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Bone morphogenetic proteins : from local to systemic therapeutics / / Slobodan Vukicevic, Kuber T. Sampath, editors
Bone morphogenetic proteins : from local to systemic therapeutics / / Slobodan Vukicevic, Kuber T. Sampath, editors
Edizione [1st ed. 2008.]
Pubbl/distr/stampa Basel ; ; Boston, : Birkhäuser, c2008
Descrizione fisica 1 online resource (348 p.)
Disciplina 612.75
616.7/1061
Altri autori (Persone) VukicevicSlobodan <1951->
SampathKuber T
Collana Progress in inflammation research
Soggetto topico Bone morphogenetic proteins
Bone morphogenetic proteins - Therapeutic use
ISBN 1-281-86256-8
9786611862565
3-7643-8552-9
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Development of a novel compression-resistant carrier for recombinant human bone morphogenetic protein-2 (rhBMP-2) and preliminary clinical results -- Use of recombinant human BMP-2 in orthopedic trauma -- The application of recombinant human bone morphogenetic protein on absorbable collagen sponge (rhBMP-2/ACS) to reconstruction of maxillofacial bone defects -- Clinical outcomes using rhBMP-2 in spinal fusion applications -- Bone morphogenetic protein signaling is fine-tuned on multiple levels -- Dissection of bone morphogenetic protein signaling using genome-engineering tools -- Alterations of BMP signaling pathway(s) in skeletal diseases -- Signaling cross-talk by bone morphogenetic proteins -- The role and mechanisms of bone morphogenetic protein 4 and 2 (BMP-4 and BMP-2) in postnatal skeletal development -- The role of bone morphogenetic protein 4 (BMP-4) in tooth development -- Bone morphogenetic protein antagonists and kidney -- Induction of cementogenesis and periodontal ligament regeneration by the bone morphogenetic proteins -- Control of bone mass by sclerostin: Inhibiting BMP- and WNT-induced bone formation -- Bone morphogenetic proteins in cartilage biology -- Systemic administration of bone morphogenetic proteins.
Record Nr. UNINA-9910825157603321
Basel ; ; Boston, : Birkhäuser, c2008
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Bone morphogenic protein / / series editor Gerald Litwack, PhD, Toluca Lake, North Hollywood, California
Bone morphogenic protein / / series editor Gerald Litwack, PhD, Toluca Lake, North Hollywood, California
Edizione [First edition.]
Pubbl/distr/stampa Waltham, MA : , : Elsevier, , 2015
Descrizione fisica 1 online resource (367 p.)
Disciplina 612.75
Collana Vitamins and Hormones
Soggetto topico Bone morphogenetic proteins
Soggetto genere / forma Electronic books.
ISBN 0-12-802592-1
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Front Cover; Bone Morphogenic Protein; Copyright; Former Editors; Contents; Contributors; Preface; Chapter One: Mechanisms of BMP-Receptor Interaction and Activation; 1. Evolutionary Expansion and Diversification of the Transforming Growth Factor β Superfamily; 2. Phylogenetic Analysis Reveals Four Functional Subfamilies for TGFβ Ligands; 3. Expression as Protease-Activated Proproteins and a Cystine-Knot Motif in the C-Terminal Mature Region as Key Features ...; 4. TGFβ Receptor Activation and Its Downstream Signaling Cascade; 5. Too Few Receptors for Too Many Ligands Lead to Promiscuity
6. Molecular Mechanisms to Ensure Ligand-Receptor Promiscuity and Specificity: The Concept of Multiple Hot Spots of Binding7. Molecular Mechanisms to Ensure Ligand-Receptor Promiscuity and Specificity: The Concept of Structural Adaptability; 8. Consequences of Promiscuity and Specificity in the TGFβ Superfamily: Conclusions; References; Chapter Two: The Bone Morphogenetic Proteins and Their Antagonists; 1. Bone Morphogenetic Proteins; 2. BMP Antagonist Proteins; 2.1. Chordin Family; 2.2. Follistatin and Follistatin-Like Proteins; 2.3. Noggin; 2.4. Twisted Gastrulation
3. Cerberus and Dan Family BMP Antagonists3.1. Cerberus; 3.2. Coco; 3.3. Dan; 3.4. Gremlin; 3.5. PRDC/Gremlin 2; 3.6. Sclerostin; 3.7. USAG-1/Wise; 4. BMP-Antagonists Binding to Heparin/HS; References; Chapter Three: BMP-7 Signaling and its Critical Roles in Kidney Development, the Responses to Renal Injury, and Chronic K ...; 1. Introduction; 2. The TGF-β/BMP Protein Superfamily; 3. The BMP-7 Protein; 4. TGF-β/BMP Signaling Pathways; 4.1. SMAD-Dependent Mechanisms for TGF-β/BMP Signaling; 4.1.1. Ligand Binding and Receptor Activation; 4.1.2. Activation of SMAD Transcription Factors
4.1.3. Heterodimerization and Nuclear Translocation of SMAD Transcription Factors4.1.4. SMAD-Dependent Regulation of Transcription; 4.2. SMAD-Independent Mechanisms for TGF-β/BMP Signaling; 4.3. Key Regulatory Steps in TGF-β/BMP Signaling; 4.3.1. Ligand Expression; 4.3.2. Ligand Availability; 4.3.3. Receptor Activation; 4.3.4. SMAD Activation; 4.3.5. Formation of Transcription Factor Complexes; 5. The Role of BMP-7 in Kidney Development; 5.1. Effects of BMP-7 Genetic Ablation on Development; 5.2. Functions of BMP-7 in the Metanephric Mesenchyme; 5.3. Functions of BMP-7 in the Ureteric Bud
5.4. Functions of BMP-7 in Stromal Cell Populations6. BMP-7, Congenital Renal Abnormalities, and Pediatric Kidney Disease; 7. The Role of BMP-7 in the Pathogenesis of CKD; 7.1. Therapeutic Effects of Recombinant BMP-7 in Models of CKD; 7.2. Renal Protective Mechanisms of Recombinant BMP-7; 7.2.1. Inhibition of Renal Fibrosis; 7.2.2. Other Important Renal Protective Mechanisms; 8. A Model for the Role of Endogenous BMP-7 in Regulating the Responses to Renal Injury; 9. Clinical Implications for BMP-7 in Patients with CKD; Acknowledgments; References
Chapter Four: The Role of BMP Signaling and NF-κB Signaling on Osteoblastic Differentiation, Cancer Development, and Vasc...
Record Nr. UNINA-9910461143403321
Waltham, MA : , : Elsevier, , 2015
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Bone morphogenic protein / / series editor Gerald Litwack, PhD, Toluca Lake, North Hollywood, California
Bone morphogenic protein / / series editor Gerald Litwack, PhD, Toluca Lake, North Hollywood, California
Edizione [First edition.]
Pubbl/distr/stampa Waltham, MA : , : Elsevier, , 2015
Descrizione fisica 1 online resource (367 p.)
Disciplina 612.75
Collana Vitamins and Hormones
Soggetto topico Bone morphogenetic proteins
ISBN 0-12-802592-1
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Front Cover; Bone Morphogenic Protein; Copyright; Former Editors; Contents; Contributors; Preface; Chapter One: Mechanisms of BMP-Receptor Interaction and Activation; 1. Evolutionary Expansion and Diversification of the Transforming Growth Factor β Superfamily; 2. Phylogenetic Analysis Reveals Four Functional Subfamilies for TGFβ Ligands; 3. Expression as Protease-Activated Proproteins and a Cystine-Knot Motif in the C-Terminal Mature Region as Key Features ...; 4. TGFβ Receptor Activation and Its Downstream Signaling Cascade; 5. Too Few Receptors for Too Many Ligands Lead to Promiscuity
6. Molecular Mechanisms to Ensure Ligand-Receptor Promiscuity and Specificity: The Concept of Multiple Hot Spots of Binding7. Molecular Mechanisms to Ensure Ligand-Receptor Promiscuity and Specificity: The Concept of Structural Adaptability; 8. Consequences of Promiscuity and Specificity in the TGFβ Superfamily: Conclusions; References; Chapter Two: The Bone Morphogenetic Proteins and Their Antagonists; 1. Bone Morphogenetic Proteins; 2. BMP Antagonist Proteins; 2.1. Chordin Family; 2.2. Follistatin and Follistatin-Like Proteins; 2.3. Noggin; 2.4. Twisted Gastrulation
3. Cerberus and Dan Family BMP Antagonists3.1. Cerberus; 3.2. Coco; 3.3. Dan; 3.4. Gremlin; 3.5. PRDC/Gremlin 2; 3.6. Sclerostin; 3.7. USAG-1/Wise; 4. BMP-Antagonists Binding to Heparin/HS; References; Chapter Three: BMP-7 Signaling and its Critical Roles in Kidney Development, the Responses to Renal Injury, and Chronic K ...; 1. Introduction; 2. The TGF-β/BMP Protein Superfamily; 3. The BMP-7 Protein; 4. TGF-β/BMP Signaling Pathways; 4.1. SMAD-Dependent Mechanisms for TGF-β/BMP Signaling; 4.1.1. Ligand Binding and Receptor Activation; 4.1.2. Activation of SMAD Transcription Factors
4.1.3. Heterodimerization and Nuclear Translocation of SMAD Transcription Factors4.1.4. SMAD-Dependent Regulation of Transcription; 4.2. SMAD-Independent Mechanisms for TGF-β/BMP Signaling; 4.3. Key Regulatory Steps in TGF-β/BMP Signaling; 4.3.1. Ligand Expression; 4.3.2. Ligand Availability; 4.3.3. Receptor Activation; 4.3.4. SMAD Activation; 4.3.5. Formation of Transcription Factor Complexes; 5. The Role of BMP-7 in Kidney Development; 5.1. Effects of BMP-7 Genetic Ablation on Development; 5.2. Functions of BMP-7 in the Metanephric Mesenchyme; 5.3. Functions of BMP-7 in the Ureteric Bud
5.4. Functions of BMP-7 in Stromal Cell Populations6. BMP-7, Congenital Renal Abnormalities, and Pediatric Kidney Disease; 7. The Role of BMP-7 in the Pathogenesis of CKD; 7.1. Therapeutic Effects of Recombinant BMP-7 in Models of CKD; 7.2. Renal Protective Mechanisms of Recombinant BMP-7; 7.2.1. Inhibition of Renal Fibrosis; 7.2.2. Other Important Renal Protective Mechanisms; 8. A Model for the Role of Endogenous BMP-7 in Regulating the Responses to Renal Injury; 9. Clinical Implications for BMP-7 in Patients with CKD; Acknowledgments; References
Chapter Four: The Role of BMP Signaling and NF-κB Signaling on Osteoblastic Differentiation, Cancer Development, and Vasc...
Record Nr. UNINA-9910797425103321
Waltham, MA : , : Elsevier, , 2015
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Bone morphogenic protein / / series editor Gerald Litwack, PhD, Toluca Lake, North Hollywood, California
Bone morphogenic protein / / series editor Gerald Litwack, PhD, Toluca Lake, North Hollywood, California
Edizione [First edition.]
Pubbl/distr/stampa Waltham, MA : , : Elsevier, , 2015
Descrizione fisica 1 online resource (367 p.)
Disciplina 612.75
Collana Vitamins and Hormones
Soggetto topico Bone morphogenetic proteins
ISBN 0-12-802592-1
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Front Cover; Bone Morphogenic Protein; Copyright; Former Editors; Contents; Contributors; Preface; Chapter One: Mechanisms of BMP-Receptor Interaction and Activation; 1. Evolutionary Expansion and Diversification of the Transforming Growth Factor β Superfamily; 2. Phylogenetic Analysis Reveals Four Functional Subfamilies for TGFβ Ligands; 3. Expression as Protease-Activated Proproteins and a Cystine-Knot Motif in the C-Terminal Mature Region as Key Features ...; 4. TGFβ Receptor Activation and Its Downstream Signaling Cascade; 5. Too Few Receptors for Too Many Ligands Lead to Promiscuity
6. Molecular Mechanisms to Ensure Ligand-Receptor Promiscuity and Specificity: The Concept of Multiple Hot Spots of Binding7. Molecular Mechanisms to Ensure Ligand-Receptor Promiscuity and Specificity: The Concept of Structural Adaptability; 8. Consequences of Promiscuity and Specificity in the TGFβ Superfamily: Conclusions; References; Chapter Two: The Bone Morphogenetic Proteins and Their Antagonists; 1. Bone Morphogenetic Proteins; 2. BMP Antagonist Proteins; 2.1. Chordin Family; 2.2. Follistatin and Follistatin-Like Proteins; 2.3. Noggin; 2.4. Twisted Gastrulation
3. Cerberus and Dan Family BMP Antagonists3.1. Cerberus; 3.2. Coco; 3.3. Dan; 3.4. Gremlin; 3.5. PRDC/Gremlin 2; 3.6. Sclerostin; 3.7. USAG-1/Wise; 4. BMP-Antagonists Binding to Heparin/HS; References; Chapter Three: BMP-7 Signaling and its Critical Roles in Kidney Development, the Responses to Renal Injury, and Chronic K ...; 1. Introduction; 2. The TGF-β/BMP Protein Superfamily; 3. The BMP-7 Protein; 4. TGF-β/BMP Signaling Pathways; 4.1. SMAD-Dependent Mechanisms for TGF-β/BMP Signaling; 4.1.1. Ligand Binding and Receptor Activation; 4.1.2. Activation of SMAD Transcription Factors
4.1.3. Heterodimerization and Nuclear Translocation of SMAD Transcription Factors4.1.4. SMAD-Dependent Regulation of Transcription; 4.2. SMAD-Independent Mechanisms for TGF-β/BMP Signaling; 4.3. Key Regulatory Steps in TGF-β/BMP Signaling; 4.3.1. Ligand Expression; 4.3.2. Ligand Availability; 4.3.3. Receptor Activation; 4.3.4. SMAD Activation; 4.3.5. Formation of Transcription Factor Complexes; 5. The Role of BMP-7 in Kidney Development; 5.1. Effects of BMP-7 Genetic Ablation on Development; 5.2. Functions of BMP-7 in the Metanephric Mesenchyme; 5.3. Functions of BMP-7 in the Ureteric Bud
5.4. Functions of BMP-7 in Stromal Cell Populations6. BMP-7, Congenital Renal Abnormalities, and Pediatric Kidney Disease; 7. The Role of BMP-7 in the Pathogenesis of CKD; 7.1. Therapeutic Effects of Recombinant BMP-7 in Models of CKD; 7.2. Renal Protective Mechanisms of Recombinant BMP-7; 7.2.1. Inhibition of Renal Fibrosis; 7.2.2. Other Important Renal Protective Mechanisms; 8. A Model for the Role of Endogenous BMP-7 in Regulating the Responses to Renal Injury; 9. Clinical Implications for BMP-7 in Patients with CKD; Acknowledgments; References
Chapter Four: The Role of BMP Signaling and NF-κB Signaling on Osteoblastic Differentiation, Cancer Development, and Vasc...
Record Nr. UNINA-9910820372003321
Waltham, MA : , : Elsevier, , 2015
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Bone Remodeling and Osseointegration of Implants / / by Andy H. Choi
Bone Remodeling and Osseointegration of Implants / / by Andy H. Choi
Autore Choi Andy H.
Edizione [1st ed. 2023.]
Pubbl/distr/stampa Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2023
Descrizione fisica 1 online resource (103 pages)
Disciplina 612.75
Collana Tissue Repair and Reconstruction
Soggetto topico Biomedical engineering
Biomechanics
Orthopedics
Biomechanical Analysis and Modeling
Orthopaedics
Soggetto non controllato Physiology
Science
ISBN 9789819914258
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Introduction -- The Finite Element Approach -- Understanding the Biomechanics -- Mathematical Analysis of the Mandible -- Understanding Bone Structures -- Patient-Specific Modeling -- Artificial Intelligence, Machine Learning, and Neural Network.
Record Nr. UNINA-9910726295503321
Choi Andy H.  
Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2023
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Bone repair biomaterials / principal editor Joseph A. Planell ; section editors Serena M. Best, Damien Lacroix and Antonio Merolli
Bone repair biomaterials / principal editor Joseph A. Planell ; section editors Serena M. Best, Damien Lacroix and Antonio Merolli
Pubbl/distr/stampa Boca Raton [etc.] : CRC
Descrizione fisica XIV, 478 p. : ill. ; 24 cm
Disciplina 612.75
Collana Woodhead publishing in materials
Soggetto topico Ossa - Biomeccanica
ISBN 978-1-4398-0195-6
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNISA-990003403600203316
Boca Raton [etc.] : CRC
Materiale a stampa
Lo trovi qui: Univ. di Salerno
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Bone research
Bone research
Pubbl/distr/stampa Chengdu, Sichuan, P.R. China : , : Sichuan University Press
Descrizione fisica 1 online resource
Disciplina 612.75
Soggetto topico Bones - Diseases
Bone and Bones
Bone Diseases
Soggetto genere / forma Periodical
Periodicals.
ISSN 2095-6231
Formato Materiale a stampa
Livello bibliografico Periodico
Lingua di pubblicazione eng
Altri titoli varianti Gu yan jiu
Record Nr. UNISA-996321072103316
Chengdu, Sichuan, P.R. China : , : Sichuan University Press
Materiale a stampa
Lo trovi qui: Univ. di Salerno
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Bone research
Bone research
Pubbl/distr/stampa Chengdu, Sichuan, P.R. China : , : Sichuan University Press
Descrizione fisica 1 online resource
Disciplina 612.75
Soggetto topico Bones - Diseases
Bone and Bones
Bone Diseases
Soggetto genere / forma Periodical
Periodicals.
ISSN 2095-6231
Formato Materiale a stampa
Livello bibliografico Periodico
Lingua di pubblicazione eng
Altri titoli varianti Gu yan jiu
Record Nr. UNINA-9910141850903321
Chengdu, Sichuan, P.R. China : , : Sichuan University Press
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Bone Structure and Metabolism [[electronic resource]]
Bone Structure and Metabolism [[electronic resource]]
Autore Symposium CIBA Foundation
Pubbl/distr/stampa Hoboken, : Wiley, 2009
Descrizione fisica 1 online resource (353 p.)
Disciplina 612.75
Collana Novartis Foundation Symposia
Soggetto topico Bone
Soggetto genere / forma Electronic books.
ISBN 0-470-71522-7
0-470-71491-3
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto CIBA FOUNDATION SYMPOSIUM ON BONE STRUCTURE AND METABOLISM; CONTENTS; Chairman's opening remarks; Structure of bone from the anatomical to the molecular level; Discussion; Structure of bone salts; Discussion; The histological remodelling of adult bone. An autoradiographic study; Discussion; Fibrogenesis and the formation of matrix in developing bone; Discussion; The mucopolysaccharides of bone; Discussion; Autoradiographic studies of the formation of the organic matrix of cartilage, bone and the tissues of teeth; Discussion
Uptake of 35S in the differentiation and growth of cartilage and boneDiscussion; In vitro uptake and exchange of bone citrate; Discussion; The magnesium content of bone in hypomagnesaemic disorders of livestock; Discussion; The mechanism of nutrition in bone and how it affects its structure, repair and fate on transplantation; Discussion; Studies on the repair of fractures using 32 P; Discussion; Metabolic studies on vitamin D; Discussion; The mode of action of vitamin D; Discussion
Variations in sensitivity to vitamin D: from vitamin D resistant rickets, vitamin D avitaminotic rickets and hypervitaminosis D to idiopathic hypercalcaemiaDiscussion; Present knowledge of parathyroid function, with especial emphasis upon its limitations; Discussion; The indirect assessment of parathyroid function; Discussion; Vascularity of bone in relation to pathological studies; Discussion; Some observations on experimental bone disease; Discussion; Osteodysmetamorphosis foetalis; Discussion; Bone as a critical organ for the deposition of radioactive materials; Discussion
General DiscussionChairman's closing remarks
Record Nr. UNINA-9910144671003321
Symposium CIBA Foundation  
Hoboken, : Wiley, 2009
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Bone Structure and Metabolism [[electronic resource]]
Bone Structure and Metabolism [[electronic resource]]
Autore Symposium CIBA Foundation
Pubbl/distr/stampa Hoboken, : Wiley, 2009
Descrizione fisica 1 online resource (353 p.)
Disciplina 612.75
Collana Novartis Foundation Symposia
Soggetto topico Bone
ISBN 0-470-71522-7
0-470-71491-3
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto CIBA FOUNDATION SYMPOSIUM ON BONE STRUCTURE AND METABOLISM; CONTENTS; Chairman's opening remarks; Structure of bone from the anatomical to the molecular level; Discussion; Structure of bone salts; Discussion; The histological remodelling of adult bone. An autoradiographic study; Discussion; Fibrogenesis and the formation of matrix in developing bone; Discussion; The mucopolysaccharides of bone; Discussion; Autoradiographic studies of the formation of the organic matrix of cartilage, bone and the tissues of teeth; Discussion
Uptake of 35S in the differentiation and growth of cartilage and boneDiscussion; In vitro uptake and exchange of bone citrate; Discussion; The magnesium content of bone in hypomagnesaemic disorders of livestock; Discussion; The mechanism of nutrition in bone and how it affects its structure, repair and fate on transplantation; Discussion; Studies on the repair of fractures using 32 P; Discussion; Metabolic studies on vitamin D; Discussion; The mode of action of vitamin D; Discussion
Variations in sensitivity to vitamin D: from vitamin D resistant rickets, vitamin D avitaminotic rickets and hypervitaminosis D to idiopathic hypercalcaemiaDiscussion; Present knowledge of parathyroid function, with especial emphasis upon its limitations; Discussion; The indirect assessment of parathyroid function; Discussion; Vascularity of bone in relation to pathological studies; Discussion; Some observations on experimental bone disease; Discussion; Osteodysmetamorphosis foetalis; Discussion; Bone as a critical organ for the deposition of radioactive materials; Discussion
General DiscussionChairman's closing remarks
Record Nr. UNINA-9910830513703321
Symposium CIBA Foundation  
Hoboken, : Wiley, 2009
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui