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Tumor-associated antigens [[electronic resource] ] : identification, characterization, and clinical applications / / edited by Olivier Gires and Barbara Seliger
| Tumor-associated antigens [[electronic resource] ] : identification, characterization, and clinical applications / / edited by Olivier Gires and Barbara Seliger |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2009 |
| Descrizione fisica | 1 online resource (386 p.) |
| Disciplina | 616.994079 |
| Altri autori (Persone) |
GiresOlivier
SeligerBarbara |
| Soggetto topico |
Tumor antigens
Tumors - Immunological aspects |
| ISBN |
1-282-02189-3
9786612021893 3-527-62597-6 3-527-62598-4 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Tumor-Associated Antigens : Identification, Characterization, and Clinical Applications; Contents; List of Contributors; Part One Tumor-associated Antigens (TAAs): Subclasses of TAAs; 1 T Cell Antigens in Cancer; 1.1 Introduction; 1.2 Generation of T-cell Epitopes; 1.2.1 Subclasses of Tumor-associated T-cell Antigens; 1.2.1.1 Unique Tumor Antigens; 1.2.1.2 Cancer Testis Antigens; 1.2.1.3 Differentiation Antigens; 1.2.1.4 Overexpressed Antigens; 1.3 Identification of T-cell Antigens and their Epitopes; 1.3.1 T-cell Antigens for Cancer Immunotherapy - How are Candidates Selected?
1.4 ConclusionsReferences; 2 Human Tumor Antigens as Targets of Immunosurveillance and Candidates for Cancer Vaccines; 2.1 Introduction; 2.2 Tumor Antigen Classes; 2.2.1 Oncofetal Antigens; 2.2.2 Oncogenes as Tumor Antigens; 2.2.3 Overexpressed Normal Molecules as Tumor Antigens; 2.2.4 Cancer-Testis (CT) Antigens; 2.2.5 Minor Histocompatibility Antigens (mHAgs) as Tumor Antigens; 2.2.6 Human Melanoma Antigens; 2.2.7 Human Glioma Antigens and Immunosurveillance in the CNS; 2.2.8 Heat Shock Proteins, Efficient Carriers of Tumor Antigens 2.2.9 Dendritic Cells, Efficient Cross-presenters of Tumor Antigens2.2.10 Spontaneous and Vaccine-induced Immunity and the Tumor Microenvironment; 2.3 Summary; References; Part Two Methods to Detect TAAs; 3 Humoral Immune Responses against Cancer Antigens: Serological Identification Methods. Part I: SEREX; 3.1 Introduction; 3.2 The SEREX Approach; 3.2.1 Identification of Human Tumor Antigens by SEREX; 3.2.2 Specificity of Human Tumor Antigens; 3.2.2.1 Shared Tumor Antigens; 3.2.2.2 Differentiation Antigens; 3.2.2.3 Antigens Encoded by Mutated Genes; 3.2.2.4 Viral Genes 3.2.2.5 Overexpressed Genes3.2.2.6 Amplified Genes; 3.2.2.7 Splice Variants of Known Genes; 3.2.2.8 Cancer-related Autoantigens; 3.2.2.9 Non-cancer-related Autoantigens; 3.2.2.10 Products of Underexpressed Genes; 3.2.3 Significance of Antibodies against SEREX Antigens; 3.2.4 Reverse T Cell Immunology; 3.2.5 Functional Significance of Human Tumor Antigens; 3.2.6 The Human Cancer Immunome; 3.2.7 Perspectives for Vaccine Development; 3.3 Conclusions; References; 4 Humoral Immune Responses against Cancer Antigens: Serological Identification Methods. Part II: Proteomex and AMIDA; 4.1 Introduction 4.1.1 A Humoral Response against Self-antigens: The Notion of Tumor-associated Antigens4.2 Implementation of Serum Antibodies: Serological Screening Technologies; 4.2.1 PROTEOMEX, alias SERPA and SPEARS; 4.2.1.1 PROTEOMEX Technology and its 'Pros' and 'Cons'; 4.2.1.2 Candidate Biomarkers Identified by PROTEOMEX; 4.2.1.3 Implementation of Candidate Biomarkers in the Clinic; 4.2.2 AMIDA; 4.2.2.1 Autologous AMIDA; 4.2.2.2 Allo-AMIDA; 4.2.3 Advantages and Disadvantages of AMIDA; 4.3 AMIDA Antigens and Clinical Application; 4.3.1 Diagnostic TAAs Detected with AMIDA Screening 4.3.2 Therapeutic Markers |
| Record Nr. | UNINA-9910841680203321 |
| Weinheim, : Wiley-VCH, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Vol. 1: Experimental models and practical approaches / edited by Serguei V. Kozlov
| Vol. 1: Experimental models and practical approaches / edited by Serguei V. Kozlov |
| Pubbl/distr/stampa | New York : Humana Press, 2009 |
| Descrizione fisica | XIV, 376 p. ; 27 cm |
| Disciplina | 616.994079 |
| Collana | Methods in molecular biology |
| Soggetto topico | Cancro - Immunologia |
| ISBN |
978-1-934115-14-5
978-1-59745-447-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-990002237110203316 |
| New York : Humana Press, 2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Vol. 2: Molecular analysis and pathways / edited by Serguei V. Kozlov
| Vol. 2: Molecular analysis and pathways / edited by Serguei V. Kozlov |
| Pubbl/distr/stampa | New York : Humana Press, 2009 |
| Descrizione fisica | XV, 401 p. ; 27 cm |
| Disciplina | 616.994079 |
| Collana | Methods in molecular biology |
| Soggetto topico | Cancro - Immunologia |
| ISBN |
978-1-60327-529-3
978-1-60327-530-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-990002236710203316 |
| New York : Humana Press, 2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
