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Lipophilicity in drug action and toxicology [[electronic resource] /] / edited by Vladimir Pliška, Bernard Testa, and Han van de Waterbeemd
| Lipophilicity in drug action and toxicology [[electronic resource] /] / edited by Vladimir Pliška, Bernard Testa, and Han van de Waterbeemd |
| Pubbl/distr/stampa | Weinheim ; ; New York, : VCH, c1996 |
| Descrizione fisica | 1 online resource (466 p.) |
| Disciplina |
615.7
615/.19 |
| Altri autori (Persone) |
PliškaVladimir
TestaBernard WaterbeemdHan van de |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Drug lipophilicity
Toxicology |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-84266-4
9786611842666 3-527-61499-0 3-527-61498-2 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Lipophilicity in Drug Action and Toxicology; Preface; A Personal Foreword; List of Contributors; Contents; 1 Lipophilicity : The Empirical Tool and the Fundamental Objective . An Introduction; 1.1 Setting the Scene; 1.2 Biological Aspects; 1.3 The Molecule in the Background; 1.4 Some Pragmatic Aspects; 1.4.1 Definitions and Symbols; 1.4.2 Experimental Techniques; 1.4.3 Computational Procedures; 1.5 Objectives of the Book; References; 2 Lipophilicity: A History; 2.1 Introduction; 2.2 Measurement of Lipophilicity; 2.3 Calculation of Lipophilicity; 2.3.1 Substitution Method
2.3.2 Fragment Additivity Method2.3.3 Fragmentation into Atoms; 2.3.4 Molecular Orbital Calculations; 2.3.5 Calculations Based on Surface Area; 2.4 The Nature of Lipophilicity; 2.4.1 Relation to Other Molecular Properties; 2.4.2 Thermodynamics of Partitioning; 2.4.2.1 Phase Transfer; 2.4.2.2 The Aqueous Phase and the "Hydrophobic Bond"; 2.5 Lipophilicity and Biological Activity; References; 3 Thermodynamics of van der Waals and Hydrophobic Interactions; 3.1 Introduction; 3.2 Outline of Thermodynamics and Auxiliary Disciplines; 3.3 Intermolecular Interactions of the van der Waals Type 3.3.1 The Physical Nature of van der Waals Interactions3.3.2 Classification of van der Waals Clusters; 3.3.3 Calculation of the Interaction Energy; 3.3.3.1 Nonempirical ab initio Variational Method; 3.3.3.2 Density Functional Theory; 3.3.3.3 Semiempirical Methods; 3.3.3.4 Empirical Procedures; 3.3.4 How to Obtain a Consistent Set of Various Calculated Properties for van der Waals Clusters; 3.3.4.1 Potential Energy Surface (P . E . S.); 3.3.4.2 Stabilization Energy; 3.3.4.3 Empirical Potential; 3.3.4.4 Vibration Frequencies; 3.3.4.5 Computer Experiments 3.4 Processes Involving Hydrophobic Effects3.5 Specific Illustrations; 3.5.1 Ab initio Evaluation of a Consistent Set of Various Properties of the Benzene ... Arn Cluster; 3.5.1.1 Potential Energy Surface; 3.5.1.2 More Accurate Calculations for the Global Minimum; 3.5.1.3 Preparation of the Empirical Potential; 3.5.1.4 Vibrational Frequencies; 3.5.1.5 Molecular Dynamics Simulations; 3.5.2 Monte Carlo Free Energy Perturbation Calculation : Solvation Free Energy of Methanol and Ethane; References; Appendices; 4 Intramolecular Interactions Encoded in Lipophilicity : Their Nature and Significance 4.1. Introduction : The Concept of Molecular Structure4.1.1 The Elementary and Geometric Levels of Description; 4.1.2 The Stereoelectronic Levels of Description; 4.1.3 Social Molecules; 4.2 Intermolecular Forces Encoded in Lipophilicity; 4.2.1 Recognition Forces in Molecular Pharmacology and Biology; 4.2.2 Factorization of Molecular Lipophilicity; 4.2.3 Polar Interactions Encoded in Lipophilicity; 4.2.4 Nonpolar Interactions Encoded in Lipophilicity; 4.2.5 Recognition Forces Encoded in Lipophilicity; 4.3 Intramolecular Interactions Affecting Lipophilicity; 4.3.1 Electronic Conjugations 4.3.1.1 In Aromatic Systems |
| Record Nr. | UNINA-9910144116703321 |
| Weinheim ; ; New York, : VCH, c1996 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Lipophilicity in drug action and toxicology [[electronic resource] /] / edited by Vladimir Pliška, Bernard Testa, and Han van de Waterbeemd
| Lipophilicity in drug action and toxicology [[electronic resource] /] / edited by Vladimir Pliška, Bernard Testa, and Han van de Waterbeemd |
| Pubbl/distr/stampa | Weinheim ; ; New York, : VCH, c1996 |
| Descrizione fisica | 1 online resource (466 p.) |
| Disciplina |
615.7
615/.19 |
| Altri autori (Persone) |
PliškaVladimir
TestaBernard WaterbeemdHan van de |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Drug lipophilicity
Toxicology |
| ISBN |
1-281-84266-4
9786611842666 3-527-61499-0 3-527-61498-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Lipophilicity in Drug Action and Toxicology; Preface; A Personal Foreword; List of Contributors; Contents; 1 Lipophilicity : The Empirical Tool and the Fundamental Objective . An Introduction; 1.1 Setting the Scene; 1.2 Biological Aspects; 1.3 The Molecule in the Background; 1.4 Some Pragmatic Aspects; 1.4.1 Definitions and Symbols; 1.4.2 Experimental Techniques; 1.4.3 Computational Procedures; 1.5 Objectives of the Book; References; 2 Lipophilicity: A History; 2.1 Introduction; 2.2 Measurement of Lipophilicity; 2.3 Calculation of Lipophilicity; 2.3.1 Substitution Method
2.3.2 Fragment Additivity Method2.3.3 Fragmentation into Atoms; 2.3.4 Molecular Orbital Calculations; 2.3.5 Calculations Based on Surface Area; 2.4 The Nature of Lipophilicity; 2.4.1 Relation to Other Molecular Properties; 2.4.2 Thermodynamics of Partitioning; 2.4.2.1 Phase Transfer; 2.4.2.2 The Aqueous Phase and the "Hydrophobic Bond"; 2.5 Lipophilicity and Biological Activity; References; 3 Thermodynamics of van der Waals and Hydrophobic Interactions; 3.1 Introduction; 3.2 Outline of Thermodynamics and Auxiliary Disciplines; 3.3 Intermolecular Interactions of the van der Waals Type 3.3.1 The Physical Nature of van der Waals Interactions3.3.2 Classification of van der Waals Clusters; 3.3.3 Calculation of the Interaction Energy; 3.3.3.1 Nonempirical ab initio Variational Method; 3.3.3.2 Density Functional Theory; 3.3.3.3 Semiempirical Methods; 3.3.3.4 Empirical Procedures; 3.3.4 How to Obtain a Consistent Set of Various Calculated Properties for van der Waals Clusters; 3.3.4.1 Potential Energy Surface (P . E . S.); 3.3.4.2 Stabilization Energy; 3.3.4.3 Empirical Potential; 3.3.4.4 Vibration Frequencies; 3.3.4.5 Computer Experiments 3.4 Processes Involving Hydrophobic Effects3.5 Specific Illustrations; 3.5.1 Ab initio Evaluation of a Consistent Set of Various Properties of the Benzene ... Arn Cluster; 3.5.1.1 Potential Energy Surface; 3.5.1.2 More Accurate Calculations for the Global Minimum; 3.5.1.3 Preparation of the Empirical Potential; 3.5.1.4 Vibrational Frequencies; 3.5.1.5 Molecular Dynamics Simulations; 3.5.2 Monte Carlo Free Energy Perturbation Calculation : Solvation Free Energy of Methanol and Ethane; References; Appendices; 4 Intramolecular Interactions Encoded in Lipophilicity : Their Nature and Significance 4.1. Introduction : The Concept of Molecular Structure4.1.1 The Elementary and Geometric Levels of Description; 4.1.2 The Stereoelectronic Levels of Description; 4.1.3 Social Molecules; 4.2 Intermolecular Forces Encoded in Lipophilicity; 4.2.1 Recognition Forces in Molecular Pharmacology and Biology; 4.2.2 Factorization of Molecular Lipophilicity; 4.2.3 Polar Interactions Encoded in Lipophilicity; 4.2.4 Nonpolar Interactions Encoded in Lipophilicity; 4.2.5 Recognition Forces Encoded in Lipophilicity; 4.3 Intramolecular Interactions Affecting Lipophilicity; 4.3.1 Electronic Conjugations 4.3.1.1 In Aromatic Systems |
| Record Nr. | UNISA-996205854103316 |
| Weinheim ; ; New York, : VCH, c1996 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Lipophilicity in drug action and toxicology [[electronic resource] /] / edited by Vladimir Pliška, Bernard Testa, and Han van de Waterbeemd
| Lipophilicity in drug action and toxicology [[electronic resource] /] / edited by Vladimir Pliška, Bernard Testa, and Han van de Waterbeemd |
| Pubbl/distr/stampa | Weinheim ; ; New York, : VCH, c1996 |
| Descrizione fisica | 1 online resource (466 p.) |
| Disciplina |
615.7
615/.19 |
| Altri autori (Persone) |
PliškaVladimir
TestaBernard WaterbeemdHan van de |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Drug lipophilicity
Toxicology |
| ISBN |
1-281-84266-4
9786611842666 3-527-61499-0 3-527-61498-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Lipophilicity in Drug Action and Toxicology; Preface; A Personal Foreword; List of Contributors; Contents; 1 Lipophilicity : The Empirical Tool and the Fundamental Objective . An Introduction; 1.1 Setting the Scene; 1.2 Biological Aspects; 1.3 The Molecule in the Background; 1.4 Some Pragmatic Aspects; 1.4.1 Definitions and Symbols; 1.4.2 Experimental Techniques; 1.4.3 Computational Procedures; 1.5 Objectives of the Book; References; 2 Lipophilicity: A History; 2.1 Introduction; 2.2 Measurement of Lipophilicity; 2.3 Calculation of Lipophilicity; 2.3.1 Substitution Method
2.3.2 Fragment Additivity Method2.3.3 Fragmentation into Atoms; 2.3.4 Molecular Orbital Calculations; 2.3.5 Calculations Based on Surface Area; 2.4 The Nature of Lipophilicity; 2.4.1 Relation to Other Molecular Properties; 2.4.2 Thermodynamics of Partitioning; 2.4.2.1 Phase Transfer; 2.4.2.2 The Aqueous Phase and the "Hydrophobic Bond"; 2.5 Lipophilicity and Biological Activity; References; 3 Thermodynamics of van der Waals and Hydrophobic Interactions; 3.1 Introduction; 3.2 Outline of Thermodynamics and Auxiliary Disciplines; 3.3 Intermolecular Interactions of the van der Waals Type 3.3.1 The Physical Nature of van der Waals Interactions3.3.2 Classification of van der Waals Clusters; 3.3.3 Calculation of the Interaction Energy; 3.3.3.1 Nonempirical ab initio Variational Method; 3.3.3.2 Density Functional Theory; 3.3.3.3 Semiempirical Methods; 3.3.3.4 Empirical Procedures; 3.3.4 How to Obtain a Consistent Set of Various Calculated Properties for van der Waals Clusters; 3.3.4.1 Potential Energy Surface (P . E . S.); 3.3.4.2 Stabilization Energy; 3.3.4.3 Empirical Potential; 3.3.4.4 Vibration Frequencies; 3.3.4.5 Computer Experiments 3.4 Processes Involving Hydrophobic Effects3.5 Specific Illustrations; 3.5.1 Ab initio Evaluation of a Consistent Set of Various Properties of the Benzene ... Arn Cluster; 3.5.1.1 Potential Energy Surface; 3.5.1.2 More Accurate Calculations for the Global Minimum; 3.5.1.3 Preparation of the Empirical Potential; 3.5.1.4 Vibrational Frequencies; 3.5.1.5 Molecular Dynamics Simulations; 3.5.2 Monte Carlo Free Energy Perturbation Calculation : Solvation Free Energy of Methanol and Ethane; References; Appendices; 4 Intramolecular Interactions Encoded in Lipophilicity : Their Nature and Significance 4.1. Introduction : The Concept of Molecular Structure4.1.1 The Elementary and Geometric Levels of Description; 4.1.2 The Stereoelectronic Levels of Description; 4.1.3 Social Molecules; 4.2 Intermolecular Forces Encoded in Lipophilicity; 4.2.1 Recognition Forces in Molecular Pharmacology and Biology; 4.2.2 Factorization of Molecular Lipophilicity; 4.2.3 Polar Interactions Encoded in Lipophilicity; 4.2.4 Nonpolar Interactions Encoded in Lipophilicity; 4.2.5 Recognition Forces Encoded in Lipophilicity; 4.3 Intramolecular Interactions Affecting Lipophilicity; 4.3.1 Electronic Conjugations 4.3.1.1 In Aromatic Systems |
| Record Nr. | UNINA-9910830132603321 |
| Weinheim ; ; New York, : VCH, c1996 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Lipophilicity in drug action and toxicology / / edited by Vladimir Pliska, Bernard Testa, and Han van de Waterbeemd
| Lipophilicity in drug action and toxicology / / edited by Vladimir Pliska, Bernard Testa, and Han van de Waterbeemd |
| Pubbl/distr/stampa | Weinheim ; ; New York, : VCH, c1996 |
| Descrizione fisica | 1 online resource (466 p.) |
| Disciplina | 615/.19 |
| Altri autori (Persone) |
PliskaVladimir
TestaBernard WaterbeemdHan van de |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Drug lipophilicity
Toxicology |
| ISBN |
1-281-84266-4
9786611842666 3-527-61499-0 3-527-61498-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Lipophilicity in Drug Action and Toxicology; Preface; A Personal Foreword; List of Contributors; Contents; 1 Lipophilicity : The Empirical Tool and the Fundamental Objective . An Introduction; 1.1 Setting the Scene; 1.2 Biological Aspects; 1.3 The Molecule in the Background; 1.4 Some Pragmatic Aspects; 1.4.1 Definitions and Symbols; 1.4.2 Experimental Techniques; 1.4.3 Computational Procedures; 1.5 Objectives of the Book; References; 2 Lipophilicity: A History; 2.1 Introduction; 2.2 Measurement of Lipophilicity; 2.3 Calculation of Lipophilicity; 2.3.1 Substitution Method
2.3.2 Fragment Additivity Method2.3.3 Fragmentation into Atoms; 2.3.4 Molecular Orbital Calculations; 2.3.5 Calculations Based on Surface Area; 2.4 The Nature of Lipophilicity; 2.4.1 Relation to Other Molecular Properties; 2.4.2 Thermodynamics of Partitioning; 2.4.2.1 Phase Transfer; 2.4.2.2 The Aqueous Phase and the "Hydrophobic Bond"; 2.5 Lipophilicity and Biological Activity; References; 3 Thermodynamics of van der Waals and Hydrophobic Interactions; 3.1 Introduction; 3.2 Outline of Thermodynamics and Auxiliary Disciplines; 3.3 Intermolecular Interactions of the van der Waals Type 3.3.1 The Physical Nature of van der Waals Interactions3.3.2 Classification of van der Waals Clusters; 3.3.3 Calculation of the Interaction Energy; 3.3.3.1 Nonempirical ab initio Variational Method; 3.3.3.2 Density Functional Theory; 3.3.3.3 Semiempirical Methods; 3.3.3.4 Empirical Procedures; 3.3.4 How to Obtain a Consistent Set of Various Calculated Properties for van der Waals Clusters; 3.3.4.1 Potential Energy Surface (P . E . S.); 3.3.4.2 Stabilization Energy; 3.3.4.3 Empirical Potential; 3.3.4.4 Vibration Frequencies; 3.3.4.5 Computer Experiments 3.4 Processes Involving Hydrophobic Effects3.5 Specific Illustrations; 3.5.1 Ab initio Evaluation of a Consistent Set of Various Properties of the Benzene ... Arn Cluster; 3.5.1.1 Potential Energy Surface; 3.5.1.2 More Accurate Calculations for the Global Minimum; 3.5.1.3 Preparation of the Empirical Potential; 3.5.1.4 Vibrational Frequencies; 3.5.1.5 Molecular Dynamics Simulations; 3.5.2 Monte Carlo Free Energy Perturbation Calculation : Solvation Free Energy of Methanol and Ethane; References; Appendices; 4 Intramolecular Interactions Encoded in Lipophilicity : Their Nature and Significance 4.1. Introduction : The Concept of Molecular Structure4.1.1 The Elementary and Geometric Levels of Description; 4.1.2 The Stereoelectronic Levels of Description; 4.1.3 Social Molecules; 4.2 Intermolecular Forces Encoded in Lipophilicity; 4.2.1 Recognition Forces in Molecular Pharmacology and Biology; 4.2.2 Factorization of Molecular Lipophilicity; 4.2.3 Polar Interactions Encoded in Lipophilicity; 4.2.4 Nonpolar Interactions Encoded in Lipophilicity; 4.2.5 Recognition Forces Encoded in Lipophilicity; 4.3 Intramolecular Interactions Affecting Lipophilicity; 4.3.1 Electronic Conjugations 4.3.1.1 In Aromatic Systems |
| Record Nr. | UNINA-9910877153103321 |
| Weinheim ; ; New York, : VCH, c1996 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The management of chemical process development in the pharmaceutical industry [[electronic resource] /] / Derek Walker
| The management of chemical process development in the pharmaceutical industry [[electronic resource] /] / Derek Walker |
| Autore | Walker Derek <1931 June 12-> |
| Pubbl/distr/stampa | Hoboken, NJ, : Wiley-Interscience, c2008 |
| Descrizione fisica | 1 online resource (426 p.) |
| Disciplina |
615.19
615/.19 |
| Soggetto topico |
Pharmaceutical chemistry
Chemical process control Chemical engineering |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-23750-7
9786611237509 0-470-25951-5 0-470-25950-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | THE MANAGEMENT OF CHEMICAL PROCESS DEVELOPMENT IN THE PHARMACEUTICAL INDUSTRY; CONTENTS; 1. Introduction; 2. People: Leadership, Visionaries, Acknowledgments, and Awards; 3. Organization; 4. Process Safety; 5. The Environment; 6. Regulatory Affairs: Meeting the U.S. Food and Drug Administration (FDA) Requirements; 7. Patents; 8. Chemical Engineering; 9. Excursions in the β-Lactam and Steroid Fields; 10. Case Studies; 11. The Future; Author Index; Subject Index |
| Record Nr. | UNINA-9910145593103321 |
Walker Derek <1931 June 12->
|
||
| Hoboken, NJ, : Wiley-Interscience, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The management of chemical process development in the pharmaceutical industry [[electronic resource] /] / Derek Walker
| The management of chemical process development in the pharmaceutical industry [[electronic resource] /] / Derek Walker |
| Autore | Walker Derek <1931 June 12-> |
| Pubbl/distr/stampa | Hoboken, NJ, : Wiley-Interscience, c2008 |
| Descrizione fisica | 1 online resource (426 p.) |
| Disciplina |
615.19
615/.19 |
| Soggetto topico |
Pharmaceutical chemistry
Chemical process control Chemical engineering |
| ISBN |
1-281-23750-7
9786611237509 0-470-25951-5 0-470-25950-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | THE MANAGEMENT OF CHEMICAL PROCESS DEVELOPMENT IN THE PHARMACEUTICAL INDUSTRY; CONTENTS; 1. Introduction; 2. People: Leadership, Visionaries, Acknowledgments, and Awards; 3. Organization; 4. Process Safety; 5. The Environment; 6. Regulatory Affairs: Meeting the U.S. Food and Drug Administration (FDA) Requirements; 7. Patents; 8. Chemical Engineering; 9. Excursions in the β-Lactam and Steroid Fields; 10. Case Studies; 11. The Future; Author Index; Subject Index |
| Record Nr. | UNINA-9910831173003321 |
|
Walker Derek <1931 June 12->
|
||
| Hoboken, NJ, : Wiley-Interscience, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The management of chemical process development in the pharmaceutical industry / / Derek Walker
| The management of chemical process development in the pharmaceutical industry / / Derek Walker |
| Autore | Walker Derek <1931 June 12-> |
| Pubbl/distr/stampa | Hoboken, NJ, : Wiley-Interscience, c2008 |
| Descrizione fisica | 1 online resource (426 p.) |
| Disciplina |
615.19
615/.19 |
| Soggetto topico |
Pharmaceutical chemistry
Chemical process control Chemical engineering |
| ISBN |
1-281-23750-7
9786611237509 0-470-25951-5 0-470-25950-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | THE MANAGEMENT OF CHEMICAL PROCESS DEVELOPMENT IN THE PHARMACEUTICAL INDUSTRY; CONTENTS; 1. Introduction; 2. People: Leadership, Visionaries, Acknowledgments, and Awards; 3. Organization; 4. Process Safety; 5. The Environment; 6. Regulatory Affairs: Meeting the U.S. Food and Drug Administration (FDA) Requirements; 7. Patents; 8. Chemical Engineering; 9. Excursions in the β-Lactam and Steroid Fields; 10. Case Studies; 11. The Future; Author Index; Subject Index |
| Record Nr. | UNINA-9910876597603321 |
|
Walker Derek <1931 June 12->
|
||
| Hoboken, NJ, : Wiley-Interscience, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Medicinal chemistry of nucleic acids / / edited by Li-He Zhang, Zhen Xi, Jyoti Chattopadhyaya
| Medicinal chemistry of nucleic acids / / edited by Li-He Zhang, Zhen Xi, Jyoti Chattopadhyaya |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2011 |
| Descrizione fisica | 1 online resource (466 pages) |
| Disciplina | 615/.19 |
| Altri autori (Persone) |
ZhangLi-He
XiZhen ChattopadhyayaJyoti |
| Collana | Wiley series in drug discovery and development |
| Soggetto topico |
Pharmaceutical chemistry
Nucleic acids - Therapeutic use |
| ISBN |
1-283-23990-6
9786613239907 1-118-09281-3 1-118-09280-5 1-118-09283-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Recent advances in carbocyclic nucleosides : synthesis and biological activity / Jianing Wang, Ravindra K. Rawal, and Chung K. Chu -- Structures and functions of nucleic acids modified with S, Se, and Teand complexed with small molecules / Wen Zhang, Jia Sheng, and Zhen Huang -- Unraveling of the NAD cyclizing and calcium signaling functions of human CD38 / Hon Cheung Lee -- DNA and RNA binding small molecules / Shibo Li and Zhen Xi -- G-quadruplex DNA and its ligands in anticancer therapy / Zhi-shu Huang ... [et al.] -- Molecular modeling in nucleic acid targeted drug design / Lidan Sun ... [et al.] -- Structure of 10-23 DNAzyme in complex with the target RNA in silico : a progress report on the mechanism of RNA cleavage by DNA enzyme / Oleksandr Plashkevych and Jyoti Chattopadhyaya -- Labeling oligonucleotides towards the biomedical probe / Il Joon Lee and Byeang Hyean Kim -- Locked nucleic acid oligonucleotides towards clinical application / Rakesh N. Veedu and Jesper Wengel -- The pharmacokinetics researches of nucleic acid drugs / Shengqi Wang -- Inducible RNAi and drug target validation / Wei Xiong ... [et al.] -- SiRNA : the specificity and off-target effects -- Quan Du, Huang Huang, Zicai Liang. |
| Record Nr. | UNINA-9910139610303321 |
| Hoboken, N.J., : Wiley, c2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Medicinal chemistry research progress [[electronic resource] /] / Giulia P. Colombo and Sofia Ricci, editors
| Medicinal chemistry research progress [[electronic resource] /] / Giulia P. Colombo and Sofia Ricci, editors |
| Pubbl/distr/stampa | New York, : Nova Biomedical Books, c2009 |
| Descrizione fisica | 1 online resource (286 p.) |
| Disciplina | 615/.19 |
| Altri autori (Persone) |
ColomboGiulia P
RicciSofia |
| Soggetto topico |
Pharmaceutical chemistry
Chemistry |
| Soggetto genere / forma | Electronic books. |
| ISBN | 1-60876-375-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910452732203321 |
| New York, : Nova Biomedical Books, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Medicinal chemistry research progress / / Giulia P. Colombo and Sofia Ricci, editors
| Medicinal chemistry research progress / / Giulia P. Colombo and Sofia Ricci, editors |
| Pubbl/distr/stampa | New York : , : Nova Biomedical Books, , 2009 |
| Descrizione fisica | 1 online resource (xi, 271 pages) : illustrations (some color) |
| Disciplina | 615/.19 |
| Altri autori (Persone) |
ColomboGiulia P
RicciSofia |
| Soggetto topico |
Pharmaceutical chemistry
Chemistry |
| ISBN | 1-60876-375-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | An open letter to the community of organic chemists / Pavol Kováč -- Alzheimer's disease, the importance of A[beta] and the hopes for chemo preventatives / Helma Antony and Ian Macreadie ; reviewed by Vidana Epa, Victor Strelsov, and Ross Fernley -- Novel class of antibacterial agents : inhibitors of enoyl-acyl carrier protein reductases FabI and Fabk / Hideo Kitagawa, Tomohiro Ozawa, and Keiichi Ajito -- Progress in the discovery of SERCA inhibitors / Stefan Paula -- G-quadruplex interactive telomerase inhibitors : an exciting field to be explored, with some open challenges on the biological evaluation / Marco Franceschin, Armandodoriano Bianco, and Maria Savino -- Polyenthylenimine in medicinal chemistry / Paola Vicennati, Andrea Masotti, and Giancarlo Ortaggi -- Multifunctional delivery vehicles for biomedical applications : polyenthylenimine as a multipurpose polymer / Andrea Masotti, Paola Vicennati, and Giancarlo Ortaggi ; reviewed by Francesco Pampaloni -- Putative bioactive conformers of small molecules : a concerted approach using NMR spectroscopy and computational chemistry / T. Mavromoustakos ... [et al.] -- The N-terminal part of the ligand-binding domain of the human estrogen receptor [alpha] : a new target for estrogen disruptors / D. Gallo, G. Leclercq, and Y. Jacquot -- Some anticancer targets with peptidomimetics as ligands / Li Su and Wenfang Xu. |
| Record Nr. | UNINA-9910779646803321 |
| New York : , : Nova Biomedical Books, , 2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
