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MARC Lista (tabellare)
Modified-release drug delivery technology / / edited by Michael J. Rathbone [et al.]
Modified-release drug delivery technology / / edited by Michael J. Rathbone [et al.]
Edizione [Second edition.]
Pubbl/distr/stampa New York : , : CRC Press, , 2008
Descrizione fisica 1 online resource (2 volumes) : illustrations
Disciplina 615/.19
Altri autori (Persone) RathboneMichael J. <1957->
HadgraftJonathan <1950->
RobertsMichael S. <1949->
LaneMajella E
Collana Drugs and the pharmaceutical sciences
Soggetto topico Controlled release technology
Controlled release preparations
Drug delivery systems
Pharmaceutical technology
ISBN 0-429-09286-5
1-4200-4526-1
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto ""Preface""; ""Contents""; ""Contributors""; ""1 The Modified-Release Drug Delivery Landscape""; ""2 The Modified-Release Drug Delivery Landscape""; ""3 The Modified-Release Drug Delivery Landscape""; ""4 The Modified-Release Drug Delivery Landscape""; ""5 Ophthalmic Drug Delivery""; ""6 Intraocular Implants for Controlled Drug Delivery""; ""7 Bioadhesive Ophthalmic Drug Inserts (BODI) for Veterinary Use""; ""8 Ion Exchange Resin Technology for Ophthalmic Applications""; ""9 Injections and Implants""; ""10 Long-Acting Protein Formulation-PLAD Technology""
""11 Long-Term Controlled Delivery of Therapeutic Agents by the Osmotically Driven DUROS Implant""; ""12 The SABERTM Delivery System for Parenteral Administration""; ""13 Improving the Delivery of Complex Formulations Using the DepotOne Needle""; ""14 ReGel Depot Technology""; ""15 The Atrigel Drug Delivery System""; ""16 Enhancing Drug Delivery by Chemical Modification""; ""17 DepoFoam Multivesicular Liposomes for the Sustained Release of Macromolecules""; ""18 ALZAMER DepotTM Bioerodible Polymer Technology""
""19 Pegylated Liposome Delivery of Chemotherapeutic Agents: Rationale and Clinical Benefit""; ""20 Dermal and Transdermal Drug Delivery""; ""21 ALZA Transdermal Drug Delivery Technologies""; ""22 Microneedles for Drug Delivery""; ""23 Transfersome: Self-Optimizing and Self-Driven Drug-Carrier, for Localized and Transdermal Drug Delivery""; ""24 Advances in Wound Healing""; ""25 Ultrasound-Mediated Transdermal Drug Delivery""; ""26 Lipid Nanoparticles with Solid Matrix for Dermal Delivery: Solid Lipid Nanoparticles and Nanostructured Lipid Carriers""
""27 LidoSite-Vyteris Iontophoretic Technology""; ""28 Nail Delivery""; ""29 Immediate Topical Drug Delivery Using Natural Nano-Injectors""; ""30 DOT Matrix Technology""; ""31 The PassPortTM System: A New Transdermal Patch for Water-Soluble Drugs, Proteins, and Carbohydrates""; ""32 Nasal Drug Delivery""; ""33 Controlled Particle Dispersion: A Twenty-First-Century Nasal Drug Delivery Platform""; ""34 DirectHalerTM Nasal: Innovative Device and Delivery Method""; ""35 Intravaginal Drug Delivery Technologies""; ""36 Vaginal Rings for Controlled-Release Drug Delivery""
""37 Phospholipids as Carriers for Vaginal Drug Delivery""; ""38 SITE RELEASE, Vaginal Bioadhesive System""; ""39 Clindamycin Vaginal Insert""; ""40 Bioresponsive Vaginal Delivery Systems""; ""41 Pulmonary Delivery of Drugs by Inhalation""; ""42 AERx Pulmonary Drug Delivery Systems""; ""43 Formulation Challenges of Powders for the Delivery of Small Molecular Weight Molecules as Aerosols""; ""44 Adaptive Aerosol Delivery (AAD) Technology""; ""45 Nebulizer Technologies""; ""46 Formulation Challenges: Protein Powders for Inhalation"" ; ""47 The Respimat, a New Soft MistTM Inhaler for Delivering Drugs to the Lungs""
Record Nr. UNINA-9910780901203321
New York : , : CRC Press, , 2008
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Modified-release drug delivery technology / / edited by Michael J. Rathbone [et al.]
Modified-release drug delivery technology / / edited by Michael J. Rathbone [et al.]
Edizione [Second edition.]
Pubbl/distr/stampa New York : , : CRC Press, , 2008
Descrizione fisica 1 online resource (2 volumes) : illustrations
Disciplina 615/.19
Altri autori (Persone) RathboneMichael J. <1957->
HadgraftJonathan <1950->
RobertsMichael S. <1949->
LaneMajella E
Collana Drugs and the pharmaceutical sciences
Soggetto topico Controlled release technology
Controlled release preparations
Drug delivery systems
Pharmaceutical technology
ISBN 0-429-09286-5
1-4200-4526-1
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto ""Preface""; ""Contents""; ""Contributors""; ""1 The Modified-Release Drug Delivery Landscape""; ""2 The Modified-Release Drug Delivery Landscape""; ""3 The Modified-Release Drug Delivery Landscape""; ""4 The Modified-Release Drug Delivery Landscape""; ""5 Ophthalmic Drug Delivery""; ""6 Intraocular Implants for Controlled Drug Delivery""; ""7 Bioadhesive Ophthalmic Drug Inserts (BODI) for Veterinary Use""; ""8 Ion Exchange Resin Technology for Ophthalmic Applications""; ""9 Injections and Implants""; ""10 Long-Acting Protein Formulation-PLAD Technology""
""11 Long-Term Controlled Delivery of Therapeutic Agents by the Osmotically Driven DUROS Implant""; ""12 The SABERTM Delivery System for Parenteral Administration""; ""13 Improving the Delivery of Complex Formulations Using the DepotOne Needle""; ""14 ReGel Depot Technology""; ""15 The Atrigel Drug Delivery System""; ""16 Enhancing Drug Delivery by Chemical Modification""; ""17 DepoFoam Multivesicular Liposomes for the Sustained Release of Macromolecules""; ""18 ALZAMER DepotTM Bioerodible Polymer Technology""
""19 Pegylated Liposome Delivery of Chemotherapeutic Agents: Rationale and Clinical Benefit""; ""20 Dermal and Transdermal Drug Delivery""; ""21 ALZA Transdermal Drug Delivery Technologies""; ""22 Microneedles for Drug Delivery""; ""23 Transfersome: Self-Optimizing and Self-Driven Drug-Carrier, for Localized and Transdermal Drug Delivery""; ""24 Advances in Wound Healing""; ""25 Ultrasound-Mediated Transdermal Drug Delivery""; ""26 Lipid Nanoparticles with Solid Matrix for Dermal Delivery: Solid Lipid Nanoparticles and Nanostructured Lipid Carriers""
""27 LidoSite-Vyteris Iontophoretic Technology""; ""28 Nail Delivery""; ""29 Immediate Topical Drug Delivery Using Natural Nano-Injectors""; ""30 DOT Matrix Technology""; ""31 The PassPortTM System: A New Transdermal Patch for Water-Soluble Drugs, Proteins, and Carbohydrates""; ""32 Nasal Drug Delivery""; ""33 Controlled Particle Dispersion: A Twenty-First-Century Nasal Drug Delivery Platform""; ""34 DirectHalerTM Nasal: Innovative Device and Delivery Method""; ""35 Intravaginal Drug Delivery Technologies""; ""36 Vaginal Rings for Controlled-Release Drug Delivery""
""37 Phospholipids as Carriers for Vaginal Drug Delivery""; ""38 SITE RELEASE, Vaginal Bioadhesive System""; ""39 Clindamycin Vaginal Insert""; ""40 Bioresponsive Vaginal Delivery Systems""; ""41 Pulmonary Delivery of Drugs by Inhalation""; ""42 AERx Pulmonary Drug Delivery Systems""; ""43 Formulation Challenges of Powders for the Delivery of Small Molecular Weight Molecules as Aerosols""; ""44 Adaptive Aerosol Delivery (AAD) Technology""; ""45 Nebulizer Technologies""; ""46 Formulation Challenges: Protein Powders for Inhalation"" ; ""47 The Respimat, a New Soft MistTM Inhaler for Delivering Drugs to the Lungs""
Record Nr. UNINA-9910800075903321
New York : , : CRC Press, , 2008
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Modified-release drug delivery technology / / edited by Michael J. Rathbone [et al.]
Modified-release drug delivery technology / / edited by Michael J. Rathbone [et al.]
Edizione [Second edition.]
Pubbl/distr/stampa New York : , : CRC Press, , 2008
Descrizione fisica 1 online resource (2 volumes) : illustrations
Disciplina 615/.19
Altri autori (Persone) RathboneMichael J. <1957->
HadgraftJonathan <1950->
RobertsMichael S. <1949->
LaneMajella E
Collana Drugs and the pharmaceutical sciences
Soggetto topico Controlled release technology
Controlled release preparations
Drug delivery systems
Pharmaceutical technology
ISBN 0-429-09286-5
1-4200-4526-1
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto ""Preface""; ""Contents""; ""Contributors""; ""1 The Modified-Release Drug Delivery Landscape""; ""2 The Modified-Release Drug Delivery Landscape""; ""3 The Modified-Release Drug Delivery Landscape""; ""4 The Modified-Release Drug Delivery Landscape""; ""5 Ophthalmic Drug Delivery""; ""6 Intraocular Implants for Controlled Drug Delivery""; ""7 Bioadhesive Ophthalmic Drug Inserts (BODI) for Veterinary Use""; ""8 Ion Exchange Resin Technology for Ophthalmic Applications""; ""9 Injections and Implants""; ""10 Long-Acting Protein Formulation-PLAD Technology""
""11 Long-Term Controlled Delivery of Therapeutic Agents by the Osmotically Driven DUROS Implant""; ""12 The SABERTM Delivery System for Parenteral Administration""; ""13 Improving the Delivery of Complex Formulations Using the DepotOne Needle""; ""14 ReGel Depot Technology""; ""15 The Atrigel Drug Delivery System""; ""16 Enhancing Drug Delivery by Chemical Modification""; ""17 DepoFoam Multivesicular Liposomes for the Sustained Release of Macromolecules""; ""18 ALZAMER DepotTM Bioerodible Polymer Technology""
""19 Pegylated Liposome Delivery of Chemotherapeutic Agents: Rationale and Clinical Benefit""; ""20 Dermal and Transdermal Drug Delivery""; ""21 ALZA Transdermal Drug Delivery Technologies""; ""22 Microneedles for Drug Delivery""; ""23 Transfersome: Self-Optimizing and Self-Driven Drug-Carrier, for Localized and Transdermal Drug Delivery""; ""24 Advances in Wound Healing""; ""25 Ultrasound-Mediated Transdermal Drug Delivery""; ""26 Lipid Nanoparticles with Solid Matrix for Dermal Delivery: Solid Lipid Nanoparticles and Nanostructured Lipid Carriers""
""27 LidoSite-Vyteris Iontophoretic Technology""; ""28 Nail Delivery""; ""29 Immediate Topical Drug Delivery Using Natural Nano-Injectors""; ""30 DOT Matrix Technology""; ""31 The PassPortTM System: A New Transdermal Patch for Water-Soluble Drugs, Proteins, and Carbohydrates""; ""32 Nasal Drug Delivery""; ""33 Controlled Particle Dispersion: A Twenty-First-Century Nasal Drug Delivery Platform""; ""34 DirectHalerTM Nasal: Innovative Device and Delivery Method""; ""35 Intravaginal Drug Delivery Technologies""; ""36 Vaginal Rings for Controlled-Release Drug Delivery""
""37 Phospholipids as Carriers for Vaginal Drug Delivery""; ""38 SITE RELEASE, Vaginal Bioadhesive System""; ""39 Clindamycin Vaginal Insert""; ""40 Bioresponsive Vaginal Delivery Systems""; ""41 Pulmonary Delivery of Drugs by Inhalation""; ""42 AERx Pulmonary Drug Delivery Systems""; ""43 Formulation Challenges of Powders for the Delivery of Small Molecular Weight Molecules as Aerosols""; ""44 Adaptive Aerosol Delivery (AAD) Technology""; ""45 Nebulizer Technologies""; ""46 Formulation Challenges: Protein Powders for Inhalation"" ; ""47 The Respimat, a New Soft MistTM Inhaler for Delivering Drugs to the Lungs""
Record Nr. UNINA-9910807468003321
New York : , : CRC Press, , 2008
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Modified-Release Drug Delivery Technology, Second Edition : Modified Release Drug Delivery Technology, Volume 2
Modified-Release Drug Delivery Technology, Second Edition : Modified Release Drug Delivery Technology, Volume 2
Autore Rathbone Michael J
Edizione [2nd ed.]
Pubbl/distr/stampa New York : , : CRC Press, , 2008
Descrizione fisica 1 online resource (727 p.)
Disciplina 615/.19
Altri autori (Persone) HadgraftJonathan
RobertsMichael S
LaneMajella E
Collana Drugs and the pharmaceutical sciences
Soggetto topico Controlled release technology
Controlled release preparations
Drug delivery systems
Pharmaceutical technology
Soggetto genere / forma Electronic books.
ISBN 0-429-09286-5
1-4200-4526-1
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto ""Preface""; ""Contents""; ""Contributors""; ""1 The Modified-Release Drug Delivery Landscape""; ""2 The Modified-Release Drug Delivery Landscape""; ""3 The Modified-Release Drug Delivery Landscape""; ""4 The Modified-Release Drug Delivery Landscape""; ""5 Ophthalmic Drug Delivery""; ""6 Intraocular Implants for Controlled Drug Delivery""; ""7 Bioadhesive Ophthalmic Drug Inserts (BODI) for Veterinary Use""; ""8 Ion Exchange Resin Technology for Ophthalmic Applications""; ""9 Injections and Implants""; ""10 Long-Acting Protein Formulation�PLAD Technology""
""11 Long-Term Controlled Delivery of Therapeutic Agents by the Osmotically Driven DUROS Implant""""12 The SABERTM Delivery System for Parenteral Administration""; ""13 Improving the Delivery of Complex Formulations Using the DepotOne Needle""; ""14 ReGel Depot Technology""; ""15 The Atrigel Drug Delivery System""; ""16 Enhancing Drug Delivery by Chemical Modification""; ""17 DepoFoam Multivesicular Liposomes for the Sustained Release of Macromolecules""; ""18 ALZAMER DepotTM Bioerodible Polymer Technology""
""19 Pegylated Liposome Delivery of Chemotherapeutic Agents: Rationale and Clinical Benefit""""20 Dermal and Transdermal Drug Delivery""; ""21 ALZA Transdermal Drug Delivery Technologies""; ""22 Microneedles for Drug Delivery""; ""23 Transfersome: Self-Optimizing and Self-Driven Drug-Carrier, for Localized and Transdermal Drug Delivery""; ""24 Advances in Wound Healing""; ""25 Ultrasound-Mediated Transdermal Drug Delivery""; ""26 Lipid Nanoparticles with Solid Matrix for Dermal Delivery: Solid Lipid Nanoparticles and Nanostructured Lipid Carriers""
""27 LidoSite�Vyteris Iontophoretic Technology""""28 Nail Delivery""; ""29 Immediate Topical Drug Delivery Using Natural Nano-Injectors""; ""30 DOT Matrix Technology""; ""31 The PassPortTM System: A New Transdermal Patch for Water-Soluble Drugs, Proteins, and Carbohydrates""; ""32 Nasal Drug Delivery""; ""33 Controlled Particle Dispersion: A Twenty-First-Century Nasal Drug Delivery Platform""; ""34 DirectHalerTM Nasal: Innovative Device and Delivery Method""; ""35 Intravaginal Drug Delivery Technologies""; ""36 Vaginal Rings for Controlled-Release Drug Delivery""
""37 Phospholipids as Carriers for Vaginal Drug Delivery""""38 SITE RELEASE, Vaginal Bioadhesive System""; ""39 Clindamycin Vaginal Insert""; ""40 Bioresponsive Vaginal Delivery Systems""; ""41 Pulmonary Delivery of Drugs by Inhalation""; ""42 AERx Pulmonary Drug Delivery Systems""; ""43 Formulation Challenges of Powders for the Delivery of Small Molecular Weight Molecules as Aerosols""; ""44 Adaptive Aerosol Delivery (AAD) Technology""; ""45 Nebulizer Technologies""; ""46 Formulation Challenges: Protein Powders for Inhalation""
""47 The Respimat, a New Soft MistTM Inhaler for Delivering Drugs to the Lungs""
Record Nr. UNINA-9910455928003321
Rathbone Michael J  
New York : , : CRC Press, , 2008
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Molecular pathology in drug discovery and development [[electronic resource] /] / edited by J. Suso Platero
Molecular pathology in drug discovery and development [[electronic resource] /] / edited by J. Suso Platero
Pubbl/distr/stampa Hoboken, N.J., : John Wiley, c2009
Descrizione fisica 1 online resource (396 p.)
Disciplina 615/.19
Altri autori (Persone) PlateroJ. Suso
Soggetto topico Drug development
Pathology, Molecular
ISBN 1-282-27956-4
9786612279560
0-470-47595-1
0-470-47594-3
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto MOLECULAR PATHOLOGY IN DRUG DISCOVERY AND DEVELOPMENT; CONTENTS; Preface; Contributors; 1 MOLECULAR PATHOLOGY AND DRUG DEVELOPMENT; 1.1. General Pathology; 1.2. General Aspects; 1.3. Molecular Pathology, the Molecular Way; 1.3.1. Loss of Gene Expression; 1.3.2. Translocations; 1.3.3. Detection of Pathogens; 1.3.4. Forensic Identification; 1.3.5. Protein Changes; 1.3.6. Other Methods of Detection; 1.4. Application of Molecular Pathology; 1.5. Molecular Pathology in Drug Development; 1.5.1. Most Important Molecular Pathologic Consideration; 1.6. Pharmaceutical Drug Development
1.6.1. Introduction1.6.2. Drug Discovery and Development; References; 2 MOLECULAR PATHOLOGY IN ONCOLOGY TARGET AND DRUG DISCOVERY; 2.1. Introduction; 2.2. History of Chemotherapy and Cancer Drug Discovery; 2.3. Target-Based Drug Discovery; 2.4. Utilization of Molecular Pathology in the Discovery of Novel Cancer Targets; 2.5. Hit Identification and In Vitro Lead Optimization; 2.6. Implications for Molecular Pathology in Cancer Drug Development and Use; 2.7. Summary and Future Considerations; References; 3 MOLECULAR PATHOLOGY AND TRANSCRIPTIONAL PROFILING IN EARLY DRUG DEVELOPMENT
3.1. Introduction3.2. Biomarkers in Clinical Setting and in Early Drug Development; 3.3. Advantages of Biomarker Implementation; 3.4. Changing Paradigm in Clinical Drug and Biomarker Development; 3.5. Promises of Transcriptional Profiling; 3.6. Biomarker Development and Validation Using Microarray Analysis; 3.7. Neoadjuvant Chemotherapy as an Intriguing Model for Biomarker Development; 3.8. Transcriptional Profiling for Identification of Individual Genes as Biomarkers; 3.9. Transcriptional Profiling for the Definition of Multigene Predictors Using Transcriptional Profiling
3.9.1. Multigene Predictors of Chemotherapy Response3.9.2. Multigene Predictor of Response to a Targeted Therapy Agent; 3.9.3. Novel Approaches to Phase II Clinical Trial Design; 3.10. Novel Tools for Pathway Analysis; 3.11. Implementation of Biomarkers into the Clinical Setting; 3.12. Conclusion; References; 4 MOLECULAR PATHOLOGY IN NONCLINICAL SAFETY ASSESSMENT; 4.1. Introduction; 4.2. Drug Development; 4.2.1. Immunohistochemistry in Drug Development; 4.3. Drug Discovery; 4.3.1. Target Validation and Target-Related Safety Concerns; 4.3.2. Off-Target Effects; 4.4. Biopharmaceuticals
4.5. SummaryReferences; 5 TOXICOGENOMICS IN DRUG DEVELOPMENT; 5.1. Introduction; 5.2. Brief Overview of Large-Scale Gene Expression Technologies; 5.2.1. RNA Quality; 5.2.2. Hybridization Platforms; 5.3. Analysis of Microarray Data; 5.3.1. Normalization and Filtering; 5.3.2. Analyzing for Differences between Experimental Samples; 5.3.3. Familywise Error Rate; 5.3.4. Resampling; 5.3.5. Expression Profile Analysis; 5.3.6. Pathway Analysis; 5.3.7. Gene Expression Databases; 5.3.8. Analyzing Relatedness of Gene Expression Profiles; 5.4. Application of Toxicogenomics in Drug Development
5.4.1. Discovery
Record Nr. UNINA-9910139922403321
Hoboken, N.J., : John Wiley, c2009
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Molecular pathology in drug discovery and development [[electronic resource] /] / edited by J. Suso Platero
Molecular pathology in drug discovery and development [[electronic resource] /] / edited by J. Suso Platero
Pubbl/distr/stampa Hoboken, N.J., : John Wiley, c2009
Descrizione fisica 1 online resource (396 p.)
Disciplina 615/.19
Altri autori (Persone) PlateroJ. Suso
Soggetto topico Drug development
Pathology, Molecular
ISBN 1-282-27956-4
9786612279560
0-470-47595-1
0-470-47594-3
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto MOLECULAR PATHOLOGY IN DRUG DISCOVERY AND DEVELOPMENT; CONTENTS; Preface; Contributors; 1 MOLECULAR PATHOLOGY AND DRUG DEVELOPMENT; 1.1. General Pathology; 1.2. General Aspects; 1.3. Molecular Pathology, the Molecular Way; 1.3.1. Loss of Gene Expression; 1.3.2. Translocations; 1.3.3. Detection of Pathogens; 1.3.4. Forensic Identification; 1.3.5. Protein Changes; 1.3.6. Other Methods of Detection; 1.4. Application of Molecular Pathology; 1.5. Molecular Pathology in Drug Development; 1.5.1. Most Important Molecular Pathologic Consideration; 1.6. Pharmaceutical Drug Development
1.6.1. Introduction1.6.2. Drug Discovery and Development; References; 2 MOLECULAR PATHOLOGY IN ONCOLOGY TARGET AND DRUG DISCOVERY; 2.1. Introduction; 2.2. History of Chemotherapy and Cancer Drug Discovery; 2.3. Target-Based Drug Discovery; 2.4. Utilization of Molecular Pathology in the Discovery of Novel Cancer Targets; 2.5. Hit Identification and In Vitro Lead Optimization; 2.6. Implications for Molecular Pathology in Cancer Drug Development and Use; 2.7. Summary and Future Considerations; References; 3 MOLECULAR PATHOLOGY AND TRANSCRIPTIONAL PROFILING IN EARLY DRUG DEVELOPMENT
3.1. Introduction3.2. Biomarkers in Clinical Setting and in Early Drug Development; 3.3. Advantages of Biomarker Implementation; 3.4. Changing Paradigm in Clinical Drug and Biomarker Development; 3.5. Promises of Transcriptional Profiling; 3.6. Biomarker Development and Validation Using Microarray Analysis; 3.7. Neoadjuvant Chemotherapy as an Intriguing Model for Biomarker Development; 3.8. Transcriptional Profiling for Identification of Individual Genes as Biomarkers; 3.9. Transcriptional Profiling for the Definition of Multigene Predictors Using Transcriptional Profiling
3.9.1. Multigene Predictors of Chemotherapy Response3.9.2. Multigene Predictor of Response to a Targeted Therapy Agent; 3.9.3. Novel Approaches to Phase II Clinical Trial Design; 3.10. Novel Tools for Pathway Analysis; 3.11. Implementation of Biomarkers into the Clinical Setting; 3.12. Conclusion; References; 4 MOLECULAR PATHOLOGY IN NONCLINICAL SAFETY ASSESSMENT; 4.1. Introduction; 4.2. Drug Development; 4.2.1. Immunohistochemistry in Drug Development; 4.3. Drug Discovery; 4.3.1. Target Validation and Target-Related Safety Concerns; 4.3.2. Off-Target Effects; 4.4. Biopharmaceuticals
4.5. SummaryReferences; 5 TOXICOGENOMICS IN DRUG DEVELOPMENT; 5.1. Introduction; 5.2. Brief Overview of Large-Scale Gene Expression Technologies; 5.2.1. RNA Quality; 5.2.2. Hybridization Platforms; 5.3. Analysis of Microarray Data; 5.3.1. Normalization and Filtering; 5.3.2. Analyzing for Differences between Experimental Samples; 5.3.3. Familywise Error Rate; 5.3.4. Resampling; 5.3.5. Expression Profile Analysis; 5.3.6. Pathway Analysis; 5.3.7. Gene Expression Databases; 5.3.8. Analyzing Relatedness of Gene Expression Profiles; 5.4. Application of Toxicogenomics in Drug Development
5.4.1. Discovery
Record Nr. UNINA-9910812380703321
Hoboken, N.J., : John Wiley, c2009
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
New developments in medicinal chemistry [[electronic resource] /] / Marta P. Ortega and Irene C. Gil, editors
New developments in medicinal chemistry [[electronic resource] /] / Marta P. Ortega and Irene C. Gil, editors
Pubbl/distr/stampa New York, : Nova Science Publishers, c2009
Descrizione fisica 1 online resource (290 p.)
Disciplina 615/.19
Altri autori (Persone) OrtegaMarta P
GilIrene C
Soggetto topico Pharmaceutical chemistry
Soggetto genere / forma Electronic books.
ISBN 1-61728-546-3
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Folate biosynthesis : reappraisal of old and novel targets in the search for new antimicrobials / James Swarbrick ... [et al.] -- Studies on anti-cancer agents : phenolic compounds and their pharmacological activity / Maria Dolors Pujol and Isabel Sánchez -- Cytotoxic anticancer drugs from medicinal plants / Anh-Tho Nguyen and Pierre Duez -- Emerging applications of quantum dots in medicinal chemistry and drug development / Ian D. Tomlinson, Michael R. Warnement and Sandra J. Rosenthal -- Medicinal chemistry of copper and vanadium bioactive compounds / Susana B. Etcheverry and Patricia A.M. Williams -- Antimalarial peroxides : from artemisinin to synthetic peroxides / Jernej Iskra -- Chemical ecology and medicinal chemistry of marine NF-kB inhibitors / F. Folmer ... [et al.] -- Layered double hydroxides and their intercalation compounds in photo-chemistry and in medicinal chemistry / Umberto Costantino and Morena Nocchetti.
Record Nr. UNINA-9910460051403321
New York, : Nova Science Publishers, c2009
Materiale a stampa
Lo trovi qui: Univ. Federico II
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New developments in medicinal chemistry / / Marta P. Ortega and Irene C. Gil, editors
New developments in medicinal chemistry / / Marta P. Ortega and Irene C. Gil, editors
Pubbl/distr/stampa New York : , : Nova Science Publishers, , 2009
Descrizione fisica 1 online resource (290 pages)
Disciplina 615/.19
Altri autori (Persone) OrtegaMarta P
GilIrene C
Soggetto topico Pharmaceutical chemistry
Drugs - Design
ISBN 1-61728-546-3
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Folate biosynthesis : reappraisal of old and novel targets in the search for new antimicrobials / James Swarbrick ... [et al.] -- Studies on anti-cancer agents : phenolic compounds and their pharmacological activity / Maria Dolors Pujol and Isabel Sánchez -- Cytotoxic anticancer drugs from medicinal plants / Anh-Tho Nguyen and Pierre Duez -- Emerging applications of quantum dots in medicinal chemistry and drug development / Ian D. Tomlinson, Michael R. Warnement and Sandra J. Rosenthal -- Medicinal chemistry of copper and vanadium bioactive compounds / Susana B. Etcheverry and Patricia A.M. Williams -- Antimalarial peroxides : from artemisinin to synthetic peroxides / Jernej Iskra -- Chemical ecology and medicinal chemistry of marine NF-kB inhibitors / F. Folmer ... [et al.] -- Layered double hydroxides and their intercalation compounds in photo-chemistry and in medicinal chemistry / Umberto Costantino and Morena Nocchetti.
Record Nr. UNINA-9910785290203321
New York : , : Nova Science Publishers, , 2009
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
New developments in medicinal chemistry / / Marta P. Ortega and Irene C. Gil, editors
New developments in medicinal chemistry / / Marta P. Ortega and Irene C. Gil, editors
Pubbl/distr/stampa New York : , : Nova Science Publishers, , 2009
Descrizione fisica 1 online resource (290 pages)
Disciplina 615/.19
Altri autori (Persone) OrtegaMarta P
GilIrene C
Soggetto topico Pharmaceutical chemistry
Drugs - Design
ISBN 1-61728-546-3
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Folate biosynthesis : reappraisal of old and novel targets in the search for new antimicrobials / James Swarbrick ... [et al.] -- Studies on anti-cancer agents : phenolic compounds and their pharmacological activity / Maria Dolors Pujol and Isabel Sánchez -- Cytotoxic anticancer drugs from medicinal plants / Anh-Tho Nguyen and Pierre Duez -- Emerging applications of quantum dots in medicinal chemistry and drug development / Ian D. Tomlinson, Michael R. Warnement and Sandra J. Rosenthal -- Medicinal chemistry of copper and vanadium bioactive compounds / Susana B. Etcheverry and Patricia A.M. Williams -- Antimalarial peroxides : from artemisinin to synthetic peroxides / Jernej Iskra -- Chemical ecology and medicinal chemistry of marine NF-kB inhibitors / F. Folmer ... [et al.] -- Layered double hydroxides and their intercalation compounds in photo-chemistry and in medicinal chemistry / Umberto Costantino and Morena Nocchetti.
Record Nr. UNINA-9910827243803321
New York : , : Nova Science Publishers, , 2009
Materiale a stampa
Lo trovi qui: Univ. Federico II
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New drug discovery and development [[electronic resource] /] / Daniel Lednicer
New drug discovery and development [[electronic resource] /] / Daniel Lednicer
Autore Lednicer Daniel <1929->
Pubbl/distr/stampa Hoboken, N.J., : Wiley-Interscience, c2007
Descrizione fisica 1 online resource (204 p.)
Disciplina 615.19
615/.19
Soggetto topico Pharmaceutical chemistry
Drugs - Design
Drug development
Soggetto genere / forma Electronic books.
ISBN 1-280-72148-0
9786610721481
0-470-06827-2
0-470-06826-4
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Antibiotics -- Antiviral drugs -- Antihypertensive agents -- Lipid lowering drugs -- Centrally acting analgesics -- Nonopiate analgesic agents -- Steroids -- Histamine -- From lab bench to pharmacy shelf.
Record Nr. UNINA-9910143680403321
Lednicer Daniel <1929->  
Hoboken, N.J., : Wiley-Interscience, c2007
Materiale a stampa
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