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Cancer risk assessment [[electronic resource] ] : chemical carcinogenesis, hazard evaluation, and risk quantification / / edited by Ching-Hung Hsu, Todd Stedeford
| Cancer risk assessment [[electronic resource] ] : chemical carcinogenesis, hazard evaluation, and risk quantification / / edited by Ching-Hung Hsu, Todd Stedeford |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2010 |
| Descrizione fisica | 1 online resource (858 p.) |
| Disciplina |
616.99/4071
616.994071 |
| Altri autori (Persone) |
HsuChing-Hung
StedefordTodd |
| Soggetto topico |
Carcinogens
Health risk assessment |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-118-03512-7
1-282-68335-7 9786612683350 0-470-62272-5 0-470-62271-7 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
CANCER RISK ASSESSMENT: Chemical Carcinogenesis, Hazard Evaluation, and Risk Quantification; CONTENTS; PREFACE; CONTRIBUTORS; ABBREVIATIONS AND ACRONYMS; PART I: CANCER RISK ASSESSMENT, SCIENCE POLICY, AND REGULATORY FRAMEWORKS; CHAPTER 1: CANCER RISK ASSESSMENT; CHAPTER 2: SCIENCE POLICY AND CANCER RISK ASSESSMENT; CHAPTER 3: HAZARD AND RISK ASSESSMENT OF CHEMICAL CARCINOGENICITY WITHIN A REGULATORY CONTEXT; CHAPTER 4: USE OF CANCER RISK ASSESSMENTS IN DETERMINATION OF REGULATORY STANDARDS; PART II: CANCER BIOLOGY AND TOXICOLOGY; CHAPTER 5: THE INTERPLAY OF CANCER AND BIOLOGY
CHAPTER 6: CHEMICAL CARCINOGENESIS: A BRIEF HISTORY OF ITS CONCEPTS WITH A FOCUS ON POLYCYCLIC AROMATIC HYDROCARBONSCHAPTER 7: HORMESIS AND CANCER RISKS: ISSUES AND RESOLUTION; CHAPTER 8: THRESHOLDS FOR GENOTOXIC CARCINOGENS: EVIDENCE FROM MECHANISM-BASED CARCINOGENICITY STUDIES; PART III: GENETIC TOXICOLOGY, TESTING GUIDELINES AND REGULATIONS, AND NOVEL ASSAYS; CHAPTER 9: DEVELOPMENT OF GENETIC TOXICOLOGY TESTING AND ITS INCORPORATION INTO REGULATORY HEALTH EFFECTS TEST REQUIREMENTS; CHAPTER 10: GENETIC TOXICOLOGY TESTING GUIDELINES AND REGULATIONS; CHAPTER 11: IN VITRO GENOTOX ASSAYS CHAPTER 12: IN VIVO GENOTOXICITY ASSAYSPART IV: ASSESSING THE HUMAN RELEVANCE OF CHEMICAL-INDUCED TUMORS; CHAPTER 13: FRAMEWORK ANALYSIS FOR DETERMINING MODE OF ACTION AND HUMAN RELEVANCE; CHAPTER 14: EXPERIMENTAL ANIMAL STUDIES AND CARCINOGENICITY; CHAPTER 15: CANCER EPIDEMIOLOGY; CHAPTER 16: RODENT HEPATOCARCINOGENESIS; CHAPTER 17: MODE OF ACTION ANALYSIS AND HUMAN RELEVANCE OF LIVER TUMORS INDUCED BY PPAR a ACTIVATION; CHAPTER 18: ALPHA 2U-GLOBULIN NEPHROPATHY AND CHRONIC PROGRESSIVE NEPHROPATHY AS MODES OF ACTION FOR RENAL TUBULE TUMOR INDUCTION IN RATS, AND THEIR POSSIBLE INTERACTION CHAPTER 19: URINARY TRACT CALCULI AND BLADDER TUMORSPART V: METHODS FOR INFORMING CANCER RISK QUANTIFICATION; CHAPTER 20: (Q) SAR ANALYSIS OF GENOTOXIC AND NONGENOTOXIC CARCINOGENS: A STATE-OF-THE-ART OVERVIEW; CHAPTER 21: PHYSIOLOGICALLY BASED PHARMACOKINETIC (PBPK) MODELS IN CANCER RISK ASSESSMENT; CHAPTER 22: GENOMICS AND ITS ROLE IN CANCER RISK ASSESSMENT; CHAPTER 23: COMPUTATIONAL TOXICOLOGY IN CANCER RISK ASSESSMENT; PART VI: GENERAL APPROACHES FOR QUANTIFYING CANCER RISKS; CHAPTER 24: LINEAR LOW-DOSE EXTRAPOLATIONS CHAPTER 25: QUANTITATIVE CANCER RISK ASSESSMENT OF NONGENOTOXIC CARCINOGENSCHAPTER 26: NONLINEAR LOW-DOSE EXTRAPOLATIONS; CHAPTER 27: CANCER RISK ASSESSMENT: MORE UNCERTAIN THAN WE THOUGHT; CHAPTER 28: COMBINING NEOPLASMS FOR EVALUATION OF RODENT CARCINOGENESIS STUDIES; CHAPTER 29: CANCER RISK BASED ON AN INDIVIDUAL TUMOR TYPE OR SUMMING OF TUMORS; CHAPTER 30: EXPOSURE RECONSTRUCTION AND CANCER RISK ESTIMATE DERIVATION; INDEX |
| Record Nr. | UNINA-9910139192103321 |
| Hoboken, N.J., : Wiley, c2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cancer risk assessment [[electronic resource] ] : chemical carcinogenesis, hazard evaluation, and risk quantification / / edited by Ching-Hung Hsu, Todd Stedeford
| Cancer risk assessment [[electronic resource] ] : chemical carcinogenesis, hazard evaluation, and risk quantification / / edited by Ching-Hung Hsu, Todd Stedeford |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2010 |
| Descrizione fisica | 1 online resource (858 p.) |
| Disciplina |
616.99/4071
616.994071 |
| Altri autori (Persone) |
HsuChing-Hung
StedefordTodd |
| Soggetto topico |
Carcinogens
Health risk assessment |
| ISBN |
1-118-03512-7
1-282-68335-7 9786612683350 0-470-62272-5 0-470-62271-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
CANCER RISK ASSESSMENT: Chemical Carcinogenesis, Hazard Evaluation, and Risk Quantification; CONTENTS; PREFACE; CONTRIBUTORS; ABBREVIATIONS AND ACRONYMS; PART I: CANCER RISK ASSESSMENT, SCIENCE POLICY, AND REGULATORY FRAMEWORKS; CHAPTER 1: CANCER RISK ASSESSMENT; CHAPTER 2: SCIENCE POLICY AND CANCER RISK ASSESSMENT; CHAPTER 3: HAZARD AND RISK ASSESSMENT OF CHEMICAL CARCINOGENICITY WITHIN A REGULATORY CONTEXT; CHAPTER 4: USE OF CANCER RISK ASSESSMENTS IN DETERMINATION OF REGULATORY STANDARDS; PART II: CANCER BIOLOGY AND TOXICOLOGY; CHAPTER 5: THE INTERPLAY OF CANCER AND BIOLOGY
CHAPTER 6: CHEMICAL CARCINOGENESIS: A BRIEF HISTORY OF ITS CONCEPTS WITH A FOCUS ON POLYCYCLIC AROMATIC HYDROCARBONSCHAPTER 7: HORMESIS AND CANCER RISKS: ISSUES AND RESOLUTION; CHAPTER 8: THRESHOLDS FOR GENOTOXIC CARCINOGENS: EVIDENCE FROM MECHANISM-BASED CARCINOGENICITY STUDIES; PART III: GENETIC TOXICOLOGY, TESTING GUIDELINES AND REGULATIONS, AND NOVEL ASSAYS; CHAPTER 9: DEVELOPMENT OF GENETIC TOXICOLOGY TESTING AND ITS INCORPORATION INTO REGULATORY HEALTH EFFECTS TEST REQUIREMENTS; CHAPTER 10: GENETIC TOXICOLOGY TESTING GUIDELINES AND REGULATIONS; CHAPTER 11: IN VITRO GENOTOX ASSAYS CHAPTER 12: IN VIVO GENOTOXICITY ASSAYSPART IV: ASSESSING THE HUMAN RELEVANCE OF CHEMICAL-INDUCED TUMORS; CHAPTER 13: FRAMEWORK ANALYSIS FOR DETERMINING MODE OF ACTION AND HUMAN RELEVANCE; CHAPTER 14: EXPERIMENTAL ANIMAL STUDIES AND CARCINOGENICITY; CHAPTER 15: CANCER EPIDEMIOLOGY; CHAPTER 16: RODENT HEPATOCARCINOGENESIS; CHAPTER 17: MODE OF ACTION ANALYSIS AND HUMAN RELEVANCE OF LIVER TUMORS INDUCED BY PPAR a ACTIVATION; CHAPTER 18: ALPHA 2U-GLOBULIN NEPHROPATHY AND CHRONIC PROGRESSIVE NEPHROPATHY AS MODES OF ACTION FOR RENAL TUBULE TUMOR INDUCTION IN RATS, AND THEIR POSSIBLE INTERACTION CHAPTER 19: URINARY TRACT CALCULI AND BLADDER TUMORSPART V: METHODS FOR INFORMING CANCER RISK QUANTIFICATION; CHAPTER 20: (Q) SAR ANALYSIS OF GENOTOXIC AND NONGENOTOXIC CARCINOGENS: A STATE-OF-THE-ART OVERVIEW; CHAPTER 21: PHYSIOLOGICALLY BASED PHARMACOKINETIC (PBPK) MODELS IN CANCER RISK ASSESSMENT; CHAPTER 22: GENOMICS AND ITS ROLE IN CANCER RISK ASSESSMENT; CHAPTER 23: COMPUTATIONAL TOXICOLOGY IN CANCER RISK ASSESSMENT; PART VI: GENERAL APPROACHES FOR QUANTIFYING CANCER RISKS; CHAPTER 24: LINEAR LOW-DOSE EXTRAPOLATIONS CHAPTER 25: QUANTITATIVE CANCER RISK ASSESSMENT OF NONGENOTOXIC CARCINOGENSCHAPTER 26: NONLINEAR LOW-DOSE EXTRAPOLATIONS; CHAPTER 27: CANCER RISK ASSESSMENT: MORE UNCERTAIN THAN WE THOUGHT; CHAPTER 28: COMBINING NEOPLASMS FOR EVALUATION OF RODENT CARCINOGENESIS STUDIES; CHAPTER 29: CANCER RISK BASED ON AN INDIVIDUAL TUMOR TYPE OR SUMMING OF TUMORS; CHAPTER 30: EXPOSURE RECONSTRUCTION AND CANCER RISK ESTIMATE DERIVATION; INDEX |
| Record Nr. | UNINA-9910830822503321 |
| Hoboken, N.J., : Wiley, c2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cancer symptom science : measurement, mechanisms, and management / / edited by Charles S. Cleeland, Michael J. Fisch [and] Adrian Dunn [[electronic resource]]
| Cancer symptom science : measurement, mechanisms, and management / / edited by Charles S. Cleeland, Michael J. Fisch [and] Adrian Dunn [[electronic resource]] |
| Pubbl/distr/stampa | Cambridge : , : Cambridge University Press, , 2011 |
| Descrizione fisica | 1 online resource (xvii, 356 pages) : digital, PDF file(s) |
| Disciplina | 616.99/4071 |
| Collana | Cambridge medicine Cancer symptom science |
| Soggetto topico |
Cancer - Pathophysiology
Symptoms |
| ISBN |
1-107-21867-5
0-511-85175-8 1-282-91852-4 9786612918520 0-511-91806-2 0-511-78086-9 0-511-91527-6 0-511-91904-2 0-511-91348-6 0-511-91708-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Machine generated contents note: Preface; Foreword; Part I. Introduction: 1. Introduction to Cancer Symptom Science Charles S. Cleeland, Adrian J. Dunn and Michael J. Fisch; 2. Researching the mechanisms underlying the symptoms of patients with cancer Adrian J. Dunn; 3. Cytokines, sickness behavior: a model for cancer symptoms Steven S. Zalcman, Randall T. Woodruff, Ruchika Mohla and Allan Siegal; Part II. Cancer Symptom Mechanisms and Models: Clinical and Basic Science: 4. The clinical science of cancer pain assessment and management Russell K. Portenoy and Victor T. Chang; 5. Pain: basic science: 5a. Mechanisms of disease-related pain in cancer: insights from the study of bone tumors Patrick W. Mantyh and Juan Miguel Jimenez Andrade; 5b. Neuropathic pain: basic science Patrick M. Dougherty and Haijun Zhang; 6. Cognitive dysfunction: is chemobrain real? Christina A. Meyers and Jeffrey S. Wefel; 7. Cognitive impairment: basic science Perry N. Fuchs, Jessica A. Boyette-Davis and Adrian J. Dunn; 8. Depression in cancer: pathophysiology at the mind-body interface Andrew H. Miller, Michael A. Burke and Charles L. Raison; 9. Depressive illness: basic science: 9a. Animal models of depressed mood and sickness behavior Adrian J. Dunn; 9b. From inflammation to sickness and depression: the cytokine connection Robert Dantzer and Keith W. Kelly; 10. Cancer-related fatigue: clinical science Xin Shelley Wang; 11. Developing translational animal models of cancer-related fatigue Mary W. Meagher; 12. Cancer anorexia/weight loss syndrome Aminah Jatoi and Nisha Lassi; 13. Appetite loss/cachexia: basic science Tristin D. Brisbois-Clarkson, Wendy V. Wismer and Vickie E. Baracos; 14. Sleep and its disorders: clinical science Sofia Ancoli-Israel and Lianqi Liu; 15. Sleep and its disorders Mark R. Opp and Luca Imeri; 16. Proteins and symptoms Bang-Ning Lee and James M. Reuben; 17. Genetic approaches to treating and preventing symptoms in patients with cancer Quiling Shi and Charles S. Cleeland; 18. Functional imaging of symptoms T. Dorina Papageorgiou, Edward F. Jackson and Javier O. Valenzuela; 19. High-dose therapy and posttransplantation symptom burden: striking a balance Sergio A. Giralt and Loretta A. Williams; Part III. Clinical Perspectives in Symptom Management and Research: 20. Promoting symptom research in cooperative groups Lynne I. Wagner and David Cella; 21. Practical aspects of symptom management in patients with cancer Richard T. Lee and Michael J. Fisch; Part IV. Symptom Measurement: 22. Symptom measurement by patient report Charles S. Cleeland and Tito R. Mendoza; 23. The economics of cancer-related symptoms: valuing supportive care interventions Lesley-Ann Miller and Jane C. Weeks; 24. Longitudinal models for symptoms Diane L. Fairclough; 25. Bayesian adaptive design: a new approach to test the effectiveness of symptom-reducing agents using patient-reported outcomes Valen E. Johnson and Tito R. Mendoza; Part V. Government and Industry Perspectives: 26. Promoting cancer symptom science research Ann O'Mara and Maria Sgambati; 27. Developing symptom management drugs Joanna M. Brell and Lori M. Minasian; 28. Cancer-related symptoms: issues for consideration in drug and therapeutic biological product label claims in the United States Jane A. Scott; 29. Symptom research: looking ahead Charles S. Cleeland, Adrian J. Dunn and Michael J. Fisch; Index. |
| Record Nr. | UNINA-9910459096203321 |
| Cambridge : , : Cambridge University Press, , 2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cancer symptom science : measurement, mechanisms, and management / / edited by Charles S. Cleeland, Michael J. Fisch [and] Adrian Dunn [[electronic resource]]
| Cancer symptom science : measurement, mechanisms, and management / / edited by Charles S. Cleeland, Michael J. Fisch [and] Adrian Dunn [[electronic resource]] |
| Pubbl/distr/stampa | Cambridge : , : Cambridge University Press, , 2011 |
| Descrizione fisica | 1 online resource (xvii, 356 pages) : digital, PDF file(s) |
| Disciplina | 616.99/4071 |
| Collana | Cambridge medicine Cancer symptom science |
| Soggetto topico |
Cancer - Pathophysiology
Symptoms |
| ISBN |
1-107-21867-5
0-511-85175-8 1-282-91852-4 9786612918520 0-511-91806-2 0-511-78086-9 0-511-91527-6 0-511-91904-2 0-511-91348-6 0-511-91708-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Machine generated contents note: Preface; Foreword; Part I. Introduction: 1. Introduction to Cancer Symptom Science Charles S. Cleeland, Adrian J. Dunn and Michael J. Fisch; 2. Researching the mechanisms underlying the symptoms of patients with cancer Adrian J. Dunn; 3. Cytokines, sickness behavior: a model for cancer symptoms Steven S. Zalcman, Randall T. Woodruff, Ruchika Mohla and Allan Siegal; Part II. Cancer Symptom Mechanisms and Models: Clinical and Basic Science: 4. The clinical science of cancer pain assessment and management Russell K. Portenoy and Victor T. Chang; 5. Pain: basic science: 5a. Mechanisms of disease-related pain in cancer: insights from the study of bone tumors Patrick W. Mantyh and Juan Miguel Jimenez Andrade; 5b. Neuropathic pain: basic science Patrick M. Dougherty and Haijun Zhang; 6. Cognitive dysfunction: is chemobrain real? Christina A. Meyers and Jeffrey S. Wefel; 7. Cognitive impairment: basic science Perry N. Fuchs, Jessica A. Boyette-Davis and Adrian J. Dunn; 8. Depression in cancer: pathophysiology at the mind-body interface Andrew H. Miller, Michael A. Burke and Charles L. Raison; 9. Depressive illness: basic science: 9a. Animal models of depressed mood and sickness behavior Adrian J. Dunn; 9b. From inflammation to sickness and depression: the cytokine connection Robert Dantzer and Keith W. Kelly; 10. Cancer-related fatigue: clinical science Xin Shelley Wang; 11. Developing translational animal models of cancer-related fatigue Mary W. Meagher; 12. Cancer anorexia/weight loss syndrome Aminah Jatoi and Nisha Lassi; 13. Appetite loss/cachexia: basic science Tristin D. Brisbois-Clarkson, Wendy V. Wismer and Vickie E. Baracos; 14. Sleep and its disorders: clinical science Sofia Ancoli-Israel and Lianqi Liu; 15. Sleep and its disorders Mark R. Opp and Luca Imeri; 16. Proteins and symptoms Bang-Ning Lee and James M. Reuben; 17. Genetic approaches to treating and preventing symptoms in patients with cancer Quiling Shi and Charles S. Cleeland; 18. Functional imaging of symptoms T. Dorina Papageorgiou, Edward F. Jackson and Javier O. Valenzuela; 19. High-dose therapy and posttransplantation symptom burden: striking a balance Sergio A. Giralt and Loretta A. Williams; Part III. Clinical Perspectives in Symptom Management and Research: 20. Promoting symptom research in cooperative groups Lynne I. Wagner and David Cella; 21. Practical aspects of symptom management in patients with cancer Richard T. Lee and Michael J. Fisch; Part IV. Symptom Measurement: 22. Symptom measurement by patient report Charles S. Cleeland and Tito R. Mendoza; 23. The economics of cancer-related symptoms: valuing supportive care interventions Lesley-Ann Miller and Jane C. Weeks; 24. Longitudinal models for symptoms Diane L. Fairclough; 25. Bayesian adaptive design: a new approach to test the effectiveness of symptom-reducing agents using patient-reported outcomes Valen E. Johnson and Tito R. Mendoza; Part V. Government and Industry Perspectives: 26. Promoting cancer symptom science research Ann O'Mara and Maria Sgambati; 27. Developing symptom management drugs Joanna M. Brell and Lori M. Minasian; 28. Cancer-related symptoms: issues for consideration in drug and therapeutic biological product label claims in the United States Jane A. Scott; 29. Symptom research: looking ahead Charles S. Cleeland, Adrian J. Dunn and Michael J. Fisch; Index. |
| Record Nr. | UNINA-9910785495303321 |
| Cambridge : , : Cambridge University Press, , 2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cancer symptom science : measurement, mechanisms, and management / / edited by Charles S. Cleeland, Michael J. Fisch [and] Adrian Dunn [[electronic resource]]
| Cancer symptom science : measurement, mechanisms, and management / / edited by Charles S. Cleeland, Michael J. Fisch [and] Adrian Dunn [[electronic resource]] |
| Pubbl/distr/stampa | Cambridge : , : Cambridge University Press, , 2011 |
| Descrizione fisica | 1 online resource (xvii, 356 pages) : digital, PDF file(s) |
| Disciplina | 616.99/4071 |
| Collana | Cambridge medicine Cancer symptom science |
| Soggetto topico |
Cancer - Pathophysiology
Symptoms |
| ISBN |
1-107-21867-5
0-511-85175-8 1-282-91852-4 9786612918520 0-511-91806-2 0-511-78086-9 0-511-91527-6 0-511-91904-2 0-511-91348-6 0-511-91708-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Machine generated contents note: Preface; Foreword; Part I. Introduction: 1. Introduction to Cancer Symptom Science Charles S. Cleeland, Adrian J. Dunn and Michael J. Fisch; 2. Researching the mechanisms underlying the symptoms of patients with cancer Adrian J. Dunn; 3. Cytokines, sickness behavior: a model for cancer symptoms Steven S. Zalcman, Randall T. Woodruff, Ruchika Mohla and Allan Siegal; Part II. Cancer Symptom Mechanisms and Models: Clinical and Basic Science: 4. The clinical science of cancer pain assessment and management Russell K. Portenoy and Victor T. Chang; 5. Pain: basic science: 5a. Mechanisms of disease-related pain in cancer: insights from the study of bone tumors Patrick W. Mantyh and Juan Miguel Jimenez Andrade; 5b. Neuropathic pain: basic science Patrick M. Dougherty and Haijun Zhang; 6. Cognitive dysfunction: is chemobrain real? Christina A. Meyers and Jeffrey S. Wefel; 7. Cognitive impairment: basic science Perry N. Fuchs, Jessica A. Boyette-Davis and Adrian J. Dunn; 8. Depression in cancer: pathophysiology at the mind-body interface Andrew H. Miller, Michael A. Burke and Charles L. Raison; 9. Depressive illness: basic science: 9a. Animal models of depressed mood and sickness behavior Adrian J. Dunn; 9b. From inflammation to sickness and depression: the cytokine connection Robert Dantzer and Keith W. Kelly; 10. Cancer-related fatigue: clinical science Xin Shelley Wang; 11. Developing translational animal models of cancer-related fatigue Mary W. Meagher; 12. Cancer anorexia/weight loss syndrome Aminah Jatoi and Nisha Lassi; 13. Appetite loss/cachexia: basic science Tristin D. Brisbois-Clarkson, Wendy V. Wismer and Vickie E. Baracos; 14. Sleep and its disorders: clinical science Sofia Ancoli-Israel and Lianqi Liu; 15. Sleep and its disorders Mark R. Opp and Luca Imeri; 16. Proteins and symptoms Bang-Ning Lee and James M. Reuben; 17. Genetic approaches to treating and preventing symptoms in patients with cancer Quiling Shi and Charles S. Cleeland; 18. Functional imaging of symptoms T. Dorina Papageorgiou, Edward F. Jackson and Javier O. Valenzuela; 19. High-dose therapy and posttransplantation symptom burden: striking a balance Sergio A. Giralt and Loretta A. Williams; Part III. Clinical Perspectives in Symptom Management and Research: 20. Promoting symptom research in cooperative groups Lynne I. Wagner and David Cella; 21. Practical aspects of symptom management in patients with cancer Richard T. Lee and Michael J. Fisch; Part IV. Symptom Measurement: 22. Symptom measurement by patient report Charles S. Cleeland and Tito R. Mendoza; 23. The economics of cancer-related symptoms: valuing supportive care interventions Lesley-Ann Miller and Jane C. Weeks; 24. Longitudinal models for symptoms Diane L. Fairclough; 25. Bayesian adaptive design: a new approach to test the effectiveness of symptom-reducing agents using patient-reported outcomes Valen E. Johnson and Tito R. Mendoza; Part V. Government and Industry Perspectives: 26. Promoting cancer symptom science research Ann O'Mara and Maria Sgambati; 27. Developing symptom management drugs Joanna M. Brell and Lori M. Minasian; 28. Cancer-related symptoms: issues for consideration in drug and therapeutic biological product label claims in the United States Jane A. Scott; 29. Symptom research: looking ahead Charles S. Cleeland, Adrian J. Dunn and Michael J. Fisch; Index. |
| Record Nr. | UNINA-9910815461503321 |
| Cambridge : , : Cambridge University Press, , 2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Carcinogens and anticarcinogens in the human diet [[electronic resource] ] : a comparison of naturally occurring and synthetic substances / / Committee on Comparative Toxicity of Naturally Occuring Carcinogens, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council
| Carcinogens and anticarcinogens in the human diet [[electronic resource] ] : a comparison of naturally occurring and synthetic substances / / Committee on Comparative Toxicity of Naturally Occuring Carcinogens, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council |
| Pubbl/distr/stampa | Washington, D.C., : National Academy Press, 1996 |
| Descrizione fisica | 1 online resource (433 p.) |
| Disciplina | 616.99/4071 |
| Soggetto topico |
Carcinogens
Food - Toxicology |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-21087-7
9786610210879 0-309-55659-7 0-585-02018-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910456088203321 |
| Washington, D.C., : National Academy Press, 1996 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Carcinogens and anticarcinogens in the human diet [[electronic resource] ] : a comparison of naturally occurring and synthetic substances / / Committee on Comparative Toxicity of Naturally Occuring Carcinogens, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council
| Carcinogens and anticarcinogens in the human diet [[electronic resource] ] : a comparison of naturally occurring and synthetic substances / / Committee on Comparative Toxicity of Naturally Occuring Carcinogens, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council |
| Pubbl/distr/stampa | Washington, D.C., : National Academy Press, 1996 |
| Descrizione fisica | 1 online resource (433 p.) |
| Disciplina | 616.99/4071 |
| Soggetto topico |
Carcinogens
Food - Toxicology |
| ISBN |
0-309-17571-2
1-280-21087-7 9786610210879 0-309-55659-7 0-585-02018-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910778659503321 |
| Washington, D.C., : National Academy Press, 1996 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Carcinogens and anticarcinogens in the human diet : a comparison of naturally occurring and synthetic substances / / Committee on Comparative Toxicity of Naturally Occuring Carcinogens, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council
| Carcinogens and anticarcinogens in the human diet : a comparison of naturally occurring and synthetic substances / / Committee on Comparative Toxicity of Naturally Occuring Carcinogens, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Washington, D.C., : National Academy Press, 1996 |
| Descrizione fisica | 1 online resource (433 p.) |
| Disciplina | 616.99/4071 |
| Soggetto topico |
Carcinogens
Food - Toxicology |
| ISBN |
0-309-17571-2
1-280-21087-7 9786610210879 0-309-55659-7 0-585-02018-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Carcinogens and Anticarcinogens in the Human Diet -- Copyright -- Preface -- Contents -- Executive Summary -- THE CHARGE TO THE COMMITTEE -- CONCLUSIONS -- Complexity of the Diet -- Carcinogenicity and Anticarcinogenicity -- Synthetic Versus Naturally Occurring Carcinogens -- Models for Identifying Carcinogens and Anticarcinogens -- RECOMMENDATIONS -- Epidemiologic Studies and Human Exposure -- Testing -- Dietary Factors -- FUTURE DIRECTIONS -- CLOSING REMARKS -- 1 Introduction -- STATEMENT OF TASK AND DELIBERATIONS OF THE COMMITTEE -- DEFINITIONS -- STRUCTURE OF THE REPORT -- REFERENCES -- 2 Naturally Occurring Carcinogens and Anticarcinogens in the Diet -- EXPOSURE TO NATURALLY OCCURRING CHEMICALS -- THE COMPOSITION OF FOODS -- The Major Components -- The Minor Components -- Complexity and Variability -- Toxicants and Nontoxicants -- The functional Role of the Components of Food -- Dietary Plants and Cancer -- NATURALLY OCCURRING CARCINOGENS FORMED DURING PROCESSING OR CONTAMINATION OF FOOD -- Mycotoxins -- Pyrolytic Products -- CURRENT STATE OF KNOWLEDGE OF HUMAN DIETARY CARCINOGENS -- Identifying Potential Human Dietary Carcinogens -- Constitutive Naturally Occurring Carcinogens -- Caffeic Acid -- Urethane (Ethyl Carbamate) -- Acquired Naturally Occurring Carcinogens: Aflatoxin B1 -- Derived Naturally Occurring Carcinogens -- PhIP (2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine) -- N-Nitrosodimethylamine -- CURRENT STATE OF KNOWLEDGE OF HUMAN DIETARY ANTICARCINOGENS -- EFFECT OF DIETARY MACRONUTRIENTS ON CARCINOGENESIS -- Calories -- Carbohydrates -- Fat -- Linoleic Acid -- Conjugated Linoleic Acid (CLA) -- Bile Acids and Free Fatty Acids -- Protein -- Alcohol -- EFFECT OF DIETARY MICRONUTRIENTS ON CARCINOGENESIS -- Vitamin A -- Vitamin C (Ascorbic Acid) -- Vitamin E (Tocopherols) -- Folic Acid -- Vitamin D and Calcium -- Selenium -- Iron.
ENGINEERING AN OPTIMAL DIET -- SUMMARY AND CONCLUSIONS -- REFERENCES -- 3 Synthetic Carcinogens in the Diet -- SYNTHETIC FOOD ADDITIVES -- OCCURRENCE AND EXPOSURE -- Drinking Water -- Foods -- MECHANISMS OF CARCINOGENESIS -- METABOLISM -- TOXICOLOGICAL COMPARISONS -- Nitrosamines -- Hydrazines -- Methylenedioxyphenyl Compounds -- Aromatic Amines and Related Chemicals -- Peroxisome Proliferators -- Phenolic Antioxidants -- Sodium Salts and Rodent Urinary Tract Carcinogenesis -- α2u-Globulin Binding Compounds -- SUMMARY AND CONCLUSIONS -- REFERENCES -- 4 Methods for Evaluating Potential Carcinogens and Anticarcinogens -- METHODS FOR EVALUATING CHEMICAL CARCINOGENESIS -- Studies in Human Populations -- Epidemiology -- Molecular Epidemiology -- Genetic Markers of Susceptibility -- Biologic Markers of Internal Dose -- Biologic Markers of Biologically Effective Dose -- Early Biological Responses and Gene Mutations -- Other Types of Biologic Markers -- Screening Tests in Model Systems -- Structure-Activity Analyses -- Short-Term Tests -- Rodent Carcinogenicity Assays -- COMPARISON OF METHODS FOR EVALUATING NATURAL AND SYNTHETIC CARCINOGENS -- CRITERIA FOR SELECTING AND TESTING -- Carcinogens -- Anticarcinogens -- SUMMARY AND CONCLUSIONS -- REFERENCES -- 5 Risk Comparisons -- MONITORING FOOD CONSUMPTION -- Sources of Information -- Sources of Variation in Food Composition and Consumption -- Factors Affecting Susceptibility -- DIETARY EXPOSURE TO POTENTIAL CARCINOGENS AND ANTICARCINOGENS -- Naturally Occurring Carcinogens -- Constitutive Exposures -- Derived -- Acquired -- Pass-Through -- Intentional Food Additives and Constituents of Spices -- Traditional Foods -- Synthetic Carcinogens -- Pesticide Residues in Foods -- Veterinary Drug Residues -- Packaging Materials -- Residues from Food Processing -- Direct Food Additives -- Anticarcinogens -- Fiber. Micronutrients -- Non-Nutritive Constituents -- Comparisons of Exposure Predictions for Naturally Occurring and Synthetic Carcinogens -- MEASURES OF CARCINOGENIC POTENCY -- Correlation Between Cancer Potency and Other Measures of Toxicity -- Interpretation of Carcinogenic Potency -- ESTIMATING HUMAN CANCER RISKS -- Risk-Estimation Methods -- Uncertainty Analysis -- Mechanistic Considerations -- Toxicologically Insignificant Exposure Levels -- Risks of Joint Exposures and Mixtures -- DIETARY CANCER RISKS -- Overall Impact of Diet on Cancer -- Impact of Dietary Constituents on Human Cancer -- Role of Calories and Fat -- Excess Calories -- Fat -- Risk Estimates Derived from Epidemiologic Studies -- Risk Estimates Derived from Toxicological Studies -- Apportionment of Dietary Cancer Risk -- Risks of Naturally Occurring Versus Synthetic Carcinogens in the Diet -- Potency of Naturally Occurring and Synthetic Carcinogens -- Distribution of Potency -- Interpretation of Results -- HERP Approach -- Additional Comparisons -- SUMMARY AND CONCLUSIONS -- OVERALL CONCLUSIONS -- REFERENCES -- 6 Conclusions, Recommendations, and Future Directions -- CONCLUSIONS -- Complexity of the Diet -- Carcinogenicity and Anticarcinogenicity -- Synthetic Versus Naturally Occurring Carcinogens -- Models for Identifying Carcinogens and Anticarcinogens -- RECOMMENDATIONS -- Epidemiologic Studies and Human Exposure -- Testing -- Dietary Factors -- FUTURE DIRECTIONS -- Resources -- Fundamental Mechanistic Studies -- Epidemiology -- Rodent and In Vitro Assays -- Analytic Methods in Structure-Activity Analyses -- Engineering a More Optimal Diet -- CLOSING REMARKS -- REFERENCES -- Appendix A Selected Substances in Food Subjected to Some Degree of Carcinogenicity Testing in Anima ... -- REFERENCES -- Appendix B Agents with Potential Carcinogenic Activity and Their Occurrence in the Diet. CAVEATS AND DISCLAIMERS -- TD01 ESTIMATION -- Appendix C Chemical Compounds Occurring in Dietary Plants that Have Been Reported to Inhibit Carcin. |
| Record Nr. | UNINA-9910828858003321 |
| Washington, D.C., : National Academy Press, 1996 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Diet, nutrition, and cancer [[electronic resource] /] / Committee on Diet, Nutrition, and Cancer, Assembly of Life Sciences, National Research Council
| Diet, nutrition, and cancer [[electronic resource] /] / Committee on Diet, Nutrition, and Cancer, Assembly of Life Sciences, National Research Council |
| Pubbl/distr/stampa | Washington, D.C., : National Academy Press, 1982 |
| Descrizione fisica | 1 online resource (492 p.) |
| Disciplina | 616.99/4071 |
| Soggetto topico |
Cancer - Nutritional aspects
Food habits |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-24619-7
9786610246199 0-309-56792-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910456054703321 |
| Washington, D.C., : National Academy Press, 1982 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Diet, nutrition, and cancer / / Committee on Diet, Nutrition, and Cancer, Assembly of Life Sciences, National Research Council
| Diet, nutrition, and cancer / / Committee on Diet, Nutrition, and Cancer, Assembly of Life Sciences, National Research Council |
| Pubbl/distr/stampa | Washington, D.C. : , : National Academy Press, , 1982 |
| Descrizione fisica | 1 online resource (xii, 478 pages) : illustrations |
| Disciplina | 616.99/4071 |
| Soggetto topico |
Cancer - Nutritional aspects
Food habits |
| ISBN |
1-280-24619-7
9786610246199 0-309-56792-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910778681603321 |
| Washington, D.C. : , : National Academy Press, , 1982 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
