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Supported ionic liquids : fundamentals and applications / / edited by Rasmus Fehrmann, Anders Riisager, and Marco Haumann
| Supported ionic liquids : fundamentals and applications / / edited by Rasmus Fehrmann, Anders Riisager, and Marco Haumann |
| Pubbl/distr/stampa | Weinheim : , : Wiley-VCH Verlag GmbH, , [2014] |
| Descrizione fisica | 1 online resource (497 p.) |
| Disciplina | 541.395 |
| Altri autori (Persone) |
FehrmannRasmus
RiisagerAnders HaumannMarco |
| Soggetto topico |
Ionic solutions
Catalysis |
| ISBN |
3-527-65480-1
3-527-65478-X 3-527-65481-X |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Supported Ionic Liquids; Contents; Preface; List of Contributors; Chapter 1 Introduction; 1.1 A Century of Supported Liquids; 1.2 Supported Ionic Liquids; 1.3 Applications in Catalysis; 1.4 Applications in Separation; 1.5 Coating of Heterogeneous Catalysts; 1.6 Monolayers of IL on Surfaces; 1.7 Conclusion; References; Part I Concept and Building Blocks; Chapter 2 Introducing Ionic Liquids; 2.1 Introduction; 2.2 Preparation; 2.3 Liquid Range; 2.4 Structures; 2.4.1 The Liquid/Solid Interface; 2.4.2 The Liquid/Gas Interface; 2.5 Physical Properties; 2.5.1 The Liquid/Solid Interface
2.5.2 The Liquid/Gas Interface2.5.3 Polarity; 2.5.4 Chromatographic Measurements and the Abraham Model of Polarity; 2.5.5 Infinite Dilution Activity Coefficients; 2.6 Effects of Ionic Liquids on Chemical Reactions; 2.7 Ionic Liquids as Process Solvents in Industry; 2.8 Summary; References; Chapter 3 Porous Inorganic Materials as Potential Supports for Ionic Liquids; 3.1 Introduction; 3.2 Porous Materials - an Overview; 3.2.1 History; 3.2.2 Pore Size; 3.2.3 Structural Aspects; 3.2.4 Chemistry; 3.2.5 Synthesis; 3.3 Silica-Based Materials - Amorphous; 3.3.1 Silica Gels 3.3.2 Precipitated Silicas3.3.3 Porous Glass; 3.4 Layered Materials; 3.5 Microporous Materials; 3.5.1 Zeolites; 3.5.2 AlPOs/SAPOs; 3.5.3 Hierarchical Porosity in Zeolite Crystals; 3.6 Ordered Mesoporous Materials; 3.6.1 Silica-Based Classical Compounds; 3.6.2 PMOs; 3.6.3 Mesoporous Carbons; 3.6.4 Other Mesoporous Oxides; 3.6.5 Anodic Oxidized Materials; 3.7 Structured Supports and Monolithic Materials; 3.7.1 Monoliths with Hierarchical Porosity; 3.7.2 Hierarchically Structured Reactors; 3.8 Conclusions; References; Chapter 4 Synthetic Methodologies for Supported Ionic Liquid Materials 4.1 Introduction4.2 Support Materials; 4.3 Preparation Methods for Supported Ionic Liquids; 4.3.1 Incipient Wetness Impregnation; 4.3.2 Freeze-Drying; 4.3.3 Spray Coating; 4.3.4 Chemically Bound Ionic Liquids; 4.3.5 IL-Silica Hybrid Materials; 4.4 Summary; References; Part II Synthesis and Properties; Chapter 5 Pore Volume and Surface Area of Supported Ionic Liquids Systems; 5.1 Example I: [EMIM][NTf2] on Porous Silica; 5.2 Example II: SCILL Catalyst (Commercial Ni catalyst) Coated with [BMIM][OcSO4]; Acknowledgments; Symbols; Abbreviations; References Chapter 6 Transport Phenomena, Evaporation, and Thermal Stability of Supported Ionic Liquids6.1 Introduction; 6.2 Diffusion of Gases and Liquids in ILs and Diffusivity of ILs in Gases; 6.2.1 Diffusivity of Gases and Liquids in ILs; 6.2.2 Diffusion Coefficient of Evaporated ILs in Gases; 6.3 Thermal Stability and Vapor Pressure of Pure ILs; 6.3.1 Drawbacks and Opportunities Regarding Stability and Vapor Pressure Measurements of ILs; 6.3.2 Experimental Methods to Determine the Stability and Vapor Pressure of ILs; 6.3.3 Data Evaluation and Modeling Methodology 6.3.3.1 Evaluation of Vapor Pressure and Decomposition of ILs by Ambient Pressure TG at Constant Heating Rate |
| Record Nr. | UNINA-9910811958803321 |
| Weinheim : , : Wiley-VCH Verlag GmbH, , [2014] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Therapeutic Fc-fusion proteins / / edited by Steven M. Chamow [and three others]
| Therapeutic Fc-fusion proteins / / edited by Steven M. Chamow [and three others] |
| Pubbl/distr/stampa | Weinheim : , : Wiley-VCH Verlag GmbH, , [2014] |
| Descrizione fisica | 1 online resource (400 p.) |
| Disciplina | 613.5 |
| Altri autori (Persone) | ChamowSteven Mark |
| Soggetto topico |
Proteins - Therapeutic use
Protein drugs |
| ISBN |
3-527-67527-2
3-527-67528-0 3-527-67529-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Therapeutic Fc-Fusion Proteins; Contents; Preface; List of Contributors; 1 Introduction: Antibody Structure and Function; 1.1 Introduction to Antibodies; 1.2 General Domain and Structure of IgG; 1.2.1 Structural Aspects Important for Fc Fusion(s); 1.2.1.1 Fc Protein-Protein Interactions; 1.2.1.2 Fc Glycosylation; 1.2.1.3 Hinge and Interchain Disulfide Bonds; 1.3 The Neonatal Fc Receptor; 1.3.1 FcRn Function and Expression; 1.3.2 Species Difference in FcRn; 1.3.3 Engineering to Modulate Pharmacokinetics; 1.3.3.1 Fc Engineering
1.3.3.2 Other Engineering Efforts to Modify PK of an IgG or Fc Fusion1.4 Introduction to FcgR- and Complement-Mediated Effector Functions; 1.4.1 Cell Lysis and Phagocytosis Mediation; 1.4.2 FcgR-Mediated Effector Functions; 1.4.2.1 FcgR Biology; 1.4.2.2 Expression Profiles; 1.4.2.3 Therapeutic Relevancy; 1.4.3 Complement; 1.4.3.1 C1q Biology; 1.4.3.2 Therapeutic Relevancy; 1.4.4 Modifying Effector Functions; 1.4.4.1 FcgR-Dependent Effector Function; 1.4.4.2 Engineering; 1.4.4.3 Glycoengineering; 1.4.4.4 Reducing and Silencing Effector Function; 1.5 Current Trends in Antibody Engineering 1.5.1 Bispecific1.5.2 Drug Conjugates; References; Part One: Methods of Production for Fc-Fusion Proteins; 2 Fc-Fusion Protein Expression Technology; 2.1 Introduction; 2.2 Expression Systems Used for Fc-Fusion Proteins; 2.2.1 Expression Using Mammalian Cell Lines; 2.2.1.1 Host Cells; 2.2.1.2 Codon Optimization; 2.2.1.3 Vectors; 2.2.1.4 Stable versus Transient Expression; 2.2.1.5 Viral Transduction and Transfection Methods; 2.2.2 Expression Using Prokaryotic Cells; 2.2.2.1 Vectors; 2.2.3 Expression Using Baculovirus/Insect Cells; 2.2.3.1 Host Cells; 2.2.3.2 Vectors 2.2.3.3 Additional Considerations2.3 Summary; References; 3 Cell Culture-Based Production; 3.1 Introduction; 3.2 Basic Aspects of Industrial Cell Culture; 3.2.1 The Central Role of the Production Cell Line; 3.2.2 Production Systems; 3.2.3 Production Mode: Fed-Batch or Perfusion?; 3.2.4 Scale-Up; 3.2.5 Raw Materials and Process Control; 3.2.6 How to Develop or Optimize a Culture Production Process for Fc-Fusion Molecules; 3.3 Speci.c Process Considerations for Fc-Fusion Molecules; 3.3.1 Product Quality Challenges; 3.3.2 Process Strategies and Process Parameters 3.3.2.1 Temperature and Misfolding3.3.2.2 Other Process Parameters; 3.3.2.3 Glycosylation; 3.4 Case Studies; 3.4.1 LTBr-Fc (Baminercept); 3.4.2 rFVIIIFc; 3.5 Conclusions; References; 4 Downstream Processing of Fc-Fusion Proteins; 4.1 Introduction and Overview of Fc-Fusion Proteins; 4.2 Biochemistry of Fc-Fusion Proteins; 4.3 Purification of Fc-Fusion Proteins from Mammalian Cells; 4.3.1 Platform Approaches for Downstream Purification; 4.3.2 Comparison of Protein A Chromatography, Viral Inactivation, and Polishing Steps; 4.4 Purification of Fc-Fusion Protein from Microbial Systems 4.5 Future Innovations in Fc-Fusion Protein Downstream Processing |
| Record Nr. | UNINA-9910138970203321 |
| Weinheim : , : Wiley-VCH Verlag GmbH, , [2014] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Therapeutic Fc-fusion proteins / / edited by Steven M. Chamow [and three others]
| Therapeutic Fc-fusion proteins / / edited by Steven M. Chamow [and three others] |
| Pubbl/distr/stampa | Weinheim : , : Wiley-VCH Verlag GmbH, , [2014] |
| Descrizione fisica | 1 online resource (400 p.) |
| Disciplina | 613.5 |
| Altri autori (Persone) | ChamowSteven Mark |
| Soggetto topico |
Proteins - Therapeutic use
Protein drugs |
| ISBN |
3-527-67527-2
3-527-67528-0 3-527-67529-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Therapeutic Fc-Fusion Proteins; Contents; Preface; List of Contributors; 1 Introduction: Antibody Structure and Function; 1.1 Introduction to Antibodies; 1.2 General Domain and Structure of IgG; 1.2.1 Structural Aspects Important for Fc Fusion(s); 1.2.1.1 Fc Protein-Protein Interactions; 1.2.1.2 Fc Glycosylation; 1.2.1.3 Hinge and Interchain Disulfide Bonds; 1.3 The Neonatal Fc Receptor; 1.3.1 FcRn Function and Expression; 1.3.2 Species Difference in FcRn; 1.3.3 Engineering to Modulate Pharmacokinetics; 1.3.3.1 Fc Engineering
1.3.3.2 Other Engineering Efforts to Modify PK of an IgG or Fc Fusion1.4 Introduction to FcgR- and Complement-Mediated Effector Functions; 1.4.1 Cell Lysis and Phagocytosis Mediation; 1.4.2 FcgR-Mediated Effector Functions; 1.4.2.1 FcgR Biology; 1.4.2.2 Expression Profiles; 1.4.2.3 Therapeutic Relevancy; 1.4.3 Complement; 1.4.3.1 C1q Biology; 1.4.3.2 Therapeutic Relevancy; 1.4.4 Modifying Effector Functions; 1.4.4.1 FcgR-Dependent Effector Function; 1.4.4.2 Engineering; 1.4.4.3 Glycoengineering; 1.4.4.4 Reducing and Silencing Effector Function; 1.5 Current Trends in Antibody Engineering 1.5.1 Bispecific1.5.2 Drug Conjugates; References; Part One: Methods of Production for Fc-Fusion Proteins; 2 Fc-Fusion Protein Expression Technology; 2.1 Introduction; 2.2 Expression Systems Used for Fc-Fusion Proteins; 2.2.1 Expression Using Mammalian Cell Lines; 2.2.1.1 Host Cells; 2.2.1.2 Codon Optimization; 2.2.1.3 Vectors; 2.2.1.4 Stable versus Transient Expression; 2.2.1.5 Viral Transduction and Transfection Methods; 2.2.2 Expression Using Prokaryotic Cells; 2.2.2.1 Vectors; 2.2.3 Expression Using Baculovirus/Insect Cells; 2.2.3.1 Host Cells; 2.2.3.2 Vectors 2.2.3.3 Additional Considerations2.3 Summary; References; 3 Cell Culture-Based Production; 3.1 Introduction; 3.2 Basic Aspects of Industrial Cell Culture; 3.2.1 The Central Role of the Production Cell Line; 3.2.2 Production Systems; 3.2.3 Production Mode: Fed-Batch or Perfusion?; 3.2.4 Scale-Up; 3.2.5 Raw Materials and Process Control; 3.2.6 How to Develop or Optimize a Culture Production Process for Fc-Fusion Molecules; 3.3 Speci.c Process Considerations for Fc-Fusion Molecules; 3.3.1 Product Quality Challenges; 3.3.2 Process Strategies and Process Parameters 3.3.2.1 Temperature and Misfolding3.3.2.2 Other Process Parameters; 3.3.2.3 Glycosylation; 3.4 Case Studies; 3.4.1 LTBr-Fc (Baminercept); 3.4.2 rFVIIIFc; 3.5 Conclusions; References; 4 Downstream Processing of Fc-Fusion Proteins; 4.1 Introduction and Overview of Fc-Fusion Proteins; 4.2 Biochemistry of Fc-Fusion Proteins; 4.3 Purification of Fc-Fusion Proteins from Mammalian Cells; 4.3.1 Platform Approaches for Downstream Purification; 4.3.2 Comparison of Protein A Chromatography, Viral Inactivation, and Polishing Steps; 4.4 Purification of Fc-Fusion Protein from Microbial Systems 4.5 Future Innovations in Fc-Fusion Protein Downstream Processing |
| Record Nr. | UNINA-9910813438303321 |
| Weinheim : , : Wiley-VCH Verlag GmbH, , [2014] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
