 1: Design strategies of dry powders for pulmonary delivery of pharmaceutical peptides -- Chapter 2. Pulmonary delivery of antibody for the treatment of respiratory diseases -- Chapter 3: Dry powder formulation of monoclonal antibodies for pulmonary delivery -- Chapter 4: Antimicrobial peptides and proteins for inhalation -- Chapter 5: Pulmonary delivery of nucleic acids -- Chapter 6: Intranasal and inhaled vaccines -- Chapter 7: Respiratory delivery of probiotics to improve lung health -- Chapter 8: Respiratory delivery of bacteriophages for the treatment of lung infections -- Chapter 9: Pharmacokinetics of inhaled medications – what do we know about biological macromolecules?. |
| Record Nr. | UNINA-9910805576803321 |
Lam Jenny
|
||
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2023 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Revising oral pharmacokinetics, bioavailability and bioequivalence based on the finite absorption time concept / / Panos Macheras and Athanasios A. Tsekouras
| Revising oral pharmacokinetics, bioavailability and bioequivalence based on the finite absorption time concept / / Panos Macheras and Athanasios A. Tsekouras |
| Autore | Macheras P (Panos) |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2023] |
| Descrizione fisica | 1 online resource (137 pages) |
| Disciplina | 615.7 |
| Soggetto topico |
Drugs - Bioavailability
Drugs - Absorption and adsorption Oral medication Pharmacokinetics Biological Availability Biopharmaceutics Drug Therapy |
| ISBN | 3-031-20025-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Foreword -- Preface -- Contents -- Part I: Oral Pharmacokinetics -- Chapter 1: From Bateman (1910) to Dost (1953) -- 1.1 Harry Bateman: First-Order Kinetics in Physics (1910) -- 1.2 Friedrich Hartmut Dost: First-Order Kinetics in Pharmacokinetics (1953) -- 1.3 Simulations Based on Bateman´s Equation -- 1.4 The Fundamental Metrics of Bioavailability/Bioequivalence Studies -- References -- Chapter 2: The Unphysical Hypothesis of Infinite Absorption Time -- 2.1 The Biopharmaceutical-Pharmacokinetic Basis of the Bateman Equation -- 2.2 State of the Art in Oral Drug Absorption -- 2.2.1 The PK Route -- 2.2.1.1 Questioning the Absorption Rate Constant, ka -- 2.2.1.2 PBPK Models -- 2.2.2 The Bioph Route -- 2.2.3 The Absorption Rate Constant (ka) Links the Bioph and PK Routes -- 2.3 The Unphysical Hypothesis of Infinite Absorption Time -- 2.4 Concluding Remarks -- References -- Chapter 3: The Finite Absorption Time (FAT) Concept -- 3.1 Sink Conditions Imply Zero-Order Kinetics -- 3.2 Finite Absorption Time -- 3.2.1 Modeling Work: Combining BCS with Absorption Kinetics -- 3.3 Simulations -- 3.3.1 Physiological Considerations -- 3.3.2 Drug Absorption: Reconsidered in Terms of the FAT -- 3.4 Fits to Data -- 3.5 Epilogue -- References -- Chapter 4: The Rise of Physiologically Based Finite Time Pharmacokinetic (PBFTPK) Models -- 4.1 Models -- 4.2 Simulations -- 4.3 Fits to Data -- 4.4 Toward a Biopharmaceutics-Pharmacokinetic Classification System (BPCS) -- 4.5 Future Work -- References -- Part II: Bioavailability-Bioequivalence -- Chapter 5: History of the Bioavailability-Bioequivalence Concepts -- 5.1 Early 1900s-Today: Variations in Response to Xenobiotics -- 5.2 1950s: The First Pharmacokinetic-Pharmacodynamic Correlations -- 5.3 1953: The Publication of Dost´s First Pharmacokinetics Book in History.
5.4 1960s: Biopharmaceutics-Pharmacokinetics at Its Infancy -- 5.5 ``The Bioavailability Problem´´ -- 5.6 The Introduction of an Official Dissolution Test in 1970 (USP Apparatus 1) -- 5.7 FDA (1977): Bioavailability Is the Rate and Extent to Which the Active Ingredient or Active Moiety Is Absorbed from a Drug... -- 5.7.1 A Persisting Problem: The Use of Cmax as a Metric of Rate of Absorption -- References -- Chapter 6: Therapeutic Equivalence Based on Bioequivalence Studies -- 6.1 From 1977 to Now: Bioequivalence Criteria and Issues -- 6.2 Highly Variable Drugs or Drug Products (HVD) -- 6.3 Epilogue -- References -- Chapter 7: Bioavailability Under the Prism of Finite Absorption Time -- 7.1 The Columbus´ Egg: Drug Absorption Takes Place Under Sink Conditions for Finite Time -- 7.2 A Paradigm Shift in Oral Drug Absorption -- 7.3 Bioavailability Parameters Under the Prism of Finite Absorption Time Concept -- 7.3.1 One Compartment Model with One Constant Input Rate Operating for Time τ -- 7.3.2 One Compartment Model with More than One Constant Input Rates Operating for a Total Time τ -- 7.3.3 One Compartment Model with First-Order Absorption Lasting for Time τ and First-Order Elimination -- 7.4 Extent (Exposure) and Rate Metrics -- 7.5 Extent and Rate of Absorption Metrics Under the Prism of Finite Absorption Time (FAT) -- 7.6 Scientific-Regulatory Implications -- 7.7 Toward the Unthinkable: Estimation of Absolute Bioavailability from Oral Data Exclusively -- References -- Chapter 8: Bioequivalence Under the Prism of Finite Absorption Time -- 8.1 Reconsidering Digoxin Bioavailability/Bioequivalence Studies in the Light of Finite Absorption Time Concept -- 8.2 Is the Proper Metric for Drug´s Extent of Absorption -- 8.3 Toward the Revision of Bioequivalence Assessment -- 8.4 Does FDA´s Bioavailability Definition of 1977 Require Reconsideration?. References. |
| Record Nr. | UNINA-9910639877503321 |
|
Macheras P (Panos)
|
||
| Cham, Switzerland : , : Springer, , [2023] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Statistics in biopharmaceutical research
| Statistics in biopharmaceutical research |
| Pubbl/distr/stampa | Alexandria, VA : , : American Statistical Association, , [2009-] |
| Disciplina | 615 |
| Soggetto topico |
Pharmacy - Statistical methods
Biopharmaceutics Biometry |
| Soggetto genere / forma | Periodicals. |
| Soggetto non controllato | Pharmacy, Therapeutics, & Pharmacology |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | SBR |
| Record Nr. | UNISA-996214803503316 |
| Alexandria, VA : , : American Statistical Association, , [2009-] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Statistics in biopharmaceutical research
| Statistics in biopharmaceutical research |
| Pubbl/distr/stampa | Alexandria, VA : , : American Statistical Association, , [2009-] |
| Disciplina | 615 |
| Soggetto topico |
Pharmacy - Statistical methods
Biopharmaceutics Biometry |
| Soggetto genere / forma | Periodicals. |
| Soggetto non controllato | Pharmacy, Therapeutics, & Pharmacology |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | SBR |
| Record Nr. | UNINA-9910172096003321 |
| Alexandria, VA : , : American Statistical Association, , [2009-] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Soggetto topico
-
Biopharmaceutics
(106)
- Pharmacology (21)
- Pharmaceutical chemistry (19)
- Drugs - Design (16)
- Drug development (14)