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Crystallization of organic compounds : an industrial perspective / / Hsien-Hsin Tung ... [et al.]
| Crystallization of organic compounds : an industrial perspective / / Hsien-Hsin Tung ... [et al.] |
| Autore | Tung Hsien-Hsin <1955-> |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2009 |
| Descrizione fisica | 1 online resource (304 p.) |
| Disciplina | 615/.19 |
| Soggetto topico |
Crystallization - Industrial applications
Pharmaceutical chemistry Pharmaceutical industry |
| ISBN |
1-282-36829-X
9786612368295 0-470-44779-6 0-470-44778-8 |
| Classificazione | VE 9500 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Crystallization of Organic Compounds; Contents; Preface; 1. Introduction to Crystallization Issues; 1.1 Crystal Properties and Polymorphism (Chapters 2 and 3); 1.2 Nucleation and Growth Kinetics (Chapter 4); 1.3 Critical Issues (Chapter 5); 1.4 Mixing and Crystallization (Chapter 6); 1.5 Crystallization Process Options (Chapters 7-10); 1.6 Special Applications (Chapter 11); 1.7 Regulatory Issues; 2. Properties; 2.1 Solubility; 2.2 Supersaturation, Metastable Zone, and Induction Time; 2.3 Oil, Amorphous, and Crystalline States; 2.4 Polymorphism; 2.5 Solvate
2.6 Solid Compound, Solid Solution, and Solid Mixture2.7 Inclusion and Occlusion; 2.8 Adsorption, Hygroscopicity, and Deliquescence; 2.9 Crystal Morphology; 2.10 Particle Size Distribution and Surface Area; 3. Polymorphism; 3.1 Phase Rule; 3.2 Phase Transition; 3.3 Examples; Example 3-1 Indomethacin; Example 3-2 Sulindac; Example 3-3 Losartan; Example 3-4 Finasteride; Example 3-5 Ibuprofen Lysinate; Example 3-6 HCl Salt of a Drug Candidate; Example 3-7 Second HCl Salt of a Drug Candidate; Example 3-8 Prednisolone t-Butylacetate; Example 3-9 Phthalylsulfathiazole; 3.4 Future Direction 4. Kinetics4.1 Supersaturation and Rate Processes; 4.2 Nucleation; 4.3 Crystal Growth; 4.4 Nucleate/Seed Aging and Ostwald Ripening; 4.5 Delivered Product: Size Distribution and Morphology; 5. Critical Issues in Crystallization Practice; 5.1 Introduction; 5.2 Nucleation; 5.3 Growth; 5.4 Oiling Out, Agglomeration/Aggregation; 5.5 Seeding; 5.6 Rate of Generation of Supersaturation; 5.7 Summary of Critical Issues; 6. Mixing and Crystallization; 6.1 Introduction; 6.2 Mixing Considerations; 6.3 Mixing Effects on Nucleation; 6.4 Mixing Effects on Crystal Growth; 6.5 Mixing Scale-up 6.6 Crystallization EquipmentExample 6-1; 7. Cooling Crystallization; 7.1 Batch Operation; 7.2 Continuous Operations; 7.3 Process Design-Examples; Example 7-1 Intermediate in a Multistep Synthesis; Example 7-2 Pure Crystallization of an API; Example 7-3 Crystallization Using the Heel from the Previous Batch as Seed; Example 7-4 Resolution of Ibuprofen Via Stereospecific Crystallization; Example 7-5 Crystallization of Pure Bulk with Polymorphism; Example 7-6 Continuous Separation of Stereoisomers; 8. Evaporative Crystallization; 8.1 Introduction; 8.2 Solubility Diagrams 8.3 Factors Affecting Nucleation and Growth8.4 Scale-up; 8.5 Equipment; Example 8-1 Crystallization of a Pharmaceutical Intermediate Salt; Example 8-2 Crystallization of the Sodium Salt of a Drug Candidate; 9. Antisolvent Crystallization; 9.1 Semibatch Operation; Example 9-1 Crystallization of an Intermediate; Example 9-2 Rejection of Isomeric Impurities of Final Bulk Active Product; Example 9-3 Crystallization of a Pharmaceutical Product with Poor Nucleation and Growth Characteristics; Example 9-4 Impact of Solvent and Supersaturation on Particle Size and Crystal Form 9.2 In-Line Mixing Crystallization |
| Record Nr. | UNINA-9910816988403321 |
Tung Hsien-Hsin <1955->
|
||
| Hoboken, N.J., : Wiley, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Development of therapeutic agents handbook [[electronic resource] /] / [edited by] Shayne Cox Gad
| Development of therapeutic agents handbook [[electronic resource] /] / [edited by] Shayne Cox Gad |
| Pubbl/distr/stampa | Hoboken, N.J., : John Wiley & Sons, c2012 |
| Descrizione fisica | 1 online resource (1278 p.) |
| Disciplina |
615.19
615/.19 |
| Altri autori (Persone) | GadShayne C. <1948-> |
| Collana | Pharmaceutical Development Series |
| Soggetto topico |
Drugs - Research
Drugs - Design Pharmaceutical chemistry Drug development Drug Design Chemistry, Pharmaceutical - methods |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-118-07711-3
1-283-31590-4 9786613315908 1-118-07710-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | pt. 1. Fundamentals and concepts -- pt. 2. Methods and techniques in drug discovery and development -- pt. 3. Therapeutics topics. |
| Record Nr. | UNINA-9910457204303321 |
| Hoboken, N.J., : John Wiley & Sons, c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Development of therapeutic agents handbook [[electronic resource] /] / [edited by] Shayne Cox Gad
| Development of therapeutic agents handbook [[electronic resource] /] / [edited by] Shayne Cox Gad |
| Pubbl/distr/stampa | Hoboken, N.J., : John Wiley & Sons, c2012 |
| Descrizione fisica | 1 online resource (1278 p.) |
| Disciplina |
615.19
615/.19 |
| Altri autori (Persone) | GadShayne C. <1948-> |
| Collana | Pharmaceutical Development Series |
| Soggetto topico |
Drugs - Research
Drugs - Design Pharmaceutical chemistry Drug development Drug Design Chemistry, Pharmaceutical - methods |
| ISBN |
1-118-07711-3
1-283-31590-4 9786613315908 1-118-07710-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | pt. 1. Fundamentals and concepts -- pt. 2. Methods and techniques in drug discovery and development -- pt. 3. Therapeutics topics. |
| Record Nr. | UNINA-9910781962103321 |
| Hoboken, N.J., : John Wiley & Sons, c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Development of therapeutic agents handbook / / [edited by] Shayne Cox Gad
| Development of therapeutic agents handbook / / [edited by] Shayne Cox Gad |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, N.J., : John Wiley & Sons, c2012 |
| Descrizione fisica | 1 online resource (1278 p.) |
| Disciplina | 615/.19 |
| Altri autori (Persone) | GadShayne C. <1948-> |
| Collana | Pharmaceutical Development Series |
| Soggetto topico |
Drugs - Research
Drugs - Design Pharmaceutical chemistry Drug development |
| ISBN |
1-118-07711-3
1-283-31590-4 9786613315908 1-118-07710-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | pt. 1. Fundamentals and concepts -- pt. 2. Methods and techniques in drug discovery and development -- pt. 3. Therapeutics topics. |
| Record Nr. | UNINA-9910808987003321 |
| Hoboken, N.J., : John Wiley & Sons, c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drug design of zinc-enzyme inhibitors [[electronic resource] ] : functional, structural, and disease applications / / edited by Claudiu T. Supuran, Jean-Yves Winum
| Drug design of zinc-enzyme inhibitors [[electronic resource] ] : functional, structural, and disease applications / / edited by Claudiu T. Supuran, Jean-Yves Winum |
| Pubbl/distr/stampa | Hoboken, NJ, : John Wiley & Sons, c2009 |
| Descrizione fisica | 1 online resource (1072 p.) |
| Disciplina | 615/.19 |
| Altri autori (Persone) |
SupuranClaudiu T. <1962->
WinumJean-Yves |
| Collana | Wiley Series in Drug Discovery and Development |
| Soggetto topico |
Zinc enzymes - Inhibitors - Therapeutic use
Drugs - Design |
| ISBN |
1-282-34608-3
9786612346088 0-470-50816-7 0-470-50815-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
DRUG DESIGN OF ZINC-ENZYME INHIBITORS; CONTENTS; PREFACE; CONTRIBUTORS; PART I INTRODUCTION; 1. Introduction to Zinc Enzymes as Drug Targets; PART II DRUG DESIGN OF CARBONIC ANHYDRASE INHIBITORS AND ACTIVATORS; 2. Carbonic Anhydrases as Drug Targets: General Presentation; 3. Zinc Binding Functions in the Design of Carbonic Anhydrase Inhibitors; 4. X-Ray Crystallography of Carbonic Anhydrase Inhibitors and Its Importance in Drug Design; 5. Antiglaucoma Carbonic Anhydrase Inhibitors as Ophthalomologic Drugs
6. Diuretics with Carbonic Anhydrase Inhibitory Activity: Toward Novel Applications for Sulfonamide Drugs7. Drug Design of Carbonic Anhydrase Inhibitors as Anticonvulsant Agents; 8. Carbonic Anhydrase Inhibitors Targeting Cancer: Therapeutic, Immunologic, and Diagnostic Tools Targeting Isoforms IX and XII; 9. Fluorescent- and Spin-Labeled Sulfonamides as Probe for Carbonic Anhydrase IX; 10. Drug Design of Antiobesity Carbonic Anhydrase Inhibitors; 11. Dual Carbonic Anhydrase and Cyclooxygenase-2 Inhibition 12. Advances in the Inhibitory and Structural Investigations on Carbonic Anhydrase Isozymes XIII and XV13. Mechanism and Inhibition of the β-Class and γ-Class Carbonic Anhydrases; 14. Fungal and Nematode Carbonic Anhydrases: Their Inhibition in Drug Design; 15. Crystallographic Studies on Carbonic Anhydrases from Fungal Pathogens for Structure-Assisted Drug Development; 16. Malaria Parasite Carbonic Anhydrase and Its Inhibition in the Development of Novel Therapies of Malaria; 17. Inhibitors of Helicobacter pylori α- and β-Carbonic Anhydrases as Novel Drugs for Gastroduodenal Diseases 18. QSAR of Carbonic Anhydrase Inhibitors and Their Impact on Drug Design19. Selectivity Issues in the Design of CA Inhibitors; 20. Bicarbonate Transport Metabolons; 21. Metal Complexes of Sulfonamides as Dual Carbonic Anhydrase Inhibitors; 22. Drug Design Studies of Carbonic Anhydrase Activators; PART III DRUG DESIGN OF MATRIX METALLOPROTEINASE INHIBITORS; 23. Matrix Metalloproteinases: An Overview; 24. MMP Inhibitors Based on Earlier Succinimide Strategies: From Early to New Approaches; 25. Drug Design of Sulfonylated MMP Inhibitors; 26. ADAMs and ADAMTs Selective Synthetic Inhibitors 27. QSAR Studies of MMP InhibitorsPART IV DRUG DESIGN OF BACTERIAL ZINC PROTEASE INHIBITORS; 28. Bacterial Zinc Proteases as Orphan Targets; 29. Botulinus Toxin, Tetanus Toxin, and Anthrax Lethal Factor Inhibitors; 30. Clostridium histolyticum Collagenase Inhibitors in the Drug Design; 31. Other Bacterial Zinc Peptidases as Potential Drug Targets; PART V DRUG DESIGN STUDIES OF OTHER ZINC-CONTAINING ENZYMES; 32. Angiotensin Converting Enzyme (ACE) Inhibitors; 33. P-III Metalloproteinase (Leucurolysin-B) from Bothrops leucurus Venom: Isolation and Possible Inhibition 34. CaaX-Protein Prenyltransferase Inhibitors |
| Record Nr. | UNINA-9910139879003321 |
| Hoboken, NJ, : John Wiley & Sons, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drug design of zinc-enzyme inhibitors [[electronic resource] ] : functional, structural, and disease applications / / edited by Claudiu T. Supuran, Jean-Yves Winum
| Drug design of zinc-enzyme inhibitors [[electronic resource] ] : functional, structural, and disease applications / / edited by Claudiu T. Supuran, Jean-Yves Winum |
| Pubbl/distr/stampa | Hoboken, NJ, : John Wiley & Sons, c2009 |
| Descrizione fisica | 1 online resource (1072 p.) |
| Disciplina | 615/.19 |
| Altri autori (Persone) |
SupuranClaudiu T. <1962->
WinumJean-Yves |
| Collana | Wiley Series in Drug Discovery and Development |
| Soggetto topico |
Zinc enzymes - Inhibitors - Therapeutic use
Drugs - Design |
| ISBN |
1-282-34608-3
9786612346088 0-470-50816-7 0-470-50815-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
DRUG DESIGN OF ZINC-ENZYME INHIBITORS; CONTENTS; PREFACE; CONTRIBUTORS; PART I INTRODUCTION; 1. Introduction to Zinc Enzymes as Drug Targets; PART II DRUG DESIGN OF CARBONIC ANHYDRASE INHIBITORS AND ACTIVATORS; 2. Carbonic Anhydrases as Drug Targets: General Presentation; 3. Zinc Binding Functions in the Design of Carbonic Anhydrase Inhibitors; 4. X-Ray Crystallography of Carbonic Anhydrase Inhibitors and Its Importance in Drug Design; 5. Antiglaucoma Carbonic Anhydrase Inhibitors as Ophthalomologic Drugs
6. Diuretics with Carbonic Anhydrase Inhibitory Activity: Toward Novel Applications for Sulfonamide Drugs7. Drug Design of Carbonic Anhydrase Inhibitors as Anticonvulsant Agents; 8. Carbonic Anhydrase Inhibitors Targeting Cancer: Therapeutic, Immunologic, and Diagnostic Tools Targeting Isoforms IX and XII; 9. Fluorescent- and Spin-Labeled Sulfonamides as Probe for Carbonic Anhydrase IX; 10. Drug Design of Antiobesity Carbonic Anhydrase Inhibitors; 11. Dual Carbonic Anhydrase and Cyclooxygenase-2 Inhibition 12. Advances in the Inhibitory and Structural Investigations on Carbonic Anhydrase Isozymes XIII and XV13. Mechanism and Inhibition of the β-Class and γ-Class Carbonic Anhydrases; 14. Fungal and Nematode Carbonic Anhydrases: Their Inhibition in Drug Design; 15. Crystallographic Studies on Carbonic Anhydrases from Fungal Pathogens for Structure-Assisted Drug Development; 16. Malaria Parasite Carbonic Anhydrase and Its Inhibition in the Development of Novel Therapies of Malaria; 17. Inhibitors of Helicobacter pylori α- and β-Carbonic Anhydrases as Novel Drugs for Gastroduodenal Diseases 18. QSAR of Carbonic Anhydrase Inhibitors and Their Impact on Drug Design19. Selectivity Issues in the Design of CA Inhibitors; 20. Bicarbonate Transport Metabolons; 21. Metal Complexes of Sulfonamides as Dual Carbonic Anhydrase Inhibitors; 22. Drug Design Studies of Carbonic Anhydrase Activators; PART III DRUG DESIGN OF MATRIX METALLOPROTEINASE INHIBITORS; 23. Matrix Metalloproteinases: An Overview; 24. MMP Inhibitors Based on Earlier Succinimide Strategies: From Early to New Approaches; 25. Drug Design of Sulfonylated MMP Inhibitors; 26. ADAMs and ADAMTs Selective Synthetic Inhibitors 27. QSAR Studies of MMP InhibitorsPART IV DRUG DESIGN OF BACTERIAL ZINC PROTEASE INHIBITORS; 28. Bacterial Zinc Proteases as Orphan Targets; 29. Botulinus Toxin, Tetanus Toxin, and Anthrax Lethal Factor Inhibitors; 30. Clostridium histolyticum Collagenase Inhibitors in the Drug Design; 31. Other Bacterial Zinc Peptidases as Potential Drug Targets; PART V DRUG DESIGN STUDIES OF OTHER ZINC-CONTAINING ENZYMES; 32. Angiotensin Converting Enzyme (ACE) Inhibitors; 33. P-III Metalloproteinase (Leucurolysin-B) from Bothrops leucurus Venom: Isolation and Possible Inhibition 34. CaaX-Protein Prenyltransferase Inhibitors |
| Record Nr. | UNINA-9910830981903321 |
| Hoboken, NJ, : John Wiley & Sons, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drug design of zinc-enzyme inhibitors : functional, structural, and disease applications / / edited by Claudiu T. Supuran, Jean-Yves Winum
| Drug design of zinc-enzyme inhibitors : functional, structural, and disease applications / / edited by Claudiu T. Supuran, Jean-Yves Winum |
| Pubbl/distr/stampa | Hoboken, NJ, : John Wiley & Sons, c2009 |
| Descrizione fisica | 1 online resource (1072 p.) |
| Disciplina | 615/.19 |
| Altri autori (Persone) |
SupuranClaudiu T. <1962->
WinumJean-Yves |
| Collana | Wiley Series in Drug Discovery and Development |
| Soggetto topico |
Zinc enzymes - Inhibitors - Therapeutic use
Drugs - Design |
| ISBN |
1-282-34608-3
9786612346088 0-470-50816-7 0-470-50815-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
DRUG DESIGN OF ZINC-ENZYME INHIBITORS; CONTENTS; PREFACE; CONTRIBUTORS; PART I INTRODUCTION; 1. Introduction to Zinc Enzymes as Drug Targets; PART II DRUG DESIGN OF CARBONIC ANHYDRASE INHIBITORS AND ACTIVATORS; 2. Carbonic Anhydrases as Drug Targets: General Presentation; 3. Zinc Binding Functions in the Design of Carbonic Anhydrase Inhibitors; 4. X-Ray Crystallography of Carbonic Anhydrase Inhibitors and Its Importance in Drug Design; 5. Antiglaucoma Carbonic Anhydrase Inhibitors as Ophthalomologic Drugs
6. Diuretics with Carbonic Anhydrase Inhibitory Activity: Toward Novel Applications for Sulfonamide Drugs7. Drug Design of Carbonic Anhydrase Inhibitors as Anticonvulsant Agents; 8. Carbonic Anhydrase Inhibitors Targeting Cancer: Therapeutic, Immunologic, and Diagnostic Tools Targeting Isoforms IX and XII; 9. Fluorescent- and Spin-Labeled Sulfonamides as Probe for Carbonic Anhydrase IX; 10. Drug Design of Antiobesity Carbonic Anhydrase Inhibitors; 11. Dual Carbonic Anhydrase and Cyclooxygenase-2 Inhibition 12. Advances in the Inhibitory and Structural Investigations on Carbonic Anhydrase Isozymes XIII and XV13. Mechanism and Inhibition of the β-Class and γ-Class Carbonic Anhydrases; 14. Fungal and Nematode Carbonic Anhydrases: Their Inhibition in Drug Design; 15. Crystallographic Studies on Carbonic Anhydrases from Fungal Pathogens for Structure-Assisted Drug Development; 16. Malaria Parasite Carbonic Anhydrase and Its Inhibition in the Development of Novel Therapies of Malaria; 17. Inhibitors of Helicobacter pylori α- and β-Carbonic Anhydrases as Novel Drugs for Gastroduodenal Diseases 18. QSAR of Carbonic Anhydrase Inhibitors and Their Impact on Drug Design19. Selectivity Issues in the Design of CA Inhibitors; 20. Bicarbonate Transport Metabolons; 21. Metal Complexes of Sulfonamides as Dual Carbonic Anhydrase Inhibitors; 22. Drug Design Studies of Carbonic Anhydrase Activators; PART III DRUG DESIGN OF MATRIX METALLOPROTEINASE INHIBITORS; 23. Matrix Metalloproteinases: An Overview; 24. MMP Inhibitors Based on Earlier Succinimide Strategies: From Early to New Approaches; 25. Drug Design of Sulfonylated MMP Inhibitors; 26. ADAMs and ADAMTs Selective Synthetic Inhibitors 27. QSAR Studies of MMP InhibitorsPART IV DRUG DESIGN OF BACTERIAL ZINC PROTEASE INHIBITORS; 28. Bacterial Zinc Proteases as Orphan Targets; 29. Botulinus Toxin, Tetanus Toxin, and Anthrax Lethal Factor Inhibitors; 30. Clostridium histolyticum Collagenase Inhibitors in the Drug Design; 31. Other Bacterial Zinc Peptidases as Potential Drug Targets; PART V DRUG DESIGN STUDIES OF OTHER ZINC-CONTAINING ENZYMES; 32. Angiotensin Converting Enzyme (ACE) Inhibitors; 33. P-III Metalloproteinase (Leucurolysin-B) from Bothrops leucurus Venom: Isolation and Possible Inhibition 34. CaaX-Protein Prenyltransferase Inhibitors |
| Record Nr. | UNINA-9910877645303321 |
| Hoboken, NJ, : John Wiley & Sons, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drug discovery and design [[electronic resource] ] : medical aspects / / edited by J. Matsoukas and T. Mavromoustakos
| Drug discovery and design [[electronic resource] ] : medical aspects / / edited by J. Matsoukas and T. Mavromoustakos |
| Pubbl/distr/stampa | Amsterdam ; ; Washington, D.C., : IOS Press |
| Descrizione fisica | 1 online resource (335 p.) |
| Disciplina | 615/.19 |
| Altri autori (Persone) |
MatsoukasJ (John)
MavromoustakosT (Thomas) |
| Collana | Biomedical and health research |
| Soggetto topico |
Drugs - Research
Drugs - Testing Pharmaceutical technology |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-50553-2
9786610505531 600-00-0403-6 1-60129-420-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Title page; Preface; Contents; Design, Synthesis and Biological Evaluation of Cyclic Angiotensin II Analogues with 3,5 Side-Chain Bridges: Role of C-Terminal Aromatic Residue and Positions 3,5 for Activity; Synthesis of RGD Analogs Incorporating Moiety of Salicylic Acid Derivatives and their Effect on Human Platelet Aggregation In Vitro; Synthesis of Substance P C-terminal Analogs Incorporating D-Amino Acids and Studies of their Antineoplastic Properties in Vitro
Synthesis of Chiral Tetramic Acids Using Activated Derivatives of N-protected α-Amino Acids as Precursors. Structural Characterization of Tetramic Acid Complexes With Metal IonsL-Asparaginase: Structure, Properties and Anti-Tumor Activity; Growth Inhibitory and Apoptotic Effects of Gonadotropin-Releasing Hormone (GnRH) on Human Hepatocellular Carcinoma; Recent Applications of the Amide Approach to the Synthesis of Medicinally Interesting Polyamine Analogues; Design and Synthesis of Fluorescent Steroidal Lipopolyamine Conjugates for Monitoring Gene Delivery Synthesis of (S)-2-Amino-oleic Acid and Other Bioactive Molecules through Glutamate SemialdehydesDevelopment of New Methods for Fluorometric Assays of Enzymes; Enhancement of the Cytogenetic and Cytostatic Activity of Chlorambucil after its Esteric Connection with a Hecogenin Lactam; In Searching for New Anti-Influenza A Drugs: Heterocyclic and Carbocyclic Aminoadamantanes Bearing a 2-Adamantyl Group with Potent Activity Against Influenza A Virus; Design, Synthesis and Conformational Properties of Linear Analogues of Human Myelin Basic Protein Epitope MBP[sub(1-11)] The Effects of Vinblastine Sulfate on Dipalmitoylphosphatidylcholine Single and Multiple Bilayer MembranesStealth Liposomal Vinca Alkaloids (Vinorelbine and Vincrastine) and In Vitro Studies on Release by Buffer and Rat Plasma; Structural Elucidation, Conformational Properties and Effects in Membrane Bilayers of the Toxin Paralysin, β-Ala-Tyr from Larvae of the Gray Flesh Fly; Effects of NSAIDs in Membrane Bilayers; The Structure of Endotoxin-Neutralizing Peptides Bound to LPS Synthesis and Conformational Analysis of Steroidal Carriers of Alkylating Agents with the Use of Two-Dimensional Nuclear Magnetic ResonanceStructure Elucidation and Conformational Properties of Irbesartan; [sup(1)]H and [sup(13)]C NMR Assignment and Conformational Studies of a Myelin Basic Protein Epitope 74-85 Implicated in Multiple Sclerosis; Conformational Analysis of Biomolecules in Solution: NMR - 3D Structures - Biological Implications; Synthesis and Structural Investigation of a Synthetic LHRH Analogue in Solution Synthesis, Biological Evaluation & NMR Solution Structural Models of New Oxytocin Analogues |
| Record Nr. | UNINA-9910455909603321 |
| Amsterdam ; ; Washington, D.C., : IOS Press | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drug discovery and design [[electronic resource] ] : medical aspects / / edited by J. Matsoukas and T. Mavromoustakos
| Drug discovery and design [[electronic resource] ] : medical aspects / / edited by J. Matsoukas and T. Mavromoustakos |
| Pubbl/distr/stampa | Amsterdam ; ; Washington, D.C., : IOS Press |
| Descrizione fisica | 1 online resource (335 p.) |
| Disciplina | 615/.19 |
| Altri autori (Persone) |
MatsoukasJ (John)
MavromoustakosT (Thomas) |
| Collana | Biomedical and health research |
| Soggetto topico |
Drugs - Research
Drugs - Testing Pharmaceutical technology |
| ISBN |
1-280-50553-2
9786610505531 600-00-0403-6 1-60129-420-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Title page; Preface; Contents; Design, Synthesis and Biological Evaluation of Cyclic Angiotensin II Analogues with 3,5 Side-Chain Bridges: Role of C-Terminal Aromatic Residue and Positions 3,5 for Activity; Synthesis of RGD Analogs Incorporating Moiety of Salicylic Acid Derivatives and their Effect on Human Platelet Aggregation In Vitro; Synthesis of Substance P C-terminal Analogs Incorporating D-Amino Acids and Studies of their Antineoplastic Properties in Vitro
Synthesis of Chiral Tetramic Acids Using Activated Derivatives of N-protected α-Amino Acids as Precursors. Structural Characterization of Tetramic Acid Complexes With Metal IonsL-Asparaginase: Structure, Properties and Anti-Tumor Activity; Growth Inhibitory and Apoptotic Effects of Gonadotropin-Releasing Hormone (GnRH) on Human Hepatocellular Carcinoma; Recent Applications of the Amide Approach to the Synthesis of Medicinally Interesting Polyamine Analogues; Design and Synthesis of Fluorescent Steroidal Lipopolyamine Conjugates for Monitoring Gene Delivery Synthesis of (S)-2-Amino-oleic Acid and Other Bioactive Molecules through Glutamate SemialdehydesDevelopment of New Methods for Fluorometric Assays of Enzymes; Enhancement of the Cytogenetic and Cytostatic Activity of Chlorambucil after its Esteric Connection with a Hecogenin Lactam; In Searching for New Anti-Influenza A Drugs: Heterocyclic and Carbocyclic Aminoadamantanes Bearing a 2-Adamantyl Group with Potent Activity Against Influenza A Virus; Design, Synthesis and Conformational Properties of Linear Analogues of Human Myelin Basic Protein Epitope MBP[sub(1-11)] The Effects of Vinblastine Sulfate on Dipalmitoylphosphatidylcholine Single and Multiple Bilayer MembranesStealth Liposomal Vinca Alkaloids (Vinorelbine and Vincrastine) and In Vitro Studies on Release by Buffer and Rat Plasma; Structural Elucidation, Conformational Properties and Effects in Membrane Bilayers of the Toxin Paralysin, β-Ala-Tyr from Larvae of the Gray Flesh Fly; Effects of NSAIDs in Membrane Bilayers; The Structure of Endotoxin-Neutralizing Peptides Bound to LPS Synthesis and Conformational Analysis of Steroidal Carriers of Alkylating Agents with the Use of Two-Dimensional Nuclear Magnetic ResonanceStructure Elucidation and Conformational Properties of Irbesartan; [sup(1)]H and [sup(13)]C NMR Assignment and Conformational Studies of a Myelin Basic Protein Epitope 74-85 Implicated in Multiple Sclerosis; Conformational Analysis of Biomolecules in Solution: NMR - 3D Structures - Biological Implications; Synthesis and Structural Investigation of a Synthetic LHRH Analogue in Solution Synthesis, Biological Evaluation & NMR Solution Structural Models of New Oxytocin Analogues |
| Record Nr. | UNINA-9910780464403321 |
| Amsterdam ; ; Washington, D.C., : IOS Press | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drug discovery and design : medical aspects / / edited by J. Matsoukas and T. Mavromoustakos
| Drug discovery and design : medical aspects / / edited by J. Matsoukas and T. Mavromoustakos |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Amsterdam ; ; Washington, D.C., : IOS Press |
| Descrizione fisica | 1 online resource (335 p.) |
| Disciplina | 615/.19 |
| Altri autori (Persone) |
MatsoukasJ (John)
MavromoustakosT (Thomas) |
| Collana | Biomedical and health research |
| Soggetto topico |
Drugs - Research
Drugs - Testing Pharmaceutical technology |
| ISBN |
1-280-50553-2
9786610505531 600-00-0403-6 1-60129-420-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Title page; Preface; Contents; Design, Synthesis and Biological Evaluation of Cyclic Angiotensin II Analogues with 3,5 Side-Chain Bridges: Role of C-Terminal Aromatic Residue and Positions 3,5 for Activity; Synthesis of RGD Analogs Incorporating Moiety of Salicylic Acid Derivatives and their Effect on Human Platelet Aggregation In Vitro; Synthesis of Substance P C-terminal Analogs Incorporating D-Amino Acids and Studies of their Antineoplastic Properties in Vitro
Synthesis of Chiral Tetramic Acids Using Activated Derivatives of N-protected α-Amino Acids as Precursors. Structural Characterization of Tetramic Acid Complexes With Metal IonsL-Asparaginase: Structure, Properties and Anti-Tumor Activity; Growth Inhibitory and Apoptotic Effects of Gonadotropin-Releasing Hormone (GnRH) on Human Hepatocellular Carcinoma; Recent Applications of the Amide Approach to the Synthesis of Medicinally Interesting Polyamine Analogues; Design and Synthesis of Fluorescent Steroidal Lipopolyamine Conjugates for Monitoring Gene Delivery Synthesis of (S)-2-Amino-oleic Acid and Other Bioactive Molecules through Glutamate SemialdehydesDevelopment of New Methods for Fluorometric Assays of Enzymes; Enhancement of the Cytogenetic and Cytostatic Activity of Chlorambucil after its Esteric Connection with a Hecogenin Lactam; In Searching for New Anti-Influenza A Drugs: Heterocyclic and Carbocyclic Aminoadamantanes Bearing a 2-Adamantyl Group with Potent Activity Against Influenza A Virus; Design, Synthesis and Conformational Properties of Linear Analogues of Human Myelin Basic Protein Epitope MBP[sub(1-11)] The Effects of Vinblastine Sulfate on Dipalmitoylphosphatidylcholine Single and Multiple Bilayer MembranesStealth Liposomal Vinca Alkaloids (Vinorelbine and Vincrastine) and In Vitro Studies on Release by Buffer and Rat Plasma; Structural Elucidation, Conformational Properties and Effects in Membrane Bilayers of the Toxin Paralysin, β-Ala-Tyr from Larvae of the Gray Flesh Fly; Effects of NSAIDs in Membrane Bilayers; The Structure of Endotoxin-Neutralizing Peptides Bound to LPS Synthesis and Conformational Analysis of Steroidal Carriers of Alkylating Agents with the Use of Two-Dimensional Nuclear Magnetic ResonanceStructure Elucidation and Conformational Properties of Irbesartan; [sup(1)]H and [sup(13)]C NMR Assignment and Conformational Studies of a Myelin Basic Protein Epitope 74-85 Implicated in Multiple Sclerosis; Conformational Analysis of Biomolecules in Solution: NMR - 3D Structures - Biological Implications; Synthesis and Structural Investigation of a Synthetic LHRH Analogue in Solution Synthesis, Biological Evaluation & NMR Solution Structural Models of New Oxytocin Analogues |
| Record Nr. | UNINA-9910821903703321 |
| Amsterdam ; ; Washington, D.C., : IOS Press | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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