Antineoplastic drugs : organic synthesis / / Daniel Lednicer |
Autore | Lednicer Daniel |
Pubbl/distr/stampa | Chichester, England : , : Wiley, , 2015 |
Descrizione fisica | 1 online resource (230 p.) |
Disciplina | 616.994061 |
Soggetto topico | Antineoplastic agents |
ISBN |
1-118-89256-9
1-118-89255-0 1-118-89257-7 |
Classificazione | SCI007000 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Title Page; Copyright Page; Contents; Preface; Introduction; Chapter 1 Alkylating Agents; 1.1 bis-Chloroethyl Amines; 1.2 Several Other Chloroethyl Agents; 1.3 Platinum-Based Antineoplastic Agents; 1.4 Miscellaneous Alkylating Agents; References; Chapter 2 Antimetabolites; 2.1 Introduction; 2.2 Folate Antagonists; 2.2.1 Compounds with Glutamate Side Chain; 2.2.2 Compounds Lacking the Glutamate Moiety; 2.2.3 Methoxylated Benzenes; 2.3 Pyrimidines and Purines; 2.3.1 Aglycones; 2.3.2 Saccharide-Linked Compounds; References; Chapter 3 Hormone Blocking Anticancer Drugs; 3.1 Introduction
3.2 Estrogen Antagonists3.2.1 Estrogen Antagonists; 3.2.2 Aromatase Inhibitors; 3.3 Androgen Antagonists; 3.3.1 Non-steroidal Antian drogens; 3.3.2 Steroid Androgen Antagonists; References; Chapter 4 Topoisomerase Inhibitors; 4.1 Introduction; 4.2 Anthracyclines; 4.3 Anthraquinones and Anthrapyrazoles; 4.3.1 Anthraquinones with Two Aminoalkyl Side Chains; 4.3.2 Anthraquinones with a Fused Pyrazole Ring; 4.3.3 Heterocyclic Anthraquinones; 4.4 Camptothecins; 4.4.1 Compounds from Modified Camptothecin; 4.4.2 Camptothecins by Total Synthesis; 4.5 Miscellaneous Topoisomerase Inhibitors; References Chapter 5 Mitotic Inhibitors5.1 Introduction; 5.2 Taxanes; 5.3 Wholly Synthetic Compounds; 5.3.1 Carbocyclic Compounds; 5.3.2 Peptide-Like Inhibitors; 5.3.3 Monocyclic Heterocyclic Inhibitors; 5.3.4 Bicyclic 5:6 Heterocyclic Inhibitors; 5.3.5 Bicyclic 6:6 Heterocyclic Tubulin Inhibitors; References; Chapter 6 Matrix Metalloproteinase Inhibitors; 6.1 Introduction; 6.2 Hydroxamates; 6.2.1 Agents with an Isobutyl Moiety; 6.2.2 A Thiomorpholine; 6.2.3 Sulfamates; 6.2.4 Miscellaneous Compounds; References; Chapter 7 Histone Deacetylase Inhibitors; 7.1 Introduction; 7.2 Hydroxamates 7.3 PhenylenediaminesReferences; Chapter 8 Enzyme Inhibitor, Part I, Tyrosine Kinases; 8.1 Introduction; 8.2 Epidermal Growth Factor Inhibitors; 8.3 VEGF; 8.3.1 Fused Ring Compounds; 8.3.2 Linear Arrays; 8.4 SRC Nonreceptor Tyrosine Kinase; 8.5 PDGF; 8.6 EGF; 8.7 Other TKI; 8.7.1 Linear Arrays; 8.7.2 Compounds with Two Fused Rings; 8.8 Janus Kinase Inhibitors; References; Chapter 9 Enzyme Inhibitors: Part II Additional Targets; 9.1 Serine-Threonine Kinase Inhibitors; 9.2 Additional Enzyme Inhibitors; 9.2.1 Farnesyl Transferase Inhibitors; 9.2.2 Cyclin-Dependent Kinase Inhibitors 9.2.3 Proteasome Inhibitors9.2.4 PARP Inhibitors; 9.2.5 Various Other Enzyme Inhibitors; References; Chapter 10 Miscellaneous Antineoplastic Agents; 10.1 Acyclic; 10.2 Monocyclic; 10.3 Two Linked Rings; 10.4 Rings on a Chain; 10.4.1 Two Rings; 10.4.2 Four and More Rings; 10.5 Fused Rings; 10.5.1 Indoles; 10.5.2 Purine-Like; 10.5.3 Tetralins and a Naphthalene; 10.5.4 Etc.; References; Appendix A; Index of Heterocycle Syntheses; Subject Index; EULA |
Record Nr. | UNINA-9910131339603321 |
Lednicer Daniel
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Chichester, England : , : Wiley, , 2015 | ||
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Lo trovi qui: Univ. Federico II | ||
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Antineoplastic drugs : organic synthesis / / Daniel Lednicer |
Autore | Lednicer Daniel |
Pubbl/distr/stampa | Chichester, England : , : Wiley, , 2015 |
Descrizione fisica | 1 online resource (230 p.) |
Disciplina | 616.994061 |
Soggetto topico | Antineoplastic agents |
ISBN |
1-118-89256-9
1-118-89255-0 1-118-89257-7 |
Classificazione | SCI007000 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Title Page; Copyright Page; Contents; Preface; Introduction; Chapter 1 Alkylating Agents; 1.1 bis-Chloroethyl Amines; 1.2 Several Other Chloroethyl Agents; 1.3 Platinum-Based Antineoplastic Agents; 1.4 Miscellaneous Alkylating Agents; References; Chapter 2 Antimetabolites; 2.1 Introduction; 2.2 Folate Antagonists; 2.2.1 Compounds with Glutamate Side Chain; 2.2.2 Compounds Lacking the Glutamate Moiety; 2.2.3 Methoxylated Benzenes; 2.3 Pyrimidines and Purines; 2.3.1 Aglycones; 2.3.2 Saccharide-Linked Compounds; References; Chapter 3 Hormone Blocking Anticancer Drugs; 3.1 Introduction
3.2 Estrogen Antagonists3.2.1 Estrogen Antagonists; 3.2.2 Aromatase Inhibitors; 3.3 Androgen Antagonists; 3.3.1 Non-steroidal Antian drogens; 3.3.2 Steroid Androgen Antagonists; References; Chapter 4 Topoisomerase Inhibitors; 4.1 Introduction; 4.2 Anthracyclines; 4.3 Anthraquinones and Anthrapyrazoles; 4.3.1 Anthraquinones with Two Aminoalkyl Side Chains; 4.3.2 Anthraquinones with a Fused Pyrazole Ring; 4.3.3 Heterocyclic Anthraquinones; 4.4 Camptothecins; 4.4.1 Compounds from Modified Camptothecin; 4.4.2 Camptothecins by Total Synthesis; 4.5 Miscellaneous Topoisomerase Inhibitors; References Chapter 5 Mitotic Inhibitors5.1 Introduction; 5.2 Taxanes; 5.3 Wholly Synthetic Compounds; 5.3.1 Carbocyclic Compounds; 5.3.2 Peptide-Like Inhibitors; 5.3.3 Monocyclic Heterocyclic Inhibitors; 5.3.4 Bicyclic 5:6 Heterocyclic Inhibitors; 5.3.5 Bicyclic 6:6 Heterocyclic Tubulin Inhibitors; References; Chapter 6 Matrix Metalloproteinase Inhibitors; 6.1 Introduction; 6.2 Hydroxamates; 6.2.1 Agents with an Isobutyl Moiety; 6.2.2 A Thiomorpholine; 6.2.3 Sulfamates; 6.2.4 Miscellaneous Compounds; References; Chapter 7 Histone Deacetylase Inhibitors; 7.1 Introduction; 7.2 Hydroxamates 7.3 PhenylenediaminesReferences; Chapter 8 Enzyme Inhibitor, Part I, Tyrosine Kinases; 8.1 Introduction; 8.2 Epidermal Growth Factor Inhibitors; 8.3 VEGF; 8.3.1 Fused Ring Compounds; 8.3.2 Linear Arrays; 8.4 SRC Nonreceptor Tyrosine Kinase; 8.5 PDGF; 8.6 EGF; 8.7 Other TKI; 8.7.1 Linear Arrays; 8.7.2 Compounds with Two Fused Rings; 8.8 Janus Kinase Inhibitors; References; Chapter 9 Enzyme Inhibitors: Part II Additional Targets; 9.1 Serine-Threonine Kinase Inhibitors; 9.2 Additional Enzyme Inhibitors; 9.2.1 Farnesyl Transferase Inhibitors; 9.2.2 Cyclin-Dependent Kinase Inhibitors 9.2.3 Proteasome Inhibitors9.2.4 PARP Inhibitors; 9.2.5 Various Other Enzyme Inhibitors; References; Chapter 10 Miscellaneous Antineoplastic Agents; 10.1 Acyclic; 10.2 Monocyclic; 10.3 Two Linked Rings; 10.4 Rings on a Chain; 10.4.1 Two Rings; 10.4.2 Four and More Rings; 10.5 Fused Rings; 10.5.1 Indoles; 10.5.2 Purine-Like; 10.5.3 Tetralins and a Naphthalene; 10.5.4 Etc.; References; Appendix A; Index of Heterocycle Syntheses; Subject Index; EULA |
Record Nr. | UNINA-9910808374903321 |
Lednicer Daniel
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Chichester, England : , : Wiley, , 2015 | ||
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Lo trovi qui: Univ. Federico II | ||
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Biochemical pathways [[electronic resource] ] : an atlas of biochemistry and molecular biology / / edited by Dietmar Schomburg, Gerhard Michal |
Edizione | [2nd ed.] |
Pubbl/distr/stampa | Hoboken, N.J., : John Wiley & Sons, c2012 |
Descrizione fisica | 1 online resource (414 p.) |
Disciplina |
572
612.3/9 612.39 |
Altri autori (Persone) |
SchomburgD (Dietmar)
MichalGerhard |
Soggetto topico | Metabolism |
ISBN |
1-118-65707-1
1-118-65690-3 |
Classificazione | SCI007000 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Machine generated contents note: Chapter 1. Introduction and general aspects, chemistry and physical chemistry Gerhard Michael and Dietmar Schomburg Chapter 2. The cell and its contents: Enzymes, nucleic acids, and polymeric carbohydrates and lipids Gerhard Michal and Dietmar Schomburg Chapter 3. General metabolism in animals, plants and bacteria 3.1 Carbohydrate Metabolism and Citrate Cycle 3.2 Amino Acids and Derivatives 3.3 Tetrapyrroles 3.4 Lipids amd Glycolipids 3.5 Steriods and Isopreniods 3.6 Nucleotides and Nucleosides 3.7 Cofactors and Vitamins 3.8 Nucleic Acid Metabolism in Bacteria 3.9 Nucleic Acid Metabolism in Eukarya 3.10 Special Bacterial Metabolism and Biosynthesis of Antimicrobials 3.11 Electron Transfer Reactions and Oxidative Phosphorylation 3.12 Photosynthesis 3.13 Plant Secondary Metabolism Chapter 4. Protein biosynthesis, modification and degradation 4.1 Protein Synthesis in Bacteria 4.2 Protein Biosynthesis in Eukarya 4.3 Cell Cycle in Eukarya 4.4 Posttranslational Modification of Proteins 4.5 Protein Folding, Transport / Targeting and Degradation Chapter 5. Viruses Klaus Klumpp Chapter 6. Transport systems 6.1 Transport Through Membranes 6.2 Transport of Lipids in Plasma 6.3 Oxygen Transport by Hemoglobin Chapter 7. Signal transduction and cellular communication Gerhard Niederfellner Chapter 8. Immune system 8.1 Components of the Immune System 8.2 Generation of a Specific Immune Response 8.3 Pathologic Immune responses 8.4 Adhesion of Leukocytes Chapter 9. Blood coagulation and fibrinolysis P. Mueller Chapter 10. Biochemical networks, bioinformatics and systems biology Dietmar Schomburg. |
Record Nr. | UNINA-9910141499503321 |
Hoboken, N.J., : John Wiley & Sons, c2012 | ||
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Lo trovi qui: Univ. Federico II | ||
|
Biochemical pathways [[electronic resource] ] : an atlas of biochemistry and molecular biology / / edited by Dietmar Schomburg, Gerhard Michal |
Edizione | [2nd ed.] |
Pubbl/distr/stampa | Hoboken, N.J., : John Wiley & Sons, c2012 |
Descrizione fisica | 1 online resource (414 p.) |
Disciplina |
572
612.3/9 612.39 |
Altri autori (Persone) |
SchomburgD (Dietmar)
MichalGerhard |
Soggetto topico | Metabolism |
ISBN |
1-118-65707-1
1-118-65690-3 |
Classificazione | SCI007000 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Machine generated contents note: Chapter 1. Introduction and general aspects, chemistry and physical chemistry Gerhard Michael and Dietmar Schomburg Chapter 2. The cell and its contents: Enzymes, nucleic acids, and polymeric carbohydrates and lipids Gerhard Michal and Dietmar Schomburg Chapter 3. General metabolism in animals, plants and bacteria 3.1 Carbohydrate Metabolism and Citrate Cycle 3.2 Amino Acids and Derivatives 3.3 Tetrapyrroles 3.4 Lipids amd Glycolipids 3.5 Steriods and Isopreniods 3.6 Nucleotides and Nucleosides 3.7 Cofactors and Vitamins 3.8 Nucleic Acid Metabolism in Bacteria 3.9 Nucleic Acid Metabolism in Eukarya 3.10 Special Bacterial Metabolism and Biosynthesis of Antimicrobials 3.11 Electron Transfer Reactions and Oxidative Phosphorylation 3.12 Photosynthesis 3.13 Plant Secondary Metabolism Chapter 4. Protein biosynthesis, modification and degradation 4.1 Protein Synthesis in Bacteria 4.2 Protein Biosynthesis in Eukarya 4.3 Cell Cycle in Eukarya 4.4 Posttranslational Modification of Proteins 4.5 Protein Folding, Transport / Targeting and Degradation Chapter 5. Viruses Klaus Klumpp Chapter 6. Transport systems 6.1 Transport Through Membranes 6.2 Transport of Lipids in Plasma 6.3 Oxygen Transport by Hemoglobin Chapter 7. Signal transduction and cellular communication Gerhard Niederfellner Chapter 8. Immune system 8.1 Components of the Immune System 8.2 Generation of a Specific Immune Response 8.3 Pathologic Immune responses 8.4 Adhesion of Leukocytes Chapter 9. Blood coagulation and fibrinolysis P. Mueller Chapter 10. Biochemical networks, bioinformatics and systems biology Dietmar Schomburg. |
Record Nr. | UNINA-9910830112203321 |
Hoboken, N.J., : John Wiley & Sons, c2012 | ||
![]() | ||
Lo trovi qui: Univ. Federico II | ||
|
Biochemical pathways : an atlas of biochemistry and molecular biology / / edited by Dietmar Schomburg, Gerhard Michal |
Edizione | [2nd ed.] |
Pubbl/distr/stampa | Hoboken, N.J., : John Wiley & Sons, c2012 |
Descrizione fisica | 1 online resource (414 p.) |
Disciplina |
572
612.3/9 612.39 |
Altri autori (Persone) |
SchomburgD (Dietmar)
MichalGerhard |
Soggetto topico | Metabolism |
ISBN |
1-118-65707-1
1-118-65690-3 |
Classificazione | SCI007000 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Machine generated contents note: Chapter 1. Introduction and general aspects, chemistry and physical chemistry Gerhard Michael and Dietmar Schomburg Chapter 2. The cell and its contents: Enzymes, nucleic acids, and polymeric carbohydrates and lipids Gerhard Michal and Dietmar Schomburg Chapter 3. General metabolism in animals, plants and bacteria 3.1 Carbohydrate Metabolism and Citrate Cycle 3.2 Amino Acids and Derivatives 3.3 Tetrapyrroles 3.4 Lipids amd Glycolipids 3.5 Steriods and Isopreniods 3.6 Nucleotides and Nucleosides 3.7 Cofactors and Vitamins 3.8 Nucleic Acid Metabolism in Bacteria 3.9 Nucleic Acid Metabolism in Eukarya 3.10 Special Bacterial Metabolism and Biosynthesis of Antimicrobials 3.11 Electron Transfer Reactions and Oxidative Phosphorylation 3.12 Photosynthesis 3.13 Plant Secondary Metabolism Chapter 4. Protein biosynthesis, modification and degradation 4.1 Protein Synthesis in Bacteria 4.2 Protein Biosynthesis in Eukarya 4.3 Cell Cycle in Eukarya 4.4 Posttranslational Modification of Proteins 4.5 Protein Folding, Transport / Targeting and Degradation Chapter 5. Viruses Klaus Klumpp Chapter 6. Transport systems 6.1 Transport Through Membranes 6.2 Transport of Lipids in Plasma 6.3 Oxygen Transport by Hemoglobin Chapter 7. Signal transduction and cellular communication Gerhard Niederfellner Chapter 8. Immune system 8.1 Components of the Immune System 8.2 Generation of a Specific Immune Response 8.3 Pathologic Immune responses 8.4 Adhesion of Leukocytes Chapter 9. Blood coagulation and fibrinolysis P. Mueller Chapter 10. Biochemical networks, bioinformatics and systems biology Dietmar Schomburg. |
Record Nr. | UNINA-9910876717903321 |
Hoboken, N.J., : John Wiley & Sons, c2012 | ||
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Lo trovi qui: Univ. Federico II | ||
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Biomimetic, bioresponsive, and bioactive materials : an introduction to integrating materials with tissues / / edited by Matteo Santin, Gary Phillips |
Edizione | [1st ed.] |
Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2012 |
Descrizione fisica | 1 online resource (249 p.) |
Disciplina | 660.6 |
Altri autori (Persone) |
SantinMatteo
PhillipsGary |
Soggetto topico |
Biomimetic polymers
Biomimetics Tissues - Mechanical properties |
ISBN |
1-280-58945-0
9786613619280 1-118-12989-X 1-118-12990-3 1-118-12987-3 |
Classificazione | SCI007000 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Biomimetic, Bioresponsive, and Bioactive Materials; CONTENTS; PREFACE; CONTRIBUTORS; 1: HISTORY OF BIOMIMETIC, BIOACTIVE, AND BIORESPONSIVE BIOMATERIALS; 1.1 THE FIRST GENERATION OF BIOMATERIALS: THE SEARCH FOR "THE BIOINERT"; 1.1.1 Bioinert: Myth, Reality, or Utopia?; 1.2 THE SECOND GENERATION OF BIOMATERIALS: BIOMIMETIC, BIORESPONSIVE, BIOACTIVE; 1.2.1 Hydroxyapatite (HA) and Bioglass®: Cell Adhesion and Stimulation; 1.2.2 Collagen, Fibrin Glue, and Hyaluronic Acid Hydrogels: Presenting the ECM; 1.2.3 Chitosan and Alginate: Replacing the ECM
1.2.4 Poly(Lactic/Glycolic) Acid Copolymers: Encouraging Tissue Remodeling by Safe Biodegradation1.2.5 Porous Metals: Favoring Mechanical Integration; 1.3 THE THIRD-GENERATION BIOMATERIALS: BIOMIMICKING NATURAL BIOACTIVE AND BIORESPONSIVE PROCESSES; 1.3.1 Principal Phases of Tissue Regeneration; 1.3.1.1 Cell Adhesion: The Cornerstone of Tissue Regeneration; 1.3.1.2 Mechanisms of Tissue Mineralization; 1.4 PRINCIPLES OF BIOMIMESIS AND BIOACTIVITY; 1.4.1 Biomimicking of the ECM; 1.4.2 Biomimicking of Cell Membrane Components; 1.4.3 Biomimicking Cell Signaling Pathways 1.4.3.1 Modulation of the Growth Factor Signaling by Gene Expression: Bioactive Gene Delivery Systems1.5 BIOACTIVE BIOMATERIALS FROM DIFFERENT NATURAL SOURCES; 1.5.1 Silk Fibroin; 1.5.2 Soybean-Based Biomaterials; 1.6 SCOPE OF THIS BOOK; REFERENCES; 2: SOFT TISSUE STRUCTURE AND FUNCTIONALITY; 2.1 OVERVIEW; 2.2 EPITHELIAL TISSUE; 2.2.1 Background; 2.3 THE SKIN; 2.3.1 Structure and Functionality; 2.3.2 Repair, Healing, and Renewal; 2.4 MUSCLE TISSUE; 2.4.1 Background; 2.4.2 Skeletal Muscle; 2.4.2.1 Structure and Functionality; 2.4.2.2 Repair, Healing, and Renewal; 2.4.3 Smooth Muscle 2.4.3.1 Structure and Functionality2.4.3.2 Repair, Healing, and Renewal; 2.4.4 Cardiac Muscle; 2.4.4.1 Structure and Functionality; 2.4.4.2 Repair, Healing, and Renewal; 2.5 CONNECTIVE TISSUE; 2.5.1 Background; 2.5.2 Embryonic Connective Tissue; 2.5.3 Connective Tissue Proper; 2.5.3.1 Cells of the Connective Tissue Proper; 2.5.3.2 Connective Tissue Proper Fibers; 2.5.3.3 Ground Substance; 2.5.4 Specialized Connective Tissues; 2.5.4.1 Structure and Function; 2.5.4.2 Repair, Healing, and Renewal of Hyaline Cartilage; 2.6 THE FOREIGN BODY RESPONSE; EXERCISES/QUESTIONS FOR CHAPTER 2; REFERENCES 3: HARD TISSUE STRUCTURE AND FUNCTIONALITY3.1 DEFINITION OF HARD TISSUES; 3.2 ARTICULAR CARTILAGE; 3.2.1 Structure of the Articular Cartilage; 3.2.2 Specific Mechanism Repair of the Articular Cartilage; 3.3 BONE TISSUE; 3.3.1 The Structure of the Bony Tissues; 3.3.2 The Functions of Bone Tissue; 3.3.3 Cell Types Involved in Bone Homeostasis: The Osteoblasts and the Osteoclasts; 3.3.4 Ossification, Turnover, and Remodeling; 3.3.5 Bone Composite Structure and Its Effect on Mechanical Performance; 3.4 CONCLUDING REMARKS; EXERCISES/QUESTIONS FOR CHAPTER 3; REFERENCES 4: BIOMEDICAL APPLICATIONS OF BIOMIMETIC POLYMERS: THE PHOSPHORYLCHOLINE-CONTAINING POLYMERS |
Record Nr. | UNINA-9910141298103321 |
Hoboken, N.J., : Wiley, c2012 | ||
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Lo trovi qui: Univ. Federico II | ||
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Chemical biology [[electronic resource] ] : approaches to drug discovery and development to targeting disease / / edited by Natanya Civjan |
Autore | Civjan Natanya |
Edizione | [1st edition] |
Pubbl/distr/stampa | Hoboken, N.J., : Wiley, 2012 |
Descrizione fisica | 1 online resource (525 p.) |
Disciplina | 572 |
Soggetto topico | Biochemistry |
ISBN |
1-283-57605-8
9786613888501 1-118-43576-1 1-118-43450-1 1-118-43767-5 |
Classificazione | SCI007000 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | pt. 1. Drug discovery and development -- pt. 2. Chemical biology to understand and target disease. |
Record Nr. | UNINA-9910141434203321 |
Civjan Natanya
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Hoboken, N.J., : Wiley, 2012 | ||
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Lo trovi qui: Univ. Federico II | ||
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Chemical biology : approaches to drug discovery and development to targeting disease / / edited by Natanya Civjan |
Autore | Civjan Natanya |
Edizione | [1st edition] |
Pubbl/distr/stampa | Hoboken, N.J., : Wiley, 2012 |
Descrizione fisica | 1 online resource (525 p.) |
Disciplina | 572 |
Soggetto topico | Biochemistry |
ISBN |
1-283-57605-8
9786613888501 1-118-43576-1 1-118-43450-1 1-118-43767-5 |
Classificazione | SCI007000 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | pt. 1. Drug discovery and development -- pt. 2. Chemical biology to understand and target disease. |
Record Nr. | UNINA-9910812578003321 |
Civjan Natanya
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Hoboken, N.J., : Wiley, 2012 | ||
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Lo trovi qui: Univ. Federico II | ||
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Chemistry and Biochemistry of Oxygen Therapeutics [[electronic resource] ] : From Transfusion to Artificial Blood |
Autore | Mozzarelli Andrea |
Pubbl/distr/stampa | Hoboken, : Wiley, 2011 |
Descrizione fisica | 1 online resource (476 p.) |
Disciplina |
615.8/36
615.836 |
Altri autori (Persone) | BettatiStefano |
Soggetto topico |
Hemoglobins - therapeutic use
Hemoglobins -- therapeutic use Nitric oxide - Physiological effect Nitric oxide -- Physiological effect Oxigen - Physiological effect Oxigen -- Physiological effect Oxygen - blood Oxygen -- blood Oxygen Consumption Oxygen Inhalation Therapy - methods Oxygen Inhalation Therapy -- methods Oxygen therapy SCIENCE / Life Sciences / Biochemistry Oxygen therapy - Physiological effect Oxygen - Physiological effect Nitric oxide Metabolic Phenomena Respiratory Therapy Investigative Techniques Body Fluids Globins Chalcogens Blood Proteins Gases Therapeutics Fluids and Secretions Elements Hemeproteins Inorganic Chemicals Proteins Amino Acids, Peptides, and Proteins Anatomy Oxygen Blood Hemoglobins Methods Oxygen Inhalation Therapy Health & Biological Sciences Pharmacy, Therapeutics, & Pharmacology |
ISBN |
1-283-17785-4
9786613177858 1-119-97542-5 1-119-97543-3 |
Classificazione | SCI007000 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Chemistry and Biochemistry of Oxygen Therapeutics; Contents; List of Contributors; Preface; 1. Introduction; References; Part I. Oxygen: Chemistry, Biochemistry, Physiology and Toxicity; 2. Hemoglobin Reactivity and Regulation; 2.1 Introduction; 2.2 Oxygen Loading and Transport; 2.3 NO Reactivity with Hb; 2.4 Hb Oxidation; 2.5 Nitrite Reactivity with Hb; 2.6 Amino-acid Determinants of Hb Reactivity: Natural and Engineered Hbs; 2.6.1 Modulation of Oxygen Affinity and Cooperativity; 2.6.2 NO Reactivity and Oxidation; 2.7 Conclusion; Acknowledgments; References
3. The Major Physiological Control Mechanisms of Blood Flow and Oxygen Delivery3.1 Introduction; 3.2 Autoregulation of Blood Flow to Changes in Perfusion Pressure; 3.3 Metabolic Regulation of Blood Flow; 3.4 O2 Transport; 3.5 O2 Delivery; 3.6 Endothelial Control of Vasomotor Tone; 3.7 Effect of Cell-free Hb on Endothelial Function; 3.8 Hypoxic Hypoxia; 3.9 Carbon Monoxide Hypoxia; 3.10 Anemia; 3.11 Conclusion; References; 4. The Main Players: Hemoglobin and Myoglobin; Nitric Oxide and Oxygen; 4.1 Introduction; 4.2 Role of Mammalian Mb in O2 Homeostasis 4.3 WhatLfs Missing in the Mb Knockout Mouse4.4 Evolutionary Origins of Mb and the Nitrogen Cycle; 4.5 Human Hb: Evolved Sensor of pO2 and Redox; 4.6 Broad Reactivity and Influence of NO: Lessons from the Microcosm Hb; 4.7 Some Fish Demonstrate a Fundamental "Need" for Hb-dependent NO Cycling, as in Humans; 4.8 Reactions of NO with Hb that Preserve NO Bioactivity; 4.9 Mammalian RBC/Hb.NO Interactions; 4.10 A Mutant Mouse Challenges the SNO-Hb Hypothesis, but does not Overthrow it; 4.11 Signaling by Hb-derived SNO: A Metabolically Responsive, Regulated Pathway 4.12 Signaling by Hb-derived SNO: Pathway Complexity Revealed by Multiple Defects in Disease States4.13 Therapeutic Implications of the Hb.NO Signaling System; 4.14 HBOCs, NO, and SNO; 4.15 Other Gaseous Hb Ligands of Potential Therapeutic Significance; 4.16 NO-related Enzymatic Activities of Hb: Reconciling Nitrite Reductase and SNO Synthase Functions; 4.17 Measuring Biologically Relevant Hb.NO Adducts; 4.18 Conclusion; Acknowledgments; References; 5. The Role of Reactive Oxygen and Nitrogen Species in Ischemia/Reperfusion Injury; 5.1 Introduction 5.2 Redox System and Free Radicals in Biological Systems5.3 Pathophysiology of Ischemia/Reperfusion Injury; 5.3.1 Cell Death; 5.3.2 The Inflammatory Response; 5.4 Protection Against I/R Injury; 5.4.1 Ischemic Pre- and Post-conditioning; 5.4.2 Pharmacological Conditioning; 5.4.2.1 The Protective Role of ROS and Antioxidants; 5.4.2.2 The Protective Role of NO; 5.4.2.3 NO-based Therapies for I/R Injury; 5.5 Conclusion; Acknowledgments; References; Part II. Medical Needs for Oxygen Supply; 6. Acute Traumatic Hemorrhage and Anemia; 6.1 Introduction; 6.2 Blood Transfusion in Trauma 6.2.1 Massive Transfusion |
Record Nr. | UNINA-9910139631203321 |
Mozzarelli Andrea
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Hoboken, : Wiley, 2011 | ||
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Lo trovi qui: Univ. Federico II | ||
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Chemistry and biochemistry of oxygen therapeutics : from transfusion to artificial blood / / edited by Andrea Mozzarelli and Stefano Bettati |
Edizione | [1st ed.] |
Pubbl/distr/stampa | Chichester [England] ; ; Hoboken, N.J., : Wiley, 2011 |
Descrizione fisica | 1 online resource (476 p.) |
Disciplina |
615.8/36
615.836 |
Altri autori (Persone) |
MozzarelliAndrea
BettatiStefano |
Soggetto topico |
Oxygen therapy
Oxigen - Physiological effect Nitric oxide - Physiological effect |
ISBN |
1-283-17785-4
9786613177858 1-119-97542-5 1-119-97543-3 |
Classificazione | SCI007000 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | pt. 1. Oxygen : chemistry, biochemistry, physiology and toxicity -- pt. 2. Medical needs for oxygen supply -- pt. 3. "Old" and new strategies for oxygen supply. |
Record Nr. | UNINA-9910806996303321 |
Chichester [England] ; ; Hoboken, N.J., : Wiley, 2011 | ||
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Lo trovi qui: Univ. Federico II | ||
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