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Genetics and philosophy : an introduction / / Paul Griffiths, Karola Stotz [[electronic resource]]
| Genetics and philosophy : an introduction / / Paul Griffiths, Karola Stotz [[electronic resource]] |
| Autore | Griffiths Paul <1962-> |
| Pubbl/distr/stampa | Cambridge : , : Cambridge University Press, , 2013 |
| Descrizione fisica | 1 online resource (viii, 270 pages) : digital, PDF file(s) |
| Disciplina | 572.8/6 |
| Collana | Cambridge introductions to philosophy and biology |
| Soggetto topico |
Genes
Genomics Genetics - Philosophy Developmental genetics |
| ISBN |
1-107-35726-8
1-107-23404-2 1-107-34389-5 1-107-25535-X 1-107-34764-5 1-107-34514-6 1-107-34139-6 0-511-74408-0 |
| Classificazione | SCI075000 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Machine generated contents note: 1. Mendel's gene; 2. The physical gene; 3. The behavioural gene; 4. The reactive genome; 5. Outside the gene; 6. The informational gene; 7. The evolving gene. |
| Altri titoli varianti | Genetics & Philosophy |
| Record Nr. | UNINA-9910786110703321 |
Griffiths Paul <1962->
|
||
| Cambridge : , : Cambridge University Press, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Genetics and philosophy : an introduction / / Paul Griffiths, Karola Stotz [[electronic resource]]
| Genetics and philosophy : an introduction / / Paul Griffiths, Karola Stotz [[electronic resource]] |
| Autore | Griffiths Paul <1962-> |
| Pubbl/distr/stampa | Cambridge : , : Cambridge University Press, , 2013 |
| Descrizione fisica | 1 online resource (viii, 270 pages) : digital, PDF file(s) |
| Disciplina | 572.8/6 |
| Collana | Cambridge introductions to philosophy and biology |
| Soggetto topico |
Genes
Genomics Genetics - Philosophy Developmental genetics |
| ISBN |
1-107-35726-8
1-107-23404-2 1-107-34389-5 1-107-25535-X 1-107-34764-5 1-107-34514-6 1-107-34139-6 0-511-74408-0 |
| Classificazione | SCI075000 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Machine generated contents note: 1. Mendel's gene; 2. The physical gene; 3. The behavioural gene; 4. The reactive genome; 5. Outside the gene; 6. The informational gene; 7. The evolving gene. |
| Altri titoli varianti | Genetics & Philosophy |
| Record Nr. | UNINA-9910821241403321 |
|
Griffiths Paul <1962->
|
||
| Cambridge : , : Cambridge University Press, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Genomics [[electronic resource] ] : the science and technology behind the human genome project / / Charles R. Cantor, Cassandra L. Smith
| Genomics [[electronic resource] ] : the science and technology behind the human genome project / / Charles R. Cantor, Cassandra L. Smith |
| Autore | Cantor Charles R. <1942-> |
| Pubbl/distr/stampa | New York, : John Wiley & Sons, c1999 |
| Descrizione fisica | 1 online resource (621 p.) |
| Disciplina |
572.8/6
572.86 |
| Altri autori (Persone) | SmithCassandra |
| Collana | Baker Lecture Series |
| Soggetto topico |
DNA - Analysis
Nucleotide sequence Gene mapping |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-36704-0
9786610367047 0-470-32291-8 0-471-46186-5 0-471-22056-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Preface; Introduction; 1 DNA Chemistry and Biology; Basic Properties of DNA; Covalent Structure; Double Helical Structure; Methylated Bases; Plasticity in DNA Structure; DNA Synthesis; DNA as a Flexible Set of Chemical Reagents; Basic DNA Biology; Genome Sizes; Number of Genes; Sources and Additional Readings; 2 A Genome Overview at the Level of Chromosomes; Basic Properties of Chromosomes; Bacterial Chromosomes; Chromosomes of Eukaryotic Organisms; Centromeres; Telomeres; Dynamic Behavior of Telomeres; Chromatin and the Higher-Order Structure of Chromosomes
Chromosomes in the Cell CycleGenome Organization; Chromosome Purification; Chromosome Number; Unusual Characteristics of Sex Chromosomes and Mitochondria; Synteny; Sources and Additional Readings; 3 Analysis of DNA Sequences by Hybridization; Basic Requirements for Selectivity and Sensitivity; Detection of Specific DNA Sequences; Equilibria between DNA Double and Single Strands; Thermodynamics of the Melting of Short Duplexes; Thermodynamics of Imperfectly Paired Duplexes; Kinetics of the Melting of Short Duplexes; Kinetics of Melting of Long DNA; Kinetics of Double-Strand Formation ComplexityHybridization on Filters; Sensitive Detection; Sources and Additional Readings; 4 Polymerase Chain Reaction and Other Methods for In Vitro DNA Amplification; Why Amplify DNA?; Basic Principles of the Polymerase Chain Reaction (PCR); Noise in PCR: Contamination; PCR Noise: Mispriming; Misincorporation; Long PCR; Incorporating Extra Functionalities; Single-Sided PCR; Reducing Complexity with PCR; Additional Variants of the Basic PCR Reaction; Total Genome Amplification Methods; Application of PCR to Detect Molecules Other Than DNA DNA Amplification without Thermal Cycling and Other Alternatives to PCRFuture of PCR; Sources and Additional Readings; 5 Principles of DNA Electrophoresis; Physical Fractionation of DNA; Separation of DNA in the Ultracentrifuge; Electrophoretic Size Separations of DNA; Electrophoresis without Gels; Motions of DNA Molecules in Gels; Complex Effects of Gel Structure and Behavior; Biased Reptation Model of DNA Behavior in Gels; Pulsed Field Gel Electrophoresis (PFG); Macroscopic Behavior of DNA in PFG; Inadequacy of Reptation Models for PFG; DNA Trapping Electrophoresis Secondary Pulsed Field Gel Electrophoresis (SPFG)Entry of DNAs into Gels; Sources and Additional Readings; 6 Genetic Analysis; Why We Need Genetics; Basic Strategy for Genetic Analysis in the Human: Linkage Mapping; A Glossary of Genetic Terms; Relationship between the Physical and the Genetic Maps; Power of Mouse Genetics; Weakness of Human Genetics; Linkage Analysis Ignoring Recombination; Linkage Analysis with Recombination; Interval Mapping; Finding Genes by Genetic Mapping; Moving from Weak Linkage Closer to a Gene; Linkage Disequilibrium Complications in Linkage Disequilibrium and Genetic Maps in General |
| Record Nr. | UNINA-9910143509103321 |
|
Cantor Charles R. <1942->
|
||
| New York, : John Wiley & Sons, c1999 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Genomics [[electronic resource] ] : the science and technology behind the human genome project / / Charles R. Cantor, Cassandra L. Smith
| Genomics [[electronic resource] ] : the science and technology behind the human genome project / / Charles R. Cantor, Cassandra L. Smith |
| Autore | Cantor Charles R. <1942-> |
| Pubbl/distr/stampa | New York, : John Wiley & Sons, c1999 |
| Descrizione fisica | 1 online resource (621 p.) |
| Disciplina |
572.8/6
572.86 |
| Altri autori (Persone) | SmithCassandra |
| Collana | Baker Lecture Series |
| Soggetto topico |
DNA - Analysis
Nucleotide sequence Gene mapping |
| ISBN |
1-280-36704-0
9786610367047 0-470-32291-8 0-471-46186-5 0-471-22056-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Preface; Introduction; 1 DNA Chemistry and Biology; Basic Properties of DNA; Covalent Structure; Double Helical Structure; Methylated Bases; Plasticity in DNA Structure; DNA Synthesis; DNA as a Flexible Set of Chemical Reagents; Basic DNA Biology; Genome Sizes; Number of Genes; Sources and Additional Readings; 2 A Genome Overview at the Level of Chromosomes; Basic Properties of Chromosomes; Bacterial Chromosomes; Chromosomes of Eukaryotic Organisms; Centromeres; Telomeres; Dynamic Behavior of Telomeres; Chromatin and the Higher-Order Structure of Chromosomes
Chromosomes in the Cell CycleGenome Organization; Chromosome Purification; Chromosome Number; Unusual Characteristics of Sex Chromosomes and Mitochondria; Synteny; Sources and Additional Readings; 3 Analysis of DNA Sequences by Hybridization; Basic Requirements for Selectivity and Sensitivity; Detection of Specific DNA Sequences; Equilibria between DNA Double and Single Strands; Thermodynamics of the Melting of Short Duplexes; Thermodynamics of Imperfectly Paired Duplexes; Kinetics of the Melting of Short Duplexes; Kinetics of Melting of Long DNA; Kinetics of Double-Strand Formation ComplexityHybridization on Filters; Sensitive Detection; Sources and Additional Readings; 4 Polymerase Chain Reaction and Other Methods for In Vitro DNA Amplification; Why Amplify DNA?; Basic Principles of the Polymerase Chain Reaction (PCR); Noise in PCR: Contamination; PCR Noise: Mispriming; Misincorporation; Long PCR; Incorporating Extra Functionalities; Single-Sided PCR; Reducing Complexity with PCR; Additional Variants of the Basic PCR Reaction; Total Genome Amplification Methods; Application of PCR to Detect Molecules Other Than DNA DNA Amplification without Thermal Cycling and Other Alternatives to PCRFuture of PCR; Sources and Additional Readings; 5 Principles of DNA Electrophoresis; Physical Fractionation of DNA; Separation of DNA in the Ultracentrifuge; Electrophoretic Size Separations of DNA; Electrophoresis without Gels; Motions of DNA Molecules in Gels; Complex Effects of Gel Structure and Behavior; Biased Reptation Model of DNA Behavior in Gels; Pulsed Field Gel Electrophoresis (PFG); Macroscopic Behavior of DNA in PFG; Inadequacy of Reptation Models for PFG; DNA Trapping Electrophoresis Secondary Pulsed Field Gel Electrophoresis (SPFG)Entry of DNAs into Gels; Sources and Additional Readings; 6 Genetic Analysis; Why We Need Genetics; Basic Strategy for Genetic Analysis in the Human: Linkage Mapping; A Glossary of Genetic Terms; Relationship between the Physical and the Genetic Maps; Power of Mouse Genetics; Weakness of Human Genetics; Linkage Analysis Ignoring Recombination; Linkage Analysis with Recombination; Interval Mapping; Finding Genes by Genetic Mapping; Moving from Weak Linkage Closer to a Gene; Linkage Disequilibrium Complications in Linkage Disequilibrium and Genetic Maps in General |
| Record Nr. | UNINA-9910830844403321 |
|
Cantor Charles R. <1942->
|
||
| New York, : John Wiley & Sons, c1999 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Genomics [[electronic resource] ] : the science and technology behind the human genome project / / Charles R. Cantor, Cassandra L. Smith
| Genomics [[electronic resource] ] : the science and technology behind the human genome project / / Charles R. Cantor, Cassandra L. Smith |
| Autore | Cantor Charles R. <1942-> |
| Pubbl/distr/stampa | New York, : John Wiley & Sons, c1999 |
| Descrizione fisica | 1 online resource (621 p.) |
| Disciplina |
572.8/6
572.86 |
| Altri autori (Persone) | SmithCassandra |
| Collana | Baker Lecture Series |
| Soggetto topico |
DNA - Analysis
Nucleotide sequence Gene mapping |
| ISBN |
1-280-36704-0
9786610367047 0-470-32291-8 0-471-46186-5 0-471-22056-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Preface; Introduction; 1 DNA Chemistry and Biology; Basic Properties of DNA; Covalent Structure; Double Helical Structure; Methylated Bases; Plasticity in DNA Structure; DNA Synthesis; DNA as a Flexible Set of Chemical Reagents; Basic DNA Biology; Genome Sizes; Number of Genes; Sources and Additional Readings; 2 A Genome Overview at the Level of Chromosomes; Basic Properties of Chromosomes; Bacterial Chromosomes; Chromosomes of Eukaryotic Organisms; Centromeres; Telomeres; Dynamic Behavior of Telomeres; Chromatin and the Higher-Order Structure of Chromosomes
Chromosomes in the Cell CycleGenome Organization; Chromosome Purification; Chromosome Number; Unusual Characteristics of Sex Chromosomes and Mitochondria; Synteny; Sources and Additional Readings; 3 Analysis of DNA Sequences by Hybridization; Basic Requirements for Selectivity and Sensitivity; Detection of Specific DNA Sequences; Equilibria between DNA Double and Single Strands; Thermodynamics of the Melting of Short Duplexes; Thermodynamics of Imperfectly Paired Duplexes; Kinetics of the Melting of Short Duplexes; Kinetics of Melting of Long DNA; Kinetics of Double-Strand Formation ComplexityHybridization on Filters; Sensitive Detection; Sources and Additional Readings; 4 Polymerase Chain Reaction and Other Methods for In Vitro DNA Amplification; Why Amplify DNA?; Basic Principles of the Polymerase Chain Reaction (PCR); Noise in PCR: Contamination; PCR Noise: Mispriming; Misincorporation; Long PCR; Incorporating Extra Functionalities; Single-Sided PCR; Reducing Complexity with PCR; Additional Variants of the Basic PCR Reaction; Total Genome Amplification Methods; Application of PCR to Detect Molecules Other Than DNA DNA Amplification without Thermal Cycling and Other Alternatives to PCRFuture of PCR; Sources and Additional Readings; 5 Principles of DNA Electrophoresis; Physical Fractionation of DNA; Separation of DNA in the Ultracentrifuge; Electrophoretic Size Separations of DNA; Electrophoresis without Gels; Motions of DNA Molecules in Gels; Complex Effects of Gel Structure and Behavior; Biased Reptation Model of DNA Behavior in Gels; Pulsed Field Gel Electrophoresis (PFG); Macroscopic Behavior of DNA in PFG; Inadequacy of Reptation Models for PFG; DNA Trapping Electrophoresis Secondary Pulsed Field Gel Electrophoresis (SPFG)Entry of DNAs into Gels; Sources and Additional Readings; 6 Genetic Analysis; Why We Need Genetics; Basic Strategy for Genetic Analysis in the Human: Linkage Mapping; A Glossary of Genetic Terms; Relationship between the Physical and the Genetic Maps; Power of Mouse Genetics; Weakness of Human Genetics; Linkage Analysis Ignoring Recombination; Linkage Analysis with Recombination; Interval Mapping; Finding Genes by Genetic Mapping; Moving from Weak Linkage Closer to a Gene; Linkage Disequilibrium Complications in Linkage Disequilibrium and Genetic Maps in General |
| Record Nr. | UNINA-9910841118203321 |
|
Cantor Charles R. <1942->
|
||
| New York, : John Wiley & Sons, c1999 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Genomics [[electronic resource] ] : essential methods / / edited by Mike Starkey, Ramnath Elaswarapu
| Genomics [[electronic resource] ] : essential methods / / edited by Mike Starkey, Ramnath Elaswarapu |
| Pubbl/distr/stampa | Hoboken, : Wiley-Blackwell, 2011 |
| Descrizione fisica | 1 online resource (360 p.) |
| Disciplina | 572.8/6 |
| Altri autori (Persone) |
StarkeyMike
ElaswarapuRamnath |
| Collana | Essential Methods |
| Soggetto topico | Genomics |
| ISBN |
1-282-88357-7
9786612883576 0-470-71167-1 0-470-71162-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Genomics; Contents; List of Contributors; Preface; 1 High-Resolution Analysis of Genomic Copy Number Changes; 2 Identification of Polymorphic Markers for Genetic Mapping; 3 Genotyping and LOH Analysis on Archival Tissue Using SNP Arrays; 4 Genetic Mapping of Complex Traits; 5 RNA Amplification Strategies: Toward Single-Cell Sensitivity; 6 Real-Time Quantitative RT-PCR for mRNA Profiling; 7 Gene Expression in Mammalian Cells; 8 Using Yeast Two-Hybrid Methods to Investigate Large Numbers of Binary Protein Interactions; 9 Prediction of Protein Function
10 Elucidating Gene Function through Use of Genetically Engineered Mice11 Delivery Systems for Gene Transfer; 12 Gene Therapy Strategies: Constructing an AAV Trojan Horse; 13 An Introduction to Proteomics Technologies for the Genomics Scientist; Index |
| Record Nr. | UNINA-9910140904703321 |
| Hoboken, : Wiley-Blackwell, 2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Genomics [[electronic resource] ] : essential methods / / edited by Mike Starkey, Ramnath Elaswarapu
| Genomics [[electronic resource] ] : essential methods / / edited by Mike Starkey, Ramnath Elaswarapu |
| Pubbl/distr/stampa | Hoboken, : Wiley-Blackwell, 2011 |
| Descrizione fisica | 1 online resource (360 p.) |
| Disciplina | 572.8/6 |
| Altri autori (Persone) |
StarkeyMike
ElaswarapuRamnath |
| Collana | Essential Methods |
| Soggetto topico | Genomics |
| ISBN |
1-282-88357-7
9786612883576 0-470-71167-1 0-470-71162-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Genomics; Contents; List of Contributors; Preface; 1 High-Resolution Analysis of Genomic Copy Number Changes; 2 Identification of Polymorphic Markers for Genetic Mapping; 3 Genotyping and LOH Analysis on Archival Tissue Using SNP Arrays; 4 Genetic Mapping of Complex Traits; 5 RNA Amplification Strategies: Toward Single-Cell Sensitivity; 6 Real-Time Quantitative RT-PCR for mRNA Profiling; 7 Gene Expression in Mammalian Cells; 8 Using Yeast Two-Hybrid Methods to Investigate Large Numbers of Binary Protein Interactions; 9 Prediction of Protein Function
10 Elucidating Gene Function through Use of Genetically Engineered Mice11 Delivery Systems for Gene Transfer; 12 Gene Therapy Strategies: Constructing an AAV Trojan Horse; 13 An Introduction to Proteomics Technologies for the Genomics Scientist; Index |
| Record Nr. | UNINA-9910823055903321 |
| Hoboken, : Wiley-Blackwell, 2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Genomics, proteomics, and vaccines [[electronic resource] /] / editor, Guido Grandi
| Genomics, proteomics, and vaccines [[electronic resource] /] / editor, Guido Grandi |
| Pubbl/distr/stampa | Chichester ; ; Hoboken, NJ, : Wiley, c2004 |
| Descrizione fisica | 1 online resource (345 p.) |
| Disciplina | 572.8/6 |
| Altri autori (Persone) | GrandiGuido |
| Soggetto topico |
Genomics
Vaccines - Biotechnology Proteomics |
| ISBN |
1-280-26948-0
9786610269488 0-470-09392-7 0-470-01253-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Genomics, Proteomics and Vaccines -- Contents -- Preface -- List of contributors -- PART 1: INTRODUCTION -- 1 Vaccination: Past, Present and Future -- 1.1 Introduction -- 1.2 Vaccination: the past -- 1.3 Vaccination: the present -- 1.4 Vaccination: the future -- 1.5 Conclusion: the intangible value of vaccination -- 2 Bioinformatics, DNA Microarrays and Proteomics in Vaccine Discovery: Competing or Complementary Technologies? -- 2.1 Introduction -- 2.2 From genome sequence to vaccine discovery -- 2.3 A case study: the anti-meningococcus B vaccine -- 2.4 Comparison of the three approaches -- 2.5 Conclusions: a 'nomics' approach to vaccine discovery -- PART 2: TECHNOLOGIES -- 3 Genome Sequencing and Analysis -- 3.1 Introduction -- 3.2 Genome sequencing -- 3.3 Genome analysis -- 3.4 Conclusion -- 4 Understanding DNA Microarrays: Sources and Magnitudes of Variances in DNA Microarray Data Sets -- 4.1 Introduction -- 4.2 DNA array formats -- 4.3 Data analysis methods -- 4.4 Sources and magnitudes of noise in DNA microarray experiments -- 4.5 Conclusions -- Acknowledgements -- 5 The Proteome, Anno Domini Two Zero Zero Three -- 5.1 Introduction -- 5.2 Some definitions -- 5.3 What methods exist to tackle the proteome complexity?5.4 Quantitative proteomics -- 5.5 Pre-fractionation in proteome analysis -- 5.6 Multi-dimensional chromatography -- 5.7 Protein chip arrays -- 5.8 Imaging mass spectrometry -- Acknowledgements -- 6 Mass Spectrometry in Proteomics -- 6.1 Introduction -- 6.2 MS technology -- 6.3 Principle of protein identification based on MS data -- 6.4 Proteomics workflows -- 7 High Throughput Cloning, Expression and Purification Technologies -- 7.1 Introduction -- 7.2 Gene cloning -- 7.3 Protein expression -- 7.4 High-throughput protein purification -- 7.5 Validation of the pipeline and outlook7.6 Conclusion -- PART 3: APPLICATIONS -- 8 Meningococcus B: from Genome to Vaccine -- 8.1 Meningococcus, a major cause of bacterial meningitis -- 8.2 Group B meningococcus as an example of reverse vaccinology -- 8.3 Conclusions -- 9 Vaccines Against Pathogenic Streptococci -- 9.1 Introduction -- 9.2 Comparative genomics of streptococci -- 9.3 A vaccine against group B streptococcus -- 9.4 A vaccine against group A streptococcus -- 9.5 Conclusions -- 10 Identification of the 'Antigenome' - a Novel Tool for Design and Development of Subunit Vaccines Against Bacterial Pathogens -- 10.1 Introduction -- 10.2 Small DNA insert libraries - a tool to cover a pathogen's 'antigenome' -- 10.3 Proper display platforms -- 10.4 Selected human sera to provide imprints of pathogen encounters -- 10.5 Cognate antibodies reveal the 'antigenome' of a pathogen -- 10.6 How to retrieve from the 'antigenome' the candidate antigens for vaccine development -- 10.7 Summary and discussion -- 11 Searching the Chlamydia Genomes for New Vaccine Candidates -- 11.1 Old problems and new perspectives for chlamydial vaccines. |
| Record Nr. | UNINA-9910145752603321 |
| Chichester ; ; Hoboken, NJ, : Wiley, c2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Genomics, proteomics, and vaccines [[electronic resource] /] / editor, Guido Grandi
| Genomics, proteomics, and vaccines [[electronic resource] /] / editor, Guido Grandi |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Chichester ; ; Hoboken, NJ, : Wiley, c2004 |
| Descrizione fisica | 1 online resource (345 p.) |
| Disciplina | 572.8/6 |
| Altri autori (Persone) | GrandiGuido |
| Soggetto topico |
Genomics
Vaccines - Biotechnology Proteomics |
| ISBN |
1-280-26948-0
9786610269488 0-470-09392-7 0-470-01253-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Genomics, Proteomics and Vaccines -- Contents -- Preface -- List of contributors -- PART 1: INTRODUCTION -- 1 Vaccination: Past, Present and Future -- 1.1 Introduction -- 1.2 Vaccination: the past -- 1.3 Vaccination: the present -- 1.4 Vaccination: the future -- 1.5 Conclusion: the intangible value of vaccination -- 2 Bioinformatics, DNA Microarrays and Proteomics in Vaccine Discovery: Competing or Complementary Technologies? -- 2.1 Introduction -- 2.2 From genome sequence to vaccine discovery -- 2.3 A case study: the anti-meningococcus B vaccine -- 2.4 Comparison of the three approaches -- 2.5 Conclusions: a 'nomics' approach to vaccine discovery -- PART 2: TECHNOLOGIES -- 3 Genome Sequencing and Analysis -- 3.1 Introduction -- 3.2 Genome sequencing -- 3.3 Genome analysis -- 3.4 Conclusion -- 4 Understanding DNA Microarrays: Sources and Magnitudes of Variances in DNA Microarray Data Sets -- 4.1 Introduction -- 4.2 DNA array formats -- 4.3 Data analysis methods -- 4.4 Sources and magnitudes of noise in DNA microarray experiments -- 4.5 Conclusions -- Acknowledgements -- 5 The Proteome, Anno Domini Two Zero Zero Three -- 5.1 Introduction -- 5.2 Some definitions -- 5.3 What methods exist to tackle the proteome complexity?5.4 Quantitative proteomics -- 5.5 Pre-fractionation in proteome analysis -- 5.6 Multi-dimensional chromatography -- 5.7 Protein chip arrays -- 5.8 Imaging mass spectrometry -- Acknowledgements -- 6 Mass Spectrometry in Proteomics -- 6.1 Introduction -- 6.2 MS technology -- 6.3 Principle of protein identification based on MS data -- 6.4 Proteomics workflows -- 7 High Throughput Cloning, Expression and Purification Technologies -- 7.1 Introduction -- 7.2 Gene cloning -- 7.3 Protein expression -- 7.4 High-throughput protein purification -- 7.5 Validation of the pipeline and outlook7.6 Conclusion -- PART 3: APPLICATIONS -- 8 Meningococcus B: from Genome to Vaccine -- 8.1 Meningococcus, a major cause of bacterial meningitis -- 8.2 Group B meningococcus as an example of reverse vaccinology -- 8.3 Conclusions -- 9 Vaccines Against Pathogenic Streptococci -- 9.1 Introduction -- 9.2 Comparative genomics of streptococci -- 9.3 A vaccine against group B streptococcus -- 9.4 A vaccine against group A streptococcus -- 9.5 Conclusions -- 10 Identification of the 'Antigenome' - a Novel Tool for Design and Development of Subunit Vaccines Against Bacterial Pathogens -- 10.1 Introduction -- 10.2 Small DNA insert libraries - a tool to cover a pathogen's 'antigenome' -- 10.3 Proper display platforms -- 10.4 Selected human sera to provide imprints of pathogen encounters -- 10.5 Cognate antibodies reveal the 'antigenome' of a pathogen -- 10.6 How to retrieve from the 'antigenome' the candidate antigens for vaccine development -- 10.7 Summary and discussion -- 11 Searching the Chlamydia Genomes for New Vaccine Candidates -- 11.1 Old problems and new perspectives for chlamydial vaccines. |
| Record Nr. | UNINA-9910828470503321 |
| Chichester ; ; Hoboken, NJ, : Wiley, c2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Interactions of herbicide atrazine with DNA [[electronic resource] /] / Maria Hepel and Magdalena Stobiecka
| Interactions of herbicide atrazine with DNA [[electronic resource] /] / Maria Hepel and Magdalena Stobiecka |
| Autore | Hepel Maria |
| Pubbl/distr/stampa | New York, : Nova Science Publishers, c2010 |
| Descrizione fisica | 1 online resource (76 p.) |
| Disciplina | 572.8/6 |
| Altri autori (Persone) | StobieckaMagdalena |
| Collana |
DNA: properties and modifications, functions and interactions, recombination and applications.
Environmental science, engineering and technology |
| Soggetto topico |
DNA-drug interactions
Atrazine - Toxicology Biosensors Environmental monitoring - Methodology |
| Soggetto genere / forma | Electronic books. |
| ISBN | 1-61761-354-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910452456703321 |
|
Hepel Maria
|
||
| New York, : Nova Science Publishers, c2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
