Info
- Utilizzare la checkbox di selezione a fianco di ciascun documento per attivare le funzionalità di stampa, invio email, download nei formati disponibili del (i) record.
Single molecule dynamics in life science [[electronic resource] /] / edited by Toshio Yanagida and Yoshiharu Ishii
| Single molecule dynamics in life science [[electronic resource] /] / edited by Toshio Yanagida and Yoshiharu Ishii |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2009 |
| Descrizione fisica | 1 online resource (348 p.) |
| Disciplina |
572.6
572.8 |
| Altri autori (Persone) |
YanagidaToshio
IshiiYoshiharu |
| Soggetto topico |
Biology
Molecules |
| ISBN |
1-282-02540-6
9786612025402 3-527-62613-1 3-527-62614-X |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Single Molecule Dynamics in Life Science; Contents; Preface; List of Contributors; 1 A Road Map to Single Molecule Dynamics; 1.1 Visualization of Single Molecules; 1.2 Single Molecule Position Tracking; 1.3 Single Molecules in Live Cells; 1.4 Fluorescence Spectroscopy and Biomolecular Dynamics; 1.5 Single Molecule Manipulation and Molecular Motors; 1.6 Mechano-Chemical Coupling of Molecular Motors; 1.7 DNA-Based Motors; 1.8 Imaging with AFM and Force Measurements; References; 2 Single Molecule Study for Elucidating the Mechanism Used by Biosystems to Utilize Thermal Fluctuations
2.1 Introduction2.1.1 Differences between Man-Made and Biological Molecular Machines; 2.1.2 Single Molecule Imaging and Nano-Detection; 2.2 Simultaneous Measurements of Individual ATP Hydrolysis Cycles and Mechanical Events by a Myosin Motor; 2.2.1 ATP Hydrolysis Cycles; 2.2.2 Mechanical Events; 2.2.3 Simultaneous Measurements; 2.3 Resolving the Process of a Displacement by Scanning Probe Nanometry; 2.3.1 Observation and Manipulation of a Single Myosin Motor; 2.3.2 Displacements; 2.3.3 Sub-steps within a Displacement; 2.3.4 Nature of Sub-steps 2.3.5 Comparing the Actions of Individual Myosin Motors with those of Muscle2.3.6 Other Types of Molecular Motors; 2.4 Biased Brownian Step Model; 2.4.1 Asymmetric Potential; 2.4.2 Comparison with Other Studies; 2.4.3 Computer Simulation: from a Single Molecular Motor to Muscle; 2.5 Conclusion for the Unique Mechanism of Biological Molecular Machines; References; 3 Imaging and Molecular Motors; 3.1 Introduction; 3.2 Methods; 3.2.1 Detection of Single Fluorophores; 3.2.2 Sub-Diffraction Localization of Fluorescent Molecules; 3.2.3 Darkfield Imaging with One Nanometer Accuracy (DIONA) 3.2.4 Single-molecule High Resolution Imaging with Photobleaching (SHRImP)3.2.5 Single Molecule Fluorescence Resonance Energy Transfer (smFRET); 3.2.6 Orientation of Single Molecules; 3.2.7 Polarized Total Internal Reection Fluorescence Microscopy (polTIRF); 3.2.8 Defocused Orientational and Positional Imaging (DOPI); 3.3 Molecular Motors; 3.3.1 Myosin V; 3.3.2 Myosin II; 3.3.3 Myosin VI; 3.3.4 Conventional Kinesin; 3.3.5 Other Kinesins; 3.3.6 Dyneins; 3.3.7 Single Molecule Intracellular Imaging; 3.4 Conclusions; References; 4 Ion Channels; 4.1 Introduction; 4.2 Articial Bilayers 4.2.1 Solid Supported Bilayers4.2.2 Self-Standing Bilayers; 4.3 Simultaneous Optical and Electrical Recording of the Single BK-Channels; 4.4 Detection of Channel Conformational Change; 4.5 ''Optical Patch-Clamping''; 4.6 Conclusion; References; 5 Signal Transduction across the Plasma Membrane; 5.1 Introduction; 5.2 Signal Transduction Mediated by Receptor Tyrosine Kinase; 5.3 Association between EGF and EGFR and Formation of the Signaling Dimers of EGFR; 5.4 Amplication and Propagation of EGFR Activation; 5.5 Dynamics of the NGF/NGFR Complex 5.6 Stochastic Signal Processing and Transduction in Living Cells |
| Record Nr. | UNINA-9910830701503321 |
| Weinheim, : Wiley-VCH, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Single molecule dynamics in life science [[electronic resource] /] / edited by Toshio Yanagida and Yoshiharu Ishii
| Single molecule dynamics in life science [[electronic resource] /] / edited by Toshio Yanagida and Yoshiharu Ishii |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2009 |
| Descrizione fisica | 1 online resource (348 p.) |
| Disciplina |
572.6
572.8 |
| Altri autori (Persone) |
YanagidaToshio
IshiiYoshiharu |
| Soggetto topico |
Biology
Molecules |
| ISBN |
1-282-02540-6
9786612025402 3-527-62613-1 3-527-62614-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Single Molecule Dynamics in Life Science; Contents; Preface; List of Contributors; 1 A Road Map to Single Molecule Dynamics; 1.1 Visualization of Single Molecules; 1.2 Single Molecule Position Tracking; 1.3 Single Molecules in Live Cells; 1.4 Fluorescence Spectroscopy and Biomolecular Dynamics; 1.5 Single Molecule Manipulation and Molecular Motors; 1.6 Mechano-Chemical Coupling of Molecular Motors; 1.7 DNA-Based Motors; 1.8 Imaging with AFM and Force Measurements; References; 2 Single Molecule Study for Elucidating the Mechanism Used by Biosystems to Utilize Thermal Fluctuations
2.1 Introduction2.1.1 Differences between Man-Made and Biological Molecular Machines; 2.1.2 Single Molecule Imaging and Nano-Detection; 2.2 Simultaneous Measurements of Individual ATP Hydrolysis Cycles and Mechanical Events by a Myosin Motor; 2.2.1 ATP Hydrolysis Cycles; 2.2.2 Mechanical Events; 2.2.3 Simultaneous Measurements; 2.3 Resolving the Process of a Displacement by Scanning Probe Nanometry; 2.3.1 Observation and Manipulation of a Single Myosin Motor; 2.3.2 Displacements; 2.3.3 Sub-steps within a Displacement; 2.3.4 Nature of Sub-steps 2.3.5 Comparing the Actions of Individual Myosin Motors with those of Muscle2.3.6 Other Types of Molecular Motors; 2.4 Biased Brownian Step Model; 2.4.1 Asymmetric Potential; 2.4.2 Comparison with Other Studies; 2.4.3 Computer Simulation: from a Single Molecular Motor to Muscle; 2.5 Conclusion for the Unique Mechanism of Biological Molecular Machines; References; 3 Imaging and Molecular Motors; 3.1 Introduction; 3.2 Methods; 3.2.1 Detection of Single Fluorophores; 3.2.2 Sub-Diffraction Localization of Fluorescent Molecules; 3.2.3 Darkfield Imaging with One Nanometer Accuracy (DIONA) 3.2.4 Single-molecule High Resolution Imaging with Photobleaching (SHRImP)3.2.5 Single Molecule Fluorescence Resonance Energy Transfer (smFRET); 3.2.6 Orientation of Single Molecules; 3.2.7 Polarized Total Internal Reection Fluorescence Microscopy (polTIRF); 3.2.8 Defocused Orientational and Positional Imaging (DOPI); 3.3 Molecular Motors; 3.3.1 Myosin V; 3.3.2 Myosin II; 3.3.3 Myosin VI; 3.3.4 Conventional Kinesin; 3.3.5 Other Kinesins; 3.3.6 Dyneins; 3.3.7 Single Molecule Intracellular Imaging; 3.4 Conclusions; References; 4 Ion Channels; 4.1 Introduction; 4.2 Articial Bilayers 4.2.1 Solid Supported Bilayers4.2.2 Self-Standing Bilayers; 4.3 Simultaneous Optical and Electrical Recording of the Single BK-Channels; 4.4 Detection of Channel Conformational Change; 4.5 ''Optical Patch-Clamping''; 4.6 Conclusion; References; 5 Signal Transduction across the Plasma Membrane; 5.1 Introduction; 5.2 Signal Transduction Mediated by Receptor Tyrosine Kinase; 5.3 Association between EGF and EGFR and Formation of the Signaling Dimers of EGFR; 5.4 Amplication and Propagation of EGFR Activation; 5.5 Dynamics of the NGF/NGFR Complex 5.6 Stochastic Signal Processing and Transduction in Living Cells |
| Record Nr. | UNINA-9910841236203321 |
| Weinheim, : Wiley-VCH, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Single nucleotide polymorphisms : methods and protocols / edited by Jonathan R. Mielenz
| Single nucleotide polymorphisms : methods and protocols / edited by Jonathan R. Mielenz |
| Edizione | [2. ed.] |
| Pubbl/distr/stampa | New York : Humana Press, 2009 |
| Descrizione fisica | XIV, 464 p. : ill. ; 26 cm |
| Disciplina | 572.8 |
| Collana |
Springer Protocols
Methods in molecular biology |
| Soggetto topico | Nuclleotidi |
| ISBN | 978-1-60327-410-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-990003369850203316 |
| New York : Humana Press, 2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Single-cell mutation monitoring systems : methodologies and applications / edited by Aftab A. Ansari, Frederick J. de Serres
| Single-cell mutation monitoring systems : methodologies and applications / edited by Aftab A. Ansari, Frederick J. de Serres |
| Pubbl/distr/stampa | New York : Plenum Press, c1984 |
| Descrizione fisica | xvi, 289 p. : ill. ; 24 cm |
| Disciplina | 572.8 |
| Altri autori (Persone) |
Ansari, Aftab A.
De Serres, Frederick J. |
| Collana | Topics in chemical mutagenesis ; 2 |
| Soggetto topico |
Mutagenicity testing
Cytological Technics Mutagenicity Texts - methods |
| ISBN | 0306415372 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISALENTO-991004006789707536 |
| New York : Plenum Press, c1984 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. del Salento | ||
| ||
SiRNA and miRNA gene silencing : from bench to bedside / edited by Mouldy Sioud
| SiRNA and miRNA gene silencing : from bench to bedside / edited by Mouldy Sioud |
| Pubbl/distr/stampa | Totowa : Humana press, 2009 |
| Descrizione fisica | XIV, 472 p. ; 26 cm |
| Disciplina | 572.8 |
| Collana | Methods in molecular biology |
| Soggetto topico | Biologia molecolare |
| ISBN | 978-1-60327-546-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-990003200590203316 |
| Totowa : Humana press, 2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
siRNA and miRNA gene silencing : from bench to bedside / edited by Mouldy Sioud
| siRNA and miRNA gene silencing : from bench to bedside / edited by Mouldy Sioud |
| Pubbl/distr/stampa | New York, N.Y., : Humana, ©2009 |
| Descrizione fisica | XIV, 472 p. : ill. ; 27 cm. |
| Disciplina | 572.8 |
| Collana | Methods in molecular biology |
| Soggetto topico | Genetica medica |
| ISBN | 9781603275460 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISANNIO-UTO1089235 |
| New York, N.Y., : Humana, ©2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. del Sannio | ||
| ||
Small molecule DNA and RNA binders [[electronic resource] ] : from synthesis to nucleic acid complexes / / M. Demeunynck, C. Bailly, W. D. Wilson (eds.)
| Small molecule DNA and RNA binders [[electronic resource] ] : from synthesis to nucleic acid complexes / / M. Demeunynck, C. Bailly, W. D. Wilson (eds.) |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2003 |
| Descrizione fisica | 1 online resource (756 p.) |
| Disciplina | 572.8 |
| Altri autori (Persone) |
DemeunynckM (Martine)
BaillyChristian WilsonW. D (W. David) |
| Soggetto topico |
DNA-drug interactions
Molecular biology Binding sites (Biochemistry) Nucleic acids |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-52066-3
9786610520664 3-527-60566-5 3-527-60178-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Small Molecule DNA and RNA Binders; Contents; Preface; Contributors; 1 Forty Years On; 1.1 Early Experiments Prior to Molecular Modeling; 1.2 Formulation of Molecular Models and Mechanisms of Binding to DNA; 1.3 Specificity of Nucleotide Sequence Recognition; 1.4 Details at the Atomic and Molecular Levels; 1.5 Identification of Motifs for Drug Design; 1.6 Actions on Nucleoproteins, Chromatin, and Enzymes; References; 2 Targeting HIV RNA with Small Molecules; 2.1 Introduction; 2.1.1 Translation; 2.1.2 RNA Viruses; 2.2 Small Molecules that Modulate RNA Activity; 2.2.1 Magnesium (II)
2.2.2 Aminoglycosides2.2.3 Ligand Specificity; 2.2.4 Goals; 2.3 The RRE and HIV Replication; 2.4 Determination of RRE-Ligand Affinity and Specificity; 2.4.1 Fluorescence Anisotropy; 2.4.2 Solid-phase (Affinity-Displacement) Assay; 2.4.3 Ethidium Bromide Displacement; 2.5 New RRE Ligands; 2.5.1 Neomycin-Acridine Conjugates; 2.5.2 Dimeric Aminoglycosides; 2.5.3 Guanidinoglycosides; 2.6 Conclusions; Acknowledgments; References; 3 RNA Targeting by Bleomycin; 3.1 Activation of Bleomycin for Polynucleotide Degradation; 3.2 Bleomycin-mediated Cleavage of Transfer RNAs and tRNA Precursor Transcripts 4.6 Combinatorial Library Approach in the Discovery of Small Molecule Drugs Targeting RNA4.6.1 Combinatorial Chemistry; 4.6.2 Split Synthesis; 4.6.3 Encoding; 4.6.4 On-bead Screening and Identification of Structure-specific TAR-Binding Ligands; 4.6.5 Ligand Sequence Analysis; 4.6.6 Heterochiral Small Molecules Target TAR RNA Bulge; 4.6.7 Inhibition of Tat trans-Activation in vivo; 4.7 Cyclic Structures as RNA-targeting Drugs; 4.8 Summary and Perspective; Acknowledgments; References; 5 DNA and RNA Recognition and Modification by Gly-Gly-His-Derived Metallopeptides; 5.1 Introduction 5.2.3.5 Guanine nucleobase modification/oxidation |
| Record Nr. | UNINA-9910146239303321 |
| Weinheim, : Wiley-VCH, c2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Small molecule DNA and RNA binders [[electronic resource] ] : from synthesis to nucleic acid complexes / / M. Demeunynck, C. Bailly, W. D. Wilson (eds.)
| Small molecule DNA and RNA binders [[electronic resource] ] : from synthesis to nucleic acid complexes / / M. Demeunynck, C. Bailly, W. D. Wilson (eds.) |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2003 |
| Descrizione fisica | 1 online resource (756 p.) |
| Disciplina | 572.8 |
| Altri autori (Persone) |
DemeunynckM (Martine)
BaillyChristian WilsonW. D (W. David) |
| Soggetto topico |
DNA-drug interactions
Molecular biology Binding sites (Biochemistry) Nucleic acids |
| ISBN |
1-280-52066-3
9786610520664 3-527-60566-5 3-527-60178-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Small Molecule DNA and RNA Binders; Contents; Preface; Contributors; 1 Forty Years On; 1.1 Early Experiments Prior to Molecular Modeling; 1.2 Formulation of Molecular Models and Mechanisms of Binding to DNA; 1.3 Specificity of Nucleotide Sequence Recognition; 1.4 Details at the Atomic and Molecular Levels; 1.5 Identification of Motifs for Drug Design; 1.6 Actions on Nucleoproteins, Chromatin, and Enzymes; References; 2 Targeting HIV RNA with Small Molecules; 2.1 Introduction; 2.1.1 Translation; 2.1.2 RNA Viruses; 2.2 Small Molecules that Modulate RNA Activity; 2.2.1 Magnesium (II)
2.2.2 Aminoglycosides2.2.3 Ligand Specificity; 2.2.4 Goals; 2.3 The RRE and HIV Replication; 2.4 Determination of RRE-Ligand Affinity and Specificity; 2.4.1 Fluorescence Anisotropy; 2.4.2 Solid-phase (Affinity-Displacement) Assay; 2.4.3 Ethidium Bromide Displacement; 2.5 New RRE Ligands; 2.5.1 Neomycin-Acridine Conjugates; 2.5.2 Dimeric Aminoglycosides; 2.5.3 Guanidinoglycosides; 2.6 Conclusions; Acknowledgments; References; 3 RNA Targeting by Bleomycin; 3.1 Activation of Bleomycin for Polynucleotide Degradation; 3.2 Bleomycin-mediated Cleavage of Transfer RNAs and tRNA Precursor Transcripts 4.6 Combinatorial Library Approach in the Discovery of Small Molecule Drugs Targeting RNA4.6.1 Combinatorial Chemistry; 4.6.2 Split Synthesis; 4.6.3 Encoding; 4.6.4 On-bead Screening and Identification of Structure-specific TAR-Binding Ligands; 4.6.5 Ligand Sequence Analysis; 4.6.6 Heterochiral Small Molecules Target TAR RNA Bulge; 4.6.7 Inhibition of Tat trans-Activation in vivo; 4.7 Cyclic Structures as RNA-targeting Drugs; 4.8 Summary and Perspective; Acknowledgments; References; 5 DNA and RNA Recognition and Modification by Gly-Gly-His-Derived Metallopeptides; 5.1 Introduction 5.2.3.5 Guanine nucleobase modification/oxidation |
| Record Nr. | UNINA-9910831076803321 |
| Weinheim, : Wiley-VCH, c2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Small molecule DNA and RNA binders [[electronic resource] ] : from synthesis to nucleic acid complexes / / M. Demeunynck, C. Bailly, W. D. Wilson (eds.)
| Small molecule DNA and RNA binders [[electronic resource] ] : from synthesis to nucleic acid complexes / / M. Demeunynck, C. Bailly, W. D. Wilson (eds.) |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2003 |
| Descrizione fisica | 1 online resource (756 p.) |
| Disciplina | 572.8 |
| Altri autori (Persone) |
DemeunynckM (Martine)
BaillyChristian WilsonW. D (W. David) |
| Soggetto topico |
DNA-drug interactions
Molecular biology Binding sites (Biochemistry) Nucleic acids |
| ISBN |
1-280-52066-3
9786610520664 3-527-60566-5 3-527-60178-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Small Molecule DNA and RNA Binders; Contents; Preface; Contributors; 1 Forty Years On; 1.1 Early Experiments Prior to Molecular Modeling; 1.2 Formulation of Molecular Models and Mechanisms of Binding to DNA; 1.3 Specificity of Nucleotide Sequence Recognition; 1.4 Details at the Atomic and Molecular Levels; 1.5 Identification of Motifs for Drug Design; 1.6 Actions on Nucleoproteins, Chromatin, and Enzymes; References; 2 Targeting HIV RNA with Small Molecules; 2.1 Introduction; 2.1.1 Translation; 2.1.2 RNA Viruses; 2.2 Small Molecules that Modulate RNA Activity; 2.2.1 Magnesium (II)
2.2.2 Aminoglycosides2.2.3 Ligand Specificity; 2.2.4 Goals; 2.3 The RRE and HIV Replication; 2.4 Determination of RRE-Ligand Affinity and Specificity; 2.4.1 Fluorescence Anisotropy; 2.4.2 Solid-phase (Affinity-Displacement) Assay; 2.4.3 Ethidium Bromide Displacement; 2.5 New RRE Ligands; 2.5.1 Neomycin-Acridine Conjugates; 2.5.2 Dimeric Aminoglycosides; 2.5.3 Guanidinoglycosides; 2.6 Conclusions; Acknowledgments; References; 3 RNA Targeting by Bleomycin; 3.1 Activation of Bleomycin for Polynucleotide Degradation; 3.2 Bleomycin-mediated Cleavage of Transfer RNAs and tRNA Precursor Transcripts 4.6 Combinatorial Library Approach in the Discovery of Small Molecule Drugs Targeting RNA4.6.1 Combinatorial Chemistry; 4.6.2 Split Synthesis; 4.6.3 Encoding; 4.6.4 On-bead Screening and Identification of Structure-specific TAR-Binding Ligands; 4.6.5 Ligand Sequence Analysis; 4.6.6 Heterochiral Small Molecules Target TAR RNA Bulge; 4.6.7 Inhibition of Tat trans-Activation in vivo; 4.7 Cyclic Structures as RNA-targeting Drugs; 4.8 Summary and Perspective; Acknowledgments; References; 5 DNA and RNA Recognition and Modification by Gly-Gly-His-Derived Metallopeptides; 5.1 Introduction 5.2.3.5 Guanine nucleobase modification/oxidation |
| Record Nr. | UNINA-9910841328303321 |
| Weinheim, : Wiley-VCH, c2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Somatic cell and molecular genetics
| Somatic cell and molecular genetics |
| Pubbl/distr/stampa | New York, NY, : Kluwer Academic Publishers |
| Disciplina | 572.8 |
| Soggetto topico |
Cytogenetics
Molecular genetics Cytogenetics - Periodicals Molecular genetics - Periodicals Somatic hybrids Molecular Biology Hybrid Cells Cytogénétique - Périodiques Génétique moléculaire - Périodiques Cytogénétique Génétique moléculaire Hybrides cellulaires |
| Soggetto genere / forma |
Periodical
Periodicals. |
| ISSN | 1572-9931 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-996217053703316 |
| New York, NY, : Kluwer Academic Publishers | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
