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From genome to therapy : integrating new technologies with drug development
| From genome to therapy : integrating new technologies with drug development |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | [Place of publication not identified], : John Wiley, 2000 |
| Descrizione fisica | 1 online resource (173 pages) |
| Disciplina | 615/.19 |
| Collana | Novartis Foundation symposium From genome to therapy |
| Soggetto topico |
Pharmacogenomics
Pharmacogenetics Pharmacology Computational Biology Drug Discovery Genetics Investigative Techniques Biology Biological Science Disciplines Health Occupations Chemistry, Pharmaceutical Natural Science Disciplines Disciplines and Occupations Chemistry Analytical, Diagnostic and Therapeutic Techniques and Equipment Drug Design Genomics Health & Biological Sciences Pharmacy, Therapeutics, & Pharmacology |
| ISBN |
1-280-55549-1
9786610555499 0-470-85183-X 0-470-84664-X |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910831047903321 |
| [Place of publication not identified], : John Wiley, 2000 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
From genome to therapy : integrating new technologies with drug development
| From genome to therapy : integrating new technologies with drug development |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | [Place of publication not identified], : John Wiley, 2000 |
| Descrizione fisica | 1 online resource (173 pages) |
| Disciplina | 615/.19 |
| Collana | Novartis Foundation symposium From genome to therapy |
| Soggetto topico |
Pharmacogenomics
Pharmacogenetics Pharmacology Computational Biology Drug Discovery Genetics Investigative Techniques Biology Biological Science Disciplines Health Occupations Chemistry, Pharmaceutical Natural Science Disciplines Disciplines and Occupations Chemistry Analytical, Diagnostic and Therapeutic Techniques and Equipment Drug Design Genomics Health & Biological Sciences Pharmacy, Therapeutics, & Pharmacology |
| ISBN |
1-280-55549-1
9786610555499 0-470-85183-X 0-470-84664-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910877828503321 |
| [Place of publication not identified], : John Wiley, 2000 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Genomics in drug discovery and development / / Dimitri Semizarov, Eric Blomme
| Genomics in drug discovery and development / / Dimitri Semizarov, Eric Blomme |
| Autore | Semizarov Dimitri |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2009 |
| Descrizione fisica | 1 online resource (496 p.) |
| Disciplina | 615/.19 |
| Altri autori (Persone) | BlommeEric |
| Soggetto topico |
Pharmacogenomics
Drug development Genetic toxicology DNA microarrays |
| ISBN |
1-281-93869-6
9786611938697 0-470-40977-0 0-470-40976-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Genomics in Drug Discovery and Development; Contents; Preface; ACKNOWLEDGMENTS; 1. Introduction: Genomics and Personalized Medicine; 1.1. Fundamentals of Genomics; 1.2. The Concept of Personalized Medicine; 1.3. Genomics Technologies in Drug Discovery; 1.4. Scope of This Book; References; 2. Genomics Technologies as Tools in Drug Discovery; 2.1. Introduction to Genomics Technologies; 2.2. Gene Expression Microarrays: Technology; 2.2.1. Standard Microarray Protocol; 2.2.2. Monitoring the Quality of Input RNA for Microarray Experiments
2.2.3. Specialized Microarray Protocols for Archived and Small Samples2.2.4. Quality of Microarray Data and Technical Parameters of Microarrays; 2.2.5. Reproducibility of Expression Microarrays and Cross-Platform Comparisons; 2.2.6. Microarray Databases and Annotation of Microarray Data; 2.2.6.1. Target Identification; 2.2.6.2. Disease Classification; 2.2.6.3. Compound Assessment; 2.3. Gene Expression Microarrays: Data Analysis; 2.3.1. Identification of Significant Gene Expression Changes; 2.3.2. Sample Classification and Class Prediction with Expression Microarrays 2.3.3. Pathway Analysis with Gene Expression Microarrays2.3.4. Common Problems Affecting the Validity of Microarray Studies; 2.4. Comparative Genomic Hybridization: Technology; 2.5. Comparative Genomic Hybridization: Data Analysis; 2.6. Microarray-Based DNA Methylation Profiling; 2.7. Microarray-Based MicroRNA Profiling; 2.8. Technical Issues in Genomics Experiments and Regulatory Submissions of Microarray Data; 2.8.1. Study of a Drug's Mechanism of Action by Gene Expression Profiling; 2.8.2. Early Assessment of Drug Toxicity in Model Systems 2.8.3. Biomarker Identification in Discovery and Early Development2.8.4. Patient Stratification in Clinical Trials with Gene Expression Signatures; 2.8.5. Genotyping of Patients in Clinical Studies to Predict Drug Response; 2.9. Conclusion; References; 3. Genomic Biomarkers; 3.1. Introduction to Genomic Biomarkers; 3.2. DNA Biomarkers; 3.2.1. DNA Copy Number Alterations; 3.2.1.1. DNA Copy Number Alterations in Cancer; 3.2.1.2. DNA Copy Number Alterations in Other Diseases; 3.2.1.3. Identification of DNA Copy Number Biomarkers in Drug Discovery; 3.2.2. Mutations; 3.2.2.1. p53 Mutations 3.2.2.2. K-ras Mutations3.2.2.3. EGFR Mutations; 3.2.2.4. Bcr-abl and KIT Mutations; 3.2.3. Epigenetic Markers; 3.3. RNA Biomarkers; 3.3.1. Gene Expression Biomarkers Validated as Diagnostic Tests; 3.3.2. Other Examples of Gene Expression Biomarkers; 3.4. Clinical Validation of Genomic Biomarkers; References; 4. Fundamental Principles of Toxicogenomics; 4.1. Introduction; 4.2. Fundamentals of Toxicogenomics; 4.2.1. Principle of Toxicogenomics; 4.2.2. Technical Reproducibility; 4.2.3. Biological Reproducibility; 4.2.4. Species Extrapolation; 4.3. Analysis of Toxicogenomics Data 4.3.1. Compound-Induced Gene Expression Changes |
| Record Nr. | UNINA-9910877991603321 |
Semizarov Dimitri
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| Hoboken, N.J., : Wiley, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Handbook of combinatorial chemistry : drugs, catalysts, materials
| Handbook of combinatorial chemistry : drugs, catalysts, materials |
| Pubbl/distr/stampa | [Place of publication not identified], : Wiley VCH, 2002 |
| Descrizione fisica | 1 online resource (1137 pages) |
| Disciplina | 615/.19 |
| Soggetto topico |
Combinatorial chemistry
Organic Chemistry Chemistry Physical Sciences & Mathematics |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-55949-7
9786610559497 3-527-60303-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910146241103321 |
| [Place of publication not identified], : Wiley VCH, 2002 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Handbook of combinatorial chemistry : drugs, catalysts, materials
| Handbook of combinatorial chemistry : drugs, catalysts, materials |
| Pubbl/distr/stampa | [Place of publication not identified], : Wiley VCH, 2002 |
| Descrizione fisica | 1 online resource (1137 pages) |
| Disciplina | 615/.19 |
| Soggetto topico |
Combinatorial chemistry
Organic Chemistry Chemistry Physical Sciences & Mathematics |
| ISBN |
1-280-55949-7
9786610559497 3-527-60303-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910830477003321 |
| [Place of publication not identified], : Wiley VCH, 2002 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Handbook of combinatorial chemistry : drugs, catalysts, materials
| Handbook of combinatorial chemistry : drugs, catalysts, materials |
| Pubbl/distr/stampa | [Place of publication not identified], : Wiley VCH, 2002 |
| Descrizione fisica | 1 online resource (1137 pages) |
| Disciplina | 615/.19 |
| Soggetto topico |
Combinatorial chemistry
Organic Chemistry Chemistry Physical Sciences & Mathematics |
| ISBN |
1-280-55949-7
9786610559497 3-527-60303-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910877045203321 |
| [Place of publication not identified], : Wiley VCH, 2002 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Handbook of molecular descriptors [[electronic resource] /] / edited by Roberto Todeschini and Vivianna Consonni
| Handbook of molecular descriptors [[electronic resource] /] / edited by Roberto Todeschini and Vivianna Consonni |
| Pubbl/distr/stampa | Weinheim ; ; Chichester, : Wiley-VCH, 2000 |
| Descrizione fisica | 1 online resource (691 p.) |
| Disciplina |
615.19
615/.19 |
| Altri autori (Persone) |
ConsonniViviana
TodeschiniRoberto |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Drugs - Design
Drug development Molecular pharmacology |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-76406-X
9786611764067 3-527-61310-2 3-527-61311-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Handbook of Molecular Descriptors; Contents; Introduction; User's Guide; Notations and Symbols; Acronyms; A - Z; Greek Alphabet Entries; Numerical Entries; Appendix A. Greek Alphabet; Appendix B. Symbols of Molecular Descriptors; Appendix C. Software; References |
| Record Nr. | UNINA-9910144132903321 |
| Weinheim ; ; Chichester, : Wiley-VCH, 2000 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Handbook of molecular descriptors [[electronic resource] /] / edited by Roberto Todeschini and Vivianna Consonni
| Handbook of molecular descriptors [[electronic resource] /] / edited by Roberto Todeschini and Vivianna Consonni |
| Pubbl/distr/stampa | Weinheim ; ; Chichester, : Wiley-VCH, 2000 |
| Descrizione fisica | 1 online resource (691 p.) |
| Disciplina |
615.19
615/.19 |
| Altri autori (Persone) |
ConsonniViviana
TodeschiniRoberto |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Drugs - Design
Drug development Molecular pharmacology |
| ISBN |
1-281-76406-X
9786611764067 3-527-61310-2 3-527-61311-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Handbook of Molecular Descriptors; Contents; Introduction; User's Guide; Notations and Symbols; Acronyms; A - Z; Greek Alphabet Entries; Numerical Entries; Appendix A. Greek Alphabet; Appendix B. Symbols of Molecular Descriptors; Appendix C. Software; References |
| Record Nr. | UNINA-9910830797203321 |
| Weinheim ; ; Chichester, : Wiley-VCH, 2000 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Handbook of molecular descriptors / / edited by Roberto Todeschini and Vivianna Consonni
| Handbook of molecular descriptors / / edited by Roberto Todeschini and Vivianna Consonni |
| Pubbl/distr/stampa | Weinheim ; ; Chichester, : Wiley-VCH, 2000 |
| Descrizione fisica | 1 online resource (691 p.) |
| Disciplina |
615.19
615/.19 |
| Altri autori (Persone) |
ConsonniViviana
TodeschiniRoberto |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Drugs - Design
Drug development Molecular pharmacology |
| ISBN |
1-281-76406-X
9786611764067 3-527-61310-2 3-527-61311-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Handbook of Molecular Descriptors; Contents; Introduction; User's Guide; Notations and Symbols; Acronyms; A - Z; Greek Alphabet Entries; Numerical Entries; Appendix A. Greek Alphabet; Appendix B. Symbols of Molecular Descriptors; Appendix C. Software; References |
| Record Nr. | UNINA-9910877578803321 |
| Weinheim ; ; Chichester, : Wiley-VCH, 2000 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Handbook of pharmaceutical biotechnology / / edited by Shayne Cox Gad
| Handbook of pharmaceutical biotechnology / / edited by Shayne Cox Gad |
| Pubbl/distr/stampa | Hoboken, N.J. : , : Wiley-Interscience, , 2007 |
| Descrizione fisica | 1 online resource (xix, 1659 pages) : illustrations |
| Disciplina | 615/.19 |
| Altri autori (Persone) | GadShayne C. <1948-> |
| Collana | Pharmaceutical Development Series |
| Soggetto topico |
Pharmaceutical biotechnology
Pharmaceutical chemistry |
| ISBN |
1-280-90013-X
9786610900138 0-470-11711-7 0-470-11710-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
HANDBOOK OF PHARMACEUTICAL BIOTECHNOLOGY; CONTRIBUTORS; CONTENTS; Preface; 1.1 From Gene to Product: The Advantage of Integrative Biotechnology; 1.2 Sequencing the Human Genome: Was It Worth It?; 1.3 Overview: Differentiating Issues in the Development of Macromolecules Compared with Small Molecules; 1.4 Integrated Development of Glycobiologics: From Discovery to Applications in the Design of Nanoparticular Drug Delivery Systems; 1.5 R&D Paradigm Shift and Billion-Dollar Biologics
2 From Defining Bioinformatics and Pharmacogenomics to Developing Information-Based Medicine and Pharmacotyping in Health Care 3.1 Toxicogenomics; 3.2 Preclinical Pharmacokinetics; 3.3 Strategies for the Cytosolic Delivery of Macromolecules: An Overview; 4.1 Basic Issues in the Manufacture of Macromoleucles; 4.2 Process Validation for Biopharmaceuticals; 4.3 Stability Assessment and Formulation Characterization; 4.4 Protein Posttranslational Modification: A Potential Target in Pharmaceutical Development 4.5 PEGylation: Camouflage of Proteins, Cells, and Nanoparticles Against Recognition by the Body's Defense Mechanism 4.6 Unexpected Benefits of a Formulation: Case Study with Erythropoetin; 5.1 Capillary Separation Techniques; 5.2 Pharmaceutical Bioassay; 5.3 Analytical Considerations for Immunoassays for Macromolecules; 5.4 Chromatography-Based Separation of Proteins, Peptides, and Amino Acids; 5.5 Bioanalytical Method Validation for Macromolecules; 5.6 Microarrays in Drug Discovery and Development; 5.7 Genetic Markers and Genotyping Analyses for Genetic Disease Studies 6.1 Proteins: Hormones, Enzymes, and Monoclonal\Antibodies-Background 6.2 Formulation and Delivery Issues of Therapeutic Proteins; 6.3 Pharmacokinetics; 6.4 Immunogenicity of Therapeutic Proteins; 6.5 Development and Characterization of High-Affinity Anti-Topotecan IgG and Fab Fragments; 6.6 Recombinant Antibodies for Pathogen Detection and Immunotherapy; 6.7 The Radiopharmaceutical Science of Monoclonal Antibodies and Peptides for Imaging and Targeted in situ Radiotherapy of Malignancies; 7.1 Gene Therapy-Basic Principles and the Road from Bench to Bedside 7.2 Plasmid DNA and Messenger RNA for Therapy 7.3 Formulations and Delivery Limitations of Nucleic-Acid-Based Therapies; 7.4 Pharmacokinetics of Nucleic-Acid-Based Therapeutics; 7.5 Case Studies-Development of Oligonucleotides; 7.6 RNA Interference: The Next Gene-Targeted Medicine; 7.7 Delivery Systems for Peptides/Oligonucleotides and Lipophilic Nucleoside Analogs; 8.1 Growth Factors and Cytokines; 8.2 Growth Factors, Cytokines, and Chemokines: Formulation, Delivery, and Pharmacokinetics; 9 Protein Engineering with Noncoded Amino Acids: Applications to Hirudin; 10.1 Production and Purification of Adenovirus Vectors for Gene Therapy |
| Record Nr. | UNINA-9910784404203321 |
| Hoboken, N.J. : , : Wiley-Interscience, , 2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
