Bone morphogenetic proteins : from local to systemic therapeutics / / Slobodan Vukicevic, Kuber T. Sampath, editors |
Edizione | [1st ed. 2008.] |
Pubbl/distr/stampa | Basel ; ; Boston, : Birkhäuser, c2008 |
Descrizione fisica | 1 online resource (348 p.) |
Disciplina |
612.75
616.7/1061 |
Altri autori (Persone) |
VukicevicSlobodan <1951->
SampathKuber T |
Collana | Progress in inflammation research |
Soggetto topico |
Bone morphogenetic proteins
Bone morphogenetic proteins - Therapeutic use |
ISBN |
1-281-86256-8
9786611862565 3-7643-8552-9 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Development of a novel compression-resistant carrier for recombinant human bone morphogenetic protein-2 (rhBMP-2) and preliminary clinical results -- Use of recombinant human BMP-2 in orthopedic trauma -- The application of recombinant human bone morphogenetic protein on absorbable collagen sponge (rhBMP-2/ACS) to reconstruction of maxillofacial bone defects -- Clinical outcomes using rhBMP-2 in spinal fusion applications -- Bone morphogenetic protein signaling is fine-tuned on multiple levels -- Dissection of bone morphogenetic protein signaling using genome-engineering tools -- Alterations of BMP signaling pathway(s) in skeletal diseases -- Signaling cross-talk by bone morphogenetic proteins -- The role and mechanisms of bone morphogenetic protein 4 and 2 (BMP-4 and BMP-2) in postnatal skeletal development -- The role of bone morphogenetic protein 4 (BMP-4) in tooth development -- Bone morphogenetic protein antagonists and kidney -- Induction of cementogenesis and periodontal ligament regeneration by the bone morphogenetic proteins -- Control of bone mass by sclerostin: Inhibiting BMP- and WNT-induced bone formation -- Bone morphogenetic proteins in cartilage biology -- Systemic administration of bone morphogenetic proteins. |
Record Nr. | UNINA-9910825157603321 |
Basel ; ; Boston, : Birkhäuser, c2008 | ||
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Lo trovi qui: Univ. Federico II | ||
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Bone morphogenic protein / / series editor Gerald Litwack, PhD, Toluca Lake, North Hollywood, California |
Edizione | [First edition.] |
Pubbl/distr/stampa | Waltham, MA : , : Elsevier, , 2015 |
Descrizione fisica | 1 online resource (367 p.) |
Disciplina | 612.75 |
Collana | Vitamins and Hormones |
Soggetto topico | Bone morphogenetic proteins |
Soggetto genere / forma | Electronic books. |
ISBN | 0-12-802592-1 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Front Cover; Bone Morphogenic Protein; Copyright; Former Editors; Contents; Contributors; Preface; Chapter One: Mechanisms of BMP-Receptor Interaction and Activation; 1. Evolutionary Expansion and Diversification of the Transforming Growth Factor β Superfamily; 2. Phylogenetic Analysis Reveals Four Functional Subfamilies for TGFβ Ligands; 3. Expression as Protease-Activated Proproteins and a Cystine-Knot Motif in the C-Terminal Mature Region as Key Features ...; 4. TGFβ Receptor Activation and Its Downstream Signaling Cascade; 5. Too Few Receptors for Too Many Ligands Lead to Promiscuity
6. Molecular Mechanisms to Ensure Ligand-Receptor Promiscuity and Specificity: The Concept of Multiple Hot Spots of Binding7. Molecular Mechanisms to Ensure Ligand-Receptor Promiscuity and Specificity: The Concept of Structural Adaptability; 8. Consequences of Promiscuity and Specificity in the TGFβ Superfamily: Conclusions; References; Chapter Two: The Bone Morphogenetic Proteins and Their Antagonists; 1. Bone Morphogenetic Proteins; 2. BMP Antagonist Proteins; 2.1. Chordin Family; 2.2. Follistatin and Follistatin-Like Proteins; 2.3. Noggin; 2.4. Twisted Gastrulation 3. Cerberus and Dan Family BMP Antagonists3.1. Cerberus; 3.2. Coco; 3.3. Dan; 3.4. Gremlin; 3.5. PRDC/Gremlin 2; 3.6. Sclerostin; 3.7. USAG-1/Wise; 4. BMP-Antagonists Binding to Heparin/HS; References; Chapter Three: BMP-7 Signaling and its Critical Roles in Kidney Development, the Responses to Renal Injury, and Chronic K ...; 1. Introduction; 2. The TGF-β/BMP Protein Superfamily; 3. The BMP-7 Protein; 4. TGF-β/BMP Signaling Pathways; 4.1. SMAD-Dependent Mechanisms for TGF-β/BMP Signaling; 4.1.1. Ligand Binding and Receptor Activation; 4.1.2. Activation of SMAD Transcription Factors 4.1.3. Heterodimerization and Nuclear Translocation of SMAD Transcription Factors4.1.4. SMAD-Dependent Regulation of Transcription; 4.2. SMAD-Independent Mechanisms for TGF-β/BMP Signaling; 4.3. Key Regulatory Steps in TGF-β/BMP Signaling; 4.3.1. Ligand Expression; 4.3.2. Ligand Availability; 4.3.3. Receptor Activation; 4.3.4. SMAD Activation; 4.3.5. Formation of Transcription Factor Complexes; 5. The Role of BMP-7 in Kidney Development; 5.1. Effects of BMP-7 Genetic Ablation on Development; 5.2. Functions of BMP-7 in the Metanephric Mesenchyme; 5.3. Functions of BMP-7 in the Ureteric Bud 5.4. Functions of BMP-7 in Stromal Cell Populations6. BMP-7, Congenital Renal Abnormalities, and Pediatric Kidney Disease; 7. The Role of BMP-7 in the Pathogenesis of CKD; 7.1. Therapeutic Effects of Recombinant BMP-7 in Models of CKD; 7.2. Renal Protective Mechanisms of Recombinant BMP-7; 7.2.1. Inhibition of Renal Fibrosis; 7.2.2. Other Important Renal Protective Mechanisms; 8. A Model for the Role of Endogenous BMP-7 in Regulating the Responses to Renal Injury; 9. Clinical Implications for BMP-7 in Patients with CKD; Acknowledgments; References Chapter Four: The Role of BMP Signaling and NF-κB Signaling on Osteoblastic Differentiation, Cancer Development, and Vasc... |
Record Nr. | UNINA-9910461143403321 |
Waltham, MA : , : Elsevier, , 2015 | ||
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Lo trovi qui: Univ. Federico II | ||
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Bone morphogenic protein / / series editor Gerald Litwack, PhD, Toluca Lake, North Hollywood, California |
Edizione | [First edition.] |
Pubbl/distr/stampa | Waltham, MA : , : Elsevier, , 2015 |
Descrizione fisica | 1 online resource (367 p.) |
Disciplina | 612.75 |
Collana | Vitamins and Hormones |
Soggetto topico | Bone morphogenetic proteins |
ISBN | 0-12-802592-1 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Front Cover; Bone Morphogenic Protein; Copyright; Former Editors; Contents; Contributors; Preface; Chapter One: Mechanisms of BMP-Receptor Interaction and Activation; 1. Evolutionary Expansion and Diversification of the Transforming Growth Factor β Superfamily; 2. Phylogenetic Analysis Reveals Four Functional Subfamilies for TGFβ Ligands; 3. Expression as Protease-Activated Proproteins and a Cystine-Knot Motif in the C-Terminal Mature Region as Key Features ...; 4. TGFβ Receptor Activation and Its Downstream Signaling Cascade; 5. Too Few Receptors for Too Many Ligands Lead to Promiscuity
6. Molecular Mechanisms to Ensure Ligand-Receptor Promiscuity and Specificity: The Concept of Multiple Hot Spots of Binding7. Molecular Mechanisms to Ensure Ligand-Receptor Promiscuity and Specificity: The Concept of Structural Adaptability; 8. Consequences of Promiscuity and Specificity in the TGFβ Superfamily: Conclusions; References; Chapter Two: The Bone Morphogenetic Proteins and Their Antagonists; 1. Bone Morphogenetic Proteins; 2. BMP Antagonist Proteins; 2.1. Chordin Family; 2.2. Follistatin and Follistatin-Like Proteins; 2.3. Noggin; 2.4. Twisted Gastrulation 3. Cerberus and Dan Family BMP Antagonists3.1. Cerberus; 3.2. Coco; 3.3. Dan; 3.4. Gremlin; 3.5. PRDC/Gremlin 2; 3.6. Sclerostin; 3.7. USAG-1/Wise; 4. BMP-Antagonists Binding to Heparin/HS; References; Chapter Three: BMP-7 Signaling and its Critical Roles in Kidney Development, the Responses to Renal Injury, and Chronic K ...; 1. Introduction; 2. The TGF-β/BMP Protein Superfamily; 3. The BMP-7 Protein; 4. TGF-β/BMP Signaling Pathways; 4.1. SMAD-Dependent Mechanisms for TGF-β/BMP Signaling; 4.1.1. Ligand Binding and Receptor Activation; 4.1.2. Activation of SMAD Transcription Factors 4.1.3. Heterodimerization and Nuclear Translocation of SMAD Transcription Factors4.1.4. SMAD-Dependent Regulation of Transcription; 4.2. SMAD-Independent Mechanisms for TGF-β/BMP Signaling; 4.3. Key Regulatory Steps in TGF-β/BMP Signaling; 4.3.1. Ligand Expression; 4.3.2. Ligand Availability; 4.3.3. Receptor Activation; 4.3.4. SMAD Activation; 4.3.5. Formation of Transcription Factor Complexes; 5. The Role of BMP-7 in Kidney Development; 5.1. Effects of BMP-7 Genetic Ablation on Development; 5.2. Functions of BMP-7 in the Metanephric Mesenchyme; 5.3. Functions of BMP-7 in the Ureteric Bud 5.4. Functions of BMP-7 in Stromal Cell Populations6. BMP-7, Congenital Renal Abnormalities, and Pediatric Kidney Disease; 7. The Role of BMP-7 in the Pathogenesis of CKD; 7.1. Therapeutic Effects of Recombinant BMP-7 in Models of CKD; 7.2. Renal Protective Mechanisms of Recombinant BMP-7; 7.2.1. Inhibition of Renal Fibrosis; 7.2.2. Other Important Renal Protective Mechanisms; 8. A Model for the Role of Endogenous BMP-7 in Regulating the Responses to Renal Injury; 9. Clinical Implications for BMP-7 in Patients with CKD; Acknowledgments; References Chapter Four: The Role of BMP Signaling and NF-κB Signaling on Osteoblastic Differentiation, Cancer Development, and Vasc... |
Record Nr. | UNINA-9910797425103321 |
Waltham, MA : , : Elsevier, , 2015 | ||
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Lo trovi qui: Univ. Federico II | ||
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Bone morphogenic protein / / series editor Gerald Litwack, PhD, Toluca Lake, North Hollywood, California |
Edizione | [First edition.] |
Pubbl/distr/stampa | Waltham, MA : , : Elsevier, , 2015 |
Descrizione fisica | 1 online resource (367 p.) |
Disciplina | 612.75 |
Collana | Vitamins and Hormones |
Soggetto topico | Bone morphogenetic proteins |
ISBN | 0-12-802592-1 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Front Cover; Bone Morphogenic Protein; Copyright; Former Editors; Contents; Contributors; Preface; Chapter One: Mechanisms of BMP-Receptor Interaction and Activation; 1. Evolutionary Expansion and Diversification of the Transforming Growth Factor β Superfamily; 2. Phylogenetic Analysis Reveals Four Functional Subfamilies for TGFβ Ligands; 3. Expression as Protease-Activated Proproteins and a Cystine-Knot Motif in the C-Terminal Mature Region as Key Features ...; 4. TGFβ Receptor Activation and Its Downstream Signaling Cascade; 5. Too Few Receptors for Too Many Ligands Lead to Promiscuity
6. Molecular Mechanisms to Ensure Ligand-Receptor Promiscuity and Specificity: The Concept of Multiple Hot Spots of Binding7. Molecular Mechanisms to Ensure Ligand-Receptor Promiscuity and Specificity: The Concept of Structural Adaptability; 8. Consequences of Promiscuity and Specificity in the TGFβ Superfamily: Conclusions; References; Chapter Two: The Bone Morphogenetic Proteins and Their Antagonists; 1. Bone Morphogenetic Proteins; 2. BMP Antagonist Proteins; 2.1. Chordin Family; 2.2. Follistatin and Follistatin-Like Proteins; 2.3. Noggin; 2.4. Twisted Gastrulation 3. Cerberus and Dan Family BMP Antagonists3.1. Cerberus; 3.2. Coco; 3.3. Dan; 3.4. Gremlin; 3.5. PRDC/Gremlin 2; 3.6. Sclerostin; 3.7. USAG-1/Wise; 4. BMP-Antagonists Binding to Heparin/HS; References; Chapter Three: BMP-7 Signaling and its Critical Roles in Kidney Development, the Responses to Renal Injury, and Chronic K ...; 1. Introduction; 2. The TGF-β/BMP Protein Superfamily; 3. The BMP-7 Protein; 4. TGF-β/BMP Signaling Pathways; 4.1. SMAD-Dependent Mechanisms for TGF-β/BMP Signaling; 4.1.1. Ligand Binding and Receptor Activation; 4.1.2. Activation of SMAD Transcription Factors 4.1.3. Heterodimerization and Nuclear Translocation of SMAD Transcription Factors4.1.4. SMAD-Dependent Regulation of Transcription; 4.2. SMAD-Independent Mechanisms for TGF-β/BMP Signaling; 4.3. Key Regulatory Steps in TGF-β/BMP Signaling; 4.3.1. Ligand Expression; 4.3.2. Ligand Availability; 4.3.3. Receptor Activation; 4.3.4. SMAD Activation; 4.3.5. Formation of Transcription Factor Complexes; 5. The Role of BMP-7 in Kidney Development; 5.1. Effects of BMP-7 Genetic Ablation on Development; 5.2. Functions of BMP-7 in the Metanephric Mesenchyme; 5.3. Functions of BMP-7 in the Ureteric Bud 5.4. Functions of BMP-7 in Stromal Cell Populations6. BMP-7, Congenital Renal Abnormalities, and Pediatric Kidney Disease; 7. The Role of BMP-7 in the Pathogenesis of CKD; 7.1. Therapeutic Effects of Recombinant BMP-7 in Models of CKD; 7.2. Renal Protective Mechanisms of Recombinant BMP-7; 7.2.1. Inhibition of Renal Fibrosis; 7.2.2. Other Important Renal Protective Mechanisms; 8. A Model for the Role of Endogenous BMP-7 in Regulating the Responses to Renal Injury; 9. Clinical Implications for BMP-7 in Patients with CKD; Acknowledgments; References Chapter Four: The Role of BMP Signaling and NF-κB Signaling on Osteoblastic Differentiation, Cancer Development, and Vasc... |
Record Nr. | UNINA-9910820372003321 |
Waltham, MA : , : Elsevier, , 2015 | ||
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Lo trovi qui: Univ. Federico II | ||
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Bone Remodeling and Osseointegration of Implants / / by Andy H. Choi |
Autore | Choi Andy H. |
Edizione | [1st ed. 2023.] |
Pubbl/distr/stampa | Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2023 |
Descrizione fisica | 1 online resource (103 pages) |
Disciplina | 612.75 |
Collana | Tissue Repair and Reconstruction |
Soggetto topico |
Biomedical engineering
Biomechanics Orthopedics Biomechanical Analysis and Modeling Orthopaedics |
Soggetto non controllato |
Physiology
Science |
ISBN | 9789819914258 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Introduction -- The Finite Element Approach -- Understanding the Biomechanics -- Mathematical Analysis of the Mandible -- Understanding Bone Structures -- Patient-Specific Modeling -- Artificial Intelligence, Machine Learning, and Neural Network. |
Record Nr. | UNINA-9910726295503321 |
Choi Andy H.
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Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2023 | ||
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Lo trovi qui: Univ. Federico II | ||
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Bone repair biomaterials / principal editor Joseph A. Planell ; section editors Serena M. Best, Damien Lacroix and Antonio Merolli |
Pubbl/distr/stampa | Boca Raton [etc.] : CRC |
Descrizione fisica | XIV, 478 p. : ill. ; 24 cm |
Disciplina | 612.75 |
Collana | Woodhead publishing in materials |
Soggetto topico | Ossa - Biomeccanica |
ISBN | 978-1-4398-0195-6 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNISA-990003403600203316 |
Boca Raton [etc.] : CRC | ||
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Lo trovi qui: Univ. di Salerno | ||
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Bone research |
Pubbl/distr/stampa | Chengdu, Sichuan, P.R. China : , : Sichuan University Press |
Descrizione fisica | 1 online resource |
Disciplina | 612.75 |
Soggetto topico |
Bones - Diseases
Bone and Bones Bone Diseases |
Soggetto genere / forma |
Periodical
Periodicals. |
ISSN | 2095-6231 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Periodico |
Lingua di pubblicazione | eng |
Altri titoli varianti | Gu yan jiu |
Record Nr. | UNISA-996321072103316 |
Chengdu, Sichuan, P.R. China : , : Sichuan University Press | ||
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Lo trovi qui: Univ. di Salerno | ||
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Bone research |
Pubbl/distr/stampa | Chengdu, Sichuan, P.R. China : , : Sichuan University Press |
Descrizione fisica | 1 online resource |
Disciplina | 612.75 |
Soggetto topico |
Bones - Diseases
Bone and Bones Bone Diseases |
Soggetto genere / forma |
Periodical
Periodicals. |
ISSN | 2095-6231 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Periodico |
Lingua di pubblicazione | eng |
Altri titoli varianti | Gu yan jiu |
Record Nr. | UNINA-9910141850903321 |
Chengdu, Sichuan, P.R. China : , : Sichuan University Press | ||
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Lo trovi qui: Univ. Federico II | ||
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Bone Structure and Metabolism [[electronic resource]] |
Autore | Symposium CIBA Foundation |
Pubbl/distr/stampa | Hoboken, : Wiley, 2009 |
Descrizione fisica | 1 online resource (353 p.) |
Disciplina | 612.75 |
Collana | Novartis Foundation Symposia |
Soggetto topico | Bone |
Soggetto genere / forma | Electronic books. |
ISBN |
0-470-71522-7
0-470-71491-3 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
CIBA FOUNDATION SYMPOSIUM ON BONE STRUCTURE AND METABOLISM; CONTENTS; Chairman's opening remarks; Structure of bone from the anatomical to the molecular level; Discussion; Structure of bone salts; Discussion; The histological remodelling of adult bone. An autoradiographic study; Discussion; Fibrogenesis and the formation of matrix in developing bone; Discussion; The mucopolysaccharides of bone; Discussion; Autoradiographic studies of the formation of the organic matrix of cartilage, bone and the tissues of teeth; Discussion
Uptake of 35S in the differentiation and growth of cartilage and boneDiscussion; In vitro uptake and exchange of bone citrate; Discussion; The magnesium content of bone in hypomagnesaemic disorders of livestock; Discussion; The mechanism of nutrition in bone and how it affects its structure, repair and fate on transplantation; Discussion; Studies on the repair of fractures using 32 P; Discussion; Metabolic studies on vitamin D; Discussion; The mode of action of vitamin D; Discussion Variations in sensitivity to vitamin D: from vitamin D resistant rickets, vitamin D avitaminotic rickets and hypervitaminosis D to idiopathic hypercalcaemiaDiscussion; Present knowledge of parathyroid function, with especial emphasis upon its limitations; Discussion; The indirect assessment of parathyroid function; Discussion; Vascularity of bone in relation to pathological studies; Discussion; Some observations on experimental bone disease; Discussion; Osteodysmetamorphosis foetalis; Discussion; Bone as a critical organ for the deposition of radioactive materials; Discussion General DiscussionChairman's closing remarks |
Record Nr. | UNINA-9910144671003321 |
Symposium CIBA Foundation
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Hoboken, : Wiley, 2009 | ||
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Lo trovi qui: Univ. Federico II | ||
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Bone Structure and Metabolism [[electronic resource]] |
Autore | Symposium CIBA Foundation |
Pubbl/distr/stampa | Hoboken, : Wiley, 2009 |
Descrizione fisica | 1 online resource (353 p.) |
Disciplina | 612.75 |
Collana | Novartis Foundation Symposia |
Soggetto topico | Bone |
ISBN |
0-470-71522-7
0-470-71491-3 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
CIBA FOUNDATION SYMPOSIUM ON BONE STRUCTURE AND METABOLISM; CONTENTS; Chairman's opening remarks; Structure of bone from the anatomical to the molecular level; Discussion; Structure of bone salts; Discussion; The histological remodelling of adult bone. An autoradiographic study; Discussion; Fibrogenesis and the formation of matrix in developing bone; Discussion; The mucopolysaccharides of bone; Discussion; Autoradiographic studies of the formation of the organic matrix of cartilage, bone and the tissues of teeth; Discussion
Uptake of 35S in the differentiation and growth of cartilage and boneDiscussion; In vitro uptake and exchange of bone citrate; Discussion; The magnesium content of bone in hypomagnesaemic disorders of livestock; Discussion; The mechanism of nutrition in bone and how it affects its structure, repair and fate on transplantation; Discussion; Studies on the repair of fractures using 32 P; Discussion; Metabolic studies on vitamin D; Discussion; The mode of action of vitamin D; Discussion Variations in sensitivity to vitamin D: from vitamin D resistant rickets, vitamin D avitaminotic rickets and hypervitaminosis D to idiopathic hypercalcaemiaDiscussion; Present knowledge of parathyroid function, with especial emphasis upon its limitations; Discussion; The indirect assessment of parathyroid function; Discussion; Vascularity of bone in relation to pathological studies; Discussion; Some observations on experimental bone disease; Discussion; Osteodysmetamorphosis foetalis; Discussion; Bone as a critical organ for the deposition of radioactive materials; Discussion General DiscussionChairman's closing remarks |
Record Nr. | UNINA-9910830513703321 |
Symposium CIBA Foundation
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Hoboken, : Wiley, 2009 | ||
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Lo trovi qui: Univ. Federico II | ||
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