Pubbl/distr/stampa	Washington, D.C., : National Academy Press, 2004
Descrizione fisica	1 online resource (309 p.)
Collana	The compass series
Soggetto topico	Gases, Asphyxiating and poisonous Hazardous substances - Environmental aspects Hazardous substances - Health aspects Chemicals - Physiological effect Chemicals - Health aspects
ISBN	0-309-16655-1 1-280-17640-7 9786610176403 0-309-53013-X
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Record Nr.	UNINA-9910777383003321

Pubbl/distr/stampa	Washington, D.C., : National Academy Press, c2002
Descrizione fisica	1 online resource (292 p.)
Disciplina	615.9
Collana	The compass series
Soggetto topico	Gases, Asphyxiating and poisonous Hazardous substances - Environmental aspects Hazardous substances - Health aspects Chemicals - Physiological effect Chemicals - Health aspects
Soggetto genere / forma	Electronic books.
ISBN	1-280-18330-6 9786610183302 0-309-56773-4
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	""Acute Exposure Guideline Levels for Selected Airborne Chemicals""; ""Copyright""; ""OTHER REPORTS OF THE BOARD ON ENVIRONMENTAL STUDIES AND TOXICOLOGY""; ""Preface""; ""Contents""; ""Introduction""; ""SUMMARY OF REPORT ON GUIDELINES FOR DEVELOPING AEGLS""; ""Roster of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances""; ""Appendix""; ""1 Phosgene: Acute Exposure Guideline Levels""; ""SUMMARY""; ""1. INTRODUCTION""; ""2. HUMAN TOXICITY DATA""; ""2.1. Acute Lethality""; ""2.2. Nonlethal Toxicity""; ""2.2.1. Case Reports"" ""2.2.2. Epidemiologic Studies""""2.3. Developmental and Reproductive Toxicity""; ""2.4. Genotoxicity""; ""2.5. Carcinogenicity""; ""2.6. Summary""; ""3. ANIMAL TOXICITY DATA""; ""3.1. Acute Lethality""; ""3.1.1. Mouse""; ""3.1.2. Rats""; ""3.1.3. Guinea Pigs""; ""3.1.4. Rabbits""; ""3.1.5. Cats""; ""3.1.6. Dogs""; ""3.1.7. Goats""; ""3.1.8. Sheep""; ""3.1.9. Nonhuman Primates""; ""3.2. Nonlethal Toxicity""; ""3.2.1. Mice""; ""3.2.2. Rats""; ""3.2.3. Guinea Pigs""; ""3.2.4. Hamsters""; ""3.2.5. Rabbits""; ""3.2.6. Dogs""; ""3.2.7. Sheep""; ""3.2.8. Goats""; ""3.2.9. Cats"" ""3.2.10. Monkeys""""3.3. Developmental and Reproductive Toxicity""; ""3.4. Genotoxicity""; ""3.5. Carcinogenicity""; ""3.6. Summary""; ""4. SPECIAL CONSIDERATIONS""; ""4.1. Metabolism and Disposition""; ""4.2. Mechanism of Toxicity""; ""4.3. Structure-Activity Relationships""; ""4.4. Other Relevant Information""; ""4.4.1. Haberâ€?s Law and Time Scaling""; ""5. RATIONALE AND PROPOSED AEGL-1""; ""5.1. Human Data Relevant to AEGL-1""; ""5.2. Animal Data Relevant to AEGL-1""; ""5.3. Derivation of AEGL-1""; ""6. RATIONALE AND PROPOSED AEGL-2""; ""6.1. Human Data Relevant to AEGL-2"" ""6.2. Animal Data Relevant to AEGL-2""""6.3. Derivation of AEGL-2""; ""7. RATIONALE AND PROPOSED AEGL-3""; ""7.1. Human Data Relevant to AEGL-3""; ""7.2. Animal Data Relevant to AEGL-3""; ""7.3. Derivation of AEGL-3""; ""8. SUMMARY OF PROPOSED AEGLS""; ""8.1. AEGL Values and Toxicity End Points""; ""8.2. Comparison with Other Standards and Guidelines""; ""8.3. Data Adequacy and Research Needs""; ""9. REFERENCES""; ""Appendixes""; ""APPENDIX A DERIVATION OF AEGL VALUES""; ""Derivation of AEGL-1""; ""Derivation of AEGL-2""; ""Derivation of AEGL-3"" ""APPENDIX B DERIVATION SUMMARY FOR ACUTE EXPOSURE GUIDELINE LEVELS FOR PHOSGENE (CAS No. 75â€?44â€?5)""""2 Propylene Glycol Dinitrate: Acute Exposure Guideline Levels""; ""SUMMARY""; ""1. INTRODUCTION""; ""2. HUMAN TOXICITY DATA""; ""2.1. Acute Lethality""; ""2.2. Nonlethal Toxicity""; ""2.2.1. Occupational Exposures""; ""2.2.2. Experimental Studies""; ""2.3. Neurotoxicity""; ""2.4. Developmental and Reproductive Effects""; ""2.5. Genotoxicity""; ""2.6. Carcinogenicity""; ""2.7. Summary""; ""3. ANIMAL TOXICITY DATA""; ""3.1. Acute Lethality""; ""3.2. Nonlethal Toxicity"" ""3.2.1. Nonhuman Primates""
Record Nr.	UNINA-9910456160403321

Pubbl/distr/stampa	Washington, D.C., : National Academy Press, c2002
Descrizione fisica	1 online resource (292 p.)
Disciplina	615.9
Collana	The compass series
Soggetto topico	Gases, Asphyxiating and poisonous Hazardous substances - Environmental aspects Hazardous substances - Health aspects Chemicals - Physiological effect Chemicals - Health aspects
ISBN	0-309-18270-0 1-280-18330-6 9786610183302 0-309-56773-4
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	Acute Exposure Guideline Levels for Selected Airborne Chemicals -- Copyright -- OTHER REPORTS OF THE BOARD ON ENVIRONMENTAL STUDIES AND TOXICOLOGY -- Preface -- Contents -- Introduction -- SUMMARY OF REPORT ON GUIDELINES FOR DEVELOPING AEGLS -- Roster of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances -- Appendix -- 1 Phosgene: Acute Exposure Guideline Levels -- SUMMARY -- 1. INTRODUCTION -- 2. HUMAN TOXICITY DATA -- 2.1. Acute Lethality -- 2.2. Nonlethal Toxicity -- 2.2.1. Case Reports -- 2.2.2. Epidemiologic Studies2.3. Developmental and Reproductive Toxicity -- 2.4. Genotoxicity -- 2.5. Carcinogenicity -- 2.6. Summary -- 3. ANIMAL TOXICITY DATA -- 3.1. Acute Lethality -- In Mouse, Rats, Guinea Pigs, Rabbits, Cats, Dogs, Goats, Sheep, Nonhuman Primates -- 3.2. Nonlethal Toxicity -- In Mice, Rats, Guinea Pigs, Hamsters, Rabbits, Dogs, Sheep, Goats, Cats, Monkeys -- 3.3. Developmental and Reproductive Toxicity -- 3.4. Genotoxicity -- 3.5. Carcinogenicity -- 3.6. Summary -- 4. SPECIAL CONSIDERATIONS -- 4.1. Metabolism and Disposition -- 4.2. Mechanism of Toxicity -- 4.3. Structure-Activity Relationships -- 4.4. Other Relevant Information -- 4.4.1. Haber's Law and Time Scaling -- 5. RATIONALE AND PROPOSED AEGL-1 -- 5.1. Human Data Relevant to AEGL-1 -- 5.2. Animal Data Relevant to AEGL-1 -- 5.3. Derivation of AEGL-1 -- 6. RATIONALE AND PROPOSED AEGL-2 -- 6.1. Human Data Relevant to AEGL-2 -- 6.2. Animal Data Relevant to AEGL-2 -- 6.3. Derivation of AEGL-2 -- 7. RATIONALE AND PROPOSED AEGL-3 -- 7.1. Human Data Relevant to AEGL-3 -- 7.2. Animal Data Relevant to AEGL-3 -- 7.3. Derivation of AEGL-3 -- 8. SUMMARY OF PROPOSED AEGLS -- 8.1. AEGL Values and Toxicity End Points -- 8.2. Comparison with Other Standards and Guidelines -- 8.3. Data Adequacy and Research Needs -- 9. REFERENCES -- Appendixes -- APPENDIX A DERIVATION OF AEGL VALUES -- Derivation of AEGL-1 -- Derivation of AEGL-2 -- Derivation of AEGL-3 -- APPENDIX B DERIVATION SUMMARY FOR ACUTE EXPOSURE GUIDELINE LEVELS FOR PHOSGENE (CAS No. 75-44-5)
Record Nr.	UNINA-9910780298503321

Pubbl/distr/stampa	Washington, D.C., : National Academy Press, c2002
Descrizione fisica	1 online resource (292 p.)
Disciplina	615.9
Collana	The compass series
Soggetto topico	Gases, Asphyxiating and poisonous Hazardous substances - Environmental aspects Hazardous substances - Health aspects Chemicals - Physiological effect Chemicals - Health aspects
ISBN	0-309-18270-0 1-280-18330-6 9786610183302 0-309-56773-4
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	Acute Exposure Guideline Levels for Selected Airborne Chemicals -- Copyright -- OTHER REPORTS OF THE BOARD ON ENVIRONMENTAL STUDIES AND TOXICOLOGY -- Preface -- Contents -- Introduction -- SUMMARY OF REPORT ON GUIDELINES FOR DEVELOPING AEGLS -- Roster of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances -- Appendix -- 1 Phosgene: Acute Exposure Guideline Levels -- SUMMARY -- 1. INTRODUCTION -- 2. HUMAN TOXICITY DATA -- 2.1. Acute Lethality -- 2.2. Nonlethal Toxicity -- 2.2.1. Case Reports -- 2.2.2. Epidemiologic Studies2.3. Developmental and Reproductive Toxicity -- 2.4. Genotoxicity -- 2.5. Carcinogenicity -- 2.6. Summary -- 3. ANIMAL TOXICITY DATA -- 3.1. Acute Lethality -- In Mouse, Rats, Guinea Pigs, Rabbits, Cats, Dogs, Goats, Sheep, Nonhuman Primates -- 3.2. Nonlethal Toxicity -- In Mice, Rats, Guinea Pigs, Hamsters, Rabbits, Dogs, Sheep, Goats, Cats, Monkeys -- 3.3. Developmental and Reproductive Toxicity -- 3.4. Genotoxicity -- 3.5. Carcinogenicity -- 3.6. Summary -- 4. SPECIAL CONSIDERATIONS -- 4.1. Metabolism and Disposition -- 4.2. Mechanism of Toxicity -- 4.3. Structure-Activity Relationships -- 4.4. Other Relevant Information -- 4.4.1. Haber's Law and Time Scaling -- 5. RATIONALE AND PROPOSED AEGL-1 -- 5.1. Human Data Relevant to AEGL-1 -- 5.2. Animal Data Relevant to AEGL-1 -- 5.3. Derivation of AEGL-1 -- 6. RATIONALE AND PROPOSED AEGL-2 -- 6.1. Human Data Relevant to AEGL-2 -- 6.2. Animal Data Relevant to AEGL-2 -- 6.3. Derivation of AEGL-2 -- 7. RATIONALE AND PROPOSED AEGL-3 -- 7.1. Human Data Relevant to AEGL-3 -- 7.2. Animal Data Relevant to AEGL-3 -- 7.3. Derivation of AEGL-3 -- 8. SUMMARY OF PROPOSED AEGLS -- 8.1. AEGL Values and Toxicity End Points -- 8.2. Comparison with Other Standards and Guidelines -- 8.3. Data Adequacy and Research Needs -- 9. REFERENCES -- Appendixes -- APPENDIX A DERIVATION OF AEGL VALUES -- Derivation of AEGL-1 -- Derivation of AEGL-2 -- Derivation of AEGL-3 -- APPENDIX B DERIVATION SUMMARY FOR ACUTE EXPOSURE GUIDELINE LEVELS FOR PHOSGENE (CAS No. 75-44-5)
Record Nr.	UNINA-9910826825603321

Pubbl/distr/stampa	Washington, D.C., : National Academy Press, c2000
Descrizione fisica	1 online resource (219 p.)
Disciplina	615.9/1
Collana	The compass series
Soggetto topico	Gases, Asphyxiating and poisonous Hazardous substances - Environmental aspects Hazardous substances - Health aspects Chemicals - Physiological effect Chemicals - Health aspects
Soggetto genere / forma	Electronic books.
ISBN	1-280-18513-9 9786610185139 0-309-56508-1
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	""Acute Exposure Guideline Levels for Selected Airborne Chemicals""; ""Copyright""; ""Preface""; ""Contents""; ""Acute Exposure Guideline Levels for Selected Airborne Chemicals""; ""Introduction""; ""SUMMARY OF REPORT ON GUIDELINES FOR DEVELOPING AEGLS""; ""REVIEW OF AEGL REPORTS""; ""REFERENCES""; ""Roster of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances""; ""COMMITTEE MEMBERS""; ""OAK RIDGE NATIONAL LABORATORY STAFF""; ""NATIONAL ADVISORY COMMITTEE STAFF""; ""Appendix""; ""1 Aniline1 Acute Exposure Guideline Levels""; ""SUMMARY"" ""1. INTRODUCTION""""2. HUMAN TOXICITY DATA""; ""2.1. Acute Lethality""; ""2.2. Nonlethal Toxicity""; ""2.2.1. Experimental Studies""; ""2.2.2. Epidemiology Studies""; ""2.2.3. Accidents""; ""2.3. Developmental and Reproductive Effects""; ""2.4. Genotoxicity""; ""2.5. Carcinogenicity""; ""2.6. Summary""; ""3. ANIMAL TOXICITY DATA""; ""3.1. Acute Lethality""; ""3.1.1. Rats""; ""3.1.2. Mice""; ""3.2. Nonlethal Toxicity""; ""3.2.1. Dogs""; ""3.2.2. Rats""; ""3.2.3. Mice""; ""3.2.4 Guinea pigs""; ""3.3. Developmental and Reproductive Effects""; ""3.4. Genotoxicity""; ""3.5. Carcinogenicity"" ""3.6. Summary""""4. SPECIAL CONSIDERATIONS""; ""4.1. Metabolism and Disposition""; ""4.2. Mechanism of Toxicity""; ""4.3. Structure-Activity Relationships""; ""4.4. Other Relevant Information""; ""4.4.1. Susceptible Subpopulations""; ""4.4.2. Species Differences""; ""4.4.3. Concentration-Exposure Duration Relationship""; ""5. DATA ANALYSIS FOR AEGL-1""; ""5.1. Human Data Relevant to AEGL-1""; ""5.2. Animal Data Relevant to AEGL-1""; ""5.3. Derivation of AEGL-1""; ""6. DATA ANALYSIS FOR AEGL-2""; ""6.1. Human Data Relevant to AEGL-2""; ""6.2. Animal Data Relevant to AEGL-2"" ""6.3. Derivation of AEGL-2""""7. DATA ANALYSIS FOR AEGL-3""; ""7.1. Human Data Relevant to AEGL-3""; ""7.2. Animal Data Relevant to AEGL-3""; ""7.3. Derivation of AEGL-3""; ""8. SUMMARY OF AEGLS""; ""8.1. AEGL Values and Toxicity Endpoints""; ""8.2. Comparisons with Other Standards and Guidelines""; ""8.3. Data Adequacy and Research Needs""; ""9. REFERENCES""; ""2 Arsine1 Acute Exposure Guideline Levels""; ""SUMMARY""; ""1. INTRODUCTION""; ""2. HUMAN TOXICITY DATA""; ""2.1. Acute Lethality""; ""2.1.1. Case Reports""; ""2.2. Nonlethal Toxicity""; ""2.2.1. Case Reports"" ""2.2.2. Epidemiologic Studies""""2.3. Developmental and Reproductive Toxicity""; ""2.4. Genotoxicity""; ""2.5. Carcinogenicity""; ""2.6. Summary""; ""3. ANIMAL TOXICITY DATA""; ""3.1. Acute Lethality""; ""3.1.1. Nonhuman Primates""; ""3.1.2. Dogs""; ""3.1.3. Cats""; ""3.1.4 Rats""; ""3.1.5. Mice""; ""3.2. Nonlethal Toxicity""; ""3.2.1. Nonhuman Primates""; ""3.2.2. Rats""; ""3.2.3. Mice""; ""3.2.4. Hamsters""; ""3.3. Developmental/Reproductive Toxicity""; ""3.3.1. Rats""; ""3.3.2. Mice""; ""3.4. Genotoxicity""; ""3.5. Carcinogenicity""; ""3.6. Summary""; ""4. SPECIAL CONSIDERATIONS"" ""4.1. Metabolism and Disposition""
Record Nr.	UNINA-9910456028003321