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A comprehensive guide to toxicology in preclinical drug development [[electronic resource] /] / edited by Ali S. Faqi
| A comprehensive guide to toxicology in preclinical drug development [[electronic resource] /] / edited by Ali S. Faqi |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Amsterdam, : Elsevier, 2013 |
| Descrizione fisica | 1 online resource (903 p.) |
| Disciplina | 615.9 |
| Altri autori (Persone) | FaqiAli S |
| Soggetto topico | Drug development |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-283-70650-4
0-12-387816-0 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; A Comprehensive Guide to Toxicology in Preclinical Drug Development; Copyright; Dedication; Contents; Foreword; Contributors; Chapter1 - Introduction; Chapter2 - ADME in Drug Discovery; INTRODUCTION; ADME; USE OF PRECLINICAL ADME DATA; TWO EVOLVING TECHNOLOGIES IMPACTING ADME IN DRUG DISCOVERY; References; Chapter3 - Pharmacokinetics and Toxicokinetics; INTRODUCTION; DRUG ADMINISTRATION AND DELIVERY; INTRAVENOUS ADMINISTRATION; ABSORPTION AFTER EXTRAVASCULAR DOSING; CALCULATION OF EXPOSURE-BASED SAFETY MARGINS; PRACTICAL CONSIDERATIONS; CONCLUSIONS; References
Chapter4 - Development of Preclinical Formulations for Toxicology StudiesINTRODUCTION; ANIMAL SPECIES, SAMPLING VOLUMES AND SAMPLING SITES; DOSING ROUTE; DOSING VOLUME; FORMULATION DEVELOPMENT; PHYSICO-CHEMICAL PROPERTY CHARACTERIZATION; SOLUBILITY ENHANCEMENT; SPECIAL DOSAGE FORMS; DECISION TREE; IN VITRO EVALUATION OF THE PERFORMANCE OF A TOXICOLOGICAL STUDY; CASE STUDY; CONCLUDING REMARKS; References; Chapter5 - Acute, Sub-Acute, Sub-Chronic and Chronic General Toxicity Testing for Preclinical Drug Development; INTRODUCTION REGULATORY CONSIDERATIONS FOR CONDUCTING PRECLINICAL TOXICOLOGY STUDIESGENERAL CONSIDERATIONS FOR THE CONDUCT OF PRECLINICAL TOXICOLOGY STUDIES; STUDY TYPES USED IN THE ASSESSMENT OF GENERAL TOXICOLOGY; SPECIAL CONSIDERATIONS FOR BIOPHARMACEUTICAL SAFETY EVALUATIONS; COMMON PROTOCOL COMPONENTS OF GENERAL TOXICITY ASSESSMENTS IN GLP STUDIES; FINAL THOUGHTS; References; Chapter6 - Contemporary Practices in Core Safety Pharmacology Assessments; BACKGROUND AND OVERVIEW; SAFETY PHARMACOLOGY AS A REGULATORY SCIENCE; TEMPORAL APPLICATION OF CURRENT EXPERIMENTAL PARADIGMS CARDIOVASCULAR SYSTEM AND MODELS OF SAFETY ASSESSMENTCARDIAC ION CHANNELS AND THE HERG ASSAY; IN VIVO CARDIOVASCULAR SAFETY STUDY; RESPIRATORY SYSTEM AND MODELS OF SAFETY ASSESSMENT; CENTRAL NERVOUS SYSTEM AND MODELS OF SAFETY ASSESSMENT; APPROACHES TO TIER I CNS SAFETY EVALUATION; EVALUATING CNS SAFETY; References; Chapter7 - Genetic Toxicology Testing; INTRODUCTION; THE CONCEPT OF THRESHOLDS; GENETIC TOXICITY TESTING TO SUPPORT CLINICAL TRIALS; THE SENSITIVITY AND SPECIFICITY OF IN VITRO ASSAYS; IN VIVO CORE TESTS; OTHER IN VIVO TESTS FOR GENOTOXICITY ADDITIONAL TESTS INDICATING GENOTOXICITYGENETOX TESTING STRATEGY: DISCOVERY THROUGH DEVELOPMENT; CONCLUDING REMARKS AND FUTURE DIRECTIONS; References; Chapter8 - Clinical Pathology; INTRODUCTION; CORE CLINICAL PATHOLOGY TESTING; HEMATOLOGY; CYTOLOGICAL EVALUATION OF BONE MARROW; EMERGING BIOMARKERS AND APPLICATION WITHIN THE CLINICAL PATHOLOGY LABORATORY; CLINICAL PATHOLOGY INDICATORS OF TARGET ORGAN TOXICITY; INTERPRETATION OF CLINICAL PATHOLOGY DATA IN PRECLINICAL SAFETY STUDIES; References; Chapter9 - Best Practice in Toxicological Pathology; INTRODUCTION HISTOPATHOLOGY PROCESSES AND PROCEDURES |
| Record Nr. | UNINA-9910462231803321 |
| Amsterdam, : Elsevier, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
A comprehensive guide to toxicology in preclinical drug development [[electronic resource] /] / edited by Ali S. Faqi
| A comprehensive guide to toxicology in preclinical drug development [[electronic resource] /] / edited by Ali S. Faqi |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Amsterdam, : Elsevier, 2013 |
| Descrizione fisica | 1 online resource (903 p.) |
| Disciplina | 615.9 |
| Altri autori (Persone) | FaqiAli S |
| Soggetto topico | Drug development |
| ISBN |
1-283-70650-4
0-12-387816-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; A Comprehensive Guide to Toxicology in Preclinical Drug Development; Copyright; Dedication; Contents; Foreword; Contributors; Chapter1 - Introduction; Chapter2 - ADME in Drug Discovery; INTRODUCTION; ADME; USE OF PRECLINICAL ADME DATA; TWO EVOLVING TECHNOLOGIES IMPACTING ADME IN DRUG DISCOVERY; References; Chapter3 - Pharmacokinetics and Toxicokinetics; INTRODUCTION; DRUG ADMINISTRATION AND DELIVERY; INTRAVENOUS ADMINISTRATION; ABSORPTION AFTER EXTRAVASCULAR DOSING; CALCULATION OF EXPOSURE-BASED SAFETY MARGINS; PRACTICAL CONSIDERATIONS; CONCLUSIONS; References
Chapter4 - Development of Preclinical Formulations for Toxicology StudiesINTRODUCTION; ANIMAL SPECIES, SAMPLING VOLUMES AND SAMPLING SITES; DOSING ROUTE; DOSING VOLUME; FORMULATION DEVELOPMENT; PHYSICO-CHEMICAL PROPERTY CHARACTERIZATION; SOLUBILITY ENHANCEMENT; SPECIAL DOSAGE FORMS; DECISION TREE; IN VITRO EVALUATION OF THE PERFORMANCE OF A TOXICOLOGICAL STUDY; CASE STUDY; CONCLUDING REMARKS; References; Chapter5 - Acute, Sub-Acute, Sub-Chronic and Chronic General Toxicity Testing for Preclinical Drug Development; INTRODUCTION REGULATORY CONSIDERATIONS FOR CONDUCTING PRECLINICAL TOXICOLOGY STUDIESGENERAL CONSIDERATIONS FOR THE CONDUCT OF PRECLINICAL TOXICOLOGY STUDIES; STUDY TYPES USED IN THE ASSESSMENT OF GENERAL TOXICOLOGY; SPECIAL CONSIDERATIONS FOR BIOPHARMACEUTICAL SAFETY EVALUATIONS; COMMON PROTOCOL COMPONENTS OF GENERAL TOXICITY ASSESSMENTS IN GLP STUDIES; FINAL THOUGHTS; References; Chapter6 - Contemporary Practices in Core Safety Pharmacology Assessments; BACKGROUND AND OVERVIEW; SAFETY PHARMACOLOGY AS A REGULATORY SCIENCE; TEMPORAL APPLICATION OF CURRENT EXPERIMENTAL PARADIGMS CARDIOVASCULAR SYSTEM AND MODELS OF SAFETY ASSESSMENTCARDIAC ION CHANNELS AND THE HERG ASSAY; IN VIVO CARDIOVASCULAR SAFETY STUDY; RESPIRATORY SYSTEM AND MODELS OF SAFETY ASSESSMENT; CENTRAL NERVOUS SYSTEM AND MODELS OF SAFETY ASSESSMENT; APPROACHES TO TIER I CNS SAFETY EVALUATION; EVALUATING CNS SAFETY; References; Chapter7 - Genetic Toxicology Testing; INTRODUCTION; THE CONCEPT OF THRESHOLDS; GENETIC TOXICITY TESTING TO SUPPORT CLINICAL TRIALS; THE SENSITIVITY AND SPECIFICITY OF IN VITRO ASSAYS; IN VIVO CORE TESTS; OTHER IN VIVO TESTS FOR GENOTOXICITY ADDITIONAL TESTS INDICATING GENOTOXICITYGENETOX TESTING STRATEGY: DISCOVERY THROUGH DEVELOPMENT; CONCLUDING REMARKS AND FUTURE DIRECTIONS; References; Chapter8 - Clinical Pathology; INTRODUCTION; CORE CLINICAL PATHOLOGY TESTING; HEMATOLOGY; CYTOLOGICAL EVALUATION OF BONE MARROW; EMERGING BIOMARKERS AND APPLICATION WITHIN THE CLINICAL PATHOLOGY LABORATORY; CLINICAL PATHOLOGY INDICATORS OF TARGET ORGAN TOXICITY; INTERPRETATION OF CLINICAL PATHOLOGY DATA IN PRECLINICAL SAFETY STUDIES; References; Chapter9 - Best Practice in Toxicological Pathology; INTRODUCTION HISTOPATHOLOGY PROCESSES AND PROCEDURES |
| Record Nr. | UNINA-9910785961603321 |
| Amsterdam, : Elsevier, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
A comprehensive guide to toxicology in preclinical drug development [[electronic resource] /] / edited by Ali S. Faqi
| A comprehensive guide to toxicology in preclinical drug development [[electronic resource] /] / edited by Ali S. Faqi |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Amsterdam, : Elsevier, 2013 |
| Descrizione fisica | 1 online resource (903 p.) |
| Disciplina | 615.9 |
| Altri autori (Persone) | FaqiAli S |
| Soggetto topico | Drug development |
| ISBN |
1-283-70650-4
0-12-387816-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; A Comprehensive Guide to Toxicology in Preclinical Drug Development; Copyright; Dedication; Contents; Foreword; Contributors; Chapter1 - Introduction; Chapter2 - ADME in Drug Discovery; INTRODUCTION; ADME; USE OF PRECLINICAL ADME DATA; TWO EVOLVING TECHNOLOGIES IMPACTING ADME IN DRUG DISCOVERY; References; Chapter3 - Pharmacokinetics and Toxicokinetics; INTRODUCTION; DRUG ADMINISTRATION AND DELIVERY; INTRAVENOUS ADMINISTRATION; ABSORPTION AFTER EXTRAVASCULAR DOSING; CALCULATION OF EXPOSURE-BASED SAFETY MARGINS; PRACTICAL CONSIDERATIONS; CONCLUSIONS; References
Chapter4 - Development of Preclinical Formulations for Toxicology StudiesINTRODUCTION; ANIMAL SPECIES, SAMPLING VOLUMES AND SAMPLING SITES; DOSING ROUTE; DOSING VOLUME; FORMULATION DEVELOPMENT; PHYSICO-CHEMICAL PROPERTY CHARACTERIZATION; SOLUBILITY ENHANCEMENT; SPECIAL DOSAGE FORMS; DECISION TREE; IN VITRO EVALUATION OF THE PERFORMANCE OF A TOXICOLOGICAL STUDY; CASE STUDY; CONCLUDING REMARKS; References; Chapter5 - Acute, Sub-Acute, Sub-Chronic and Chronic General Toxicity Testing for Preclinical Drug Development; INTRODUCTION REGULATORY CONSIDERATIONS FOR CONDUCTING PRECLINICAL TOXICOLOGY STUDIESGENERAL CONSIDERATIONS FOR THE CONDUCT OF PRECLINICAL TOXICOLOGY STUDIES; STUDY TYPES USED IN THE ASSESSMENT OF GENERAL TOXICOLOGY; SPECIAL CONSIDERATIONS FOR BIOPHARMACEUTICAL SAFETY EVALUATIONS; COMMON PROTOCOL COMPONENTS OF GENERAL TOXICITY ASSESSMENTS IN GLP STUDIES; FINAL THOUGHTS; References; Chapter6 - Contemporary Practices in Core Safety Pharmacology Assessments; BACKGROUND AND OVERVIEW; SAFETY PHARMACOLOGY AS A REGULATORY SCIENCE; TEMPORAL APPLICATION OF CURRENT EXPERIMENTAL PARADIGMS CARDIOVASCULAR SYSTEM AND MODELS OF SAFETY ASSESSMENTCARDIAC ION CHANNELS AND THE HERG ASSAY; IN VIVO CARDIOVASCULAR SAFETY STUDY; RESPIRATORY SYSTEM AND MODELS OF SAFETY ASSESSMENT; CENTRAL NERVOUS SYSTEM AND MODELS OF SAFETY ASSESSMENT; APPROACHES TO TIER I CNS SAFETY EVALUATION; EVALUATING CNS SAFETY; References; Chapter7 - Genetic Toxicology Testing; INTRODUCTION; THE CONCEPT OF THRESHOLDS; GENETIC TOXICITY TESTING TO SUPPORT CLINICAL TRIALS; THE SENSITIVITY AND SPECIFICITY OF IN VITRO ASSAYS; IN VIVO CORE TESTS; OTHER IN VIVO TESTS FOR GENOTOXICITY ADDITIONAL TESTS INDICATING GENOTOXICITYGENETOX TESTING STRATEGY: DISCOVERY THROUGH DEVELOPMENT; CONCLUDING REMARKS AND FUTURE DIRECTIONS; References; Chapter8 - Clinical Pathology; INTRODUCTION; CORE CLINICAL PATHOLOGY TESTING; HEMATOLOGY; CYTOLOGICAL EVALUATION OF BONE MARROW; EMERGING BIOMARKERS AND APPLICATION WITHIN THE CLINICAL PATHOLOGY LABORATORY; CLINICAL PATHOLOGY INDICATORS OF TARGET ORGAN TOXICITY; INTERPRETATION OF CLINICAL PATHOLOGY DATA IN PRECLINICAL SAFETY STUDIES; References; Chapter9 - Best Practice in Toxicological Pathology; INTRODUCTION HISTOPATHOLOGY PROCESSES AND PROCEDURES |
| Record Nr. | UNINA-9910811688603321 |
| Amsterdam, : Elsevier, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Comprehensive toxicology [Risorsa elettronica] / editor-in-chief Charlene A. McQueen
| Comprehensive toxicology [Risorsa elettronica] / editor-in-chief Charlene A. McQueen |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | [s.l.] : Elsevier [distributor], c2010 |
| Disciplina | 615.9 |
| ISBN | 9780080468846 |
| Formato | Risorse elettroniche  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-990009836070403321 |
| [s.l.] : Elsevier [distributor], c2010 | ||
| Risorse elettroniche | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Comprehensive toxicology / editor-in-chief, Charlene A. McQueen
| Comprehensive toxicology / editor-in-chief, Charlene A. McQueen |
| Edizione | [2. ed.] |
| Pubbl/distr/stampa | Amsterdam, : Elsevier Science, 2010 |
| Descrizione fisica | Testo elettronico (PDF) (14 volumi, 6448 p.) |
| Disciplina | 615.9 |
| Soggetto topico | Tossicologia |
| ISBN | 978-0-08-046884-6 |
| Formato | Risorse elettroniche |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-996400849703316 |
| Amsterdam, : Elsevier Science, 2010 | ||
| Risorse elettroniche | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Comprehensive toxicology / / editor-in-chief, Charlene A. McQueen
| Comprehensive toxicology / / editor-in-chief, Charlene A. McQueen |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Amsterdam, : Elsevier/Academic Press, 2010 |
| Descrizione fisica | 1 online resource (14 volumes (various pagings)) : illustrations (some color) |
| Disciplina | 615.9 |
| Collana | Gale eBooks |
| Soggetto topico | Toxicology |
| ISBN |
1-78034-561-5
1-282-95370-2 9786612953705 0-08-046884-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | v. 1. General principles -- v. 2. Cellular and molecular toxicology -- v. 3. Toxicology testing and evaluation -- v. 4. Biotransformaton -- v. 5. Immune system toxicology -- v. 6. Cardiovascular toxicology -- v. 7. Renal toxicology -- v. 8. Respiratory toxicology -- v. 9. Hepatic toxicology -- v. 10. Gastrointestinal toxicology -- v. 11. Reproductive and endocrine toxicology -- v. 12. Developmental toxicology. |
| Record Nr. | UNINA-9910141040903321 |
| Amsterdam, : Elsevier/Academic Press, 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Computational toxicology [[electronic resource] ] : risk assessment for pharmaceutical and environmental chemicals / / edited by Sean Ekins
| Computational toxicology [[electronic resource] ] : risk assessment for pharmaceutical and environmental chemicals / / edited by Sean Ekins |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley-Interscience, c2007 |
| Descrizione fisica | 1 online resource (855 p.) |
| Disciplina |
615.9
615.9001/5118 |
| Altri autori (Persone) | EkinsSean |
| Collana | Wiley series on technologies for the pharmaceutical industry |
| Soggetto topico |
Toxicology - Mathematical models
Toxicology - Computer simulation QSAR (Biochemistry) |
| ISBN |
1-280-91669-9
9786610916696 0-470-14589-7 0-470-14588-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
COMPUTATIONAL TOXICOLOGY; CONTENTS; SERIES INTRODUCTION; PREFACE; ACKNOWLEDGMENTS; CONTRIBUTORS; PART I INTRODUCTION TO TOXICOLOGY METHODS; 1 An Introduction to Toxicology and Its Methodologies; 2 In vitro Toxicology: Bringing the In silico and In vivo Worlds Closer; 3 Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling; 4 Species Differences in Receptor-Mediated Gene Regulation; 5 Toxicogenomics and Systems Toxicology; PART II COMPUTATIONAL METHODS; 6 Toxicoinformatics: An Introduction
7 Computational Approaches for Assessment of Toxicity: A Historical Perspective and Current Status8 Current QSAR Techniques for Toxicology; PART III APPLYING COMPUTERS TO TOXICOLOGY ASSESSMENT: PHARMACEUTICAL; 9 The Prediction of Physicochemical Properties; 10 Applications of QSAR to Enzymes Involved in Toxicology; 11 QSAR Studies on Drug Transporters Involved in Toxicology; 12 Computational Modeling of Receptor-Mediated Toxicity; 13 Applications of QSAR Methods to Ion Channels; 14 Predictive Mutagenicity Computer Models 15 Novel Applications of Kernel-Partial Least Squares to Modeling a Comprehensive Array of Properties for Drug Discovery16 Homology Models Applied to Toxicology; 17 Crystal Structures of Toxicology Targets; 18 Expert Systems; 19 Strategies for Using Computational Toxicology Methods in Pharmaceutical R&D; 20 Application of Interpretable Models to ADME/TOX Problems; PART IV APPLYING COMPUTERS TO TOXICOLOGY ASSESSMENT: ENVIRONMENTAL; 21 The Toxicity and Risk of Chemical Mixtures; 22 Environmental and Ecological Toxicology: Computational Risk Assessment 23 Application of QSARs in Aquatic Toxicology24 Dermatotoxicology: Computational Risk Assessment; PART V NEW TECHNOLOGIES FOR TOXICOLOGY: FUTURE AND REGULATORY PERSPECTIVES; 25 Novel Cell Culture Systems: Nano and Microtechnology for Toxicology; 26 Future of Computational Toxicology: Broad Application into Human Disease and Therapeutics; 27 Computational Tools for Regulatory Needs; INDEX |
| Record Nr. | UNINA-9910143688003321 |
| Hoboken, N.J., : Wiley-Interscience, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Computational toxicology [[electronic resource] ] : risk assessment for pharmaceutical and environmental chemicals / / edited by Sean Ekins
| Computational toxicology [[electronic resource] ] : risk assessment for pharmaceutical and environmental chemicals / / edited by Sean Ekins |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley-Interscience, c2007 |
| Descrizione fisica | 1 online resource (855 p.) |
| Disciplina |
615.9
615.9001/5118 |
| Altri autori (Persone) | EkinsSean |
| Collana | Wiley series on technologies for the pharmaceutical industry |
| Soggetto topico |
Toxicology - Mathematical models
Toxicology - Computer simulation QSAR (Biochemistry) |
| ISBN |
1-280-91669-9
9786610916696 0-470-14589-7 0-470-14588-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
COMPUTATIONAL TOXICOLOGY; CONTENTS; SERIES INTRODUCTION; PREFACE; ACKNOWLEDGMENTS; CONTRIBUTORS; PART I INTRODUCTION TO TOXICOLOGY METHODS; 1 An Introduction to Toxicology and Its Methodologies; 2 In vitro Toxicology: Bringing the In silico and In vivo Worlds Closer; 3 Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling; 4 Species Differences in Receptor-Mediated Gene Regulation; 5 Toxicogenomics and Systems Toxicology; PART II COMPUTATIONAL METHODS; 6 Toxicoinformatics: An Introduction
7 Computational Approaches for Assessment of Toxicity: A Historical Perspective and Current Status8 Current QSAR Techniques for Toxicology; PART III APPLYING COMPUTERS TO TOXICOLOGY ASSESSMENT: PHARMACEUTICAL; 9 The Prediction of Physicochemical Properties; 10 Applications of QSAR to Enzymes Involved in Toxicology; 11 QSAR Studies on Drug Transporters Involved in Toxicology; 12 Computational Modeling of Receptor-Mediated Toxicity; 13 Applications of QSAR Methods to Ion Channels; 14 Predictive Mutagenicity Computer Models 15 Novel Applications of Kernel-Partial Least Squares to Modeling a Comprehensive Array of Properties for Drug Discovery16 Homology Models Applied to Toxicology; 17 Crystal Structures of Toxicology Targets; 18 Expert Systems; 19 Strategies for Using Computational Toxicology Methods in Pharmaceutical R&D; 20 Application of Interpretable Models to ADME/TOX Problems; PART IV APPLYING COMPUTERS TO TOXICOLOGY ASSESSMENT: ENVIRONMENTAL; 21 The Toxicity and Risk of Chemical Mixtures; 22 Environmental and Ecological Toxicology: Computational Risk Assessment 23 Application of QSARs in Aquatic Toxicology24 Dermatotoxicology: Computational Risk Assessment; PART V NEW TECHNOLOGIES FOR TOXICOLOGY: FUTURE AND REGULATORY PERSPECTIVES; 25 Novel Cell Culture Systems: Nano and Microtechnology for Toxicology; 26 Future of Computational Toxicology: Broad Application into Human Disease and Therapeutics; 27 Computational Tools for Regulatory Needs; INDEX |
| Record Nr. | UNINA-9910829834103321 |
| Hoboken, N.J., : Wiley-Interscience, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Computational toxicology [[electronic resource] ] : risk assessment for pharmaceutical and environmental chemicals / / edited by Sean Ekins
| Computational toxicology [[electronic resource] ] : risk assessment for pharmaceutical and environmental chemicals / / edited by Sean Ekins |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley-Interscience, c2007 |
| Descrizione fisica | 1 online resource (855 p.) |
| Disciplina |
615.9
615.9001/5118 |
| Altri autori (Persone) | EkinsSean |
| Collana | Wiley series on technologies for the pharmaceutical industry |
| Soggetto topico |
Toxicology - Mathematical models
Toxicology - Computer simulation QSAR (Biochemistry) |
| ISBN |
1-280-91669-9
9786610916696 0-470-14589-7 0-470-14588-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
COMPUTATIONAL TOXICOLOGY; CONTENTS; SERIES INTRODUCTION; PREFACE; ACKNOWLEDGMENTS; CONTRIBUTORS; PART I INTRODUCTION TO TOXICOLOGY METHODS; 1 An Introduction to Toxicology and Its Methodologies; 2 In vitro Toxicology: Bringing the In silico and In vivo Worlds Closer; 3 Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling; 4 Species Differences in Receptor-Mediated Gene Regulation; 5 Toxicogenomics and Systems Toxicology; PART II COMPUTATIONAL METHODS; 6 Toxicoinformatics: An Introduction
7 Computational Approaches for Assessment of Toxicity: A Historical Perspective and Current Status8 Current QSAR Techniques for Toxicology; PART III APPLYING COMPUTERS TO TOXICOLOGY ASSESSMENT: PHARMACEUTICAL; 9 The Prediction of Physicochemical Properties; 10 Applications of QSAR to Enzymes Involved in Toxicology; 11 QSAR Studies on Drug Transporters Involved in Toxicology; 12 Computational Modeling of Receptor-Mediated Toxicity; 13 Applications of QSAR Methods to Ion Channels; 14 Predictive Mutagenicity Computer Models 15 Novel Applications of Kernel-Partial Least Squares to Modeling a Comprehensive Array of Properties for Drug Discovery16 Homology Models Applied to Toxicology; 17 Crystal Structures of Toxicology Targets; 18 Expert Systems; 19 Strategies for Using Computational Toxicology Methods in Pharmaceutical R&D; 20 Application of Interpretable Models to ADME/TOX Problems; PART IV APPLYING COMPUTERS TO TOXICOLOGY ASSESSMENT: ENVIRONMENTAL; 21 The Toxicity and Risk of Chemical Mixtures; 22 Environmental and Ecological Toxicology: Computational Risk Assessment 23 Application of QSARs in Aquatic Toxicology24 Dermatotoxicology: Computational Risk Assessment; PART V NEW TECHNOLOGIES FOR TOXICOLOGY: FUTURE AND REGULATORY PERSPECTIVES; 25 Novel Cell Culture Systems: Nano and Microtechnology for Toxicology; 26 Future of Computational Toxicology: Broad Application into Human Disease and Therapeutics; 27 Computational Tools for Regulatory Needs; INDEX |
| Record Nr. | UNINA-9910841408603321 |
| Hoboken, N.J., : Wiley-Interscience, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Consilium de universali praeservatione contra venena / Pietro Tommasi ; traduzione e commento di Emanuele Djalma Vitali
| Consilium de universali praeservatione contra venena / Pietro Tommasi ; traduzione e commento di Emanuele Djalma Vitali |
| Autore | Tommasi, Pietro |
| Pubbl/distr/stampa | Roma, : Arti Grafiche Cossidente, 1963 |
| Descrizione fisica | XII, 125 p., [1] c. di tav. ; 24 cm |
| Disciplina | 615.9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione |
ita
lat |
| Record Nr. | UNICAS-RML0305934 |
Tommasi, Pietro
|
||
| Roma, : Arti Grafiche Cossidente, 1963 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Cassino | ||
| ||
