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Solid phase synthesis and combinatorial technologies [[electronic resource] /] / Pierfausto Seneci
| Solid phase synthesis and combinatorial technologies [[electronic resource] /] / Pierfausto Seneci |
| Autore | Seneci Pierfausto <1960-> |
| Pubbl/distr/stampa | New York, : John Wiley & Sons, c2000 |
| Descrizione fisica | 1 online resource (653 p.) |
| Disciplina |
547.2
547/.2 |
| Soggetto topico |
Solid-phase synthesis
Combinatorial chemistry |
| ISBN |
1-280-36647-8
9786610366477 0-470-35261-2 0-471-46073-7 0-471-22039-6 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
SOLID-PHASE SYNTHESIS AND COMBINATORIAL TECHNOLOGIES; CONTENTS; Preface; 1 Solid-Phase Synthesis: Basic Principles; 1.1 Solid Supports; 1.2 Linkers; 1.3 Reaction Monitoring in Solid-Phase Synthesis; 1.4 Purity and Yield Determination in Solid-Phase Synthesis; References; 2 Solid-Phase Synthesis: Oligomeric Molecules; 2.1 Peptides; 2.2 Oligonucleotides; 2.3 Oligosaccharides; References; 3 Solid-Phase Synthesis: Small Organic Molecules; 3.1 Small Organic Molecules on Solid Phase: Target Selection and Solution Studies; 3.2 Small Organic Molecules on Solid Phase: Solid-Phase Synthesis
3.3 Small Organic Molecules on Solid Phase: From Solid-Phase Synthesis to Synthetic Organic Libraries3.4 An Example: Solid-Phase Synthesis of 1H-[2]Pyrindinones; 3.5 Solid-Phase Synthetic Strategies: Selected Examples; References; 4 Combinatorial Technologies: Basic Principles; 4.1 Combinatorial Technologies; 4.2 Combinatorial Libraries; References; 5 Synthetic Organic Libraries: Library Design and Properties; 5.1 Primary Libraries: Shooting in the Dark?; 5.2 Focused Libraries: High-Throughput Structure--Activity Relationships; 5.3 Biased-Targeted Libraries: Information-Rich Primary Libraries 5.4 Library Design via Computational ToolsReferences; 6 Synthetic Organic Libraries: Solid-Phase Discrete Libraries; 6.1 Synthesis of Solid-Phase Discrete Libraries; 6.2 Structure Determination, Quality Control, and Purification of Solid-Phase Discrete Libraries; 6.3 Examples of Solid-Phase Discrete Library Synthesis; 6.4 New Trends in Solid-Phase Discrete Library Synthesis; References; 7 Synthetic Organic Libraries: Solid-Phase Pool Libraries; 7.1 Synthesis of Solid-Phase Pool Libraries; 7.2 Direct Structure Determination of Positives from Solid-Phase Pool Libraries 7.3 Deconvolution Methods for Solid-Phase Pool Libraries7.4 Encoding Methods for Solid-Phase Pool Libraries; 7.5 New Trends in Solid-Phase Pool Libraries; References; 8 Synthetic Organic Libraries: Solution-Phase Libraries; 8.1 Solution- Versus Solid-Phase Synthetic Libraries: Which Ones to Use?; 8.2 Solution-Phase Discrete Libraries; 8.3 Purification of Solution-Phase Library Intermediates and Final Compounds: Liquid-Liquid and Solid-Phase Extraction Systems; 8.4 Solid-Phase Assisted Solution-Phase Library Synthesis and Purification 8.5 Soluble Supports in Solution-Phase Combinatorial Synthesis8.6 New Trends in Solution-Phase Combinatorial Synthesis; References; 9 Applications of Synthetic Libraries; 9.1 Pharmaceutical Applications; 9.2 Agrochemical and Food-Related Applications; 9.3 Applications to Combinatorial Reaction Optimization; 9.4 Applications to Catalysis; 9.5 Applications to Molecular Recognition; References; 10 Biosynthetic Combinatorial Libraries; 10.1 Biosynthetic Polypeptide Libraries; 10.2 Biosynthetic Oligonucleotide Libraries; 10.3 Combinatorial Biosynthesis of Natural Products 10.4 Combinatorial Biocatalysis |
| Record Nr. | UNINA-9910829959403321 |
Seneci Pierfausto <1960->
|
||
| New York, : John Wiley & Sons, c2000 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Solid phase synthesis and combinatorial technologies / / Pierfausto Seneci
| Solid phase synthesis and combinatorial technologies / / Pierfausto Seneci |
| Autore | Seneci Pierfausto <1960-> |
| Pubbl/distr/stampa | New York, : John Wiley & Sons, c2000 |
| Descrizione fisica | 1 online resource (653 p.) |
| Disciplina | 547/.2 |
| Soggetto topico |
Solid-phase synthesis
Combinatorial chemistry |
| ISBN |
1-280-36647-8
9786610366477 0-470-35261-2 0-471-46073-7 0-471-22039-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
SOLID-PHASE SYNTHESIS AND COMBINATORIAL TECHNOLOGIES; CONTENTS; Preface; 1 Solid-Phase Synthesis: Basic Principles; 1.1 Solid Supports; 1.2 Linkers; 1.3 Reaction Monitoring in Solid-Phase Synthesis; 1.4 Purity and Yield Determination in Solid-Phase Synthesis; References; 2 Solid-Phase Synthesis: Oligomeric Molecules; 2.1 Peptides; 2.2 Oligonucleotides; 2.3 Oligosaccharides; References; 3 Solid-Phase Synthesis: Small Organic Molecules; 3.1 Small Organic Molecules on Solid Phase: Target Selection and Solution Studies; 3.2 Small Organic Molecules on Solid Phase: Solid-Phase Synthesis
3.3 Small Organic Molecules on Solid Phase: From Solid-Phase Synthesis to Synthetic Organic Libraries3.4 An Example: Solid-Phase Synthesis of 1H-[2]Pyrindinones; 3.5 Solid-Phase Synthetic Strategies: Selected Examples; References; 4 Combinatorial Technologies: Basic Principles; 4.1 Combinatorial Technologies; 4.2 Combinatorial Libraries; References; 5 Synthetic Organic Libraries: Library Design and Properties; 5.1 Primary Libraries: Shooting in the Dark?; 5.2 Focused Libraries: High-Throughput Structure--Activity Relationships; 5.3 Biased-Targeted Libraries: Information-Rich Primary Libraries 5.4 Library Design via Computational ToolsReferences; 6 Synthetic Organic Libraries: Solid-Phase Discrete Libraries; 6.1 Synthesis of Solid-Phase Discrete Libraries; 6.2 Structure Determination, Quality Control, and Purification of Solid-Phase Discrete Libraries; 6.3 Examples of Solid-Phase Discrete Library Synthesis; 6.4 New Trends in Solid-Phase Discrete Library Synthesis; References; 7 Synthetic Organic Libraries: Solid-Phase Pool Libraries; 7.1 Synthesis of Solid-Phase Pool Libraries; 7.2 Direct Structure Determination of Positives from Solid-Phase Pool Libraries 7.3 Deconvolution Methods for Solid-Phase Pool Libraries7.4 Encoding Methods for Solid-Phase Pool Libraries; 7.5 New Trends in Solid-Phase Pool Libraries; References; 8 Synthetic Organic Libraries: Solution-Phase Libraries; 8.1 Solution- Versus Solid-Phase Synthetic Libraries: Which Ones to Use?; 8.2 Solution-Phase Discrete Libraries; 8.3 Purification of Solution-Phase Library Intermediates and Final Compounds: Liquid-Liquid and Solid-Phase Extraction Systems; 8.4 Solid-Phase Assisted Solution-Phase Library Synthesis and Purification 8.5 Soluble Supports in Solution-Phase Combinatorial Synthesis8.6 New Trends in Solution-Phase Combinatorial Synthesis; References; 9 Applications of Synthetic Libraries; 9.1 Pharmaceutical Applications; 9.2 Agrochemical and Food-Related Applications; 9.3 Applications to Combinatorial Reaction Optimization; 9.4 Applications to Catalysis; 9.5 Applications to Molecular Recognition; References; 10 Biosynthetic Combinatorial Libraries; 10.1 Biosynthetic Polypeptide Libraries; 10.2 Biosynthetic Oligonucleotide Libraries; 10.3 Combinatorial Biosynthesis of Natural Products 10.4 Combinatorial Biocatalysis |
| Record Nr. | UNINA-9910876832503321 |
|
Seneci Pierfausto <1960->
|
||
| New York, : John Wiley & Sons, c2000 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Solid-phase organic synthesis [[electronic resource] ] : concepts, strategies, and applications / / edited by Patrick H. Toy, Yulin Lam
| Solid-phase organic synthesis [[electronic resource] ] : concepts, strategies, and applications / / edited by Patrick H. Toy, Yulin Lam |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, NJ, : Wiley, 2012 |
| Descrizione fisica | 1 online resource (562 p.) |
| Disciplina | 547/.2 |
| Altri autori (Persone) |
ToyPatrick H
LamYulin |
| Soggetto topico |
Solid-phase synthesis
Organic compounds - Synthesis |
| ISBN |
1-283-40957-7
9786613409577 1-118-14163-6 1-118-14164-4 1-118-14162-8 |
| Classificazione | SCI013050 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
SOLID-PHASE ORGANIC SYNTHESIS: Concepts, Strategies, and Applications; CONTENTS; Preface; Acknowledgments; Contributors; Part I: CONCEPTS AND STRATEGIES; 1 LINKER STRATEGIES IN MODERN SOLID-PHASE ORGANIC SYNTHESIS; 1.1 Introduction; 1.2 Classical Linker Strategies; 1.2.1 Acid and Base Cleavable Linker Units; 1.2.2 Cyclorelease Linker Units; 1.2.3 Traceless Linker Units; 1.2.4 Photolabile Linker Units; 1.2.5 Safety-Catch Linker Units; 1.3 Multifunctional Linker Strategies; 1.3.1 Nitrogen Linker Units; 1.3.1.1 Triazene Linker Units; 1.3.1.2 Hydrazone Linker Units
1.3.1.3 Benzotriazole Linker Units1.3.2 Sulfur Linker Units; 1.3.3 Phosphorus Linker Units; 1.3.4 Selenium and Tellurium Linker Units; 1.3.5 Silyl and Germyl Linker Units; 1.3.6 Boron and Stannane Linker Units; 1.3.7 Bismuth Linker Units; 1.3.8 Alkene Linker Units; 1.4 Conclusions; References; 2 COLORIMETRIC TEST FOR SOLID-PHASE ORGANIC SYNTHESIS; 2.1 Introduction; 2.2 Functional Group Tests; 2.2.1 Amine Groups; 2.2.1.1 Ninhydrin (Kaiser) Test; 2.2.1.2 TNBSA Test; 2.2.1.3 Bromophenol Blue Test; 2.2.1.4 Chloranil Test; 2.2.1.5 DABITC Test; 2.2.1.6 MGI Test; 2.2.1.7 Isatin Test 2.2.1.8 DESC Test2.2.1.9 NPIT Test; 2.2.1.10 NF31 Test; 2.2.1.11 Nondestructive NF31 Test; 2.2.1.12 Naphthol Test; 2.2.1.13 2-Amino-3-chloro-1,4-naphthoquinone Test; 2.2.2 Alcohols; 2.2.2.1 PNBP Test; 2.2.2.2 TCT-AliR and TCT-Fluorescein Test; 2.2.2.3 Diphenyldichlorosilane-Methyl Red Test; 2.2.2.4 9-Anthronylnitrile Test; 2.2.2.5 NMA Test; 2.2.2.6 Protecting Group NPB Test; 2.2.2.7 Methyl Red/DIC Test; 2.2.2.8 Other Methods; 2.2.3 Thiol Groups; 2.2.3.1 Ellman's Test; 2.2.3.2 Other Methods; 2.2.4 Halogen Groups; 2.2.4.1 Fluorescein Test; 2.2.4.2 Other Methods; 2.2.5 Carboxylic Acid Groups 2.2.5.1 Malachite Green Test2.2.5.2 PDAM Test; 2.2.6 Aldehyde and Ketone Groups; 2.2.6.1 Fluorescent Dansylhydrazine Test; 2.2.6.2 p-Anisaldehyde Test; 2.2.6.3 Purpald Test; 2.3 Conclusions; References; 3 PRACTICAL ASPECTS OF COMBINATORIAL SOLID-PHASE SYNTHESIS; 3.1 Introduction; 3.1.1 What Is Combinatorial Chemistry; 3.1.2 What Is Not Combinatorial Chemistry; 3.1.3 History of Combinatorial Chemistry: Breakthrough Discoveries That Shaped the Future of the Combinatorial Chemistry Field; 3.1.3.1 Solid-Phase Synthesis; 3.1.3.2 Pooling Strategy; 3.1.3.3 Parallel Synthesis 3.2 Strategies in Combinatorial Solid-Phase Synthesis3.2.1 Random Split-and-Pool Method; 3.2.1.1 One-Bead-One-Compound Concept; 3.2.1.2 Encoding Methods for the OBOC Technique; 3.2.1.3 Organized Mixtures; 3.2.2 Directed Split-and-Pool Method in Practice; 3.2.2.1 Formulation of Solid-Phase Supports for the Directed Split-and-Pool Technique; 3.2.2.2 Chemical History of the Resin Formulations; 3.3 Equipment and Instrumentation; 3.3.1 Manual Solid-Phase Synthesis; 3.3.2 Integrated Semiautomated Synthesis; 3.3.3 Fully Automated Synthesizers (Gone with the Wind); 3.3.4 Instruments for Sorting 3.4 Characterization and Purification |
| Record Nr. | UNINA-9910141164703321 |
| Hoboken, NJ, : Wiley, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Solid-phase organic synthesis : concepts, strategies, and applications / / edited by Patrick H. Toy, Yulin Lam
| Solid-phase organic synthesis : concepts, strategies, and applications / / edited by Patrick H. Toy, Yulin Lam |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, NJ, : Wiley, 2012 |
| Descrizione fisica | 1 online resource (562 p.) |
| Disciplina | 547/.2 |
| Altri autori (Persone) |
ToyPatrick H
LamYulin |
| Soggetto topico |
Solid-phase synthesis
Organic compounds - Synthesis |
| ISBN |
1-283-40957-7
9786613409577 1-118-14163-6 1-118-14164-4 1-118-14162-8 |
| Classificazione | SCI013050 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
SOLID-PHASE ORGANIC SYNTHESIS: Concepts, Strategies, and Applications; CONTENTS; Preface; Acknowledgments; Contributors; Part I: CONCEPTS AND STRATEGIES; 1 LINKER STRATEGIES IN MODERN SOLID-PHASE ORGANIC SYNTHESIS; 1.1 Introduction; 1.2 Classical Linker Strategies; 1.2.1 Acid and Base Cleavable Linker Units; 1.2.2 Cyclorelease Linker Units; 1.2.3 Traceless Linker Units; 1.2.4 Photolabile Linker Units; 1.2.5 Safety-Catch Linker Units; 1.3 Multifunctional Linker Strategies; 1.3.1 Nitrogen Linker Units; 1.3.1.1 Triazene Linker Units; 1.3.1.2 Hydrazone Linker Units
1.3.1.3 Benzotriazole Linker Units1.3.2 Sulfur Linker Units; 1.3.3 Phosphorus Linker Units; 1.3.4 Selenium and Tellurium Linker Units; 1.3.5 Silyl and Germyl Linker Units; 1.3.6 Boron and Stannane Linker Units; 1.3.7 Bismuth Linker Units; 1.3.8 Alkene Linker Units; 1.4 Conclusions; References; 2 COLORIMETRIC TEST FOR SOLID-PHASE ORGANIC SYNTHESIS; 2.1 Introduction; 2.2 Functional Group Tests; 2.2.1 Amine Groups; 2.2.1.1 Ninhydrin (Kaiser) Test; 2.2.1.2 TNBSA Test; 2.2.1.3 Bromophenol Blue Test; 2.2.1.4 Chloranil Test; 2.2.1.5 DABITC Test; 2.2.1.6 MGI Test; 2.2.1.7 Isatin Test 2.2.1.8 DESC Test2.2.1.9 NPIT Test; 2.2.1.10 NF31 Test; 2.2.1.11 Nondestructive NF31 Test; 2.2.1.12 Naphthol Test; 2.2.1.13 2-Amino-3-chloro-1,4-naphthoquinone Test; 2.2.2 Alcohols; 2.2.2.1 PNBP Test; 2.2.2.2 TCT-AliR and TCT-Fluorescein Test; 2.2.2.3 Diphenyldichlorosilane-Methyl Red Test; 2.2.2.4 9-Anthronylnitrile Test; 2.2.2.5 NMA Test; 2.2.2.6 Protecting Group NPB Test; 2.2.2.7 Methyl Red/DIC Test; 2.2.2.8 Other Methods; 2.2.3 Thiol Groups; 2.2.3.1 Ellman's Test; 2.2.3.2 Other Methods; 2.2.4 Halogen Groups; 2.2.4.1 Fluorescein Test; 2.2.4.2 Other Methods; 2.2.5 Carboxylic Acid Groups 2.2.5.1 Malachite Green Test2.2.5.2 PDAM Test; 2.2.6 Aldehyde and Ketone Groups; 2.2.6.1 Fluorescent Dansylhydrazine Test; 2.2.6.2 p-Anisaldehyde Test; 2.2.6.3 Purpald Test; 2.3 Conclusions; References; 3 PRACTICAL ASPECTS OF COMBINATORIAL SOLID-PHASE SYNTHESIS; 3.1 Introduction; 3.1.1 What Is Combinatorial Chemistry; 3.1.2 What Is Not Combinatorial Chemistry; 3.1.3 History of Combinatorial Chemistry: Breakthrough Discoveries That Shaped the Future of the Combinatorial Chemistry Field; 3.1.3.1 Solid-Phase Synthesis; 3.1.3.2 Pooling Strategy; 3.1.3.3 Parallel Synthesis 3.2 Strategies in Combinatorial Solid-Phase Synthesis3.2.1 Random Split-and-Pool Method; 3.2.1.1 One-Bead-One-Compound Concept; 3.2.1.2 Encoding Methods for the OBOC Technique; 3.2.1.3 Organized Mixtures; 3.2.2 Directed Split-and-Pool Method in Practice; 3.2.2.1 Formulation of Solid-Phase Supports for the Directed Split-and-Pool Technique; 3.2.2.2 Chemical History of the Resin Formulations; 3.3 Equipment and Instrumentation; 3.3.1 Manual Solid-Phase Synthesis; 3.3.2 Integrated Semiautomated Synthesis; 3.3.3 Fully Automated Synthesizers (Gone with the Wind); 3.3.4 Instruments for Sorting 3.4 Characterization and Purification |
| Record Nr. | UNINA-9910817949103321 |
| Hoboken, NJ, : Wiley, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Solid-phase organic synthesis [[electronic resource] /] / edited by Kevin Burgess
| Solid-phase organic synthesis [[electronic resource] /] / edited by Kevin Burgess |
| Pubbl/distr/stampa | New York, : Wiley-Interscience, c2000 |
| Descrizione fisica | 1 online resource (294 p.) |
| Disciplina |
547.2
547/.2 |
| Altri autori (Persone) | BurgessKevin L. <1968-> |
| Soggetto topico |
Organic compounds - Synthesis
Solid-phase synthesis |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-54169-5
9786610541690 0-471-45845-7 0-471-22824-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
CONTENTS; PREFACE; CONTRIBUTORS; 1 SOLID-PHASE SYNTHESES OF GUANIDINES; 1.1. Introduction; 1.2. Outline of Some Solution-Phase Approaches to Guanidines; 1.3. Solid-Phase Syntheses Involving Resin-Bound Electrophiles; 1.4. Solid-Phase Syntheses Involving Electrophiles in Solution; 1.5. Other Supported Guanidines; 1.6. Conclusion; References; 2 PALLADIUM-CATALYZED CARBON-CARBON BOND FORMATION ON SOLID SUPPORT; 2.1. Introduction; 2.2. Heck Reaction; 2.3. Stille Reaction; 2.4. Suzuki Reaction; 2.5. Miscellaneous Reactions; 2.6. Concluding Remarks; References
3 BENZOFUSED HETEROCYCLES VIA SOLID-PHASE S[sub(N)]AR REACTIONS3.1. Introduction; 3.2. Formation of [6,7]- and [6,8]-Fused Systems; 3.3. Formation of [6,6]-Fused Systems; 3.4. Formation of [6,5]-Fused Systems; 3.5. Conclusions and Outlook; References; 4 SOLID-PHASE SYNTHESIS OF SEQUENCE-SPECIFIC PHENYLACETYLENE OLIGOMERS; 4.1. Introduction; 4.2. Strategies; 4.3. Synthetic Tactics; 4.4. Illustrative Applications; 4.5. Scope and Limitations; 4.6. Conclusion; 4.7. Representative Procedures; References; 5 POLYMER-ASSISTED SOLUTION-PHASE METHODS FOR CHEMICAL LIBRARY SYNTHESIS; 5.1. Introduction 5.2. Reactant Sequestration5.3. Byproduct Sequestration; 5.4. Solution-Phase Derivatization to Facilitate Polymer-Assisted Sequestration; 5.5. Soluble Bifunctional Reagents; 5.6. Polymer-Supported Substrates; 5.7. Polymer-Supported Reagents; 5.8. Polymer-Supported Catalysts; 5.9. Polymers for Reaction Quenching/Workup; 5.10. Combinations of Solid- and Solution-Phase Techniques in Organic Synthesis; 5.11. Multistep/One-Chamber Solution-Phase Synthesis; 5.12. Polymer-Assisted Technologies in Multistep Solution-Phase Syntheses; 5.13. Conclusion; References 6 SOLID-PHASE ORGANIC SYNTHESIS ON RADIATION-GRAFTED POLYMER SURFACES: APPLICATION OF SYNPHASE CROWNS TO MULTIPLE PARALLEL SYNTHESES6.1. Multiple Parallel Syntheses of Individual Compounds; 6.2. Synthetic Applications of Synphase Crowns; 6.3. Linker Development Using Synphase Crowns; 6.4. Tagging Methods for Identifying Individual Crowns; 6.5. Future Developments; References; 7 VIBRATIONAL SPECTROSCOPY FOR OPTIMIZATION OF SOLID-PHASE ORGANIC SYNTHESES; 7.1. Introduction; 7.2. Spectroscopic Methods Applicable to Different Sample Sizes; 7.3. Optimization in Solid-Phase Organic Syntheses 7.4. ConclusionReferences; 8 RECENT ADVANCES IN SOLID-PHASE SYNTHESIS OF NATURAL PRODUCTS; 8.1. Introduction; 8.2. Prostaglandins; 8.3. Epothilone a; 8.4. (S)-Zearalenone; 8.5. DL-Muscone; 8.6. Taxoid Libraries from Baccatin III; 8.7. Sarcodictyin Libraries; 8.8. Lavendustin A; 8.9. Indolyl Diketopiperazines; 8.10. Balanol Analogs; 8.11. Pseudoalkaloids from Shikimic Acid; 8.12. Conclusions; References; INDEX; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; Q; R; S; T; U; V; W; Y; Z |
| Record Nr. | UNINA-9910143199003321 |
| New York, : Wiley-Interscience, c2000 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Solid-phase organic synthesis [[electronic resource] /] / edited by Kevin Burgess
| Solid-phase organic synthesis [[electronic resource] /] / edited by Kevin Burgess |
| Pubbl/distr/stampa | New York, : Wiley-Interscience, c2000 |
| Descrizione fisica | 1 online resource (294 p.) |
| Disciplina |
547.2
547/.2 |
| Altri autori (Persone) | BurgessKevin L. <1968-> |
| Soggetto topico |
Organic compounds - Synthesis
Solid-phase synthesis |
| ISBN |
1-280-54169-5
9786610541690 0-471-45845-7 0-471-22824-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
CONTENTS; PREFACE; CONTRIBUTORS; 1 SOLID-PHASE SYNTHESES OF GUANIDINES; 1.1. Introduction; 1.2. Outline of Some Solution-Phase Approaches to Guanidines; 1.3. Solid-Phase Syntheses Involving Resin-Bound Electrophiles; 1.4. Solid-Phase Syntheses Involving Electrophiles in Solution; 1.5. Other Supported Guanidines; 1.6. Conclusion; References; 2 PALLADIUM-CATALYZED CARBON-CARBON BOND FORMATION ON SOLID SUPPORT; 2.1. Introduction; 2.2. Heck Reaction; 2.3. Stille Reaction; 2.4. Suzuki Reaction; 2.5. Miscellaneous Reactions; 2.6. Concluding Remarks; References
3 BENZOFUSED HETEROCYCLES VIA SOLID-PHASE S[sub(N)]AR REACTIONS3.1. Introduction; 3.2. Formation of [6,7]- and [6,8]-Fused Systems; 3.3. Formation of [6,6]-Fused Systems; 3.4. Formation of [6,5]-Fused Systems; 3.5. Conclusions and Outlook; References; 4 SOLID-PHASE SYNTHESIS OF SEQUENCE-SPECIFIC PHENYLACETYLENE OLIGOMERS; 4.1. Introduction; 4.2. Strategies; 4.3. Synthetic Tactics; 4.4. Illustrative Applications; 4.5. Scope and Limitations; 4.6. Conclusion; 4.7. Representative Procedures; References; 5 POLYMER-ASSISTED SOLUTION-PHASE METHODS FOR CHEMICAL LIBRARY SYNTHESIS; 5.1. Introduction 5.2. Reactant Sequestration5.3. Byproduct Sequestration; 5.4. Solution-Phase Derivatization to Facilitate Polymer-Assisted Sequestration; 5.5. Soluble Bifunctional Reagents; 5.6. Polymer-Supported Substrates; 5.7. Polymer-Supported Reagents; 5.8. Polymer-Supported Catalysts; 5.9. Polymers for Reaction Quenching/Workup; 5.10. Combinations of Solid- and Solution-Phase Techniques in Organic Synthesis; 5.11. Multistep/One-Chamber Solution-Phase Synthesis; 5.12. Polymer-Assisted Technologies in Multistep Solution-Phase Syntheses; 5.13. Conclusion; References 6 SOLID-PHASE ORGANIC SYNTHESIS ON RADIATION-GRAFTED POLYMER SURFACES: APPLICATION OF SYNPHASE CROWNS TO MULTIPLE PARALLEL SYNTHESES6.1. Multiple Parallel Syntheses of Individual Compounds; 6.2. Synthetic Applications of Synphase Crowns; 6.3. Linker Development Using Synphase Crowns; 6.4. Tagging Methods for Identifying Individual Crowns; 6.5. Future Developments; References; 7 VIBRATIONAL SPECTROSCOPY FOR OPTIMIZATION OF SOLID-PHASE ORGANIC SYNTHESES; 7.1. Introduction; 7.2. Spectroscopic Methods Applicable to Different Sample Sizes; 7.3. Optimization in Solid-Phase Organic Syntheses 7.4. ConclusionReferences; 8 RECENT ADVANCES IN SOLID-PHASE SYNTHESIS OF NATURAL PRODUCTS; 8.1. Introduction; 8.2. Prostaglandins; 8.3. Epothilone a; 8.4. (S)-Zearalenone; 8.5. DL-Muscone; 8.6. Taxoid Libraries from Baccatin III; 8.7. Sarcodictyin Libraries; 8.8. Lavendustin A; 8.9. Indolyl Diketopiperazines; 8.10. Balanol Analogs; 8.11. Pseudoalkaloids from Shikimic Acid; 8.12. Conclusions; References; INDEX; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; Q; R; S; T; U; V; W; Y; Z |
| Record Nr. | UNISA-996201908803316 |
| New York, : Wiley-Interscience, c2000 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Solid-phase organic synthesis [[electronic resource] /] / edited by Kevin Burgess
| Solid-phase organic synthesis [[electronic resource] /] / edited by Kevin Burgess |
| Pubbl/distr/stampa | New York, : Wiley-Interscience, c2000 |
| Descrizione fisica | 1 online resource (294 p.) |
| Disciplina |
547.2
547/.2 |
| Altri autori (Persone) | BurgessKevin L. <1968-> |
| Soggetto topico |
Organic compounds - Synthesis
Solid-phase synthesis |
| ISBN |
1-280-54169-5
9786610541690 0-471-45845-7 0-471-22824-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
CONTENTS; PREFACE; CONTRIBUTORS; 1 SOLID-PHASE SYNTHESES OF GUANIDINES; 1.1. Introduction; 1.2. Outline of Some Solution-Phase Approaches to Guanidines; 1.3. Solid-Phase Syntheses Involving Resin-Bound Electrophiles; 1.4. Solid-Phase Syntheses Involving Electrophiles in Solution; 1.5. Other Supported Guanidines; 1.6. Conclusion; References; 2 PALLADIUM-CATALYZED CARBON-CARBON BOND FORMATION ON SOLID SUPPORT; 2.1. Introduction; 2.2. Heck Reaction; 2.3. Stille Reaction; 2.4. Suzuki Reaction; 2.5. Miscellaneous Reactions; 2.6. Concluding Remarks; References
3 BENZOFUSED HETEROCYCLES VIA SOLID-PHASE S[sub(N)]AR REACTIONS3.1. Introduction; 3.2. Formation of [6,7]- and [6,8]-Fused Systems; 3.3. Formation of [6,6]-Fused Systems; 3.4. Formation of [6,5]-Fused Systems; 3.5. Conclusions and Outlook; References; 4 SOLID-PHASE SYNTHESIS OF SEQUENCE-SPECIFIC PHENYLACETYLENE OLIGOMERS; 4.1. Introduction; 4.2. Strategies; 4.3. Synthetic Tactics; 4.4. Illustrative Applications; 4.5. Scope and Limitations; 4.6. Conclusion; 4.7. Representative Procedures; References; 5 POLYMER-ASSISTED SOLUTION-PHASE METHODS FOR CHEMICAL LIBRARY SYNTHESIS; 5.1. Introduction 5.2. Reactant Sequestration5.3. Byproduct Sequestration; 5.4. Solution-Phase Derivatization to Facilitate Polymer-Assisted Sequestration; 5.5. Soluble Bifunctional Reagents; 5.6. Polymer-Supported Substrates; 5.7. Polymer-Supported Reagents; 5.8. Polymer-Supported Catalysts; 5.9. Polymers for Reaction Quenching/Workup; 5.10. Combinations of Solid- and Solution-Phase Techniques in Organic Synthesis; 5.11. Multistep/One-Chamber Solution-Phase Synthesis; 5.12. Polymer-Assisted Technologies in Multistep Solution-Phase Syntheses; 5.13. Conclusion; References 6 SOLID-PHASE ORGANIC SYNTHESIS ON RADIATION-GRAFTED POLYMER SURFACES: APPLICATION OF SYNPHASE CROWNS TO MULTIPLE PARALLEL SYNTHESES6.1. Multiple Parallel Syntheses of Individual Compounds; 6.2. Synthetic Applications of Synphase Crowns; 6.3. Linker Development Using Synphase Crowns; 6.4. Tagging Methods for Identifying Individual Crowns; 6.5. Future Developments; References; 7 VIBRATIONAL SPECTROSCOPY FOR OPTIMIZATION OF SOLID-PHASE ORGANIC SYNTHESES; 7.1. Introduction; 7.2. Spectroscopic Methods Applicable to Different Sample Sizes; 7.3. Optimization in Solid-Phase Organic Syntheses 7.4. ConclusionReferences; 8 RECENT ADVANCES IN SOLID-PHASE SYNTHESIS OF NATURAL PRODUCTS; 8.1. Introduction; 8.2. Prostaglandins; 8.3. Epothilone a; 8.4. (S)-Zearalenone; 8.5. DL-Muscone; 8.6. Taxoid Libraries from Baccatin III; 8.7. Sarcodictyin Libraries; 8.8. Lavendustin A; 8.9. Indolyl Diketopiperazines; 8.10. Balanol Analogs; 8.11. Pseudoalkaloids from Shikimic Acid; 8.12. Conclusions; References; INDEX; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; Q; R; S; T; U; V; W; Y; Z |
| Record Nr. | UNINA-9910830810003321 |
| New York, : Wiley-Interscience, c2000 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Solid-phase organic synthesis / / edited by Kevin Burgess
| Solid-phase organic synthesis / / edited by Kevin Burgess |
| Pubbl/distr/stampa | New York, : Wiley-Interscience, c2000 |
| Descrizione fisica | 1 online resource (294 p.) |
| Disciplina | 547/.2 |
| Altri autori (Persone) | BurgessKevin L. <1968-> |
| Soggetto topico |
Organic compounds - Synthesis
Solid-phase synthesis |
| ISBN |
1-280-54169-5
9786610541690 0-471-45845-7 0-471-22824-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
CONTENTS; PREFACE; CONTRIBUTORS; 1 SOLID-PHASE SYNTHESES OF GUANIDINES; 1.1. Introduction; 1.2. Outline of Some Solution-Phase Approaches to Guanidines; 1.3. Solid-Phase Syntheses Involving Resin-Bound Electrophiles; 1.4. Solid-Phase Syntheses Involving Electrophiles in Solution; 1.5. Other Supported Guanidines; 1.6. Conclusion; References; 2 PALLADIUM-CATALYZED CARBON-CARBON BOND FORMATION ON SOLID SUPPORT; 2.1. Introduction; 2.2. Heck Reaction; 2.3. Stille Reaction; 2.4. Suzuki Reaction; 2.5. Miscellaneous Reactions; 2.6. Concluding Remarks; References
3 BENZOFUSED HETEROCYCLES VIA SOLID-PHASE S[sub(N)]AR REACTIONS3.1. Introduction; 3.2. Formation of [6,7]- and [6,8]-Fused Systems; 3.3. Formation of [6,6]-Fused Systems; 3.4. Formation of [6,5]-Fused Systems; 3.5. Conclusions and Outlook; References; 4 SOLID-PHASE SYNTHESIS OF SEQUENCE-SPECIFIC PHENYLACETYLENE OLIGOMERS; 4.1. Introduction; 4.2. Strategies; 4.3. Synthetic Tactics; 4.4. Illustrative Applications; 4.5. Scope and Limitations; 4.6. Conclusion; 4.7. Representative Procedures; References; 5 POLYMER-ASSISTED SOLUTION-PHASE METHODS FOR CHEMICAL LIBRARY SYNTHESIS; 5.1. Introduction 5.2. Reactant Sequestration5.3. Byproduct Sequestration; 5.4. Solution-Phase Derivatization to Facilitate Polymer-Assisted Sequestration; 5.5. Soluble Bifunctional Reagents; 5.6. Polymer-Supported Substrates; 5.7. Polymer-Supported Reagents; 5.8. Polymer-Supported Catalysts; 5.9. Polymers for Reaction Quenching/Workup; 5.10. Combinations of Solid- and Solution-Phase Techniques in Organic Synthesis; 5.11. Multistep/One-Chamber Solution-Phase Synthesis; 5.12. Polymer-Assisted Technologies in Multistep Solution-Phase Syntheses; 5.13. Conclusion; References 6 SOLID-PHASE ORGANIC SYNTHESIS ON RADIATION-GRAFTED POLYMER SURFACES: APPLICATION OF SYNPHASE CROWNS TO MULTIPLE PARALLEL SYNTHESES6.1. Multiple Parallel Syntheses of Individual Compounds; 6.2. Synthetic Applications of Synphase Crowns; 6.3. Linker Development Using Synphase Crowns; 6.4. Tagging Methods for Identifying Individual Crowns; 6.5. Future Developments; References; 7 VIBRATIONAL SPECTROSCOPY FOR OPTIMIZATION OF SOLID-PHASE ORGANIC SYNTHESES; 7.1. Introduction; 7.2. Spectroscopic Methods Applicable to Different Sample Sizes; 7.3. Optimization in Solid-Phase Organic Syntheses 7.4. ConclusionReferences; 8 RECENT ADVANCES IN SOLID-PHASE SYNTHESIS OF NATURAL PRODUCTS; 8.1. Introduction; 8.2. Prostaglandins; 8.3. Epothilone a; 8.4. (S)-Zearalenone; 8.5. DL-Muscone; 8.6. Taxoid Libraries from Baccatin III; 8.7. Sarcodictyin Libraries; 8.8. Lavendustin A; 8.9. Indolyl Diketopiperazines; 8.10. Balanol Analogs; 8.11. Pseudoalkaloids from Shikimic Acid; 8.12. Conclusions; References; INDEX; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; Q; R; S; T; U; V; W; Y; Z |
| Record Nr. | UNINA-9910878101303321 |
| New York, : Wiley-Interscience, c2000 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Strategies and tactics in organic synthesis / / edited by Michael Harmata
| Strategies and tactics in organic synthesis / / edited by Michael Harmata |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Amsterdam, : Elsevier Academic Press, 2005 |
| Descrizione fisica | 1 online resource (501 p.) |
| Disciplina | 547/.2 |
| Altri autori (Persone) | HarmataMichael |
| Collana | Strategies and tactics in organic synthesis |
| Soggetto topico |
Organic compounds - Synthesis
Chemistry, Organic |
| ISBN |
1-280-63068-X
9786610630684 0-08-045884-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
COVER; STRATEGIES AND TACTICS IN ORGANIC SYNTHESIS; Copyright Page; CONTENTS; CONTRIBUTORS; Foreword; Preface; Dedication; CHAPTER 1. THE TOTAL SYNTHESIS OF LUZOPEPTINS; I. Introduction; II. Background; III. Synthesis of Quinaldic Acid and gly-sar-mhv Tripeptide Fragments; IV. Synthesis and Chemistry of the Piperazic Acid Fragment; V. Initial Cyclization Experiments; VI. The Total Synthesis; VII. Epilogue; VIII. Acknowledgements; References and Footnotes; CHAPTER 2. SYNTHESIS OF GELDANAMYCIN USING GLYCOLATE ALDOL REACTIONS; I. Introduction; II. Retrosynthetic Analysis
III. Ansamycin Antitumor AntibioticsIV. Synthesis of the C12-C21 Quinone Precursor Portion using Evans Asymmetric Alkylation; V. Development of Anti-Selective Glycolate Aldol Methodology Based on the 2,3-Diary1 1,4-Dioxan-5-one Template; VI. Installation of the C11-12 Hydroxy Methoxy Functionality; VII. Difficulties Associated with the C10 methyl and the C8-9 Trisubstituted Alkene; VIII. Syn Glycolate Aldol Methodology Based on the Masamune Norephedrine Auxiliary; IX. Construction of the C2-5 Diene and Macrolactamization; X. Unsuccessful RCM-Based Convergent Approach XI. Unanticipated Problematic Para-Quinone FormationXII. Successful Strategy for Para-Quinone formation Using a 1,4-Di-Protected Hydroquinone Precursor; XIII. Conclusions; References and Footnotes; CHAPTER 3. FROM METHYLENE BRIDGED GLYCOLURIL DIMERS TO CUCURBIT[N]URIL ANALOGS WITH SOME DETOURS ALONG THE WAY; I. Introduction; II. Retrosynthetic Analysis of the Cucurbit[n]uril Family; III. A Few Lucky Breaks Lead to C- and S-Shaped Methylene Bridged Glycoluril Dimers; IV. The Hard Work; V. Three Related Synthetic Procedures Lead to S- and C-shaped Methylene Bridged Glycoluril Dimers VI. Interlude. Molecular Clips Capable of Enantiomeric Self-Recognition, Heterochiral Recognition, and Self-SortingVII. Implications for the Mechanism of CB[n] Formation and the Synthesis of Cucurbit[n]uril Derivatives; VIII. Mechanism of the S- to C-Shaped Interconversion and Implications for the Synthesis of Cucurbit[n]uril Derivatives; IX. Methylene Bridged Glycoluril Oligomers; X. Phthalhydrazides are Nucleophilic Glycoluril Surrogates; XI. Cucurbit[n]uril Analogs; XII. Conclusions; References and Footnotes CHAPTER 4. APPLICATION OF SILICON-ASSISTED INTRAMOLECULAR CROSS-COUPLING IN TOTAL SYNTHESIS OF (+)-BRASILENYNEI. Introduction and Background; II. Preliminary Studies; III. Synthetic Strategies; IV. Synthesis of (+)-Brasilenyne; V. Conformational Analysis; VI. Summary; References and Footnotes; CHAPTER 5. SAMARIUM(II) PROMOTED KETYL OLEFIN CYCLIZATIONS APPLIED TO THE TOTAL SYNTHESES OF (-)-STEGANONE AND (+)-ISOSCHIZANDRIN; I. Introduction; II. Samarium(II) Promoted Ketyl-Olefin Cyclizations; III. Total Synthesis of (-)-Steganone; IV. Total Synthesis of (+)-Isoschizandrin; V. Conclusion References and Footnotes |
| Record Nr. | UNINA-9910812298003321 |
| Amsterdam, : Elsevier Academic Press, 2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Superelectrophiles and their chemistry [[electronic resource] /] / George A. Olah, Douglas A. Klumpp
| Superelectrophiles and their chemistry [[electronic resource] /] / George A. Olah, Douglas A. Klumpp |
| Autore | Olah George A (George Andrew), <1927-> |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley-Interscience, c2008 |
| Descrizione fisica | 1 online resource (312 p.) |
| Disciplina | 547/.2 |
| Altri autori (Persone) | KlumppDouglas A |
| Soggetto topico |
Superelectrophiles
Chemical affinity Organic compounds - Synthesis |
| ISBN |
1-281-13477-5
9786611134778 0-470-18512-0 0-470-18511-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | General aspects -- Study of superelectrophiles -- Generating superelectrophiles -- Gitonic geminal superelectrophiles -- Gitonic vicinal superelectrophiles -- Gitonic 1,3-superelectrophiles -- Distonic superelectrophiles -- Significance and outlook. |
| Record Nr. | UNINA-9910145283503321 |
|
Olah George A (George Andrew), <1927->
|
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| Hoboken, N.J., : Wiley-Interscience, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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