In silico lead discovery [[electronic resource] /] / by Maria A. Miteva |
Autore | Miteva Maria A |
Edizione | [1st ed.] |
Pubbl/distr/stampa | [Saif Zone, Sharjah, United Arab Emirates], : Bentham Science Publishers Ltd., [2011] |
Descrizione fisica | 1 online resource (201 p.) |
Disciplina | 615/.19 |
Soggetto topico |
Drug development
Drug development - Computer simulation |
ISBN | 1-60805-142-0 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | 01 Title.pdf; 02 Cover Page; 03 eBooks End User License Agreement-Website; 04 Content; 05 Foreword_Grigirov; 06 Preface_Miteva; 07 Contributors_Proposal_forEbook-MariaMiteva; 08 Chapter 1 Lagorce_et al_revised 2; 09 Chapter 2 Sperandio_et al_revised 2; 10 Chapter 3 Guyon_Tuffery_corrected 2; 11 Chapter 4 Todorov_corrected 2; 12 Chapter 5 Alexov_revised 2; 13 Chapter 6 Miteva_revised 2; 14 Chapter 7 Roche-revised 2; 15 Chapter 8 Pajeva_Wiese_revised 2; 16 Chapter 9 Moro_revised 2; 17 Chapter 10 Lee; 18 Index |
Record Nr. | UNINA-9910814940003321 |
Miteva Maria A | ||
[Saif Zone, Sharjah, United Arab Emirates], : Bentham Science Publishers Ltd., [2011] | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Industrial pharmaceutical biotechnology |
Autore | Klefenz Heinrich |
Pubbl/distr/stampa | [Place of publication not identified], : Wiley VCH, 2002 |
Descrizione fisica | 1 online resource (312 pages) |
Disciplina | 615/.19 |
Soggetto topico |
Pharmaceutical biotechnology
Biotechnology Pharmaceutical Preparations Drug Industry Chemicals and Drugs Biological Science Disciplines Industry Technology Technology, Industry, and Agriculture Natural Science Disciplines Technology, Industry, Agriculture Disciplines and Occupations Pharmacy, Therapeutics, & Pharmacology Health & Biological Sciences |
Soggetto genere / forma | Electronic books. |
ISBN |
1-280-55756-7
9786610557561 3-527-60012-4 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910146051603321 |
Klefenz Heinrich | ||
[Place of publication not identified], : Wiley VCH, 2002 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Industrial pharmaceutical biotechnology |
Autore | Klefenz Heinrich |
Pubbl/distr/stampa | [Place of publication not identified], : Wiley VCH, 2002 |
Descrizione fisica | 1 online resource (312 pages) |
Disciplina | 615/.19 |
Soggetto topico |
Pharmaceutical biotechnology
Biotechnology Pharmaceutical Preparations Drug Industry Chemicals and Drugs Biological Science Disciplines Industry Technology Technology, Industry, and Agriculture Natural Science Disciplines Technology, Industry, Agriculture Disciplines and Occupations Pharmacy, Therapeutics, & Pharmacology Health & Biological Sciences |
ISBN |
1-280-55756-7
9786610557561 3-527-60012-4 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910829838103321 |
Klefenz Heinrich | ||
[Place of publication not identified], : Wiley VCH, 2002 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Industrial pharmaceutical biotechnology |
Autore | Klefenz Heinrich |
Pubbl/distr/stampa | [Place of publication not identified], : Wiley VCH, 2002 |
Descrizione fisica | 1 online resource (312 pages) |
Disciplina | 615/.19 |
Soggetto topico |
Pharmaceutical biotechnology
Biotechnology Pharmaceutical Preparations Drug Industry Chemicals and Drugs Biological Science Disciplines Industry Technology Technology, Industry, and Agriculture Natural Science Disciplines Technology, Industry, Agriculture Disciplines and Occupations Pharmacy, Therapeutics, & Pharmacology Health & Biological Sciences |
ISBN |
1-280-55756-7
9786610557561 3-527-60012-4 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910841406903321 |
Klefenz Heinrich | ||
[Place of publication not identified], : Wiley VCH, 2002 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Integrated strategies for drug discovery using mass spectrometry [[electronic resource] /] / [edited by] Mike S. Lee |
Pubbl/distr/stampa | Hoboken, N.J., : Wiley-Interscience, c2005 |
Descrizione fisica | 1 online resource (570 p.) |
Disciplina |
615.19
615/.19 |
Altri autori (Persone) | LeeMike S. <1960-> |
Collana | Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods |
Soggetto topico |
Mass spectrometry
Drugs - Analysis High throughput screening (Drug development) |
ISBN |
1-280-27658-4
9786610276585 0-470-24248-5 0-471-72103-4 0-471-72102-6 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Miniaturized formats for efficient liquid chromatography mass spectrometry-based proteomics and therapeutic development / Gary A. Valaskovic -- Mass spectrometry based drug screening assays for early phases in drug discovery / Marshall M. Siegel -- ESI-FTICR as a high throughput drug discovery platform / Kristin A. Sannes-Lowery -- Mass spectrometry based proteomic approaches for disease diagnosis and biomarker discovery / Thomas P. Conrads -- Metabonomic applications in toxicity screening and disease diagnosis / John P. Shockcor -- The central role of mass spectrometry in natural products discovery / Jeffrey R. Gilbert -- Application of mass spectrometry to compound library generation, analysis, and management / Xueheng Cheng -- A Combinatorial process for drug discovery / David S. Wagner -- Application of technological advances in biotransformation studies / Carmen L. Fernandez-Metzler -- Applications of mass spectrometry for the characterization of reactive metabolites of drugs in discovery / Jim Wang -- Advances in high-throughput quantitative drug discovery bioanalysis / Bradley L. Ackermann -- New strategies for the implementation and support of bioanalysis in a drug metabolism environment / Walter A. Korfmacher -- An integrated LC/MS strategy for preclinical candidate optimization / Jonathan L. Josephs -- New approaches for method development and purification in lead optimization / Yining Zhao -- High throughput metabolic and physicochemical property analysis / Edward H. Kerns -- Organ perfusion and mass spectrometry / C. Gerald Curtis -- Sample preparation for drug discovery bioanalysis / David A. Wells -- Automation / John D. Laycock. |
Record Nr. | UNINA-9910143579703321 |
Hoboken, N.J., : Wiley-Interscience, c2005 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Integrated strategies for drug discovery using mass spectrometry [[electronic resource] /] / [edited by] Mike S. Lee |
Pubbl/distr/stampa | Hoboken, N.J., : Wiley-Interscience, c2005 |
Descrizione fisica | 1 online resource (570 p.) |
Disciplina |
615.19
615/.19 |
Altri autori (Persone) | LeeMike S. <1960-> |
Collana | Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods |
Soggetto topico |
Mass spectrometry
Drugs - Analysis High throughput screening (Drug development) |
ISBN |
1-280-27658-4
9786610276585 0-470-24248-5 0-471-72103-4 0-471-72102-6 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Miniaturized formats for efficient liquid chromatography mass spectrometry-based proteomics and therapeutic development / Gary A. Valaskovic -- Mass spectrometry based drug screening assays for early phases in drug discovery / Marshall M. Siegel -- ESI-FTICR as a high throughput drug discovery platform / Kristin A. Sannes-Lowery -- Mass spectrometry based proteomic approaches for disease diagnosis and biomarker discovery / Thomas P. Conrads -- Metabonomic applications in toxicity screening and disease diagnosis / John P. Shockcor -- The central role of mass spectrometry in natural products discovery / Jeffrey R. Gilbert -- Application of mass spectrometry to compound library generation, analysis, and management / Xueheng Cheng -- A Combinatorial process for drug discovery / David S. Wagner -- Application of technological advances in biotransformation studies / Carmen L. Fernandez-Metzler -- Applications of mass spectrometry for the characterization of reactive metabolites of drugs in discovery / Jim Wang -- Advances in high-throughput quantitative drug discovery bioanalysis / Bradley L. Ackermann -- New strategies for the implementation and support of bioanalysis in a drug metabolism environment / Walter A. Korfmacher -- An integrated LC/MS strategy for preclinical candidate optimization / Jonathan L. Josephs -- New approaches for method development and purification in lead optimization / Yining Zhao -- High throughput metabolic and physicochemical property analysis / Edward H. Kerns -- Organ perfusion and mass spectrometry / C. Gerald Curtis -- Sample preparation for drug discovery bioanalysis / David A. Wells -- Automation / John D. Laycock. |
Record Nr. | UNINA-9910830715203321 |
Hoboken, N.J., : Wiley-Interscience, c2005 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Integrated strategies for drug discovery using mass spectrometry [[electronic resource] /] / [edited by] Mike S. Lee |
Pubbl/distr/stampa | Hoboken, N.J., : Wiley-Interscience, c2005 |
Descrizione fisica | 1 online resource (570 p.) |
Disciplina |
615.19
615/.19 |
Altri autori (Persone) | LeeMike S. <1960-> |
Collana | Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods |
Soggetto topico |
Mass spectrometry
Drugs - Analysis High throughput screening (Drug development) |
ISBN |
1-280-27658-4
9786610276585 0-470-24248-5 0-471-72103-4 0-471-72102-6 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Miniaturized formats for efficient liquid chromatography mass spectrometry-based proteomics and therapeutic development / Gary A. Valaskovic -- Mass spectrometry based drug screening assays for early phases in drug discovery / Marshall M. Siegel -- ESI-FTICR as a high throughput drug discovery platform / Kristin A. Sannes-Lowery -- Mass spectrometry based proteomic approaches for disease diagnosis and biomarker discovery / Thomas P. Conrads -- Metabonomic applications in toxicity screening and disease diagnosis / John P. Shockcor -- The central role of mass spectrometry in natural products discovery / Jeffrey R. Gilbert -- Application of mass spectrometry to compound library generation, analysis, and management / Xueheng Cheng -- A Combinatorial process for drug discovery / David S. Wagner -- Application of technological advances in biotransformation studies / Carmen L. Fernandez-Metzler -- Applications of mass spectrometry for the characterization of reactive metabolites of drugs in discovery / Jim Wang -- Advances in high-throughput quantitative drug discovery bioanalysis / Bradley L. Ackermann -- New strategies for the implementation and support of bioanalysis in a drug metabolism environment / Walter A. Korfmacher -- An integrated LC/MS strategy for preclinical candidate optimization / Jonathan L. Josephs -- New approaches for method development and purification in lead optimization / Yining Zhao -- High throughput metabolic and physicochemical property analysis / Edward H. Kerns -- Organ perfusion and mass spectrometry / C. Gerald Curtis -- Sample preparation for drug discovery bioanalysis / David A. Wells -- Automation / John D. Laycock. |
Record Nr. | UNINA-9910841232003321 |
Hoboken, N.J., : Wiley-Interscience, c2005 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Label-free technologies for drug discovery [[electronic resource] /] / editors, Matthew Cooper, Lorenz Mayr |
Pubbl/distr/stampa | Chichester, West Sussex, U.K., : John Wiley & Sons, 2011 |
Descrizione fisica | 1 online resource (350 p.) |
Disciplina |
615.19
615/.19 |
Altri autori (Persone) |
CooperM. A (Matthew A.)
MayrLorenz |
Soggetto topico |
Drug development
Biosensors Pharmaceutical biotechnology |
ISBN |
1-119-99027-0
1-283-37396-3 9786613373960 0-470-97913-5 0-470-97912-7 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Label-Free TechnologiesFor Drug Discovery; Contents; Preface; List of Contributors; 1 The Revolution of Real-Time, Label-Free Biosensor Applications; 1.1 Introduction; 1.2 SPR Pessimists; 1.3 Setting Up Experiments; 1.4 Data Processing and Analysis; 1.5 The Good News; References; 2 Design and Implementation of Vertically Emitting Distributed Feedback Lasers for Biological Sensing; 2.1 Introduction; 2.2 DFB Laser Biosensor Design; 2.3 Fabrication and Instrumentation; 2.4 Experimental Results; 2.4.1 Vertically Emitting DFB Laser; 2.4.2 Bulk Material Sensing; 2.4.3 Sensitivity Resolution
2.4.4 Small Molecule Binding Detection2.5 Conclusions; Acknowledgements; References; 3 SPR Screening of Chemical Microarrays for Fragment-Based Discovery; 3.1 Introduction; 3.2 Key Features of Fragment Screening; 3.3 SPR Fragment Screening; 3.4 Synthesis of Library Compounds; 3.5 Library Design and Array Content; 3.6 Chemical Microarray Production; 3.7 Surface Plasmon Resonance; 3.8 SPR Imaging; 3.9 Array Visualization and Analysis; 3.10 Follow-up; 3.11 Applications: MMP Case Study; 3.11.1 Search for New Binding Modes; 3.11.2 Selectivity Studies; 3.12 Other Target Classes; 3.13 Conclusion References4 The CellKey R System: A Label-Free Cell-Based Assay Platform for Early Drug Discovery Applications; 4.1 Introduction; 4.2 Cellular Impedance Technology; 4.3 Target Identification and Validation; 4.4 Screening and Lead Optimization; 4.5 Conclusion; References; 5 Dynamic and Label-Free Cell-Based Assays Using the xCELLigence System; 5.1 Introduction; 5.2 The xCELLigence System; 5.3 Principle of Detection; 5.4 Applications; 5.4.1 Cell Proliferation, Cytotoxicity and Time Dependent Cellular Response Profiling; 5.5 Functional Assays for G-Protein Coupled Receptors; 5.6 Conclusion References6 Selecting the Best HTS Hits to Move Forward: ITC Ligand Binding Characterization Provides Guidance; 6.1 Introduction; 6.2 Principles of Isothermal Titration Calorimetry (ITC); 6.3 Applications of ITC in Hit Validation; 6.3.1 Assay Design for Hit Confirmation and Affinity Determination; 6.3.2 Identification of Nonspecific Binders, Unstable Protein Targets and Multiple Binding Sites; 6.3.3 High Speed ITC Hit Characterization Assays; 6.4 Applications of ITC in Fragment-Based Drug Discovery; 6.4.1 Measuring Weak Affinities by ITC; 6.5 Applications of ITC in Mechanism of Action Studies 6.6 Applications of ITC in Lead Optimization6.7 ITC as an Enzyme Activity Monitor; 6.8 Conclusion; References; 7 Incorporating Transmitted Light Modalities into High-Content Analysis Assays; 7.1 Introduction; 7.2 Transmitted Light (Bright Field) Imaging; 7.3 Image Analysis of Phase Contrast Images; 7.4 Conclusion; References; 8 Nonradioactive Rubidium Efflux Assay Technology for Screening of Ion Channels; 8.1 Introduction; 8.2 Ion Channels as Drug Targets; 8.3 Ion Channel Assays and Screening; 8.4 Nonradioactive Rubidium Efflux Assay Based on Atomic Absorption Spectrometry 8.5 A Typical Assay Protocol |
Record Nr. | UNINA-9910133454603321 |
Chichester, West Sussex, U.K., : John Wiley & Sons, 2011 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Label-free technologies for drug discovery [[electronic resource] /] / editors, Matthew Cooper, Lorenz Mayr |
Pubbl/distr/stampa | Chichester, West Sussex, U.K., : John Wiley & Sons, 2011 |
Descrizione fisica | 1 online resource (350 p.) |
Disciplina |
615.19
615/.19 |
Altri autori (Persone) |
CooperM. A (Matthew A.)
MayrLorenz |
Soggetto topico |
Drug development
Biosensors Pharmaceutical biotechnology |
ISBN |
1-119-99027-0
1-283-37396-3 9786613373960 0-470-97913-5 0-470-97912-7 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Label-Free TechnologiesFor Drug Discovery; Contents; Preface; List of Contributors; 1 The Revolution of Real-Time, Label-Free Biosensor Applications; 1.1 Introduction; 1.2 SPR Pessimists; 1.3 Setting Up Experiments; 1.4 Data Processing and Analysis; 1.5 The Good News; References; 2 Design and Implementation of Vertically Emitting Distributed Feedback Lasers for Biological Sensing; 2.1 Introduction; 2.2 DFB Laser Biosensor Design; 2.3 Fabrication and Instrumentation; 2.4 Experimental Results; 2.4.1 Vertically Emitting DFB Laser; 2.4.2 Bulk Material Sensing; 2.4.3 Sensitivity Resolution
2.4.4 Small Molecule Binding Detection2.5 Conclusions; Acknowledgements; References; 3 SPR Screening of Chemical Microarrays for Fragment-Based Discovery; 3.1 Introduction; 3.2 Key Features of Fragment Screening; 3.3 SPR Fragment Screening; 3.4 Synthesis of Library Compounds; 3.5 Library Design and Array Content; 3.6 Chemical Microarray Production; 3.7 Surface Plasmon Resonance; 3.8 SPR Imaging; 3.9 Array Visualization and Analysis; 3.10 Follow-up; 3.11 Applications: MMP Case Study; 3.11.1 Search for New Binding Modes; 3.11.2 Selectivity Studies; 3.12 Other Target Classes; 3.13 Conclusion References4 The CellKey R System: A Label-Free Cell-Based Assay Platform for Early Drug Discovery Applications; 4.1 Introduction; 4.2 Cellular Impedance Technology; 4.3 Target Identification and Validation; 4.4 Screening and Lead Optimization; 4.5 Conclusion; References; 5 Dynamic and Label-Free Cell-Based Assays Using the xCELLigence System; 5.1 Introduction; 5.2 The xCELLigence System; 5.3 Principle of Detection; 5.4 Applications; 5.4.1 Cell Proliferation, Cytotoxicity and Time Dependent Cellular Response Profiling; 5.5 Functional Assays for G-Protein Coupled Receptors; 5.6 Conclusion References6 Selecting the Best HTS Hits to Move Forward: ITC Ligand Binding Characterization Provides Guidance; 6.1 Introduction; 6.2 Principles of Isothermal Titration Calorimetry (ITC); 6.3 Applications of ITC in Hit Validation; 6.3.1 Assay Design for Hit Confirmation and Affinity Determination; 6.3.2 Identification of Nonspecific Binders, Unstable Protein Targets and Multiple Binding Sites; 6.3.3 High Speed ITC Hit Characterization Assays; 6.4 Applications of ITC in Fragment-Based Drug Discovery; 6.4.1 Measuring Weak Affinities by ITC; 6.5 Applications of ITC in Mechanism of Action Studies 6.6 Applications of ITC in Lead Optimization6.7 ITC as an Enzyme Activity Monitor; 6.8 Conclusion; References; 7 Incorporating Transmitted Light Modalities into High-Content Analysis Assays; 7.1 Introduction; 7.2 Transmitted Light (Bright Field) Imaging; 7.3 Image Analysis of Phase Contrast Images; 7.4 Conclusion; References; 8 Nonradioactive Rubidium Efflux Assay Technology for Screening of Ion Channels; 8.1 Introduction; 8.2 Ion Channels as Drug Targets; 8.3 Ion Channel Assays and Screening; 8.4 Nonradioactive Rubidium Efflux Assay Based on Atomic Absorption Spectrometry 8.5 A Typical Assay Protocol |
Record Nr. | UNINA-9910830744603321 |
Chichester, West Sussex, U.K., : John Wiley & Sons, 2011 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Label-free technologies for drug discovery [[electronic resource] /] / editors, Matthew Cooper, Lorenz Mayr |
Pubbl/distr/stampa | Chichester, West Sussex, U.K., : John Wiley & Sons, 2011 |
Descrizione fisica | 1 online resource (350 p.) |
Disciplina |
615.19
615/.19 |
Altri autori (Persone) |
CooperM. A (Matthew A.)
MayrLorenz |
Soggetto topico |
Drug development
Biosensors Pharmaceutical biotechnology |
ISBN |
1-119-99027-0
1-283-37396-3 9786613373960 0-470-97913-5 0-470-97912-7 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Label-Free TechnologiesFor Drug Discovery; Contents; Preface; List of Contributors; 1 The Revolution of Real-Time, Label-Free Biosensor Applications; 1.1 Introduction; 1.2 SPR Pessimists; 1.3 Setting Up Experiments; 1.4 Data Processing and Analysis; 1.5 The Good News; References; 2 Design and Implementation of Vertically Emitting Distributed Feedback Lasers for Biological Sensing; 2.1 Introduction; 2.2 DFB Laser Biosensor Design; 2.3 Fabrication and Instrumentation; 2.4 Experimental Results; 2.4.1 Vertically Emitting DFB Laser; 2.4.2 Bulk Material Sensing; 2.4.3 Sensitivity Resolution
2.4.4 Small Molecule Binding Detection2.5 Conclusions; Acknowledgements; References; 3 SPR Screening of Chemical Microarrays for Fragment-Based Discovery; 3.1 Introduction; 3.2 Key Features of Fragment Screening; 3.3 SPR Fragment Screening; 3.4 Synthesis of Library Compounds; 3.5 Library Design and Array Content; 3.6 Chemical Microarray Production; 3.7 Surface Plasmon Resonance; 3.8 SPR Imaging; 3.9 Array Visualization and Analysis; 3.10 Follow-up; 3.11 Applications: MMP Case Study; 3.11.1 Search for New Binding Modes; 3.11.2 Selectivity Studies; 3.12 Other Target Classes; 3.13 Conclusion References4 The CellKey R System: A Label-Free Cell-Based Assay Platform for Early Drug Discovery Applications; 4.1 Introduction; 4.2 Cellular Impedance Technology; 4.3 Target Identification and Validation; 4.4 Screening and Lead Optimization; 4.5 Conclusion; References; 5 Dynamic and Label-Free Cell-Based Assays Using the xCELLigence System; 5.1 Introduction; 5.2 The xCELLigence System; 5.3 Principle of Detection; 5.4 Applications; 5.4.1 Cell Proliferation, Cytotoxicity and Time Dependent Cellular Response Profiling; 5.5 Functional Assays for G-Protein Coupled Receptors; 5.6 Conclusion References6 Selecting the Best HTS Hits to Move Forward: ITC Ligand Binding Characterization Provides Guidance; 6.1 Introduction; 6.2 Principles of Isothermal Titration Calorimetry (ITC); 6.3 Applications of ITC in Hit Validation; 6.3.1 Assay Design for Hit Confirmation and Affinity Determination; 6.3.2 Identification of Nonspecific Binders, Unstable Protein Targets and Multiple Binding Sites; 6.3.3 High Speed ITC Hit Characterization Assays; 6.4 Applications of ITC in Fragment-Based Drug Discovery; 6.4.1 Measuring Weak Affinities by ITC; 6.5 Applications of ITC in Mechanism of Action Studies 6.6 Applications of ITC in Lead Optimization6.7 ITC as an Enzyme Activity Monitor; 6.8 Conclusion; References; 7 Incorporating Transmitted Light Modalities into High-Content Analysis Assays; 7.1 Introduction; 7.2 Transmitted Light (Bright Field) Imaging; 7.3 Image Analysis of Phase Contrast Images; 7.4 Conclusion; References; 8 Nonradioactive Rubidium Efflux Assay Technology for Screening of Ion Channels; 8.1 Introduction; 8.2 Ion Channels as Drug Targets; 8.3 Ion Channel Assays and Screening; 8.4 Nonradioactive Rubidium Efflux Assay Based on Atomic Absorption Spectrometry 8.5 A Typical Assay Protocol |
Record Nr. | UNINA-9910841044503321 |
Chichester, West Sussex, U.K., : John Wiley & Sons, 2011 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|