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Diversity-oriented synthesis [[electronic resource]] : basics and applications in organic synthesis, drug discovery, and chemical biology / / edited by Andrea Trabocchi
| Diversity-oriented synthesis [[electronic resource]] : basics and applications in organic synthesis, drug discovery, and chemical biology / / edited by Andrea Trabocchi |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2013 |
| Descrizione fisica | 1 online resource (681 p.) |
| Disciplina | 547/.2 |
| Altri autori (Persone) | TrabocchiAndrea |
| Soggetto topico |
Organic compounds - Synthesis
Drug development Biosynthesis |
| ISBN |
1-118-61811-4
1-118-61794-0 1-118-61814-9 |
| Classificazione | SCI013040 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Machine generated contents note: Foreword Stuart L. Schreiber Preface List of Contributors Abbreviations 1 The Basics of Diversity-Oriented Synthesis Kieron M. G. O'Connell, Warren R. J. D. Galloway and David R. Spring 1.1 Introduction 1.2 What is Diversity-Oriented Synthesis? 1.3 Small Molecules and Biology 1.4 Comparing DOS, TOS and Combinatorial Chemistry (Focused Library Synthesis) 1.5 Molecular Diversity 1.6 Molecular Diversity and Chemical Space 1.7 Synthetic Strategies for Creating Molecular Diversity 1.8 Reagent-Based Approaches to Diversity Generation 1.9 A Substrate-Based Approach to Skeletal Diversity Generation 1.10 Other Build/Couple/Pair Examples 1.11 Concluding Remarks 1.12 References Part I Chemical Methodology in Diversity-Oriented Synthesis 2 Strategies Applications of Multicomponent Reactions (MCRs) to Diversity-Oriented Synthesis John M. Knapp, Mark J. Kurth, Jared T. Shaw and Ashkaan Younai 2.1 Introduction 2.2 MCR Products for HTS 2.3 MCRs as Starting Points for DOS 2.4 Conclusion 2.5 References 3 Cycloaddition Reactions in Diversity-Oriented Synthesis Giovanni Muncipinto 3.1 Introduction 3.2 [4+2] Cycloaddition Reactions 3.3 Diels-Alder Reaction 3.4 Inverse Electron Demand Diels-Alder Reaction 3.5 1,3-dipolar Cycloaddition Reactions 3.6 Miscellaneous Cycloadditions 3.7 Conclusion 3.8 References 4 Phosphine Organocatalysis as the Platform for Diversity-Oriented Synthesis Ohyun Kwon and Zhiming Wang 4.1 Introduction 4.2 DOS using Phosphine Organocatalysis 4.2.1 Phosphine Organocatalysis of Allenes with Imines 4.3 Skeletal Diversity Based on a Phosphine Catalysis/Combinatorial Scaffolding Strategy 4.4 A DOS Library Based on Phosphine Organocatalysis: Biological Screening, Analogue Synthesis, and Structure-Activity Relationship Analysis 4.5 Conclusions 4.6 References 5 Domino Reactions in Library Synthesis Matthew G. LaPorte, John R. Goodell, Sammi Tsegay and Peter Wipf 5.1 Introduction 5.2 Pericyclic Domino Reactions 5.3 Anionic Domino Reactions 5.4 Transition Metal Mediated Domino Reactions 5.5 Radical Domino Reactions 5.6 Conclusions 5.7 References 6 Diversity-Oriented Synthesis of Amino Acid-Derived Scaffolds and Peptidomimetics: A Perspective Andrea Trabocchi 6.1 Introduction 6.2 Definition and Classification of Peptidomimetics 6.3 Early Combinatorial Approaches to Peptidomimetic Scaffolds 6.4 Amino Acid-Derived Scaffolds 6.5 Macrocyclic Peptidomimetic Scaffolds 6.6 Conclusion 6.7 References 7 Solid-phase Synthesis Enabling Chemical Diversity Viktor Krchňák and Nadĕ Cankařová 7.1 Introduction 7.2 Skeletal Diversity 7.3 Substrate-Based Strategy (Folding Process) 7.4 Stereochemical Diversity 7.5 Appendages Diversity 7.6 Build/Couple/Pair Strategy 7.7 Scaffold Hopping 7.8 Conclusion 7.9 References 8 Macrocycles as Templates for Diversity Generation in Drug Discovery Eric Marsault 8.1 Introduction 8.2 Challenges Associated with Macrocycles 8.3 Macrocyclic Peptides 8.4 Peptidomimetic Macrocycles 8.5 Diversity-Oriented Strategies Based on Nonpeptidic Natural Products 8.6 Conclusion 8.7 References Part II Chemical Libraries and Diversity-Oriented Synthesis 9 Diversity-Oriented Synthesis of Natural Product-Based Libraries Mark Dow, Francesco Marchetti and Adam Nelson 9.1 Introduction 9.2 Libraries Inspired by Natural Product Scaffolds 9.3 Folding Pathways in the Synthesis of Natural Product-Like Libraries 9.4 Branching Pathways in the Synthesis of Natural Product-Like Libraries 9.5 Oligomer-Based Approaches to Natural Product-Like Libraries 9.6 Summary 9.7 References 10 Chemoinformatic Characterization of the Chemical Space and Molecular Diversity of Compound Libraries Jose Luis Medina-Franco 10.1 Introduction 10.2 Concept of Chemical Space 10.3 General Aspects of Chemoinformatic Methods to Analyze the Chemical Space 10.4 Chemoinformatic-Based Analysis of Libraries Using Different Representations 10.5 Recent Trends in Computational Approaches to Characterize Compound Libraries 10.6 Concluding Remarks 10.7 References 11 DNA-Encoded Chemical Libraries Luca Mannocci 11.1 Introduction 11.2 DNA-Encoded Chemical Libraries (DECL) 11.3 Selection and Decoding 11.4 Drug Discovery by DNA-Encoded Chemical Libraries 11.5 DNA-Encoded Chemical Libraries: Prospects and Outlook 11.6 Conclusion 11.7 References PART III Screening Methods and Lead Identification 12 Experimental Approaches for Rapid Profiling and Characterization of Specific Biological Effects of Diversity-Oriented Synthesis Compounds Eduard A. Sergienko and Susanne Heynen-Genel 12.1 Introduction 12.2 Basic Principles of HTS 12.3 Common Assay Methods and Techniques 12.4 Future Perspectives 12.5 References 13 Small-Molecule Microarrays Hongyan Sun 13.1 Introduction 13.2 Chemical Library Design and Synthesis 13.3 Fabrication of SMMs 13.4 Applications of SMM 13.5 Summary and Outlook 13.6 References 14 Yeast as a Model in High-Throughput Screening of Small Molecule Libraries Duccio Cavalieri, Carlotta De Filippo and Irene Stefanini 14.1 Introduction 14.2 Chemical Genetics and S. cerevisiae 14.3 Chemical Genomics and S. cerevisiae 14.4 Conclusions: the Route of Drug Discovery with the Budding Yeast 14.5 References 15 Virtual Screening Methods Jurgen Bajorath 15.1 Introduction 15.2 Basic Virtual Screening Concepts 15.3 Molecular Similarity in Virtual Screening 15.4 Spectrum of Virtual Screening Approaches 15.5 Docking 15.6 Similarity Searching 15.7 Compound Classification 15.8 Machine Learning 15.9 Conclusions 15.10 References 16 Structure-Activity Relationship Data Analysis: Activity Landscapes and Activity Cliffs Jurgen Bajorath 16.1 Introduction 16.2 Numerical SAR Analysis Functions 16.3 Principles and Intrinsic Limitations of Activity Landscape Design 16.4 Activity Landscape Representations 16.5 Defining and Identifying Activity Cliffs 16.6 Activity Cliff Survey 16.7 Activity Cliffs and SAR Information 16.8 Concluding Remarks 16.9 References PART IV Applications in Chemical Biology and Drug Discovery 17 Diversity-Oriented Synthesis and Drug Development: Facilitating the Discovery of Novel Probes and Therapeutics Jeremy R. Duvall, Eamon Comer and Sivaraman Dandapani 17.1 Introduction 17.2 Case Study 1 - Inhibition of Cytokine-Induced [symbol for a square]-Cell Apoptosis 17.3 Case Study 2 - Identification of Anti-Malarials 17.4 Case Study 3 - Targeting Protein-Protein and Protein-DNA Interactions 17.5 Conclusion 17.6 References 18 DOS-Derived Small-Molecule Probes in Chemical Biology Nicholas Hill, Lingyan Du and Qiu Wang 18.1 Introduction 18.2 DOS-Derived Small-Molecule Probes 18.3 Developing Small-Molecule Probes of Complex Biological Pathways 18.4 Expanding the Collection of Important Biological Probes 18.5 Developing Probes for Therapeutically Desirable Phenotypes 18.6 Natural Product-Inspired Small-Molecule Probes Developed from DOS and Biology-Oriented Synthesis 18.7 Summary and Outlook 18.8 References Index . |
| Record Nr. | UNINA-9910841187603321 |
| Hoboken, N.J., : Wiley, c2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Efficiency in natural product total synthesis / / edited by Pei-Qiang Huang, Zhu-Jun Yao, Richard P. Hsung
| Efficiency in natural product total synthesis / / edited by Pei-Qiang Huang, Zhu-Jun Yao, Richard P. Hsung |
| Edizione | [First edition.] |
| Pubbl/distr/stampa | Hoboken, NJ : , : Wiley, , 2018 |
| Descrizione fisica | 1 online resource (514 pages) |
| Disciplina | 547/.2 |
| Soggetto topico |
Natural products - Synthesis
Organic compounds - Synthesis |
| ISBN |
1-118-94021-0
1-118-94020-2 1-118-94022-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910555060303321 |
| Hoboken, NJ : , : Wiley, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Efficiency in natural product total synthesis / / edited by Pei-Qiang Huang, Zhu-Jun Yao, Richard P. Hsung
| Efficiency in natural product total synthesis / / edited by Pei-Qiang Huang, Zhu-Jun Yao, Richard P. Hsung |
| Edizione | [First edition.] |
| Pubbl/distr/stampa | Hoboken, NJ : , : Wiley, , 2018 |
| Descrizione fisica | 1 online resource (514 pages) |
| Disciplina | 547/.2 |
| Soggetto topico |
Natural products - Synthesis
Organic compounds - Synthesis |
| ISBN |
1-118-94021-0
1-118-94020-2 1-118-94022-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910824473303321 |
| Hoboken, NJ : , : Wiley, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Enzymes in organic synthesis / / [editors: Ruth Porter (organizer) and Sarah Clark
| Enzymes in organic synthesis / / [editors: Ruth Porter (organizer) and Sarah Clark |
| Pubbl/distr/stampa | London, : Pitman |
| Descrizione fisica | 1 online resource (258 pages) : illustrations |
| Disciplina | 547/.2 |
| Altri autori (Persone) |
PorterRuth
ClarkSarah |
| Collana | Ciba Foundation symposium |
| Soggetto topico |
Organic compounds - Synthesis
Enzymes |
| ISBN |
1-280-78415-6
9786613694546 0-470-72092-1 0-470-71862-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Enzymes in organic synthesis; Contents; Chairman's introduction; An illustrative example of a synthetically useful enzyme: horse liver alcohol dehydrogenase; Discussion; Enzymic synthesis of labelled chiral substances; Discussion; Enzyme-controlled reactions giving alkanols of use in the synthesis of biologically active molecules; Discussion; Large-scale purification of enzymes; Discussion; Immobilized enzymes in organic synthesis; Discussion; General discussion I Synthesis of 5,6-dihydroxycyclohexa-l,3-die; Applications of cell-free enzymes in organic synthesis; Discussion
Chiral products from non-pyridine nucleotide-dependent reductases and methods for NAD(P)H regeneration Discussion; Stereochemistry and synthetic applications of products of fermentation of a,p-unsaturated aromatic aldehydes by baker's yeast; Discussion; Extending the applicability of esterases of low enantioselectivity in asymmetric synthesis; Discussion; Microbial transformations of some monoterpenoids and sesquiterpenoids; Discussion; General discussion I1 Synthesis of tetrahydrofolate derivatives; Synthesis of optically active propylene oxides Creation of novel chiral synthons with enzymes: application to enantioselective synthesis of antibiotics Discussion; Kinetics of trypsin catalysis in the industrial conversion of porcine insulin to human insulin; Discussion; Redesigning enzymes by site-directed mutagenesis; Discussion; The design of new enzyme active sites for the catalysis of specific chemical reactions; Discussion; Final general discussion NAD+ degradation by resting cells; Economic aspects; Applications of enzyme methodology; Index of contributors; Subject index |
| Record Nr. | UNISA-996202090303316 |
| London, : Pitman | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Enzymes in organic synthesis / / [editors: Ruth Porter (organizer) and Sarah Clark
| Enzymes in organic synthesis / / [editors: Ruth Porter (organizer) and Sarah Clark |
| Pubbl/distr/stampa | London, : Pitman |
| Descrizione fisica | 1 online resource (258 pages) : illustrations |
| Disciplina | 547/.2 |
| Altri autori (Persone) |
PorterRuth
ClarkSarah |
| Collana | Ciba Foundation symposium |
| Soggetto topico |
Organic compounds - Synthesis
Enzymes |
| ISBN |
1-280-78415-6
9786613694546 0-470-72092-1 0-470-71862-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Enzymes in organic synthesis; Contents; Chairman's introduction; An illustrative example of a synthetically useful enzyme: horse liver alcohol dehydrogenase; Discussion; Enzymic synthesis of labelled chiral substances; Discussion; Enzyme-controlled reactions giving alkanols of use in the synthesis of biologically active molecules; Discussion; Large-scale purification of enzymes; Discussion; Immobilized enzymes in organic synthesis; Discussion; General discussion I Synthesis of 5,6-dihydroxycyclohexa-l,3-die; Applications of cell-free enzymes in organic synthesis; Discussion
Chiral products from non-pyridine nucleotide-dependent reductases and methods for NAD(P)H regeneration Discussion; Stereochemistry and synthetic applications of products of fermentation of a,p-unsaturated aromatic aldehydes by baker's yeast; Discussion; Extending the applicability of esterases of low enantioselectivity in asymmetric synthesis; Discussion; Microbial transformations of some monoterpenoids and sesquiterpenoids; Discussion; General discussion I1 Synthesis of tetrahydrofolate derivatives; Synthesis of optically active propylene oxides Creation of novel chiral synthons with enzymes: application to enantioselective synthesis of antibiotics Discussion; Kinetics of trypsin catalysis in the industrial conversion of porcine insulin to human insulin; Discussion; Redesigning enzymes by site-directed mutagenesis; Discussion; The design of new enzyme active sites for the catalysis of specific chemical reactions; Discussion; Final general discussion NAD+ degradation by resting cells; Economic aspects; Applications of enzyme methodology; Index of contributors; Subject index |
| Record Nr. | UNINA-9910144664803321 |
| London, : Pitman | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Enzymes in organic synthesis / / [editors: Ruth Porter (organizer) and Sarah Clark
| Enzymes in organic synthesis / / [editors: Ruth Porter (organizer) and Sarah Clark |
| Pubbl/distr/stampa | London, : Pitman |
| Descrizione fisica | 1 online resource (258 pages) : illustrations |
| Disciplina | 547/.2 |
| Altri autori (Persone) |
PorterRuth
ClarkSarah |
| Collana | Ciba Foundation symposium |
| Soggetto topico |
Organic compounds - Synthesis
Enzymes |
| ISBN |
1-280-78415-6
9786613694546 0-470-72092-1 0-470-71862-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Enzymes in organic synthesis; Contents; Chairman's introduction; An illustrative example of a synthetically useful enzyme: horse liver alcohol dehydrogenase; Discussion; Enzymic synthesis of labelled chiral substances; Discussion; Enzyme-controlled reactions giving alkanols of use in the synthesis of biologically active molecules; Discussion; Large-scale purification of enzymes; Discussion; Immobilized enzymes in organic synthesis; Discussion; General discussion I Synthesis of 5,6-dihydroxycyclohexa-l,3-die; Applications of cell-free enzymes in organic synthesis; Discussion
Chiral products from non-pyridine nucleotide-dependent reductases and methods for NAD(P)H regeneration Discussion; Stereochemistry and synthetic applications of products of fermentation of a,p-unsaturated aromatic aldehydes by baker's yeast; Discussion; Extending the applicability of esterases of low enantioselectivity in asymmetric synthesis; Discussion; Microbial transformations of some monoterpenoids and sesquiterpenoids; Discussion; General discussion I1 Synthesis of tetrahydrofolate derivatives; Synthesis of optically active propylene oxides Creation of novel chiral synthons with enzymes: application to enantioselective synthesis of antibiotics Discussion; Kinetics of trypsin catalysis in the industrial conversion of porcine insulin to human insulin; Discussion; Redesigning enzymes by site-directed mutagenesis; Discussion; The design of new enzyme active sites for the catalysis of specific chemical reactions; Discussion; Final general discussion NAD+ degradation by resting cells; Economic aspects; Applications of enzyme methodology; Index of contributors; Subject index |
| Record Nr. | UNINA-9910818863303321 |
| London, : Pitman | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Essential reagents for organic synthesis / / edited by Philip L. Fuchs [and three others]
| Essential reagents for organic synthesis / / edited by Philip L. Fuchs [and three others] |
| Pubbl/distr/stampa | West Sussex, England : , : Wiley, , 2016 |
| Descrizione fisica | 1 online resource (639 pages) |
| Disciplina | 547/.2 |
| Soggetto topico |
Chemical tests and reagents
Organic compounds - Synthesis |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-78785-154-0
1-5231-1068-6 1-119-27987-9 1-119-27983-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Essential Reagents for Organic Synthesis; Contents; Preface; Short Note on InChIs and InChIKeys; General Abbreviations; Bis(dibenzylideneacetone)palladium(0); 9-Borabicyclo[3.3.1]nonane Dimer; Boron Trifluoride Etherate; N-Bromosuccinimide; n-Butyllithium; N,N'-Carbonyl Diimidazole; Cerium(IV) Ammonium Nitrate; m-Chloroperbenzoic Acid; N-Chlorosuccinimide; Chlorotrimethylsilane; Chlorotris(triphenylphosphine)-rhodium(I); (Diacetoxyiodo)benzene; Diazomethane; 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone; Diisobutylaluminum Hydride; 4-Dimethylaminopyridine; Dimethyldioxirane
1-Ethyl-3-(3 -dimethylaminopropyl)carbodiimide HydrochlorideN-Iodosuccinimide; Iodotrimethylsilane; 2-Iodoxybenzoic Acid; Lithium Aluminum Hydride; Lithium Diisopropylamide; Lithium Naphthalenide; Manganese Dioxide; Osmium Tetroxide; Oxalyl Chloride; Oxalyl Chloride-Dimethylformamide; Ozone; Pinacolborane; Potassium Hexamethyldisilazide; Potassium Monoperoxysulfate; Potassium tert-Butoxide; Ruthenium(II), Tris(2,2'-bipyridine-κN1,κN1')-, (OC-6-11); Samarium(II) Iodide; Scandium Trifluoromethanesulfonate; Sodium Azide; Sodium Borohydride; Sodium Cyanoborohydride; Sodium Hexamethyldisilazide Sodium HydrideSodium Periodate; Tetrabutylammonium Fluoride; Tetrakis(triphenylphosphine)-palladium(0); Tetra-n-propylammonium Perruthenate; p-Toluenesulfonyl Chloride; Triethylsilane; Trifluoromethanesulfonic Acid; Trifluoromethanesulfonic Anhydride; Trimethylsilyl Trifluoromethanesulfonate; Trimethylsilyldiazomethane; Zinc-Acetic Acid; List of Contributors; Subject Index; End User License Agreement |
| Record Nr. | UNINA-9910466207303321 |
| West Sussex, England : , : Wiley, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Essential reagents for organic synthesis / / edited by Philip L. Fuchs [and three others]
| Essential reagents for organic synthesis / / edited by Philip L. Fuchs [and three others] |
| Pubbl/distr/stampa | West Sussex, England : , : Wiley, , 2016 |
| Descrizione fisica | 1 online resource (639 pages) |
| Disciplina | 547/.2 |
| Soggetto topico |
Chemical tests and reagents
Organic compounds - Synthesis |
| ISBN |
1-78785-154-0
1-5231-1068-6 1-119-27987-9 1-119-27983-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Essential Reagents for Organic Synthesis; Contents; Preface; Short Note on InChIs and InChIKeys; General Abbreviations; Bis(dibenzylideneacetone)palladium(0); 9-Borabicyclo[3.3.1]nonane Dimer; Boron Trifluoride Etherate; N-Bromosuccinimide; n-Butyllithium; N,N'-Carbonyl Diimidazole; Cerium(IV) Ammonium Nitrate; m-Chloroperbenzoic Acid; N-Chlorosuccinimide; Chlorotrimethylsilane; Chlorotris(triphenylphosphine)-rhodium(I); (Diacetoxyiodo)benzene; Diazomethane; 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone; Diisobutylaluminum Hydride; 4-Dimethylaminopyridine; Dimethyldioxirane
1-Ethyl-3-(3 -dimethylaminopropyl)carbodiimide HydrochlorideN-Iodosuccinimide; Iodotrimethylsilane; 2-Iodoxybenzoic Acid; Lithium Aluminum Hydride; Lithium Diisopropylamide; Lithium Naphthalenide; Manganese Dioxide; Osmium Tetroxide; Oxalyl Chloride; Oxalyl Chloride-Dimethylformamide; Ozone; Pinacolborane; Potassium Hexamethyldisilazide; Potassium Monoperoxysulfate; Potassium tert-Butoxide; Ruthenium(II), Tris(2,2'-bipyridine-κN1,κN1')-, (OC-6-11); Samarium(II) Iodide; Scandium Trifluoromethanesulfonate; Sodium Azide; Sodium Borohydride; Sodium Cyanoborohydride; Sodium Hexamethyldisilazide Sodium HydrideSodium Periodate; Tetrabutylammonium Fluoride; Tetrakis(triphenylphosphine)-palladium(0); Tetra-n-propylammonium Perruthenate; p-Toluenesulfonyl Chloride; Triethylsilane; Trifluoromethanesulfonic Acid; Trifluoromethanesulfonic Anhydride; Trimethylsilyl Trifluoromethanesulfonate; Trimethylsilyldiazomethane; Zinc-Acetic Acid; List of Contributors; Subject Index; End User License Agreement |
| Record Nr. | UNINA-9910798542203321 |
| West Sussex, England : , : Wiley, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Essential reagents for organic synthesis / / edited by Philip L. Fuchs [and three others]
| Essential reagents for organic synthesis / / edited by Philip L. Fuchs [and three others] |
| Pubbl/distr/stampa | West Sussex, England : , : Wiley, , 2016 |
| Descrizione fisica | 1 online resource (639 pages) |
| Disciplina | 547/.2 |
| Soggetto topico |
Chemical tests and reagents
Organic compounds - Synthesis |
| ISBN |
1-78785-154-0
1-5231-1068-6 1-119-27987-9 1-119-27983-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Essential Reagents for Organic Synthesis; Contents; Preface; Short Note on InChIs and InChIKeys; General Abbreviations; Bis(dibenzylideneacetone)palladium(0); 9-Borabicyclo[3.3.1]nonane Dimer; Boron Trifluoride Etherate; N-Bromosuccinimide; n-Butyllithium; N,N'-Carbonyl Diimidazole; Cerium(IV) Ammonium Nitrate; m-Chloroperbenzoic Acid; N-Chlorosuccinimide; Chlorotrimethylsilane; Chlorotris(triphenylphosphine)-rhodium(I); (Diacetoxyiodo)benzene; Diazomethane; 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone; Diisobutylaluminum Hydride; 4-Dimethylaminopyridine; Dimethyldioxirane
1-Ethyl-3-(3 -dimethylaminopropyl)carbodiimide HydrochlorideN-Iodosuccinimide; Iodotrimethylsilane; 2-Iodoxybenzoic Acid; Lithium Aluminum Hydride; Lithium Diisopropylamide; Lithium Naphthalenide; Manganese Dioxide; Osmium Tetroxide; Oxalyl Chloride; Oxalyl Chloride-Dimethylformamide; Ozone; Pinacolborane; Potassium Hexamethyldisilazide; Potassium Monoperoxysulfate; Potassium tert-Butoxide; Ruthenium(II), Tris(2,2'-bipyridine-κN1,κN1')-, (OC-6-11); Samarium(II) Iodide; Scandium Trifluoromethanesulfonate; Sodium Azide; Sodium Borohydride; Sodium Cyanoborohydride; Sodium Hexamethyldisilazide Sodium HydrideSodium Periodate; Tetrabutylammonium Fluoride; Tetrakis(triphenylphosphine)-palladium(0); Tetra-n-propylammonium Perruthenate; p-Toluenesulfonyl Chloride; Triethylsilane; Trifluoromethanesulfonic Acid; Trifluoromethanesulfonic Anhydride; Trimethylsilyl Trifluoromethanesulfonate; Trimethylsilyldiazomethane; Zinc-Acetic Acid; List of Contributors; Subject Index; End User License Agreement |
| Record Nr. | UNINA-9910815882303321 |
| West Sussex, England : , : Wiley, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Flash chemistry [[electronic resource] ] : fast organic synthesis in microsystems / / Jun-ichi Yoshida
| Flash chemistry [[electronic resource] ] : fast organic synthesis in microsystems / / Jun-ichi Yoshida |
| Autore | Yoshida Junʼichi <1952-> |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, 2008 |
| Descrizione fisica | 1 online resource (248 p.) |
| Disciplina |
547.2
547/.2 |
| Soggetto topico |
Organic compounds - Synthesis
Intermediates (Chemistry) Microreactors Organic reaction mechanisms |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-94011-9
9786611940119 0-470-72342-4 0-470-72341-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Flash Chemistry Fast Organic Synthesis in Microsystems; Contents; Preface; 1 Introduction; 1.1 Flask Chemistry; 1.2 Flash Chemistry; 1.3 Flask Chemistry or Flash Chemistry; References; 2 The Background to Flash Chemistry; 2.1 How do Chemical Reactions Take Place?; 2.1.1 Macroscopic View of Chemical Reactions; 2.1.2 Thermodynamic Equilibrium and Kinetics; 2.1.3 Kinetics; 2.1.4 Transition State Theory; 2.1.5 Femtosecond Chemistry and Reaction Dynamics; 2.1.6 Reactions for Dynamics and Reactions for Synthesis; 2.1.7 Bimolecular Reactions in the Gas Phase
2.1.8 Bimolecular Reactions in the Solution Phase2.1.9 Fast Chemical Synthesis Inspired by Reaction Dynamics; References; 3 What is Flash Chemistry?; 4 Why is Flash Chemistry Needed?; 4.1 Chemical Reaction, an Extremely Fast Process at Molecular Level; 4.2 Rapid Construction of Chemical Libraries; 4.3 Rapid Synthesis of Radioactive Positron Emission Tomography Probes; 4.4 On-demand Rapid Synthesis i n Industry 304.5 Conclusions; References; 5 Methods of Activating Molecules; 5.1 Thermal Activation of Organic Molecules; 5.1.1 High Temperature Reactions; 5.1.2 Flash Vacuum Pyrolysis 5.1.3 Microwave Reactions5.2 Photochemical Activation; 5.3 Electrochemical Activation; 5.4 Chemical Activation; 5.5 Accumulation of Reactive Species; 5.5.1 The Cation-pool Method; 5.6 Continuous Generation of Reactive Species in a Flow System; 5.7 Interconversion Between Reactive Species; 5.8 Conclusions; References; 6 Control of Extremely Fast Reactions; 6.1 Mixing; 6.1.1 How Does Mixing Take Place?; 6.1.2 Molecular Diffusion and Brownian Motion; 6.1.3 Disguised Chemical Selectivity; 6.1.4 Lowering the Reaction Temperature; 6.1.5 The High Dilution Method; 6.1.6 Micromixing 6.1.7 Friedel-Crafts Alkylation Using anN-acyliminium Ion Pool6.1.8 Micromixing as a Powerful Tool for Flash Chemistry; 6.1.9 Disguised Chemical Selectivity in Competitive Parallel Reactions; 6.2 Temperature Control; 6.2.1 Exothermicity of Fast Reactions; 6.2.2 Hammond's Postulate; 6.2.3 The Friedel-Crafts Reaction; 6.2.4 Solvent; 6.2.5 Heat Transfer; 6.2.6 Precise Temperature Control in Microflow Systems; 6.3 Residence Time Control; 6.3.1 The Discovery of Benzyne. The Concept of Reactive Intermediates; 6.3.2 o -Bromophenyllithi um; 6.4 Conclusions; References 7 Microfluidic Devices and Microflow Systems7.1 Brief History; 7.1.1 Microflow Systems for Chemical Analysis; 7.1.2 Microflow Systems for Chemical Synthesis; 7.2 Characteristic Features of Microflow Systems; 7.3 Microstructured Fluidic Devices; 7.3.1 Microchip Reactors; 7.3.2 Microtube Reactors; 7.3.3 Micromixer; 7.3.4 Passive Micromixers; 7.3.5 Microheat Exchanger; 7.3.6 Photochemical Microflow Reactor; 7.3.7 Electrochemical Microflow Reactor; 7.3.8 Catalyst-containing Microflow Reactor; 7.3.9 Microflow Reactors for High-pressure and High-temperature Conditions; 7.4 Conclusions; References 8 Applications of Flash Chemistry in Organic Synthesis |
| Record Nr. | UNINA-9910144100303321 |
Yoshida Junʼichi <1952->
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| Hoboken, N.J., : Wiley, 2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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