Info
- Utilizzare la checkbox di selezione a fianco di ciascun documento per attivare le funzionalità di stampa, invio email, download nei formati disponibili del (i) record.
Molecular Mechanisms of Angiogenesis : From Ontogenesis to Oncogenesis / / edited by Jean-Jacques Feige, Gilles Pagès, Fabrice Soncin
| Molecular Mechanisms of Angiogenesis : From Ontogenesis to Oncogenesis / / edited by Jean-Jacques Feige, Gilles Pagès, Fabrice Soncin |
| Edizione | [1st ed. 2014.] |
| Pubbl/distr/stampa | Paris : , : Springer Paris : , : Imprint : Springer, , 2014 |
| Descrizione fisica | 1 online resource (501 p.) |
| Disciplina |
610
611.01816 612.13 614.5999 |
| Soggetto topico |
Molecular biology
Oncology Cancer research Angiology Cardiology Ophthalmology Molecular Medicine Oncology Cancer Research |
| ISBN | 2-8178-0466-X |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Emergence of Endothelial Cells During Vascular Development -- Lymphatic Vascular Morphogenesis -- Finding New Partnerships; The Function of Individual Extracellular Receptor Domains in Angiogenic Signalling by VEGF Receptors -- Wnt/ Frizzled Signaling in the Vasculature -- BMP9, BMP10 And ALK1: An Emerging Vascular Signaling Pathway With Therapeutic Applications -- Apeling Signaling in Retinal Angiogenesis -- Emerging Role of the Two Related Basic Helix-Loop-Helix Proteins -- TAL1 and LYL1 In Angiogenesis -- Hypoxia and Extracellular Matrix Remodeling -- Sphingosine-1-Phosphate in Hypoxic Signaling -- Reciprocal Crosstalk Between Angiogenesis and Metabolism -- Endothelial Progenitor Cells and Cardiovascular Ischemic Diseases: Characterization, Functions and Potential Clinical Applications as Biomarker and Therapeutic Tools -- Endothelial Cell Reactions to Oxygen: Implications For Cancer -- Tumor Angiogenesis and Lymphangiogenesis: Microenvironmental Soil For Tumor Progression And Metastatic Dissemination -- Angiogenesis And Invasion in Malignant Glioma: Friends or Foes? -- Role of Endothelial Cells in Tumor Escape From Immunity -- Tumor High-Endothelial Venules and Lymphocyte Trafficking -- Post-Transcriptional Regulation of Angiogenesis Through AU-Rich Mrna Degradation: Potential Application in Cancer Therapy -- Antiangiogenic Drugs in Cancer Therapy, Effect on Advanced Renal Cell Carcinoma -- Anti-Angiogenic Therapies in Colorectal Cancer -- Resistance to Anti-Angiogenic Treatments via Up-Regulation of Substitution Pathways -- VEGF-A Splice Variants: Do They Play a Role in Tumor Responses to Anti-Angiogenic Therapies? -- Progenitor Endothelial Cells as Biomarkers of Anti-Vascular Agents -- Soluble Vascular Endothelial (VE)-Cadherin : Toward a Marker of Endotelial Dysfunction -- The Prognostic and Predictive Value of VEGF Across Various Tumor Types. |
| Record Nr. | UNINA-9910298316603321 |
| Paris : , : Springer Paris : , : Imprint : Springer, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Molecular Oncology: Underlying Mechanisms and Translational Advancements / / edited by Ammad Ahmad Farooqi, Muhammad Ismail
| Molecular Oncology: Underlying Mechanisms and Translational Advancements / / edited by Ammad Ahmad Farooqi, Muhammad Ismail |
| Edizione | [1st ed. 2017.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017 |
| Descrizione fisica | 1 online resource (X, 302 p. 27 illus., 24 illus. in color.) |
| Disciplina | 614.5999 |
| Soggetto topico |
Cancer research
Oncology Cancer Research Oncology |
| ISBN | 3-319-53082-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | - Microtubule targeting agents in cancer therapy: Elucidating the underlying molecular mechanisms -- Adenosine signaling pathways as potential therapeutic targets in cancer disease -- Anticancer activities of Hippophae rhamnoides: Journey from Benchtop to the Bedside -- Emerging role of ncRNAs in cancer biology: techniques for diagnostic monitoring and potential ncRNA-based therapies -- Clinical and translational research on the pathophysiology of several ocular tumors types -- Exosomes and cancer: from diagnosis to therapy -- Blood-based Cancer Detection: Towards Solving Diagnostic Puzzle -- Non-coding RNAs, Critical Therapy Targets against Cancer - Detection of Virus-caused Cancer in Publicly Available Next Generation Sequencing Data -- TRAIL mediated signaling in prostate cancer -- Index. |
| Record Nr. | UNINA-9910253911703321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Molecular Pathology of Breast Cancer / / edited by Sunil Badve, Yesim Gökmen-Polar
| Molecular Pathology of Breast Cancer / / edited by Sunil Badve, Yesim Gökmen-Polar |
| Edizione | [1st ed. 2016.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 |
| Descrizione fisica | 1 online resource (VIII, 428 p. 54 illus. in color.) |
| Disciplina | 614.5999 |
| Soggetto topico |
Cancer research
Cancer Research |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Preface -- Translating Markers in Clinical Practice -- Pre-analytical Variables, Tissue Quality and Clinical Samples from Breast Cancer Patients -- Impact of Analytical Variables in Breast Cancer Biomarkers Analysis -- Hormone Receptors in Breast Cancer -- Human Epidermal Growth Factor Receptor 2 (HER2) -- Triple Negative Breast Cancer -- Proliferation Markers in Breast Cancer -- Novel IHC Based Biomarkers in Breast Cancer.-Tumor Heterogeneity in Breast Cancer -- Breast Cancer Stem Cells -- The Tumor Microenvironmen t as a Metastasis Biomarker in Breast Cancer -- Tumor Infiltrating Lymphocytes as a prognostic and predictive biomarker in breast cancer -- Novel Imaging Based Biomarkers in Breast Cancer -- Circulating Tumor Markers for Breast Cancer Managgement -- Circulating Tumor Cells -- Circulating Nucleic acids (RNA/DNA)in Breast Cancer -- Prognostic Factors for Ductal Carcinoma in Situ of the Breast -- Prognostic and Predictive Gene Expression Signatures in Breast Cancer -- Genomic Markers ER-negative Breast Cancer -- Next-Generation Seguencing Basxed Testing for Breast Cancer -- Epigenetic Mechanism in Breast Cancer -- Nocoding RNAs in Breast Cancer -- Alternative Splicing in Breast Cancer -- Pharmagocenomics of Breast Cancer -- Applied Proteomics in Breast Cancer -- Biomarkers in the Clinic -- Index. |
| Record Nr. | UNINA-9910155333103321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Molecular Targets and Strategies in Cancer Prevention / / edited by Malay Chatterjee
| Molecular Targets and Strategies in Cancer Prevention / / edited by Malay Chatterjee |
| Edizione | [1st ed. 2016.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 |
| Descrizione fisica | 1 online resource (V, 180 p. 12 illus., 9 illus. in color.) |
| Disciplina | 614.5999 |
| Soggetto topico |
Cancer research
Molecular biology Oncology Cancer Research Molecular Medicine Oncology |
| ISBN | 3-319-31254-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Strategies to Target Pancreatic Cancer -- MICROBIOTA AND CHRONIC INFLAMMATION AS TARGETS FOR COLORECTAL CANCER PREVENTION -- Challenges in multiple myeloma chemoprevention: potential role of natural, synthetic and endogenous molecules -- Targeting MicroRNAs: Molecular basis of cancer prevention -- A new level of complexity in cancer regulation and a promising source of biomarkers: The liquid biopsies -- Targeting Tumor Angiogenesis for Cancer Prevention -- Molecular Targets and Strategies in Cancer Prevention. |
| Record Nr. | UNINA-9910253864303321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Molecular Testing in Cancer / / edited by George M. Yousef, Serge Jothy
| Molecular Testing in Cancer / / edited by George M. Yousef, Serge Jothy |
| Edizione | [1st ed. 2014.] |
| Pubbl/distr/stampa | New York, NY : , : Springer New York : , : Imprint : Springer, , 2014 |
| Descrizione fisica | 1 online resource (437 p.) |
| Disciplina |
610
610724 614.5999 616.07 |
| Soggetto topico |
Pathology
Hematology Laboratory medicine Cancer research Laboratory Medicine Cancer Research |
| ISBN | 1-4899-8050-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Transitioning Diagnostic Molecular Pathology to the Genomic Era: Cancer Somatic Mutation Panel Testing -- Conventional and Molecular Cytogenetics in Cancer -- Comparative Genomic Hybridization and Array based CGH in Cancer -- Polymerase Chain Reaction -- Single Nucleotide Polymorphisms (SNPs) -- Clinical Application of DNA Sequencing: Sanger and Next-Generation Platforms -- Microarray-based Investigations in Cancer -- Proteomics in Cancer Diagnostics -- Circulating Tumor Cells: A Non-Invasive Liquid Biopsy in Cancer -- Molecular Testing in Hematological Malignancies -- Molecular Testing in Breast Cancer -- Molecular Pathology of Gastrointestinal Tumors -- Molecular Testing in Pulmonary Tumors -- Molecular testing in Gynecological Malignancies -- Molecular Testing in Central Nervous System tumors -- Molecular Testing in Adult Kidney Tumors -- Molecular Testing in Prostate Cancer -- Molecular Testing in Urothelial Tumors -- Molecular Testing in Thyroid Cancer -- Molecular Testing of Head and Neck Tumors -- Molecular Testing in Bone and Soft Tissue Tumors -- Molecular testing in Cutaneous Melanoma -- Molecular Testing in Pediatric Tumors -- Pharmacogenomics in Molecular Oncology -- Quality Assurance in Molecular Testing of Cancer. |
| Record Nr. | UNINA-9910300077103321 |
| New York, NY : , : Springer New York : , : Imprint : Springer, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Mucins and cancer / / editors, Joyce Taylor-Papadimitriou, Joy M. Burchell
| Mucins and cancer / / editors, Joyce Taylor-Papadimitriou, Joy M. Burchell |
| Pubbl/distr/stampa | London, England : , : Future Medicine Ltd, , 2013 |
| Descrizione fisica | 1 online resource (145 pages) : color illustrations |
| Disciplina | 614.5999 |
| Collana | Future Medecine |
| Soggetto topico | Cancer - Etiology |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-78084-421-2
1-78084-420-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910464380303321 |
| London, England : , : Future Medicine Ltd, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Mucins and cancer / / editors, Joyce Taylor-Papadimitriou, Joy M. Burchell
| Mucins and cancer / / editors, Joyce Taylor-Papadimitriou, Joy M. Burchell |
| Pubbl/distr/stampa | London, England : , : Future Medicine Ltd, , 2013 |
| Descrizione fisica | 1 online resource (145 pages) : color illustrations |
| Disciplina | 614.5999 |
| Collana | Future Medecine |
| Soggetto topico | Cancer - Etiology |
| ISBN |
1-78084-421-2
1-78084-420-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910788804803321 |
| London, England : , : Future Medicine Ltd, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Mucins and cancer / / editors, Joyce Taylor-Papadimitriou, Joy M. Burchell
| Mucins and cancer / / editors, Joyce Taylor-Papadimitriou, Joy M. Burchell |
| Pubbl/distr/stampa | London, England : , : Future Medicine Ltd, , 2013 |
| Descrizione fisica | 1 online resource (145 pages) : color illustrations |
| Disciplina | 614.5999 |
| Collana | Future Medecine |
| Soggetto topico | Cancer - Etiology |
| ISBN |
1-78084-421-2
1-78084-420-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910823941403321 |
| London, England : , : Future Medicine Ltd, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Multi-drug resistance in cancer : mechanism and treatment strategies / / edited by Rishabha Malviya, Arun Kumar Singh, and Deepika Yadav
| Multi-drug resistance in cancer : mechanism and treatment strategies / / edited by Rishabha Malviya, Arun Kumar Singh, and Deepika Yadav |
| Pubbl/distr/stampa | Hoboken, NJ : , : John Wiley & Sons, , [2023] |
| Descrizione fisica | 1 online resource (216 pages) |
| Disciplina | 614.5999 |
| Soggetto topico |
Multidrug resistance
Drug resistance in cancer cells Drug interactions |
| Soggetto non controllato |
Pharmacology
Medical |
| ISBN |
1-394-20986-X
1-394-20985-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover -- Title Page -- Copyright Page -- Contents -- Foreword -- Preface -- Acknowledgment -- Chapter 1 Multi-Drug Rmesistance in Cancer: Understanding of Treatment Strategies -- 1.1 Introduction -- 1.2 Both Congenital and Developed Resistance to Drugs -- 1.2.1 Intrinsic Resistance -- 1.2.2 Acquired Resistance -- 1.3 Drug-Resistance Mechanisms -- 1.3.1 Increased Efflux of Drugs -- 1.3.2 Impact on Medication Target -- 1.3.3 Improved DNA-Damage Repair -- 1.4 Senescence Escape -- 1.5 Epigenetic Alterations -- 1.6 Tumor Heterogeneity -- 1.7 Tumor Microenvironment -- 1.8 Epithelial to Mesenchymal Transition -- 1.9 Conclusion -- References -- Chapter 2 Understanding Different Mechanisms Involved in Cancer Drug Resistance: Proposing Novel Strategies to Overcome MDR -- 2.1 Introduction -- 2.2 Drug Resistance: Internal and External Variables -- 2.2.1 Phenotypic Variation of Tumors -- 2.2.2 Tumor Microenvironment -- 2.2.3 Cancer Stem Cells -- 2.2.4 Inactivation of the Anticancer Drugs -- 2.2.5 Multi-Drug Resistance -- 2.2.6 Increasing the Release of Drugs Outside the Cell -- 2.2.7 Reducing the Absorption of the Drugs -- 2.2.8 Inhibition of Cell Death (Apoptosis Pathway Blocking) -- 2.3 Improving the Pharmacokinetics -- 2.4 Changing the Aim of the Chemotherapy Agents -- 2.5 Improving the DNA Repair Process -- 2.5.1 Augmentation of a Gene -- 2.5.2 Epigenetic Altering Caused Drug Resistance -- 2.6 MicroRNA in Cancer Drug Resistance -- 2.7 Conclusion -- References -- Chapter 3 Molecular Mechanism of Multi-Drug Resistant Cancer Cells -- 3.1 Introduction -- 3.2 Types of Drug Resistance -- 3.3 Mechanisms of Drug Resistance -- 3.3.1 Drug Efflux via ABC Transporters -- 3.3.2 Permeability Glycoprotein/MDR-1 -- 3.3.3 Multi-Drug Resistance Protein -- 3.3.4 Breast Cancer Resistance Protein -- 3.4 Reduction in Drug Activity and Cellular Absorption.
3.5 Instability in the Genome and Medication Resistance -- 3.5.1 Mutation and Medication Target Alteration -- 3.5.2 Restoration of DNA Integrity -- 3.5.3 Resistant Genes and Epigenetic Modifications -- 3.5.4 Drug Resistance and Programmed Cell Death -- 3.6 RNA Interference Therapy -- 3.7 Methods of Physical Intervention to Treat MDR -- 3.8 Conclusion -- References -- Chapter 4 Natural Products for Clinical Management of Drug Resistant Cancer Cells -- 4.1 Introduction -- 4.2 Resistance Mechanisms -- 4.3 Antitumor Plants for Multi-Drug-Resistant Cells -- 4.4 Qualea Species and Their Medical Applications -- 4.5 Antitumor Activity of Qualea Grandiflora and Qualea Multiflora -- 4.6 Conclusion -- References -- Chapter 5 Understanding of Autophagy to Combat MDR During Anticancer Therapy -- 5.1 Introduction -- 5.2 Mechanisms of Autophagy -- 5.2.1 Phagophore Assembly -- 5.2.2 Autophagosome Formation and Maturation -- 5.2.3 Autolysosome Degradation -- 5.2.4 Core Regulator of Autophagy -- 5.3 Mechanisms of MDR -- 5.4 Correlation Between Autophagy and Multi-Drug Resistance -- 5.5 The Cytoprotective Effect of Autophagy in the Regulation of Multi-Drug Resistance -- 5.6 Increased Autophagy Facilitates Multi-Drug Resistance -- 5.7 Autophagy Inhibition Improves Chemotherapy in MDR Cancers -- 5.8 Overcoming MDR With Autophagic Cell Death -- 5.9 Autophagy Kills Apoptosis-Deficient MDR Cancer Cells -- 5.10 Autophagy Promotes Chemosensitivity -- 5.11 Conclusion -- References -- Chapter 6 Transporter Inhibitors: A Chemotherapeutic Regimen to Improve the Clinical Outcome of Colorectal Cancer -- 6.1 Introduction -- 6.2 CRC Transporters or ATP-Binding Cassette -- 6.2.1 ABC Transporter Family -- 6.2.2 ABC Transporters and CRC Initiation -- 6.2.3 ABC Transporters and the Resistance of Cancer Cells to Chemotherapy. 6.3 Clinical Evidence for the Function of ABC Transporters in CRC MDR -- 6.3.1 Intrinsic Drug Resistance in Colon Cancer Upregulation of P-gp at Detection -- 6.3.2 Proliferating Tumor Cells Have MRP1 on Their Surface -- 6.4 General Approaches -- 6.5 By Blocking Tyrosine Kinase Inhibitors from Inhibiting MDR Transporters -- 6.6 Components Produced from Natural Sources that Inhibit MDR Transporters -- 6.7 Inhibiting ABC Transporters in Other Ways for CRC MDR Circumvention -- 6.8 Challenges and Future Prospective -- 6.9 Conclusion -- References -- Chapter 7 Epithelial to Mesenchymal Transition (EMT): Major Contribution to Cancer Drug Therapy Resistance -- 7.1 Introduction -- 7.2 EMT and Tumor Resistance: In Vitro, In Vivo, and Clinical Trials -- 7.3 Tumor Microenvironment Regulates EMT -- 7.3.1 Hypoxia -- 7.3.2 The Extracellular Matrix -- 7.3.3 The Inflammatory and Immune Microenvironment -- 7.3.4 EMT Microenvironment: Medication Resistance -- 7.4 Drug Resistance and EMT Bioinformatics -- 7.4.1 Bioinformatics and Pharmacogenomics to Optimize Drugs and Targets and Identify Medication Resistance -- 7.4.2 Drug Resistance: Hereditary or Acquired -- 7.4.3 Therapies for EMT-Induced Medication Resistance -- 7.5 Conclusion -- References -- Chapter 8 Advances in Metallodrug-Driven Combination Therapy for Treatment of Cancer -- 8.1 Introduction -- 8.2 Cancer Treatment Using Combination Therapy -- 8.3 Combined Treatment with Metallodrugs for Cancer Treatment -- 8.3.1 Platinum Metallodrugs -- 8.4 Nonplatinum Metallodrugs -- 8.5 Conclusion -- References -- Chapter 9 Novel Strategies Preventing Emergence of MDR in Breast Cancer -- 9.1 Introduction -- 9.2 Breast Cancer Categorization and Epidemiological Studies -- 9.2.1 Treatment Options for Women With Breast Cancer -- 9.3 Multi-Drug Resistance in Breast Cancer -- 9.3.1 Breast Cancer Chemoresistance. 9.3.2 Multi-Drug Resistance and ABC Channels in Breast Cancer -- 9.4 Drug Efflux Transporters in Breast Cancer -- 9.4.1 Exocytosis Transporters in the Stem Cell Population of Breast Cancer -- 9.4.2 Drug Efflux Channel Upregulation in Breast Cancer -- 9.4.3 Techniques for Breast Cancer MDR Reversal -- 9.4.4 Direct Pharmacologic Inhibition With MDR Inhibitors -- 9.5 Excessive Synthesis or Overexpression of Transporters for the Expulsion of Drugs -- 9.6 Nanotherapeutic Approach for MDR Reversal -- 9.7 Breast Cancer's MDR Cure Problems and Future Outlook -- 9.8 Conclusion -- References -- Index -- EULA. |
| Record Nr. | UNINA-9910830428803321 |
| Hoboken, NJ : , : John Wiley & Sons, , [2023] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Multi-Targeted Approach to Treatment of Cancer / / edited by Varsha Gandhi, Kapil Mehta, Rajesh Grover, Sen Pathak, Bharat B. Aggarwal
| Multi-Targeted Approach to Treatment of Cancer / / edited by Varsha Gandhi, Kapil Mehta, Rajesh Grover, Sen Pathak, Bharat B. Aggarwal |
| Edizione | [1st ed. 2015.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Adis, , 2015 |
| Descrizione fisica | 1 online resource (407 p.) |
| Disciplina |
610
614.5999 615.19 616994 |
| Soggetto topico |
Cancer research
Pharmaceutical technology Oncology Cancer Research Pharmaceutical Sciences/Technology Oncology |
| ISBN | 3-319-12253-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Contributors; Part I: Genetics/Genome/Microenvironment; Chapter 1: Diversity of Chromosomal Characteristics Among Mammals: With Special Reference to Laboratory Mouse in Cancer Resear...; 1.1 Introduction; 1.2 Do Large Size Mammals Have Longer and High Number of Chromosomes?; 1.3 Do X and Y Chromosomes Exist Intact in All Mammals?; 1.4 Distribution of Constitutive Heterochromatin in Mammalian Species; 1.5 Locations of Ribosomal Cistrons in Mammalian Chromosomes; 1.6 Distribution of Telomeric DNA in Mammalian Species
1.7 Laboratory Mouse: Is the Animal Model or Muddle in Cancer Research1.8 Human Cloning and Producing Mini-Organs in Culture; References; Chapter 2: Genome-Based Multi-targeting of Cancer: Hype or Hope?; 2.1 Introduction; 2.2 Cancer Is an Age-Old Disease; 2.3 Cancer Is a Disease of Old Age; 2.4 Cancer Is More Common in Western/Developed Countries; 2.5 Cancer Is a Multigenic Disease; 2.6 Target-Specific Anticancer Drugs; 2.7 Anticancer Potential of Targeted Drugs; 2.8 Benefits of Most Targeted Drugs Is Marginal; 2.9 Most Targeted Drugs Are Highly Expensive 2.10 Adverse Effects Associated with Targeted Therapies2.11 Multi-targeted Drugs Derived from Mother Nature Are Needed; Conclusions; References; Chapter 3: Chronic Lymphocytic Leukemia at the Genomic Level; 3.1 Rai and Binet Staging; 3.2 IgVH Gene Mutation and ZAP-70 Status; 3.2.1 IgVH Mutation Status; 3.2.2 ZAP-70 Status; 3.3 Cytogenetic Abnormalities; 3.3.1 13q14 Deletion; 3.3.2 17p Deletion; 3.3.3 11q Deletion; 3.3.4 Trisomy 12; 3.4 Genomics of CLL; 3.4.1 WGS and WES; 3.4.1.1 NOTCH1; 3.4.1.2 SF3B1; 3.4.1.3 BIRC3; 3.4.1.4 XPO1; 3.4.1.5 MYD88; 3.4.1.6 Clonal Evolution in CLL 3.5 Transcriptome ProfilingReferences; Chapter 4: Apoptosis Pathways in Chronic Lymphocytic Leukemia: Role of the Microenvironment and Therapeutic Strategies; 4.1 Introduction; 4.2 Intrinsic and Extrinsic Factors Contribute to Biology of CLL Cells; 4.2.1 Intrinsic Factors: Genetic Aberrations in CLL; 4.2.2 Intrinsic Factors: Apoptotic Imbalance in CLL Cells; 4.2.3 Extrinsic Factors: Contribution of the Microenvironment to CLL Cell Survival; 4.3 Role of Apoptosis Pathway Members in CLL Pathophysiology; 4.3.1 B-cell Receptor, TNF Receptor Super Family, DED, and CARD Family 4.3.2 NF-kappaB, Caspase, and IAP Families4.3.3 Bcl-2 Family Antiapoptotic and Proapoptotic Proteins; 4.4 Microenvironment-Dependent Regulation of Apoptotic Pathway Proteins; 4.5 Therapeutic Strategies to Counter Survival Signals in CLL; 4.5.1 CLL Therapy: Standard of Care; 4.5.2 CLL Therapy: Targeting BCR Pathway; 4.5.3 CLL Therapy: Targeting Bcl-2 and IAPs; Conclusions; References; Chapter 5: Tumor-Associated Macrophages in Tumor Progression: From Bench to Bedside; 5.1 Introduction; 5.2 TAM Origin and Accumulation 5.3 Polarized Activation of Macrophages and Cancer-Related Functional Aspects |
| Record Nr. | UNINA-9910298273203321 |
| Cham : , : Springer International Publishing : , : Imprint : Adis, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
