Info
- Utilizzare la checkbox di selezione a fianco di ciascun documento per attivare le funzionalità di stampa, invio email, download nei formati disponibili del (i) record.
Drug delivery [[electronic resource] ] : engineering principles for drug therapy / / W. Mark Saltzman
| Drug delivery [[electronic resource] ] : engineering principles for drug therapy / / W. Mark Saltzman |
| Autore | Saltzman W. Mark |
| Pubbl/distr/stampa | Oxford [England] ; ; New York, : Oxford University Press, 2001 |
| Descrizione fisica | 1 online resource (385 p.) |
| Disciplina | 615/.7 |
| Collana | Topics in chemical engineering |
| Soggetto topico |
Drug delivery systems
Biomedical materials |
| Soggetto genere / forma | Electronic books. |
| ISBN |
0-19-756050-4
1-62870-158-7 1-280-44217-4 9786610442171 1-4237-5766-1 0-19-802469-X 1-60129-952-4 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; 1 Introduction; 2 Drug administration and drug effectiveness; 3 Diffusion and drug dispersion; 4 Diffusion in biological systems; 5 Drug permeation through biological barriers; 6 Drug transport by fluid motion; 7 Pharmacokinetics of drug distribution; 8 Drug modification; 9 Controlled drug delivery systems; 10 Case studies in drug delivery; 11 Postscript; Appendix A: Overview of polymeric biomaterials; A.1 Non-degradable polymers; A.2 Biodegradable polymers; A.3 Water-soluble polymers; Appendix B: Useful data and nomenclature; B.1 Physiological parameters; B.2 Cardiovascular system
B.3 Clinical chemistryB.4 Permeation and diffusion; B.5 Protein properties; B.6 Mathematical tables and functions; B.7 Nomenclature; Index; A; B; C; D; E; F; G; H; I; K; L; M; N; O; P; R; S; T; V; W |
| Record Nr. | UNINA-9910458546803321 |
Saltzman W. Mark
|
||
| Oxford [England] ; ; New York, : Oxford University Press, 2001 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drug disposition and pharmacokinetics : from principles to applications / / Stephen H. Curry, Robin Whelpton
| Drug disposition and pharmacokinetics : from principles to applications / / Stephen H. Curry, Robin Whelpton |
| Autore | Curry Stephen H. |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Chichester, West Sussex, England : , : Wiley-Blackwell, , 2011 |
| Descrizione fisica | 1 online resource (840 p.) |
| Disciplina |
615.7
615/.7 |
| Soggetto topico |
Pharmacokinetics
Biopharmaceutics Drugs - Metabolism |
| Soggetto genere / forma | Electronic books. |
| ISBN |
0-470-66522-X
0-470-66519-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Title; Copyright; Preface; About the Authors; 1: Chemical Introduction: Sources, Classification and Chemical Properties of Drugs; 1.1 Introduction; 1.2 Drug nomenclature and classification; 1.3 Properties of molecules; 1.4 Physicochemical interactions between drugs and other chemicals; 1.5 Law of mass action; 1.6 Ionization; 1.7 Partition coefficients; 1.8 Stereochemistry; Further reading and references; 2: Drug Administration and Distribution; 2.1 Introduction; 2.2 Drug transfer across biological membranes; 2.3 Drug administration; 2.4 Drug distribution; 2.5 Plasma protein binding
2.6 SummaryReferences and further reading; 3: Drug Elimination; 3.1 Introduction; 3.2 Metabolism; 3.3 Excretion; References and further reading; 4: Elementary Pharmacokinetics; 4.1 Introduction; 4.2 Single-compartment models; 4.3 Non-linear kinetics; 4.4 Relationship between dose, onset and duration of effect; 4.5 Limitations of single-compartment models; 4.6 Summary; References and further reading; 5: More Complex and Model Independent Pharmacokinetic Models; 5.1 Introduction; 5.2 Multiple compartment models; 5.3 Curve fitting and choice of most appropriate model 5.4 Model independent approaches5.5 Population pharmacokinetics; 5.6 Summary; References and further reading; 6: Kinetics of Metabolism and Excretion; 6.1 Introduction; 6.2 Metabolite kinetics; 6.3 Renal excretion; 6.4 Excretion in faeces; References and further reading; 7: Further Consideration of Clearance, and Physiological Modelling; 7.1 Introduction; 7.2 Clearance in vitro (metabolic stability); 7.3 Clearance in vivo; 7.4 Hepatic intrinsic clearance; 7.5 In vitro to in vivo extrapolation; 7.6 Limiting values of clearance; 7.7 Safe and effective use of clearance 7.8 Physiological modelling7.9 Inhomogeneity of plasma; References and further reading; 8: Drug Formulation: Bioavailability, Bioequivalence and Controlled-Release Preparations; 8.1 Introduction; 8.2 Dissolution; 8.3 Systemic availability; 8.4 Formulation factors affecting bioavailability; 8.5 Bioequivalence; 8.6 Controlled-release preparations; 8.7 Conclusions; References and further reading; 9: Factors Affecting Plasma Concentrations; 9.1 Introduction; 9.2 Time of administration of dose; 9.3 Food, diet and nutrition; 9.4 Smoking; 9.5 Circadian rhythms; 9.6 Weight and obesity; 9.7 Sex 9.8 Pregnancy9.9 Ambulation, posture and exercise; References and further reading; 10: Pharmacogenetics and Pharmacogenomics; 10.1 Introduction; 10.2 Methods for the study of pharmacogenetics; 10.3 N-acetyltransferase; 10.4 Plasma cholinesterase; 10.5 Cytochrome P450 polymorphisms; 10.6 Alcohol dehydrogenase and acetaldehyde dehydrogenase; 10.7 Thiopurine methyltransferase; 10.8 Phase 2 enzymes; 10.9 Transporters; 10.10 Pharmacodynamic differences; References and further reading; 11: Developmental Pharmacology and Age-related Phenomena; 11.1 Introduction 11.2 Scientific and regulatory environment in regard to younger and older patients |
| Record Nr. | UNINA-9910139399403321 |
|
Curry Stephen H.
|
||
| Chichester, West Sussex, England : , : Wiley-Blackwell, , 2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drug metabolism in drug design and development [[electronic resource] ] : basic concepts and practice / / edited by Donglu Zhang, Mingshe Zhu, W. Griffith Humphreys
| Drug metabolism in drug design and development [[electronic resource] ] : basic concepts and practice / / edited by Donglu Zhang, Mingshe Zhu, W. Griffith Humphreys |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley-Interscience, c2008 |
| Descrizione fisica | 1 online resource (633 p.) |
| Disciplina |
615.7
615/.7 |
| Altri autori (Persone) |
ZhangDonglu
ZhuMingshe HumphreysW. Griffith |
| Soggetto topico |
Drugs - Metabolism
Drugs - Design Drug development |
| ISBN |
1-281-09423-4
9786611094232 0-470-19169-4 0-470-19168-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
DRUG METABOLISM IN DRUG DESIGN AND DEVELOPMENT; CONTENTS; Preface; Contributors; PART I BASIC CONCEPTS OF DRUG METABOLISM; 1 Overview: Drug Metabolism in the Modern Pharmaceutical Industry; 1.1 Introduction; 1.2 Technology; 1.3 Breadth of Science; 1.3.1 Chemistry; 1.3.2 Enzymology and Molecular Biology; 1.4 Impact of Drug Metabolism on Efficacy and Safety; 1.4.1 Efficacy; 1.4.2 Safety; 1.5 Regulatory Impact and IP Position; 1.6 Summary; References; 2 Oxidative, Reductive, and Hydrolytic Metabolism of Drugs; 2.1 Introduction; 2.2 Nomenclature and Terminology
2.3 General Features of the Enzymes2.4 Fractional Contributions of Different Enzymes; 2.5 Oxidation Enzymes; 2.5.1 Cytochrome P450 (P450, CYP); 2.5.2 Flavin-Containing Monooxygenase (FMO); 2.5.3 Monoamine Oxidase (MAO); 2.5.4 Aldehyde Oxidase and Xanthine Dehydrogenase; 2.5.5 Peroxidases; 2.5.6 Alcohol Dehydrogenases (ADH); 2.5.7 Aldehyde Dehydrogenases (ALDH); 2.6 Reduction; 2.6.1 P450, ADH; 2.6.2 NADPH-P450 Reductase; 2.6.3 Aldo-Keto Reductases (AKR); 2.6.4 Quinone Reductase (NQO); 2.6.5 Glutathione Peroxidase (GPX); 2.7 Hydrolysis; 2.7.1 Epoxide Hydrolase; 2.7.2 Esterases and Amidases 2.8 SummaryReferences; 3 Conjugative Metabolism of Drugs; 3.1 UDP-Glucuronosyltransferases; 3.1.1 Location Within the Cell; 3.1.2 Endogenous Substrates; 3.1.3 Enzyme Multiplicity; 3.1.4 Inducibility; 3.1.5 Pharmacogenetics; 3.1.6 Experimental Considerations; 3.1.7 Enzyme Selective Substrates and Inhibitors; 3.1.8 Drug-Drug Interactions and Glucuronidation; 3.1.9 Summary; 3.2 Cytosolic Sulfotransferases; 3.2.1 Cellular Location and Tissue Expression; 3.2.2 The SULT Superfamily of Cytosolic Enzymes; 3.2.3 Inducibility; 3.2.4 SULT Pharmacogenetics 3.2.5 Analytical Detection of Sulfonated Metabolites3.2.6 SULT Inhibitors (Pacifici and Coughtrie, 2005); 3.2.7 Drug-Drug Interactions and Sulfonation; 3.2.8 Summary; 3.3 Glutathione-S-Transferases; 3.3.1 General Overview; 3.3.2 Classification of the GST Enzymes; 3.3.3 Localization and Expression; 3.3.4 Reactions Catalyzed by GSTs; 3.3.5 Regulation of GSTs; 3.3.6 GST Alpha Class; 3.3.7 GST Mu Class; 3.3.8 GST Pi Class; 3.3.9 GST Theta Class; 3.3.10 GST Zeta Class; 3.3.11 Incubation Conditions and Analytical Methods; 3.3.12 Glutathione Conjugate Metabolism (Mercapturic Acid Pathway) References4 Enzyme Kinetics; 4.1 Introduction; 4.2 Enzyme Catalysis; 4.3 Michaelis-Menten Kinetics; 4.3.1 Meanings of K(m), V(max) and Their Clinical Relevance; 4.4 Graphical Kinetic Plots; 4.5 Atypical Kinetics-Allosteric Effects; 4.5.1 Overview of Atypical Kinetic Phenomena; 4.5.2 Homotropic Cooperativity; 4.5.3 Heterotropic Cooperativity; 4.6 Graphical Analysis of Atypical Kinetic Data; 4.7 Enzyme Inhibition Kinetics; 4.7.1 Overview; 4.7.2 Competitive Inhibition; 4.7.3 Mixed Inhibition; 4.7.4 Noncompetitive Inhibition; 4.7.5 Uncompetitive Inhibition 4.7.6 Summary of Effects of Various Inhibition Types of Kinetic Parameters |
| Record Nr. | UNINA-9910143981703321 |
| Hoboken, N.J., : Wiley-Interscience, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drug metabolism in drug design and development [[electronic resource] ] : basic concepts and practice / / edited by Donglu Zhang, Mingshe Zhu, W. Griffith Humphreys
| Drug metabolism in drug design and development [[electronic resource] ] : basic concepts and practice / / edited by Donglu Zhang, Mingshe Zhu, W. Griffith Humphreys |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley-Interscience, c2008 |
| Descrizione fisica | 1 online resource (633 p.) |
| Disciplina |
615.7
615/.7 |
| Altri autori (Persone) |
ZhangDonglu
ZhuMingshe HumphreysW. Griffith |
| Soggetto topico |
Drugs - Metabolism
Drugs - Design Drug development |
| ISBN |
1-281-09423-4
9786611094232 0-470-19169-4 0-470-19168-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
DRUG METABOLISM IN DRUG DESIGN AND DEVELOPMENT; CONTENTS; Preface; Contributors; PART I BASIC CONCEPTS OF DRUG METABOLISM; 1 Overview: Drug Metabolism in the Modern Pharmaceutical Industry; 1.1 Introduction; 1.2 Technology; 1.3 Breadth of Science; 1.3.1 Chemistry; 1.3.2 Enzymology and Molecular Biology; 1.4 Impact of Drug Metabolism on Efficacy and Safety; 1.4.1 Efficacy; 1.4.2 Safety; 1.5 Regulatory Impact and IP Position; 1.6 Summary; References; 2 Oxidative, Reductive, and Hydrolytic Metabolism of Drugs; 2.1 Introduction; 2.2 Nomenclature and Terminology
2.3 General Features of the Enzymes2.4 Fractional Contributions of Different Enzymes; 2.5 Oxidation Enzymes; 2.5.1 Cytochrome P450 (P450, CYP); 2.5.2 Flavin-Containing Monooxygenase (FMO); 2.5.3 Monoamine Oxidase (MAO); 2.5.4 Aldehyde Oxidase and Xanthine Dehydrogenase; 2.5.5 Peroxidases; 2.5.6 Alcohol Dehydrogenases (ADH); 2.5.7 Aldehyde Dehydrogenases (ALDH); 2.6 Reduction; 2.6.1 P450, ADH; 2.6.2 NADPH-P450 Reductase; 2.6.3 Aldo-Keto Reductases (AKR); 2.6.4 Quinone Reductase (NQO); 2.6.5 Glutathione Peroxidase (GPX); 2.7 Hydrolysis; 2.7.1 Epoxide Hydrolase; 2.7.2 Esterases and Amidases 2.8 SummaryReferences; 3 Conjugative Metabolism of Drugs; 3.1 UDP-Glucuronosyltransferases; 3.1.1 Location Within the Cell; 3.1.2 Endogenous Substrates; 3.1.3 Enzyme Multiplicity; 3.1.4 Inducibility; 3.1.5 Pharmacogenetics; 3.1.6 Experimental Considerations; 3.1.7 Enzyme Selective Substrates and Inhibitors; 3.1.8 Drug-Drug Interactions and Glucuronidation; 3.1.9 Summary; 3.2 Cytosolic Sulfotransferases; 3.2.1 Cellular Location and Tissue Expression; 3.2.2 The SULT Superfamily of Cytosolic Enzymes; 3.2.3 Inducibility; 3.2.4 SULT Pharmacogenetics 3.2.5 Analytical Detection of Sulfonated Metabolites3.2.6 SULT Inhibitors (Pacifici and Coughtrie, 2005); 3.2.7 Drug-Drug Interactions and Sulfonation; 3.2.8 Summary; 3.3 Glutathione-S-Transferases; 3.3.1 General Overview; 3.3.2 Classification of the GST Enzymes; 3.3.3 Localization and Expression; 3.3.4 Reactions Catalyzed by GSTs; 3.3.5 Regulation of GSTs; 3.3.6 GST Alpha Class; 3.3.7 GST Mu Class; 3.3.8 GST Pi Class; 3.3.9 GST Theta Class; 3.3.10 GST Zeta Class; 3.3.11 Incubation Conditions and Analytical Methods; 3.3.12 Glutathione Conjugate Metabolism (Mercapturic Acid Pathway) References4 Enzyme Kinetics; 4.1 Introduction; 4.2 Enzyme Catalysis; 4.3 Michaelis-Menten Kinetics; 4.3.1 Meanings of K(m), V(max) and Their Clinical Relevance; 4.4 Graphical Kinetic Plots; 4.5 Atypical Kinetics-Allosteric Effects; 4.5.1 Overview of Atypical Kinetic Phenomena; 4.5.2 Homotropic Cooperativity; 4.5.3 Heterotropic Cooperativity; 4.6 Graphical Analysis of Atypical Kinetic Data; 4.7 Enzyme Inhibition Kinetics; 4.7.1 Overview; 4.7.2 Competitive Inhibition; 4.7.3 Mixed Inhibition; 4.7.4 Noncompetitive Inhibition; 4.7.5 Uncompetitive Inhibition 4.7.6 Summary of Effects of Various Inhibition Types of Kinetic Parameters |
| Record Nr. | UNINA-9910830456403321 |
| Hoboken, N.J., : Wiley-Interscience, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drug metabolism in drug design and development [[electronic resource] ] : basic concepts and practice / / edited by Donglu Zhang, Mingshe Zhu, W. Griffith Humphreys
| Drug metabolism in drug design and development [[electronic resource] ] : basic concepts and practice / / edited by Donglu Zhang, Mingshe Zhu, W. Griffith Humphreys |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley-Interscience, c2008 |
| Descrizione fisica | 1 online resource (633 p.) |
| Disciplina |
615.7
615/.7 |
| Altri autori (Persone) |
ZhangDonglu
ZhuMingshe HumphreysW. Griffith |
| Soggetto topico |
Drugs - Metabolism
Drugs - Design Drug development |
| ISBN |
1-281-09423-4
9786611094232 0-470-19169-4 0-470-19168-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
DRUG METABOLISM IN DRUG DESIGN AND DEVELOPMENT; CONTENTS; Preface; Contributors; PART I BASIC CONCEPTS OF DRUG METABOLISM; 1 Overview: Drug Metabolism in the Modern Pharmaceutical Industry; 1.1 Introduction; 1.2 Technology; 1.3 Breadth of Science; 1.3.1 Chemistry; 1.3.2 Enzymology and Molecular Biology; 1.4 Impact of Drug Metabolism on Efficacy and Safety; 1.4.1 Efficacy; 1.4.2 Safety; 1.5 Regulatory Impact and IP Position; 1.6 Summary; References; 2 Oxidative, Reductive, and Hydrolytic Metabolism of Drugs; 2.1 Introduction; 2.2 Nomenclature and Terminology
2.3 General Features of the Enzymes2.4 Fractional Contributions of Different Enzymes; 2.5 Oxidation Enzymes; 2.5.1 Cytochrome P450 (P450, CYP); 2.5.2 Flavin-Containing Monooxygenase (FMO); 2.5.3 Monoamine Oxidase (MAO); 2.5.4 Aldehyde Oxidase and Xanthine Dehydrogenase; 2.5.5 Peroxidases; 2.5.6 Alcohol Dehydrogenases (ADH); 2.5.7 Aldehyde Dehydrogenases (ALDH); 2.6 Reduction; 2.6.1 P450, ADH; 2.6.2 NADPH-P450 Reductase; 2.6.3 Aldo-Keto Reductases (AKR); 2.6.4 Quinone Reductase (NQO); 2.6.5 Glutathione Peroxidase (GPX); 2.7 Hydrolysis; 2.7.1 Epoxide Hydrolase; 2.7.2 Esterases and Amidases 2.8 SummaryReferences; 3 Conjugative Metabolism of Drugs; 3.1 UDP-Glucuronosyltransferases; 3.1.1 Location Within the Cell; 3.1.2 Endogenous Substrates; 3.1.3 Enzyme Multiplicity; 3.1.4 Inducibility; 3.1.5 Pharmacogenetics; 3.1.6 Experimental Considerations; 3.1.7 Enzyme Selective Substrates and Inhibitors; 3.1.8 Drug-Drug Interactions and Glucuronidation; 3.1.9 Summary; 3.2 Cytosolic Sulfotransferases; 3.2.1 Cellular Location and Tissue Expression; 3.2.2 The SULT Superfamily of Cytosolic Enzymes; 3.2.3 Inducibility; 3.2.4 SULT Pharmacogenetics 3.2.5 Analytical Detection of Sulfonated Metabolites3.2.6 SULT Inhibitors (Pacifici and Coughtrie, 2005); 3.2.7 Drug-Drug Interactions and Sulfonation; 3.2.8 Summary; 3.3 Glutathione-S-Transferases; 3.3.1 General Overview; 3.3.2 Classification of the GST Enzymes; 3.3.3 Localization and Expression; 3.3.4 Reactions Catalyzed by GSTs; 3.3.5 Regulation of GSTs; 3.3.6 GST Alpha Class; 3.3.7 GST Mu Class; 3.3.8 GST Pi Class; 3.3.9 GST Theta Class; 3.3.10 GST Zeta Class; 3.3.11 Incubation Conditions and Analytical Methods; 3.3.12 Glutathione Conjugate Metabolism (Mercapturic Acid Pathway) References4 Enzyme Kinetics; 4.1 Introduction; 4.2 Enzyme Catalysis; 4.3 Michaelis-Menten Kinetics; 4.3.1 Meanings of K(m), V(max) and Their Clinical Relevance; 4.4 Graphical Kinetic Plots; 4.5 Atypical Kinetics-Allosteric Effects; 4.5.1 Overview of Atypical Kinetic Phenomena; 4.5.2 Homotropic Cooperativity; 4.5.3 Heterotropic Cooperativity; 4.6 Graphical Analysis of Atypical Kinetic Data; 4.7 Enzyme Inhibition Kinetics; 4.7.1 Overview; 4.7.2 Competitive Inhibition; 4.7.3 Mixed Inhibition; 4.7.4 Noncompetitive Inhibition; 4.7.5 Uncompetitive Inhibition 4.7.6 Summary of Effects of Various Inhibition Types of Kinetic Parameters |
| Record Nr. | UNINA-9910840505403321 |
| Hoboken, N.J., : Wiley-Interscience, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drug targeting : organ-specific strategies
| Drug targeting : organ-specific strategies |
| Pubbl/distr/stampa | [Place of publication not identified], : Wiley VCH, 2001 |
| Descrizione fisica | 1 online resource (406 pages) |
| Disciplina | 615/.7 |
| Collana | Methods and principles in medicinal chemistry Drug targeting |
| Soggetto topico |
Drug targeting
Drug Delivery Systems Drug Therapy Therapeutics Analytical, Diagnostic and Therapeutic Techniques and Equipment Pharmacy, Therapeutics, & Pharmacology Health & Biological Sciences |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-64441-9
9786610644414 3-527-60006-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910146052003321 |
| [Place of publication not identified], : Wiley VCH, 2001 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drug targeting : organ-specific strategies
| Drug targeting : organ-specific strategies |
| Pubbl/distr/stampa | [Place of publication not identified], : Wiley VCH, 2001 |
| Descrizione fisica | 1 online resource (406 pages) |
| Disciplina | 615/.7 |
| Collana | Methods and principles in medicinal chemistry Drug targeting |
| Soggetto topico |
Drug targeting
Drug Delivery Systems Drug Therapy Therapeutics Analytical, Diagnostic and Therapeutic Techniques and Equipment Pharmacy, Therapeutics, & Pharmacology Health & Biological Sciences |
| ISBN |
1-280-64441-9
9786610644414 3-527-60006-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910830782703321 |
| [Place of publication not identified], : Wiley VCH, 2001 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drug targeting : organ-specific strategies
| Drug targeting : organ-specific strategies |
| Pubbl/distr/stampa | [Place of publication not identified], : Wiley VCH, 2001 |
| Descrizione fisica | 1 online resource (406 pages) |
| Disciplina | 615/.7 |
| Collana | Methods and principles in medicinal chemistry Drug targeting |
| Soggetto topico |
Drug targeting
Drug Delivery Systems Drug Therapy Therapeutics Analytical, Diagnostic and Therapeutic Techniques and Equipment Pharmacy, Therapeutics, & Pharmacology Health & Biological Sciences |
| ISBN |
1-280-64441-9
9786610644414 3-527-60006-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910841010703321 |
| [Place of publication not identified], : Wiley VCH, 2001 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Fifty Years of Cytochrome P450 Research [[electronic resource] /] / edited by Hiroshi Yamazaki
| Fifty Years of Cytochrome P450 Research [[electronic resource] /] / edited by Hiroshi Yamazaki |
| Edizione | [1st ed. 2014.] |
| Pubbl/distr/stampa | Tokyo : , : Springer Japan : , : Imprint : Springer, , 2014 |
| Descrizione fisica | 1 online resource (403 p.) |
| Disciplina |
599.935
615/.7 |
| Soggetto topico |
Pharmaceutical technology
Medical genetics Pharmacology Human genetics Pharmaceutical Sciences/Technology Gene Function Pharmacology/Toxicology Human Genetics |
| ISBN | 4-431-54992-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Preface -- Part 1 Cytochrome P450 History -- 1 Pioneers in the Early Years of Cytochrome P450 Research -- 2 Fifty Years of Progress in Drug Metabolism and Toxicology: What Do We Still Need to Know About Cytochrome P450 Enzymes? -- 3 Fifty Years of Cytochrome P450 Research: Examples of What We Know and Don’t Know -- Part 2 Structure, Function, and Practical Applications of P450 -- 4 Cytochrome P450 Dynamics -- 5 Structural and Functional Diversity of Cytochrome P450 -- 6 Oxygenation of Non native Substrates Using a Malfunction State of Cytochrome P450s -- 7 Plant Cytochrome P450s in Triterpenoid Biosynthesis: Diversity and Application to Combinatorial Biosynthesis -- 8 Mammalian and Bacterial Cytochromes P450 Involved in Steroid Hydroxylation: Regulation of Catalysis and Selectivity and Potential Applications -- 9 Neurosteroids: Regional Steroidogenesis -- 10 Whole Cell-Dependent Biosynthesis of Drug Metabolites Using Genetically Engineered Budding Yeast -- 11 Metabolic Diversity and Cytochromes P450 of Fungi -- 12 Metabolic Engineering of Flower Colour Pathways Using Cytochromes P450 -- Part 3 Gene Regulation of P450 -- 13 Aryl Hydrocarbon Receptor Suppresses Cecal Carcinogenesis -- 14 Epidermal Growth Factor Receptor: The Phenobarbital Receptor That Elicits CAR Activation Signal for P450 Induction -- 15 Steroidogenic Cytochrome P450 Gene CYP11A1: Functions and Regulation -- 16 Cooperative Regulation of Expression of Cytochrome P450 Enzymes by Aryl Hydrocarbon Receptor and Vitamin D Receptor -- Part 4 Drug Metabolism -- 17 Species, Ethnic and Individual Differences in Human Drug-Metabolizing Cytochrome P450 Enzymes -- 18 Cytochrome P450-Depedent Change in UDP- Glucuronosyltransferase Function and Its Reverse Regulation -- 19 Control of Xeno/Endobiotics-Metabolizing Cytochrome P450s by Micro RNAs -- 20 The Pharmacogenomics of Cytochrome P450s: From Molecular to Clinical Application -- 21 Cytochrome P450 Polymorphisms of Clinical Importance -- BM Epilogue -- Index. |
| Record Nr. | UNINA-9910298344103321 |
| Tokyo : , : Springer Japan : , : Imprint : Springer, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Formulation and process development strategies for manufacturing biopharmaceuticals [[electronic resource] /] / edited by Feroz Jameel, Susan Hershenson
| Formulation and process development strategies for manufacturing biopharmaceuticals [[electronic resource] /] / edited by Feroz Jameel, Susan Hershenson |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2010 |
| Descrizione fisica | 1 online resource (986 p.) |
| Disciplina |
615.19
615/.7 |
| Altri autori (Persone) |
JameelFeroz
HershensonSusan |
| Soggetto topico |
Biopharmaceutics
Pharmaceutical technology |
| ISBN |
1-282-70758-2
9786612707582 0-470-59588-4 0-470-59587-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
FORMULATION AND PROCESS DEVELOPMENT STRATEGIES FOR MANUFACTURING BIOPHARMACEUTICALS; CONTENTS; FOREWORD; PREFACE; CONTRIBUTORS; PART I PREFORMULATION AND DEVELOPMENT OF STABILITY-INDICATING ASSAYS: BIOPHYSICAL CHARACTERIZATION TECHNIQUES; 1 THE STRUCTURE OF BIOLOGICAL THERAPEUTICS; 2 CHEMICAL INSTABILITY IN PEPTIDE AND PROTEIN PHARMACEUTICALS; 3 PHYSICAL STABILITY OF PROTEIN PHARMACEUTICALS; 4 IMMUNOGENICITY OF THERAPEUTIC PROTEINS; 5 PREFORMULATION RESEARCH: ASSESSING PROTEIN; 6 FORMULATION DEVELOPMENT OF PHASE 1-2 BIOPHARMACEUTICALS: AN EFFICIENT AND TIMELY APPROACH
7 LATE-STAGE FORMULATION DEVELOPMENT AND CHARACTERIZATION OF BIOPHARMACEUTICALS8 AN EMPIRICAL PHASE DIAGRAM-HIGH-THROUGHPUT SCREENING APPROACH TO THE CHARACTERIZATION AND FORMULATION OF BIOPHARMACEUTICALS; 9 FLUORESCENCE AND PHOSPHORESCENCE METHODS TO PROBE PROTEIN STRUCTURE AND STABILITY IN ICE: THE CASE OF AZURIN; 10 APPLICATIONS OF SEDIMENTATION VELOCITY ANALYTICAL ULTRACENTRIFUGATION; 11 FIELD FLOW FRACTIONATION WITH MULTIANGLE LIGHT SCATTERING FOR MEASURING PARTICLE SIZE DISTRIBUTIONS OF VIRUS-LIKE PARTICLES 12 LIGHT-SCATTERING TECHNIQUES AND THEIR APPLICATION TO FORMULATION AND AGGREGATION CONCERNSPART II DEVELOPMENT OF A FORMULATION FOR LIQUID DOSAGE FORM; 13 EFFECTIVE APPROACHES TO FORMULATION DEVELOPMENT OF BIOPHARMACEUTICALS; 14 PREDICTION OF AGGREGATION PROPENSITY FROM PRIMARY SEQUENCE INFORMATION; 15 HIGH-CONCENTRATION ANTIBODY FORMULATIONS; 16 DEVELOPMENT OF FORMULATIONS FOR THERAPEUTIC MONOCLONAL ANTIBODIES AND Fc FUSION PROTEINS; 17 REVERSIBLE SELF-ASSOCIATION OF PHARMACEUTICAL PROTEINS: CHARACTERIZATION AND CASE STUDIES; PART III DEVELOPMENT OF A FORMULATION FOR LYOPHILIZED DOSAGE FORM 18 DESIGN OF A FORMULATION FOR FREEZE DRYING19 PROTEIN CONFORMATION AND REACTIVITY IN AMORPHOUS SOLIDS; 20 THE IMPACT OF BUFFER ON SOLID-STATE PROPERTIES AND STABILITY OF FREEZE-DRIED DOSAGE FORMS; 21 STABILIZATION OF LYOPHILIZED PHARMACEUTICALS BY CONTROL OF MOLECULAR MOBILITY: IMPACT OF THERMAL HISTORY; 22 STRUCTURAL ANALYSIS OF PROTEINS IN DRIED MATRICES; 23 THE IMPACT OF FORMULATION AND DRYING PROCESSES ON THE CHARACTERISTICS AND PERFORMANCE OF BIOPHARMACEUTICAL POWDERS; PART IV MANUFACTURING SCIENCES; 24 MANUFACTURING FUNDAMENTALS FOR BIOPHARMACEUTICALS 25 PROTEIN STABILITY DURING BIOPROCESSING26 FREEZING AND THAWING OF PROTEIN SOLUTIONS; 27 STRATEGIES FOR BULK STORAGE AND SHIPMENT OF PROTEINS; 28 DRYING PROCESS METHODS FOR BIOPHARMACEUTICAL PRODUCTS: AN OVERVIEW; 29 SPRAY DRYING OF BIOPHARMACEUTICALS AND VACCINES; 30 DEVELOPMENT AND OPTIMIZATION OF THE FREEZE-DRYING PROCESSES; 31 CONSIDERATIONS FOR SUCCESSFUL LYOPHILIZATION PROCESS SCALE-UP, TECHNOLOGY TRANSFER, AND ROUTINE PRODUCTION; 32 PROCESS ROBUSTNESS IN FREEZE DRYING OF BIOPHARMACEUTICALS; 33 FILLING PROCESSES AND TECHNOLOGIES FOR LIQUID BIOPHARMACEUTICALS 34 LEACHABLES AND EXTRACTABLES |
| Record Nr. | UNINA-9910140773403321 |
| Hoboken, N.J., : Wiley, c2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
