Info
- Utilizzare la checkbox di selezione a fianco di ciascun documento per attivare le funzionalità di stampa, invio email, download nei formati disponibili del (i) record.
Catalytically Active Nucleic Acids / / edited by Harald Seitz, Frank Stahl, Johanna-Gabriela Walter
| Catalytically Active Nucleic Acids / / edited by Harald Seitz, Frank Stahl, Johanna-Gabriela Walter |
| Edizione | [1st ed. 2020.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 |
| Descrizione fisica | 1 online resource (VII, 123 p. 38 illus., 12 illus. in color.) |
| Disciplina | 574.87328 |
| Collana | Advances in Biochemical Engineering/Biotechnology |
| Soggetto topico |
Biochemical engineering
Nucleic acids Enzymology Biochemical Engineering Nucleic Acid Chemistry |
| ISBN | 3-030-29646-6 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | RNA G-Quadruplexes as key Motifs of the Transcriptome -- Challenges and Perspectives in Nucleic Acid Enzyme Engineering -- Strategies for Characterization of Enzymatic Nucleic Acids -- Bioanalytical Application of Peroxidase Mimicking DNAzymes: Status and Challenges -- Hemin/G-Quadruplex Horseradish Peroxidase-Mimicking DNAzyme: Principle and Biosensing Application -- Aptazymes: Expanding the Specificity of Natural Catalytic Nucleic Acids by Application of In Vitro Selected Oligonucleotides. |
| Record Nr. | UNINA-9910367241803321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cellular-Molecular Mechanisms in Epigenetic Evolutionary Biology / / by John Torday, William Miller Jr
| Cellular-Molecular Mechanisms in Epigenetic Evolutionary Biology / / by John Torday, William Miller Jr |
| Autore | Torday John |
| Edizione | [1st ed. 2020.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 |
| Descrizione fisica | 1 online resource (XV, 214 p. 10 illus., 7 illus. in color.) |
| Disciplina | 574.87328 |
| Soggetto topico |
Evolutionary biology
Biology—Philosophy Developmental biology Physiology Genetics Biochemistry Evolutionary Biology Philosophy of Biology Developmental Biology Genetics and Genomics Biochemistry, general |
| ISBN | 3-030-38133-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Chapter 1. Introduction -- Chapter 2. Darwin, the Modern Synthesis, and a New Biology -- Chapter 3. Cognition and the living condition -- Chapter 4. What is consciousness? An Evolutionary Perspective -- Chapter 5. Networking from the Cell to Quantum Mechanics as Consciousness -- Chapter 6. The Nature of information and its communication -- Chapter 7. The information cycle and biological information management -- Chapter 8. Communication and the accumulation of genetic information -- Chapter 9. Non-genic means of information reception and exchange -- Chapter 10. The primacy of the unicellular state -- Chapter 11. Phenotype, niche construction and natural cellular engineering -- Chapter 12. Holobionts -- Chapter 13. Four Domains: Cognition-based evolution -- Chapter 14. Reconciling physics and biology -- Chapter 15. What does this mean for evolution? -- Chapter 16. Conclusion: Cellular-molecular evolution in the 21st century. . |
| Record Nr. | UNINA-9910380742503321 |
Torday John
|
||
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The chemical biology of long noncoding RNAs / / Stefan Jurga, Jan Barciszewski, editors
| The chemical biology of long noncoding RNAs / / Stefan Jurga, Jan Barciszewski, editors |
| Edizione | [1st ed. 2020.] |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2021] |
| Descrizione fisica | 1 online resource (X, 544 p. 49 illus., 45 illus. in color.) |
| Disciplina | 574.87328 |
| Collana | RNA technologies |
| Soggetto topico | Nucleic acids |
| ISBN | 3-030-44743-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Long Non-Coding RNAs Diversity in Form and Function - from Microbes to Humans -- Evolving Roles of Long Noncoding RNAs -- Biogenesis and Function of the Noncoding Isoform-Type LncRNAs -- Long Non-Coding RNAs in a Single Cell Type: Function and Subcellular Localization -- Long Non-Coding RNAs as Scaffolds for Multiprotein Signalling Complexes -- Landscape of Long Non-Coding RNA Genes, Pseudogenes and Protein Genes in Segmental Duplications in the Critical Human Chromosomal Region 22q11.2 -- Long Non-Coding RNAs and Cancer Cells’ Drug Resistance: an Unexpected Connection -- Long Noncoding RNAs as Drivers of Acquired Chemoresistance in Hepatocellular Carcinoma -- Single Cell Analysis May Shed new Lights on the Role of LncRNAs in Chemo-Resistance in Gastrointestinal Cancers -- LncRNAs in the Development, Progression, and Therapy Resistance of Hormone-Dependent Cancer -- Tumorigenesis-Related Long Non-Coding RNAs and their Targeting as Therapeutic Approach in Cancer -- Long Non-Coding RNAs in Non-Small Cell Lung Cancer: State of the Art -- Long Non-Coding RNAs in Cardiovascular Diseases -- Long Non-Coding RNAs in Cardiovascular Development and Diseases.-Long Noncoding RNAs as Players in Breast Tumorigenesis -- Drosophila Models to Study Long Non-Coding RNAs Related to Neurological Disorders -- Regulatory Roles of Long Non-Coding RNAs in Skeletal Muscle Differentiation, Regeneration, and Disorders -- Long Noncoding RNAs in Substance Use Disorders -- The Multifaceted Roles of LncRNAs in Diabetic Complications: a Promising, yet Perplexing Paradigm -- Long Non-Coding RNAs in Diabetes and β-cell Regulation. |
| Record Nr. | UNINA-9910424634703321 |
| Cham, Switzerland : , : Springer, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Chemistry and biology of non-canonical nucleic acids / / Naoki Sugimoto
| Chemistry and biology of non-canonical nucleic acids / / Naoki Sugimoto |
| Autore | Sugimoto N (Naoki) |
| Pubbl/distr/stampa | Weinheim, Germany : , : Wiley-VCH, , [2021] |
| Descrizione fisica | 1 online resource (xii, 276 pages) : illustrations |
| Disciplina | 574.87328 |
| Soggetto topico | Nucleic acids |
| Soggetto genere / forma | Electronic books. |
| ISBN |
3-527-81786-7
3-527-81788-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover -- Title Page -- Copyright -- Contents -- Preface -- Chapter 1 History for Canonical and Non‐canonical Structures of Nucleic Acids -- 1.1 Introduction -- 1.2 History of Duplex -- 1.3 Non‐Watson-Crick Base Pair -- 1.4 Nucleic Acid Structures Including Non‐Watson-Crick Base Pairs -- 1.5 Perspective of the Research for Non‐canonical Nucleic Acid Structures -- 1.6 Conclusion and Perspective -- References -- Chapter 2 Structures of Nucleic Acids Now -- 2.1 Introduction -- 2.2 Unusual Base Pairs in a Duplex -- 2.2.1 Hoogsteen Base Pair -- 2.2.2 Purine-Pyrimidine Mismatches -- 2.2.3 Purine-Purine Mismatches -- 2.2.4 Pyrimidine-Pyrimidine Mismatches -- 2.3 Non‐canonical Backbone Shapes in DNA Duplex -- 2.4 Branched DNA with Junction -- 2.5 Multi‐stranded DNA Helices -- 2.6 Structures in RNA -- 2.6.1 Basic Structure Distinctions of RNA -- 2.6.2 Elements in RNA Secondary Structures -- 2.6.2.1 Hairpin Loop -- 2.6.2.2 Bulge Loop -- 2.6.2.3 Internal Loop -- 2.6.3 Elements in Tertiary Interactions of RNA -- 2.6.3.1 A‐Minor Interactions -- 2.6.3.2 Ribose Zipper -- 2.6.3.3 T‐Loop Motif -- 2.6.3.4 Kissing‐Loop Interaction -- 2.6.3.5 GNRA Tetraloop Receptor Interaction -- 2.6.3.6 Pseudoknot Crosslinking Distant Stem Regions -- 2.7 Conclusion -- References -- Chapter 3 Stability of Non‐canonical Nucleic Acids -- 3.1 Introduction -- 3.2 Factors Influencing Stabilities of the Canonical Duplexes -- 3.2.1 Hydrogen Bond Formations -- 3.2.2 Stacking Interactions -- 3.2.3 Conformational Entropy -- 3.3 Thermodynamic Analysis for the Formation of Duplex -- 3.4 Factors Influencing Stabilities of the Non‐canonical Nucleic Acids -- 3.4.1 Factors Influencing Stability of Triplexes -- 3.4.2 Factors Influencing Stability of Quadruplex -- 3.4.2.1 G‐Quadruplexes -- 3.4.2.2 i‐Motif -- 3.5 Thermodynamic Analysis for the Non‐canonical Nucleic Acids.
3.5.1 Thermodynamic Analysis for the Intramolecular Triplex and Tetraplex -- 3.5.2 Thermodynamic Analysis for the Intermolecular Triplex -- 3.5.3 Thermodynamic Analysis for the Tetraplex -- 3.6 Conclusion -- References -- Chapter 4 Physicochemical Properties of Non‐canonical Nucleic Acids -- 4.1 Introduction -- 4.2 Spectroscopic Properties of Non‐canonical Nucleic Acids -- 4.2.1 Effect of Non‐canonical Structure on UV Absorption -- 4.2.2 Circular Dichroism of Non‐canonical Nucleic Acids -- 4.2.3 NMR Spectroscopy -- 4.2.4 Other Spectroscopic Characteristics of Non‐canonical Nucleic Acids -- 4.3 Chemical Interactions on Non‐canonical Nucleic Acids -- 4.3.1 Hydration -- 4.3.2 Cation Binding -- 4.3.3 pH Effect -- 4.3.4 Chemical Modification -- 4.4 Chemical Platform on the Non‐canonical Structures -- 4.4.1 Specificity of a Ligand to Non‐canonical Structures -- 4.4.2 Fluorescence Platform of Non‐canonical Structures -- 4.4.3 Interface Between Proteins and Nucleic Acids -- 4.5 Physicochemical Property of Non‐canonical Nucleic Acids in Cell -- 4.5.1 Molecular Crowding Condition that Reflects Cellular Environments -- 4.5.2 Effects of Crowding Reagents on Non‐canonical Nucleic Acid Structures -- 4.5.3 Quantification of Physical Properties of Non‐canonical Structures in Crowding Condition -- 4.5.4 Non‐canonical Structures Under Mimicking Organelle Environment -- 4.5.5 Insight for the Formation of Non‐canonical Nucleic Acids in Cells -- 4.6 Conclusion -- References -- Chapter 5 Telomere -- 5.1 Introduction -- 5.2 Structural Properties of Telomere -- 5.2.1 Structures of Telomere -- 5.2.2 Structural Properties of Human Telomeric G4s -- 5.2.3 Structure of Repeats of Human Telomeric G4s -- 5.3 Biological Relevance of Telomere G4 -- 5.3.1 Telomerase Activity -- 5.3.2 Telomerase Repeated Amplification Protocol (TRAP) Assay. 5.3.3 Alternative Lengthening of Telomere (ALT) Mechanism -- 5.4 Other Non‐canonical Structures Related to Telomere Region -- 5.4.1 Telomere i‐Motif -- 5.4.2 Telomere RNA -- 5.5 Conclusion -- References -- Chapter 6 Transcription -- 6.1 Introduction -- 6.2 Transcription Process -- 6.2.1 Transcription Initiation -- 6.2.2 Transcription Elongation -- 6.2.3 Transcription Termination -- 6.3 Transcription Process Perturbed by Certain Sequences of DNA and RNA -- 6.4 Transcription Process Perturbed by Non‐canonical Structures of DNA and RNA -- 6.5 Conclusion -- References -- Chapter 7 Translation -- 7.1 Introduction -- 7.2 RNAs Involved in Translation Machinery -- 7.3 General Process of Translation -- 7.3.1 Translation Initiation -- 7.3.2 Translation Elongation -- 7.3.3 Translation Termination -- 7.4 RNA Structures Affecting Translation Reaction -- 7.4.1 Modulation of Translation Initiation in Prokaryotes -- 7.4.2 Modulation of Translation Initiation in Eukaryotes -- 7.4.3 RNA Structures Affecting Translation Elongation -- 7.4.4 RNA Structures Affecting Translation Termination -- 7.5 Conclusion -- References -- Chapter 8 Replication -- 8.1 Introduction -- 8.2 Replication Machineries -- 8.3 Replication Initiation -- 8.3.1 Mechanism of Activation of Replication Origins -- 8.3.2 Activation Control of Origins by G4s -- 8.3.3 Control of Timing of Replication Initiation by G4s -- 8.4 DNA Strand Elongation -- 8.4.1 Mechanism of DNA Strand Elongation -- 8.4.2 Impact of G4 and i‐Motif Formations on DNA Strand Synthesis -- 8.4.3 Relationship Between G4 and Epigenetic Modification -- 8.4.4 Expansion and Contraction of Replicating Strand Induced by Hairpin Structures -- 8.5 Termination of Replication -- 8.6 Chemistry of the Replication and Its Regulation -- 8.6.1 Cellular Environments -- 8.6.2 Control of Replication by Chemical Compounds -- 8.7 Conclusion -- References. Chapter 9 Helicase -- 9.1 Introduction -- 9.2 Function and Structure of Helicases -- 9.3 Unwinding of Non‐canonical DNA Structures by Helicases -- 9.4 G4 Helicases in Gene Expressions -- 9.5 G4 Helicases in Replication -- 9.6 G4 Helicases in Telomere Maintenance -- 9.7 Relation to Diseases by Loss of G4 Helicases -- 9.8 Insight into Specific Properties of Activities of G4 Helicase Under Cellular Conditions -- 9.9 Conclusion -- References -- Chapter 10 Dynamic Regulation of Biosystems by Nucleic Acids with Non‐canonical Structures -- 10.1 Introduction -- 10.2 Time Scale of Biological Reactions -- 10.2.1 Cell Cycle -- 10.2.2 Central Dogma -- 10.2.3 Dynamic Structures of Nucleic Acids -- 10.3 Processes in the Central Dogma Affected by Dynamics of Nucleic Acid Structures -- 10.3.1 Epigenetic Regulation Caused by Chemical Modification of DNA -- 10.3.2 Co‐transcriptional Formation of Metastable RNA Structures -- 10.3.3 Co‐transcriptional Translation and Transcription Attenuation -- 10.3.4 Co‐transcriptional Ligand Binding and Gene Regulation -- 10.3.5 Translation Elongation and Co‐translational Protein Folding -- 10.4 Conclusion -- References -- Chapter 11 Cancer and Nucleic Acid Structures -- 11.1 Introduction -- 11.2 Detail Mechanism of Cancer -- 11.2.1 Cancer Incidence -- 11.2.2 The Relationship Between Genes and Cancer -- 11.3 Non‐canonical Structures of Nucleic Acids in Cancer Cells -- 11.3.1 Structural Characteristics of Nucleic Acids in Cancer Cells -- 11.3.2 Non‐canonical Structures Perturb Gene Expression of Cancer‐Related Genes -- 11.4 Roles of Non‐canonical Structures of Nucleic Acids in Cancer Cells -- 11.4.1 Monitoring of Non‐canonical Structures in Cancer Cells -- 11.4.2 Regulation of Gene Expressions by the Non‐canonical Structures in Cancer Cells -- 11.5 Conclusion -- References. Chapter 12 Neurodegenerative Diseases and Nucleic Acid Structures -- 12.1 Introduction -- 12.2 Protein Aggregation‐Induced Neurodegenerative Diseases -- 12.3 DNA Shows Key Role for Neurodegenerative Diseases -- 12.4 RNA Toxic Plays a Key Role for Neurological Diseases -- 12.5 Conclusion -- References -- Chapter 13 Therapeutic Applications -- 13.1 Introduction -- 13.2 Oligonucleotide Therapeutics -- 13.2.1 Antisense Oligonucleotide -- 13.2.2 Functions of Antisense Oligonucleotide Therapeutics -- 13.2.3 Chemical Modifications in Therapeutic Oligonucleotides -- 13.2.3.1 Backbone Modified Oligonucleotides -- 13.2.3.2 Ribose Modified Oligonucleotides -- 13.2.3.3 Oligonucleotides with Unnatural Backbone -- 13.2.4 Oligonucleotide Therapeutics Other Than Antisense Oligonucleotide -- 13.2.4.1 Oligonucleotide Therapeutics Functioning Through RNA Interference -- 13.2.4.2 Oligonucleotide Therapeutics Functioning Through Binding to Protein -- 13.3 Non‐canonical Nucleic Acid Structures as Therapeutic Targets -- 13.3.1 Traditional Antibiotics Targeting Structured Region of RNAs -- 13.3.2 Strategies for Constructing Therapeutic Materials Targeting Structured Nucleic Acids -- 13.4 Non‐canonical Nucleic Acid Materials for Inducing Non‐canonical Structures -- 13.5 Conclusion -- References -- Chapter 14 Materials Science and Nanotechnology of Nucleic Acids -- 14.1 Introduction -- 14.2 Non‐canonical Structure‐Based Nanomaterials Resembling Protein Functions -- 14.2.1 Aptamer -- 14.2.2 DNAzyme -- 14.2.3 Ion Channel -- 14.3 Protein Engineering Using G4‐Binding Protein -- 14.4 Regulation of Gene Expression by G4‐Inducing Materials -- 14.5 Environmental Sensing -- 14.5.1 Sensing Temperature in Cells -- 14.5.2 Sensing pH in Cells -- 14.5.3 Sensing K+ Ion in Cells -- 14.5.4 Sensing Crowding Condition in Cells -- 14.6 Conclusion -- References. Chapter 15 Future Outlook for Chemistry and Biology of Non‐canonical Nucleic Acids. |
| Record Nr. | UNINA-9910555058803321 |
|
Sugimoto N (Naoki)
|
||
| Weinheim, Germany : , : Wiley-VCH, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Chemistry and biology of non-canonical nucleic acids / / Naoki Sugimoto
| Chemistry and biology of non-canonical nucleic acids / / Naoki Sugimoto |
| Autore | Sugimoto N (Naoki) |
| Pubbl/distr/stampa | Weinheim, Germany : , : Wiley-VCH, , [2021] |
| Descrizione fisica | 1 online resource (xii, 276 pages) : illustrations |
| Disciplina | 574.87328 |
| Soggetto topico | Nucleic acids |
| ISBN |
3-527-81786-7
3-527-81788-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover -- Title Page -- Copyright -- Contents -- Preface -- Chapter 1 History for Canonical and Non‐canonical Structures of Nucleic Acids -- 1.1 Introduction -- 1.2 History of Duplex -- 1.3 Non‐Watson-Crick Base Pair -- 1.4 Nucleic Acid Structures Including Non‐Watson-Crick Base Pairs -- 1.5 Perspective of the Research for Non‐canonical Nucleic Acid Structures -- 1.6 Conclusion and Perspective -- References -- Chapter 2 Structures of Nucleic Acids Now -- 2.1 Introduction -- 2.2 Unusual Base Pairs in a Duplex -- 2.2.1 Hoogsteen Base Pair -- 2.2.2 Purine-Pyrimidine Mismatches -- 2.2.3 Purine-Purine Mismatches -- 2.2.4 Pyrimidine-Pyrimidine Mismatches -- 2.3 Non‐canonical Backbone Shapes in DNA Duplex -- 2.4 Branched DNA with Junction -- 2.5 Multi‐stranded DNA Helices -- 2.6 Structures in RNA -- 2.6.1 Basic Structure Distinctions of RNA -- 2.6.2 Elements in RNA Secondary Structures -- 2.6.2.1 Hairpin Loop -- 2.6.2.2 Bulge Loop -- 2.6.2.3 Internal Loop -- 2.6.3 Elements in Tertiary Interactions of RNA -- 2.6.3.1 A‐Minor Interactions -- 2.6.3.2 Ribose Zipper -- 2.6.3.3 T‐Loop Motif -- 2.6.3.4 Kissing‐Loop Interaction -- 2.6.3.5 GNRA Tetraloop Receptor Interaction -- 2.6.3.6 Pseudoknot Crosslinking Distant Stem Regions -- 2.7 Conclusion -- References -- Chapter 3 Stability of Non‐canonical Nucleic Acids -- 3.1 Introduction -- 3.2 Factors Influencing Stabilities of the Canonical Duplexes -- 3.2.1 Hydrogen Bond Formations -- 3.2.2 Stacking Interactions -- 3.2.3 Conformational Entropy -- 3.3 Thermodynamic Analysis for the Formation of Duplex -- 3.4 Factors Influencing Stabilities of the Non‐canonical Nucleic Acids -- 3.4.1 Factors Influencing Stability of Triplexes -- 3.4.2 Factors Influencing Stability of Quadruplex -- 3.4.2.1 G‐Quadruplexes -- 3.4.2.2 i‐Motif -- 3.5 Thermodynamic Analysis for the Non‐canonical Nucleic Acids.
3.5.1 Thermodynamic Analysis for the Intramolecular Triplex and Tetraplex -- 3.5.2 Thermodynamic Analysis for the Intermolecular Triplex -- 3.5.3 Thermodynamic Analysis for the Tetraplex -- 3.6 Conclusion -- References -- Chapter 4 Physicochemical Properties of Non‐canonical Nucleic Acids -- 4.1 Introduction -- 4.2 Spectroscopic Properties of Non‐canonical Nucleic Acids -- 4.2.1 Effect of Non‐canonical Structure on UV Absorption -- 4.2.2 Circular Dichroism of Non‐canonical Nucleic Acids -- 4.2.3 NMR Spectroscopy -- 4.2.4 Other Spectroscopic Characteristics of Non‐canonical Nucleic Acids -- 4.3 Chemical Interactions on Non‐canonical Nucleic Acids -- 4.3.1 Hydration -- 4.3.2 Cation Binding -- 4.3.3 pH Effect -- 4.3.4 Chemical Modification -- 4.4 Chemical Platform on the Non‐canonical Structures -- 4.4.1 Specificity of a Ligand to Non‐canonical Structures -- 4.4.2 Fluorescence Platform of Non‐canonical Structures -- 4.4.3 Interface Between Proteins and Nucleic Acids -- 4.5 Physicochemical Property of Non‐canonical Nucleic Acids in Cell -- 4.5.1 Molecular Crowding Condition that Reflects Cellular Environments -- 4.5.2 Effects of Crowding Reagents on Non‐canonical Nucleic Acid Structures -- 4.5.3 Quantification of Physical Properties of Non‐canonical Structures in Crowding Condition -- 4.5.4 Non‐canonical Structures Under Mimicking Organelle Environment -- 4.5.5 Insight for the Formation of Non‐canonical Nucleic Acids in Cells -- 4.6 Conclusion -- References -- Chapter 5 Telomere -- 5.1 Introduction -- 5.2 Structural Properties of Telomere -- 5.2.1 Structures of Telomere -- 5.2.2 Structural Properties of Human Telomeric G4s -- 5.2.3 Structure of Repeats of Human Telomeric G4s -- 5.3 Biological Relevance of Telomere G4 -- 5.3.1 Telomerase Activity -- 5.3.2 Telomerase Repeated Amplification Protocol (TRAP) Assay. 5.3.3 Alternative Lengthening of Telomere (ALT) Mechanism -- 5.4 Other Non‐canonical Structures Related to Telomere Region -- 5.4.1 Telomere i‐Motif -- 5.4.2 Telomere RNA -- 5.5 Conclusion -- References -- Chapter 6 Transcription -- 6.1 Introduction -- 6.2 Transcription Process -- 6.2.1 Transcription Initiation -- 6.2.2 Transcription Elongation -- 6.2.3 Transcription Termination -- 6.3 Transcription Process Perturbed by Certain Sequences of DNA and RNA -- 6.4 Transcription Process Perturbed by Non‐canonical Structures of DNA and RNA -- 6.5 Conclusion -- References -- Chapter 7 Translation -- 7.1 Introduction -- 7.2 RNAs Involved in Translation Machinery -- 7.3 General Process of Translation -- 7.3.1 Translation Initiation -- 7.3.2 Translation Elongation -- 7.3.3 Translation Termination -- 7.4 RNA Structures Affecting Translation Reaction -- 7.4.1 Modulation of Translation Initiation in Prokaryotes -- 7.4.2 Modulation of Translation Initiation in Eukaryotes -- 7.4.3 RNA Structures Affecting Translation Elongation -- 7.4.4 RNA Structures Affecting Translation Termination -- 7.5 Conclusion -- References -- Chapter 8 Replication -- 8.1 Introduction -- 8.2 Replication Machineries -- 8.3 Replication Initiation -- 8.3.1 Mechanism of Activation of Replication Origins -- 8.3.2 Activation Control of Origins by G4s -- 8.3.3 Control of Timing of Replication Initiation by G4s -- 8.4 DNA Strand Elongation -- 8.4.1 Mechanism of DNA Strand Elongation -- 8.4.2 Impact of G4 and i‐Motif Formations on DNA Strand Synthesis -- 8.4.3 Relationship Between G4 and Epigenetic Modification -- 8.4.4 Expansion and Contraction of Replicating Strand Induced by Hairpin Structures -- 8.5 Termination of Replication -- 8.6 Chemistry of the Replication and Its Regulation -- 8.6.1 Cellular Environments -- 8.6.2 Control of Replication by Chemical Compounds -- 8.7 Conclusion -- References. Chapter 9 Helicase -- 9.1 Introduction -- 9.2 Function and Structure of Helicases -- 9.3 Unwinding of Non‐canonical DNA Structures by Helicases -- 9.4 G4 Helicases in Gene Expressions -- 9.5 G4 Helicases in Replication -- 9.6 G4 Helicases in Telomere Maintenance -- 9.7 Relation to Diseases by Loss of G4 Helicases -- 9.8 Insight into Specific Properties of Activities of G4 Helicase Under Cellular Conditions -- 9.9 Conclusion -- References -- Chapter 10 Dynamic Regulation of Biosystems by Nucleic Acids with Non‐canonical Structures -- 10.1 Introduction -- 10.2 Time Scale of Biological Reactions -- 10.2.1 Cell Cycle -- 10.2.2 Central Dogma -- 10.2.3 Dynamic Structures of Nucleic Acids -- 10.3 Processes in the Central Dogma Affected by Dynamics of Nucleic Acid Structures -- 10.3.1 Epigenetic Regulation Caused by Chemical Modification of DNA -- 10.3.2 Co‐transcriptional Formation of Metastable RNA Structures -- 10.3.3 Co‐transcriptional Translation and Transcription Attenuation -- 10.3.4 Co‐transcriptional Ligand Binding and Gene Regulation -- 10.3.5 Translation Elongation and Co‐translational Protein Folding -- 10.4 Conclusion -- References -- Chapter 11 Cancer and Nucleic Acid Structures -- 11.1 Introduction -- 11.2 Detail Mechanism of Cancer -- 11.2.1 Cancer Incidence -- 11.2.2 The Relationship Between Genes and Cancer -- 11.3 Non‐canonical Structures of Nucleic Acids in Cancer Cells -- 11.3.1 Structural Characteristics of Nucleic Acids in Cancer Cells -- 11.3.2 Non‐canonical Structures Perturb Gene Expression of Cancer‐Related Genes -- 11.4 Roles of Non‐canonical Structures of Nucleic Acids in Cancer Cells -- 11.4.1 Monitoring of Non‐canonical Structures in Cancer Cells -- 11.4.2 Regulation of Gene Expressions by the Non‐canonical Structures in Cancer Cells -- 11.5 Conclusion -- References. Chapter 12 Neurodegenerative Diseases and Nucleic Acid Structures -- 12.1 Introduction -- 12.2 Protein Aggregation‐Induced Neurodegenerative Diseases -- 12.3 DNA Shows Key Role for Neurodegenerative Diseases -- 12.4 RNA Toxic Plays a Key Role for Neurological Diseases -- 12.5 Conclusion -- References -- Chapter 13 Therapeutic Applications -- 13.1 Introduction -- 13.2 Oligonucleotide Therapeutics -- 13.2.1 Antisense Oligonucleotide -- 13.2.2 Functions of Antisense Oligonucleotide Therapeutics -- 13.2.3 Chemical Modifications in Therapeutic Oligonucleotides -- 13.2.3.1 Backbone Modified Oligonucleotides -- 13.2.3.2 Ribose Modified Oligonucleotides -- 13.2.3.3 Oligonucleotides with Unnatural Backbone -- 13.2.4 Oligonucleotide Therapeutics Other Than Antisense Oligonucleotide -- 13.2.4.1 Oligonucleotide Therapeutics Functioning Through RNA Interference -- 13.2.4.2 Oligonucleotide Therapeutics Functioning Through Binding to Protein -- 13.3 Non‐canonical Nucleic Acid Structures as Therapeutic Targets -- 13.3.1 Traditional Antibiotics Targeting Structured Region of RNAs -- 13.3.2 Strategies for Constructing Therapeutic Materials Targeting Structured Nucleic Acids -- 13.4 Non‐canonical Nucleic Acid Materials for Inducing Non‐canonical Structures -- 13.5 Conclusion -- References -- Chapter 14 Materials Science and Nanotechnology of Nucleic Acids -- 14.1 Introduction -- 14.2 Non‐canonical Structure‐Based Nanomaterials Resembling Protein Functions -- 14.2.1 Aptamer -- 14.2.2 DNAzyme -- 14.2.3 Ion Channel -- 14.3 Protein Engineering Using G4‐Binding Protein -- 14.4 Regulation of Gene Expression by G4‐Inducing Materials -- 14.5 Environmental Sensing -- 14.5.1 Sensing Temperature in Cells -- 14.5.2 Sensing pH in Cells -- 14.5.3 Sensing K+ Ion in Cells -- 14.5.4 Sensing Crowding Condition in Cells -- 14.6 Conclusion -- References. Chapter 15 Future Outlook for Chemistry and Biology of Non‐canonical Nucleic Acids. |
| Record Nr. | UNINA-9910830012203321 |
|
Sugimoto N (Naoki)
|
||
| Weinheim, Germany : , : Wiley-VCH, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Gene structure and transcription / Trevor Beebee and Julian Burke
| Gene structure and transcription / Trevor Beebee and Julian Burke |
| Autore | Beebee, Trevor J. C. |
| Pubbl/distr/stampa | Oxford, England, : IRL Press, 1988 |
| Descrizione fisica | x, 77 p. ; 23 cm |
| Disciplina | 574.87328 |
| Altri autori (Persone) | Burke, Julian |
| Collana | In focus |
| Soggetto non controllato | Genetica |
| ISBN | 1852210141 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910870100103321 |
|
Beebee, Trevor J. C.
|
||
| Oxford, England, : IRL Press, 1988 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Genetica molecolare umana / Peter Sudbery
| Genetica molecolare umana / Peter Sudbery |
| Autore | SUDBERY, Peter |
| Pubbl/distr/stampa | Bologna : Zanichelli, copyr. 2000 |
| Descrizione fisica | XV, 269 p. ; 25 cm |
| Disciplina | 574.87328 |
| Soggetto topico | Genetica molecolare |
| ISBN | 88-08-09290-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | ita |
| Record Nr. | UNISA-990000400190203316 |
|
SUDBERY, Peter
|
||
| Bologna : Zanichelli, copyr. 2000 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Genetica umana molecolare / Tom Strachan, Andrew P. Read ; ed. italiana a cura di Gian Antonio Danieli ; con la collaborazione di Maria Serena Scariolo
| Genetica umana molecolare / Tom Strachan, Andrew P. Read ; ed. italiana a cura di Gian Antonio Danieli ; con la collaborazione di Maria Serena Scariolo |
| Autore | Strachan, Tom <1952- > |
| Edizione | [2. ed.] |
| Pubbl/distr/stampa | Torino : UTET, 2001 |
| Descrizione fisica | XXIII, 611 p. : ill. ; 27 cm |
| Disciplina | 574.87328 |
| Altri autori (Persone) | Read, Andrew P. <1939- > |
| Soggetto non controllato | Genetica molecolare |
| ISBN | 88-02-05736-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | ita |
| Record Nr. | UNINA-990002410690403321 |
|
Strachan, Tom <1952- >
|
||
| Torino : UTET, 2001 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Genetica umana molecolare / Tom Strachan, Andrew P. Read
| Genetica umana molecolare / Tom Strachan, Andrew P. Read |
| Autore | Strachan, Tom |
| Edizione | [Ed. italiana] |
| Pubbl/distr/stampa | Torino : UTET, 2001 |
| Descrizione fisica | XXIII, 611 p. : ill. ; 27 cm. |
| Disciplina | 574.87328 |
| Altri autori (Persone) | Read, Andrew P. |
| Soggetto topico | Genetica molecolare |
| ISBN | 88-02-05736-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | ita |
| Record Nr. | UNICAMPANIA-SUN0031762 |
|
Strachan, Tom
|
||
| Torino : UTET, 2001 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Vanvitelli | ||
| ||
Genetica umana molecolare / Tom Strachan, Andrew P. Read
| Genetica umana molecolare / Tom Strachan, Andrew P. Read |
| Autore | Strachan, Tom |
| Edizione | [Ed. italiana] |
| Pubbl/distr/stampa | Torino, : UTET, 2001 |
| Descrizione fisica | XXIII, 611 p. : ill. ; 27 cm. |
| Disciplina | 574.87328 |
| Altri autori (Persone) | Read, Andrew P. |
| Soggetto topico | Genetica molecolare |
| ISBN | 88-02-05736-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | ita |
| Titolo uniforme | |
| Record Nr. | UNICAMPANIA-VAN0031762 |
|
Strachan, Tom
|
||
| Torino, : UTET, 2001 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Vanvitelli | ||
| ||
