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Peptides : chemistry and biology / / Norbert Sewald and Hans-Dieter Jakubke
| Peptides : chemistry and biology / / Norbert Sewald and Hans-Dieter Jakubke |
| Autore | Sewald Norbert |
| Edizione | [Second, revised and updated edition.] |
| Pubbl/distr/stampa | Weinheim : , : Wiley-VCH Verlag GmbH & Co. KGaA, , [2009] |
| Descrizione fisica | 1 online resource (698 pages) : illustrations (some color), tables |
| Disciplina | 612.015756 |
| Soggetto topico |
Peptides
Peptides - Synthesis Biochemistry |
| ISBN |
3-527-80265-7
3-527-62603-4 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910830943103321 |
Sewald Norbert
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| Weinheim : , : Wiley-VCH Verlag GmbH & Co. KGaA, , [2009] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Textbook of Energy Balance, Neuropeptide Hormones, and Neuroendocrine Function [[electronic resource] /] / edited by Eduardo A. Nillni
| Textbook of Energy Balance, Neuropeptide Hormones, and Neuroendocrine Function [[electronic resource] /] / edited by Eduardo A. Nillni |
| Edizione | [1st ed. 2018.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2018 |
| Descrizione fisica | 1 online resource (XIV, 378 p. 49 illus., 47 illus. in color.) |
| Disciplina | 612.015756 |
| Soggetto topico |
Neurochemistry
Endocrinology Human physiology Endocrinology Human Physiology |
| ISBN | 3-319-89506-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1. The Evolution from Lean to Obese State and the Influence of Modern Human Society -- 2. Neuropeptides Controlling Our Behavior -- 3. Transcriptional Regulation of Hypothalamic Energy Balance Genes -- 4. Brain Inflammation and Endoplasmic Reticulum Stress -- 5. The Cell Biology of Neuropeptide Hormones -- 6. Nutrient Sensors Regulating Peptides -- 7. Gatrointestinal Hormones Controlling Energy Homeostasis and Their Potential Role in Obesity -- 8. The Complexity of Adipose Tissue -- 9. Adipokines, Inflammation and Insulin Resistance in Obesity -- 10. The Thyroid Hormone Axis: Its Roles in Body Weight Regulation, Obesity and Weight Loss -- 11. Obesity and Stress: The Melanocortin Connection -- 12. Obesity and the Growth Hormone Axis -- 13. Brain, Environment, Hormone-Based in of Appetite, Ingestive Behavior, and Body Weight. |
| Record Nr. | UNINA-9910298398003321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Virus Protein and Nucleoprotein Complexes [[electronic resource] /] / edited by J. Robin Harris, David Bhella
| Virus Protein and Nucleoprotein Complexes [[electronic resource] /] / edited by J. Robin Harris, David Bhella |
| Edizione | [1st ed. 2018.] |
| Pubbl/distr/stampa | Singapore : , : Springer Singapore : , : Imprint : Springer, , 2018 |
| Descrizione fisica | 1 online resource (viii, 442 pages) |
| Disciplina | 612.015756 |
| Collana | Subcellular Biochemistry |
| Soggetto topico |
Proteins
Protein Science |
| ISBN | 981-10-8456-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Virus proteins and nucleoproteins – an overview -- A structural view of negative sense rna virus nucleocapsid protein and its functions beyond -- Viral rna-dependent rna polymerases. a structural overview -- Filovirus filament proteins -- Structure and function of influenza virus ribonucleoprotein -- Structural homology between nucleoproteins of ssrna viruses -- Zika virus envelope protein and antibody complexes -- The retrovirus capsid core -- Nucleoprotein intermediates in hiv-1 dna integration: structure and function of hiv-1 intasomes -- Oligomerization of retrovirus integrases -- Structure and function of the human respiratory syncytial virus m2-1 protein -- Filamentous bacteriophage proteins and assembly -- Protein-rna interactions in the single-stranded rna bacteriophages -- The bacteriophage head-to-tail interface -- Beyond channel activity: protein-protein interactions involving viroporins -- Protein complexes and virus-like particle technology -- The role of flaviviral proteins in the induction of innate immunity. |
| Record Nr. | UNINA-9910298422503321 |
| Singapore : , : Springer Singapore : , : Imprint : Springer, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Vitamins and hormones . Volume ninety-seven Nociceptin opioid / / series editor, Gerald Litwack
| Vitamins and hormones . Volume ninety-seven Nociceptin opioid / / series editor, Gerald Litwack |
| Edizione | [First edition.] |
| Pubbl/distr/stampa | Waltham, Massachusetts : , : Academic Press, , 2015 |
| Descrizione fisica | 1 online resource (392 p.) |
| Disciplina | 612.015756 |
| Collana | Vitamins and Hormones |
| Soggetto topico |
Neuropeptides
Opioid peptides Nociceptive pain |
| Soggetto genere / forma | Electronic books. |
| ISBN |
0-12-802593-X
0-12-802443-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Nociceptin Opioid; Copyright; Contents; Contributors; Preface; Chapter 1: Helix-Constrained Nociceptin Peptides Are Potent Agonists and Antagonists of ORL-1 and Nociception; 1. Nociception in Brief; 1.1. Opioid receptor-like receptor-ORL-1; 1.2. Nociceptin; 1.3. Interrogating the activation and address domains of nociceptin(1-17); 2. Prospecting the Importance of the N-Terminal Tetrapeptide of Nociceptin(1-17); 3. Other Modifications to Nociceptin(1-17); 4. The Importance of Structure in Nociceptin Analogues; 4.1. Importance of helicity; 4.2. Other nociceptin derivatives
5. Recent Advances in ORL-1 Active Nociceptin Peptides6. The Development of New Helix-Constrained Nociceptin Analogues; 6.1. Design of helix-constrained nociceptin analogues; 6.2. Helical structure of nociceptin(1-17)-NH2 analogues in water; 6.3. Nuclear magnetic resonance spectra-derived structures; 7. Biological Properties of Helical Nociceptin Mimetics; 7.1. Cellular expression of ORL-1 and ERK phosphorylation; 7.2. Agonist and antagonist activity of nociceptin(1-17)-NH2 and analogues; 7.3. Effects of helical constraint on biological activity in Neuro-2a cells 7.4. Stability and cell toxicity of helix-constrained versus unconstrained peptides7.5. In vivo activity of helix-constrained versus unconstrained nociceptin analogues; 8. Concluding Remarks; References; Chapter 2: Bioinformatics and Evolution of Vertebrate Nociceptin and Opioid Receptors; 1. Introduction; 1.1. The origin of G protein-coupled receptors; 1.2. A brief history of opioid receptors; 1.3. Evidence for opioid receptors in nonmammalian vertebrates; 2. The Vertebrate Opioid Receptor Sequence Database; 2.1. Alignment of protein sequences 2.2. Phylogenetic analysis of vertebrate opioid receptors2.3. Divergence and convergence of opioid receptor types; 3. The Human Genome and the Evolution of Opioid Receptors; 3.1. Duplicated opioid family receptor genes in the human genome; 3.2. Variation in human opioid receptor genes; 4. The Molecular Evolution of Vertebrate Opioid Family Receptors; 5. Future Directions; 6. Conclusions; Acknowledgments; References; Chapter 3: Ancestral Vertebrate Complexity of the Opioid System; 1. Introduction; 2. Opioid Peptide Family; 3. Opioid Receptor Family 4. Discussion: Complexity, Coevolution, and Divergence5. Conclusions; Acknowledgement; References; Chapter 4: Synthesis and Biological Activity of Small Peptides as NOP and Opioid Receptors' Ligands: View on Current Devel...; 1. Introduction; 2. Endogenous Opioid Peptides and Receptors: Nociceptin and NOP Receptor Ligands; 3. Hexapeptides with NOP Receptor Affinity; 4. Solid-Phase Peptide Synthesis; 5. Conclusions; Acknowledgment; References; Chapter 5: Pain Regulation by Nocistatin-Targeting Molecules: G Protein-Coupled-Receptor and Nocistatin-Interacting Protein; 1. Introduction 2. Biological Activity by NST Through G Protein-Coupled Receptor |
| Record Nr. | UNINA-9910460751403321 |
| Waltham, Massachusetts : , : Academic Press, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Vitamins and hormones . Volume ninety-seven Nociceptin opioid / / series editor, Gerald Litwack
| Vitamins and hormones . Volume ninety-seven Nociceptin opioid / / series editor, Gerald Litwack |
| Edizione | [First edition.] |
| Pubbl/distr/stampa | Waltham, Massachusetts : , : Academic Press, , 2015 |
| Descrizione fisica | 1 online resource (392 p.) |
| Disciplina | 612.015756 |
| Collana | Vitamins and Hormones |
| Soggetto topico |
Neuropeptides
Opioid peptides Nociceptive pain |
| ISBN |
0-12-802593-X
0-12-802443-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Nociceptin Opioid; Copyright; Contents; Contributors; Preface; Chapter 1: Helix-Constrained Nociceptin Peptides Are Potent Agonists and Antagonists of ORL-1 and Nociception; 1. Nociception in Brief; 1.1. Opioid receptor-like receptor-ORL-1; 1.2. Nociceptin; 1.3. Interrogating the activation and address domains of nociceptin(1-17); 2. Prospecting the Importance of the N-Terminal Tetrapeptide of Nociceptin(1-17); 3. Other Modifications to Nociceptin(1-17); 4. The Importance of Structure in Nociceptin Analogues; 4.1. Importance of helicity; 4.2. Other nociceptin derivatives
5. Recent Advances in ORL-1 Active Nociceptin Peptides6. The Development of New Helix-Constrained Nociceptin Analogues; 6.1. Design of helix-constrained nociceptin analogues; 6.2. Helical structure of nociceptin(1-17)-NH2 analogues in water; 6.3. Nuclear magnetic resonance spectra-derived structures; 7. Biological Properties of Helical Nociceptin Mimetics; 7.1. Cellular expression of ORL-1 and ERK phosphorylation; 7.2. Agonist and antagonist activity of nociceptin(1-17)-NH2 and analogues; 7.3. Effects of helical constraint on biological activity in Neuro-2a cells 7.4. Stability and cell toxicity of helix-constrained versus unconstrained peptides7.5. In vivo activity of helix-constrained versus unconstrained nociceptin analogues; 8. Concluding Remarks; References; Chapter 2: Bioinformatics and Evolution of Vertebrate Nociceptin and Opioid Receptors; 1. Introduction; 1.1. The origin of G protein-coupled receptors; 1.2. A brief history of opioid receptors; 1.3. Evidence for opioid receptors in nonmammalian vertebrates; 2. The Vertebrate Opioid Receptor Sequence Database; 2.1. Alignment of protein sequences 2.2. Phylogenetic analysis of vertebrate opioid receptors2.3. Divergence and convergence of opioid receptor types; 3. The Human Genome and the Evolution of Opioid Receptors; 3.1. Duplicated opioid family receptor genes in the human genome; 3.2. Variation in human opioid receptor genes; 4. The Molecular Evolution of Vertebrate Opioid Family Receptors; 5. Future Directions; 6. Conclusions; Acknowledgments; References; Chapter 3: Ancestral Vertebrate Complexity of the Opioid System; 1. Introduction; 2. Opioid Peptide Family; 3. Opioid Receptor Family 4. Discussion: Complexity, Coevolution, and Divergence5. Conclusions; Acknowledgement; References; Chapter 4: Synthesis and Biological Activity of Small Peptides as NOP and Opioid Receptors' Ligands: View on Current Devel...; 1. Introduction; 2. Endogenous Opioid Peptides and Receptors: Nociceptin and NOP Receptor Ligands; 3. Hexapeptides with NOP Receptor Affinity; 4. Solid-Phase Peptide Synthesis; 5. Conclusions; Acknowledgment; References; Chapter 5: Pain Regulation by Nocistatin-Targeting Molecules: G Protein-Coupled-Receptor and Nocistatin-Interacting Protein; 1. Introduction 2. Biological Activity by NST Through G Protein-Coupled Receptor |
| Record Nr. | UNINA-9910787429703321 |
| Waltham, Massachusetts : , : Academic Press, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Vitamins and hormones . Volume ninety-seven Nociceptin opioid / / series editor, Gerald Litwack
| Vitamins and hormones . Volume ninety-seven Nociceptin opioid / / series editor, Gerald Litwack |
| Edizione | [First edition.] |
| Pubbl/distr/stampa | Waltham, Massachusetts : , : Academic Press, , 2015 |
| Descrizione fisica | 1 online resource (392 p.) |
| Disciplina | 612.015756 |
| Collana | Vitamins and Hormones |
| Soggetto topico |
Neuropeptides
Opioid peptides Nociceptive pain |
| ISBN |
0-12-802593-X
0-12-802443-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Nociceptin Opioid; Copyright; Contents; Contributors; Preface; Chapter 1: Helix-Constrained Nociceptin Peptides Are Potent Agonists and Antagonists of ORL-1 and Nociception; 1. Nociception in Brief; 1.1. Opioid receptor-like receptor-ORL-1; 1.2. Nociceptin; 1.3. Interrogating the activation and address domains of nociceptin(1-17); 2. Prospecting the Importance of the N-Terminal Tetrapeptide of Nociceptin(1-17); 3. Other Modifications to Nociceptin(1-17); 4. The Importance of Structure in Nociceptin Analogues; 4.1. Importance of helicity; 4.2. Other nociceptin derivatives
5. Recent Advances in ORL-1 Active Nociceptin Peptides6. The Development of New Helix-Constrained Nociceptin Analogues; 6.1. Design of helix-constrained nociceptin analogues; 6.2. Helical structure of nociceptin(1-17)-NH2 analogues in water; 6.3. Nuclear magnetic resonance spectra-derived structures; 7. Biological Properties of Helical Nociceptin Mimetics; 7.1. Cellular expression of ORL-1 and ERK phosphorylation; 7.2. Agonist and antagonist activity of nociceptin(1-17)-NH2 and analogues; 7.3. Effects of helical constraint on biological activity in Neuro-2a cells 7.4. Stability and cell toxicity of helix-constrained versus unconstrained peptides7.5. In vivo activity of helix-constrained versus unconstrained nociceptin analogues; 8. Concluding Remarks; References; Chapter 2: Bioinformatics and Evolution of Vertebrate Nociceptin and Opioid Receptors; 1. Introduction; 1.1. The origin of G protein-coupled receptors; 1.2. A brief history of opioid receptors; 1.3. Evidence for opioid receptors in nonmammalian vertebrates; 2. The Vertebrate Opioid Receptor Sequence Database; 2.1. Alignment of protein sequences 2.2. Phylogenetic analysis of vertebrate opioid receptors2.3. Divergence and convergence of opioid receptor types; 3. The Human Genome and the Evolution of Opioid Receptors; 3.1. Duplicated opioid family receptor genes in the human genome; 3.2. Variation in human opioid receptor genes; 4. The Molecular Evolution of Vertebrate Opioid Family Receptors; 5. Future Directions; 6. Conclusions; Acknowledgments; References; Chapter 3: Ancestral Vertebrate Complexity of the Opioid System; 1. Introduction; 2. Opioid Peptide Family; 3. Opioid Receptor Family 4. Discussion: Complexity, Coevolution, and Divergence5. Conclusions; Acknowledgement; References; Chapter 4: Synthesis and Biological Activity of Small Peptides as NOP and Opioid Receptors' Ligands: View on Current Devel...; 1. Introduction; 2. Endogenous Opioid Peptides and Receptors: Nociceptin and NOP Receptor Ligands; 3. Hexapeptides with NOP Receptor Affinity; 4. Solid-Phase Peptide Synthesis; 5. Conclusions; Acknowledgment; References; Chapter 5: Pain Regulation by Nocistatin-Targeting Molecules: G Protein-Coupled-Receptor and Nocistatin-Interacting Protein; 1. Introduction 2. Biological Activity by NST Through G Protein-Coupled Receptor |
| Record Nr. | UNINA-9910821059903321 |
| Waltham, Massachusetts : , : Academic Press, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
