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Biblioteca

MARC Lista (tabellare)
Molecular modelling and bonding [[electronic resource] /] / edited by Elaine Moore
Molecular modelling and bonding [[electronic resource] /] / edited by Elaine Moore
Pubbl/distr/stampa Cambridge, UK, : Royal Society of Chemistry, 2002
Descrizione fisica 1 online resource (154 p.)
Disciplina 541.224
Altri autori (Persone) MooreElaine (Elaine A.)
Collana The molecular world
Soggetto topico Chemical bonds
Molecular structure
Molecules - Models
ISBN 1-62870-358-X
1-84755-781-3
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto BK9780854046751-FX001; BK9780854046751-FP001; BK9780854046751-FP003; BK9780854046751-FP004; BK9780854046751-FP005; BK9780854046751-00009; BK9780854046751-00011; BK9780854046751-00020; BK9780854046751-00038; BK9780854046751-00067; BK9780854046751-00076; BK9780854046751-00091; BK9780854046751-00093; BK9780854046751-00111; BK9780854046751-00113; BK9780854046751-00123; BK9780854046751-00124; BK9780854046751-00125; BK9780854046751-00127; BK9780854046751-00131; BK9780854046751-00135; BK9780854046751-00139; BK9780854046751-00147; BK9780854046751-00148; BK9780854046751-00149
Record Nr. UNINA-9910778210903321
Cambridge, UK, : Royal Society of Chemistry, 2002
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Molecular modelling and bonding [[electronic resource] /] / edited by Elaine Moore
Molecular modelling and bonding [[electronic resource] /] / edited by Elaine Moore
Edizione [1st ed.]
Pubbl/distr/stampa Cambridge, UK, : Royal Society of Chemistry, 2002
Descrizione fisica 1 online resource (154 p.)
Disciplina 541.224
Altri autori (Persone) MooreElaine (Elaine A.)
Collana The molecular world
Soggetto topico Chemical bonds
Molecular structure
Molecules - Models
ISBN 1-62870-358-X
1-84755-781-3
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto BK9780854046751-FX001; BK9780854046751-FP001; BK9780854046751-FP003; BK9780854046751-FP004; BK9780854046751-FP005; BK9780854046751-00009; BK9780854046751-00011; BK9780854046751-00020; BK9780854046751-00038; BK9780854046751-00067; BK9780854046751-00076; BK9780854046751-00091; BK9780854046751-00093; BK9780854046751-00111; BK9780854046751-00113; BK9780854046751-00123; BK9780854046751-00124; BK9780854046751-00125; BK9780854046751-00127; BK9780854046751-00131; BK9780854046751-00135; BK9780854046751-00139; BK9780854046751-00147; BK9780854046751-00148; BK9780854046751-00149
Record Nr. UNINA-9910826258603321
Cambridge, UK, : Royal Society of Chemistry, 2002
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Multivalency : concepts, research & applications / / edited by Jurriaan Huskens [and three others]
Multivalency : concepts, research & applications / / edited by Jurriaan Huskens [and three others]
Autore Huskens Jurriaan
Edizione [1st edition]
Pubbl/distr/stampa Hoboken, New Jersey : , : Wiley, , 2018
Descrizione fisica 1 online resource (1 volume) : illustrations
Disciplina 541.224
Soggetto topico Valence (Theoretical chemistry)
Multivalent molecules
Soggetto genere / forma Electronic books.
ISBN 1-119-14349-7
1-119-14347-0
1-119-14350-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910270899503321
Huskens Jurriaan  
Hoboken, New Jersey : , : Wiley, , 2018
Materiale a stampa
Lo trovi qui: Univ. Federico II
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The nature of the mechanical bond : from molecules to machines / / Carson J. Bruns, J. Fraser Stoddart ; with a foreword by Professor Jean-Pierre Sauvage and Professor Makoto Fujita
The nature of the mechanical bond : from molecules to machines / / Carson J. Bruns, J. Fraser Stoddart ; with a foreword by Professor Jean-Pierre Sauvage and Professor Makoto Fujita
Autore Bruns Carson J. <1985->
Pubbl/distr/stampa Hoboken, New Jersey : , : Wiley, , 2017
Descrizione fisica 1 online resource (784 p.)
Disciplina 541.224
Soggetto topico Chemical bonds - Mechanical properties
Intermolecular forces
ISBN 1-119-04676-9
1-119-04675-0
1-119-04412-X
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Title Page ; Copyright Page; Contents; Foreword; Preface; Acknowledgments; About the Authors; Abbreviations, Acronyms, and Symbols; Part 1 Introducing Mechanical Bonds ; Chapter 1 An Introduction to the Mechanical Bond ; Conspectus; Introduction; 1.1 The Ubiquity of the Mechanical Bond; 1.1.1 Mechanical Bonds in Nature; 1.1.2 Mechanical Bonds in Art; 1.1.3 Mechanical Bonds in Everyday Life; 1.2 Representing Molecular Mechanical Bonds; 1.2.1 A Historical Perspective; 1.2.2 Perspective Stereoformulas; 1.2.3 Depictions in Color; 1.2.4 Solid-State Portrayals; 1.2.5 Graphical Representations
1.2.6 Technomorphs1.3 Aesthetics of Mechanical Bonds; 1.3.1 Beauty in Diversity; 1.3.2 Topological Beauty; 1.3.3 Architectural Beauty; 1.3.4 Simplicity and Elegance; 1.3.5 Complexity and Emergence; 1.3.6 Beautiful Machines with Mechanical Bonds; 1.3.7 The Art of the Mechanical Bond; 1.4 Evolution of Mechanostereochemistry; References; Part 2 Making Mechanical Bonds ; Chapter 2 The Fundamentals of Making Mechanical Bonds ; Conspectus; Introduction; 2.1 Statistical Synthesis; 2.2 Directed Synthesis; 2.2.1 Covalent Templates; 2.2.2 Covalent-Directed Capture; 2.2.3 The Möbius Approach
2.3 Template-Directed Synthesis2.3.1 Solvophobic Forces; 2.3.2 Transition Metals Templates; 2.3.3 π-Donor/π-Acceptor Templates; 2.3.4 Hydrogen-Bonded Templates; 2.3.5 Halogen-Bonded Templates; 2.3.6 Anion-Binding Templates; 2.3.7 Ion-Pair Templates; 2.3.8 Other Cationic Templates; 2.3.9 Macrocyclic Arenes and Heteroarenes; 2.3.10 Radical-Pair Templates; 2.3.11 Homophilic Templates; 2.3.12 Biomolecular Templates; 2.4 Active Template Synthesis; 2.4.1 Active Copper Templates; 2.4.2 Active Zinc Templates; 2.4.3 Active Palladium Templates; 2.4.4 Active Nickel Templates; Conclusions and Outlook
Chapter 4 Molecular Topologies and Architectures with Mechanical Bonds
Record Nr. UNINA-9910135033203321
Bruns Carson J. <1985->  
Hoboken, New Jersey : , : Wiley, , 2017
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Neutrons in soft matter [Risorsa elettronica] / edited by Toyoko Imae ... [et al.]
Neutrons in soft matter [Risorsa elettronica] / edited by Toyoko Imae ... [et al.]
Autore Imae, Toyoko
Pubbl/distr/stampa Hoboken, N. J. : Wiley, 2011
Disciplina 541.224
Soggetto non controllato Chimica fisica
ISBN 9780470933886
Formato Risorse elettroniche
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-990009789230403321
Imae, Toyoko  
Hoboken, N. J. : Wiley, 2011
Risorse elettroniche
Lo trovi qui: Univ. Federico II
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On chirality and the universal asymmetry : reflections on image and mirror image / / Georges H. Wagnière
On chirality and the universal asymmetry : reflections on image and mirror image / / Georges H. Wagnière
Autore Wagnière Georges Henry <1933->
Pubbl/distr/stampa Zürich, Switzerland : , : Wiley-VCH, , 2007
Descrizione fisica 1 online resource (259 p.)
Disciplina 541.224
Soggetto topico Chirality
Asymmetry (Chemistry)
ISBN 1-281-84281-8
9786611842819
3-906390-59-4
3-906390-60-8
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto On Chirality and the Universal Asymmetry Reflections on Image and Mirror Image; Preface; Contents; Introduction; 1. Image and Mirror Image in Molecules; 1.1. The Homochirality of Life; 1.2. The Discovery of Natural Optical Activity; 1.3. Chirality and the Birth of Stereochemistry; 1.4. Absolute Configuration; 1.5. Asymmetric Synthesis; 2. The Violation of Parity; 2.1. Through the Looking Glass; 2.2. Parity and the Laws of Physics; 2.3. Time Reversal and the CPT Theorem; 2.4. The Selectivity of theWeak Forces; 2.5. Parity Violation in a Nuclear Reaction
2.6. Parity and Selection Rules in Atoms2.7. The Violation of Parity in Atoms; 2.8. The Violation of Parity in Molecules; 2.9. The Interconversion of Enantiomers; 2.10. From Meson Decay to Molecular Homochirality; 3. Light, Magnetism, and Chirality; 3.1. Electromagnetism and Light; 3.2. On the Interaction of Light with Molecules; 3.3. Natural Optical Activity; 3.4. Magnetic Optical Activity; 3.5. The Magnetochiral Effect; 3.6. The Magnetochiral Effect in an Atom; 3.7. The Magnetochiral Effect in Molecular Fluids; 3.8. Magnetochiral Photochemistry; 4. The PT Triangle
4.1. Definition of Chirality4.2. The Triangle of P and T Symmetry; 4.3. The Inverse Magnetochiral Birefringence; 4.4. The Magnetochiral Effect in Electric Conduction; 4.5. Magnetochirodynamics; 5. Journey into Outer Space; 5.1. Remarks on the History of Science; 5.2. The Evolution of the Universe; 5.3. The Birth and Death of Stars; 5.4. Is There a Temporal Evolution of the Basic Symmetries?; 5.5. Galactic and Intergalactic Matter; 5.6. Stellar and Galactic Magnetic Fields; 5.7. The Fractal and Chiral Universe; 6. Return to Earth; 6.1. The Chaotic and Chiral Solar System
6.2. Asymmetry on Earth6.3. Chaos in the Atmosphere; 6.4. Geological and Mineralogical Chirality; 7. Chirality at the Nano- and Micrometer Scale; 7.1. On Chiral Crystals; 7.2. Chirality in Liquid Crystals; 7.3. Chiral Surfaces; 7.4. Chiral Carbon Nanotubes; 7.5. Observing Vortices; 8. Chiral Models; 8.1. The Use of Models for the Description of Nature; 8.2. Dissecting a Cube and a Sphere; 8.3. From Dihedral Angles to the Classification of Knots; 8.4. From Ligand Partitions to Chirality Functions; 8.5. Sector Rules to Interpret CD and ORD Spectra; 8.6. From Helices to Möbius Strips
8.7. Coupled and Asymmetric Classical Harmonic Oscillators8.8. An Early Quantum-Mechanical Model; 8.9. Are There Absolute Measures of Chirality?; 8.10. On Multipole Expansions; 8.11. Magnetochiral Scattering of Light; 9. Pathways to Homochirality; 9.1. Chiral Intermolecular Interactions; 9.2. Enantioselectivity at Phase Boundaries; 9.3. Enantioselective Adsorption on Chiral Surfaces; 9.4. Chiral Chromatography; 9.5. Enantioselectivity by Achiral Chromatography; 9.6. Enantiomeric Excess by Chiral Catalysis; 9.7. Homochiral Polymerization: Oligopeptides
9.8. Homochiral Polymerization: Polypeptides
Record Nr. UNINA-9910144111603321
Wagnière Georges Henry <1933->  
Zürich, Switzerland : , : Wiley-VCH, , 2007
Materiale a stampa
Lo trovi qui: Univ. Federico II
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On chirality and the universal asymmetry : reflections on image and mirror image / / Georges H. Wagnière
On chirality and the universal asymmetry : reflections on image and mirror image / / Georges H. Wagnière
Autore Wagnière Georges Henry <1933->
Pubbl/distr/stampa Zürich, Switzerland : , : Wiley-VCH, , 2007
Descrizione fisica 1 online resource (259 p.)
Disciplina 541.224
Soggetto topico Chirality
Asymmetry (Chemistry)
ISBN 1-281-84281-8
9786611842819
3-906390-59-4
3-906390-60-8
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto On Chirality and the Universal Asymmetry Reflections on Image and Mirror Image; Preface; Contents; Introduction; 1. Image and Mirror Image in Molecules; 1.1. The Homochirality of Life; 1.2. The Discovery of Natural Optical Activity; 1.3. Chirality and the Birth of Stereochemistry; 1.4. Absolute Configuration; 1.5. Asymmetric Synthesis; 2. The Violation of Parity; 2.1. Through the Looking Glass; 2.2. Parity and the Laws of Physics; 2.3. Time Reversal and the CPT Theorem; 2.4. The Selectivity of theWeak Forces; 2.5. Parity Violation in a Nuclear Reaction
2.6. Parity and Selection Rules in Atoms2.7. The Violation of Parity in Atoms; 2.8. The Violation of Parity in Molecules; 2.9. The Interconversion of Enantiomers; 2.10. From Meson Decay to Molecular Homochirality; 3. Light, Magnetism, and Chirality; 3.1. Electromagnetism and Light; 3.2. On the Interaction of Light with Molecules; 3.3. Natural Optical Activity; 3.4. Magnetic Optical Activity; 3.5. The Magnetochiral Effect; 3.6. The Magnetochiral Effect in an Atom; 3.7. The Magnetochiral Effect in Molecular Fluids; 3.8. Magnetochiral Photochemistry; 4. The PT Triangle
4.1. Definition of Chirality4.2. The Triangle of P and T Symmetry; 4.3. The Inverse Magnetochiral Birefringence; 4.4. The Magnetochiral Effect in Electric Conduction; 4.5. Magnetochirodynamics; 5. Journey into Outer Space; 5.1. Remarks on the History of Science; 5.2. The Evolution of the Universe; 5.3. The Birth and Death of Stars; 5.4. Is There a Temporal Evolution of the Basic Symmetries?; 5.5. Galactic and Intergalactic Matter; 5.6. Stellar and Galactic Magnetic Fields; 5.7. The Fractal and Chiral Universe; 6. Return to Earth; 6.1. The Chaotic and Chiral Solar System
6.2. Asymmetry on Earth6.3. Chaos in the Atmosphere; 6.4. Geological and Mineralogical Chirality; 7. Chirality at the Nano- and Micrometer Scale; 7.1. On Chiral Crystals; 7.2. Chirality in Liquid Crystals; 7.3. Chiral Surfaces; 7.4. Chiral Carbon Nanotubes; 7.5. Observing Vortices; 8. Chiral Models; 8.1. The Use of Models for the Description of Nature; 8.2. Dissecting a Cube and a Sphere; 8.3. From Dihedral Angles to the Classification of Knots; 8.4. From Ligand Partitions to Chirality Functions; 8.5. Sector Rules to Interpret CD and ORD Spectra; 8.6. From Helices to Möbius Strips
8.7. Coupled and Asymmetric Classical Harmonic Oscillators8.8. An Early Quantum-Mechanical Model; 8.9. Are There Absolute Measures of Chirality?; 8.10. On Multipole Expansions; 8.11. Magnetochiral Scattering of Light; 9. Pathways to Homochirality; 9.1. Chiral Intermolecular Interactions; 9.2. Enantioselectivity at Phase Boundaries; 9.3. Enantioselective Adsorption on Chiral Surfaces; 9.4. Chiral Chromatography; 9.5. Enantioselectivity by Achiral Chromatography; 9.6. Enantiomeric Excess by Chiral Catalysis; 9.7. Homochiral Polymerization: Oligopeptides
9.8. Homochiral Polymerization: Polypeptides
Record Nr. UNINA-9910830819803321
Wagnière Georges Henry <1933->  
Zürich, Switzerland : , : Wiley-VCH, , 2007
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Principles of free radical biomedicine [[electronic resource] ] . Volume I / / Kostas Pantopoulos and Hyman M. Schipper, editors
Principles of free radical biomedicine [[electronic resource] ] . Volume I / / Kostas Pantopoulos and Hyman M. Schipper, editors
Pubbl/distr/stampa New York, : Nova Biomedical Books, 2012
Descrizione fisica 1 online resource (330 p.)
Disciplina 541.224
Altri autori (Persone) PantopoulosKostas
SchipperHyman M
Collana Biochemistry research trends
Principles of free radical biomedicine
Soggetto topico Free radicals (Chemistry)
Free radical reactions
Soggetto genere / forma Electronic books.
ISBN 1-62081-778-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910453204403321
New York, : Nova Biomedical Books, 2012
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Principles of free radical biomedicine [[electronic resource] ] . Volume I / / Kostas Pantopoulos and Hyman M. Schipper, editors
Principles of free radical biomedicine [[electronic resource] ] . Volume I / / Kostas Pantopoulos and Hyman M. Schipper, editors
Pubbl/distr/stampa New York, : Nova Biomedical Books, 2012
Descrizione fisica 1 online resource (330 p.)
Disciplina 541.224
Altri autori (Persone) PantopoulosKostas
SchipperHyman M
Collana Biochemistry research trends
Principles of free radical biomedicine
Soggetto topico Free radicals (Chemistry)
Free radical reactions
ISBN 1-62081-778-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910779603103321
New York, : Nova Biomedical Books, 2012
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Principles of free radical biomedicine [[electronic resource] ] . Volume I / / Kostas Pantopoulos and Hyman M. Schipper, editors
Principles of free radical biomedicine [[electronic resource] ] . Volume I / / Kostas Pantopoulos and Hyman M. Schipper, editors
Edizione [1st ed.]
Pubbl/distr/stampa New York, : Nova Biomedical Books, 2012
Descrizione fisica 1 online resource (330 p.)
Disciplina 541.224
Altri autori (Persone) PantopoulosKostas
SchipperHyman M
Collana Biochemistry research trends
Principles of free radical biomedicine
Soggetto topico Free radicals (Chemistry)
Free radical reactions
ISBN 1-62081-778-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Intro -- PRINCIPLES OF FREE RADICAL BIOMEDICINE -- PRINCIPLES OF FREE RADICAL BIOMEDICINE -- Contents -- Preface -- Acknowledgments -- The Evolution of Oxidative Stress -- 1. Introduction -- 2. The Origin and Significance of Chemiosmotic Coupling -- 3. The Origin and Consequences of an Oxygen Atmosphere -- 4. Oxidative Stress and the Chimeric Origin of Eukaryotes -- 5. Why Oxidative Stress Is Central to the Evolution of Eukaryotes -- References -- Oxygen Radicals and Related Species -- 1. Introduction : Oxygen and its Metabolites Imprinted the Evolution of Life -- 2. Molecular Oxygen, a Sluggish Oxidant -- 3. Producer of Reactive Species -- 3. Free Radicals in Biology: An Historical Account -- 4. Oxygen Radicals and Related Species: General Aspects of the Reactivity of One- and Two-electron Oxidants -- 5. Chemistry of Biologically Relevant Oxygen-Derived Radicals -- 5.1. Superoxide (O2●-) and Hydroperoxyl (HO2●-) Radical -- 5.2. Hydroxyl Radical (HO●) -- 5.3. Carbonate Radical (CO3●-) -- 5.4. Peroxyl(ROO●) and Alkoxyl (RO●) Radicals -- 6. Chemistry of Biologically Relevant Non-radical Oxygen Species -- 6.1. Hydrogen Peroxide (H2O2) -- 6.2. Hypochlorous acid (HOCl) and Related Species -- 6.3. Singlet Molecular Oxygen (1O2) -- 6.4. Organic Hydroperoxides from Biomolecules -- 6.5. Ozone (O3) -- Conclusions -- Acknowledgments -- References -- Nitric Oxide and Derived Oxidants -- Introduction -- 2. Chemistry of Nitric Oxide and Related Nitrogen Species -- 3. Nitric Oxide -- 3.1. Formation and Signaling Actions -- 3.2. Chemical and Physico-chemical Properties of Nitric Oxide -- 3.3. Reaction Chemistry -- 4. Nitrogen Dioxide -- 4.1. Formation -- 4.2. Chemical Properties -- 4.3. Reaction Chemistry -- 5. Peroxynitrite -- 5.1. Formation -- 5.2. Chemical Properties -- 5.3. Reaction Chemistry -- 6. Nitrite and Nitrate.
7. Dinitrogen Trioxide and Dinitrogen Tetraoxide -- 8. Nitryl Chloride -- 9. Diffusion of Reactive Nitrogen Species in Biological Systems -- 10. Reactivity of Nitric Oxide and Derived Oxidants with Selected Biomolecules -- 10.1. Metal Centers: Nitrosylation and Redox Reactions -- 10.2. Thiols: S-nitrosylation and Oxidation Reactions -- 10.3. Tyrosine: Nitration and other Oxidation Reactions -- 10.4. Reaction of Reactive Nitrogen Species with other Amino Acids -- 10.5. Lipids -- 10.6. Sugars -- 10.7. Nitrogen Bases -- 10.8. Low Molecular Weight Antioxidants -- Conclusions -- Acknowledgments -- References -- Sulfur-centered Radicals -- 1. Introduction -- 2. Formation of Thiyl and Perthiyl Radicals -- 3. Reactions of Thiyl Radicals -- 4. Reactions of Perthiyl Radicals -- 5. Formation of Met Radical Cations -- 6. Reactions of Met Radical Cations -- Conclusions -- Acknowledgment -- References -- Redox-Active Metals: Iron and Copper -- 1. Introduction -- 2. Redox Active Iron and Copper In Vivo -- 3. Biological Oxidants -- 4. Redox Chemistry and Biochemistry of Iron: The Historical Context -- 5. Biological Relevance of the Fenton Reaction -- 6. Cautionary Remarks -- Conclusions -- References -- Protein Oxidation -- 1. Introduction: Why does Protein Damage Matter? -- 2. How does Damage Occur? -- 3. Chemistry of Protein Oxidation -- 3.1. Backbone Damage -- 3.2. Aliphatic Residues -- 3.3. Carbonylated Proteins -- 3.4. Oxidation of Sulfur Centers -- 3.5. Oxidation of Aromatic Residues -- 4. Oxidative Modifications of Amino Acid Residues due to RNS -- 4.1. 3-Nitrotyrosine -- 5. Reactions of Relevant Oxidants -- 5.1. Hydroxyl Radical -- 5.2. Superoxide Anion Radical and Hydrogen Peroxide -- 5.3. Hypochlorite -- 5.4. Chloramines -- 6. Protein Aggregation due to Oxidation -- 7. Repair of Protein Damage -- 7.1. Methione Sulfoxide Reductase.
7.2. Thioredoxin/thioredoxin Reductase System -- 7.3. Protein Disulfide Isomerase -- 8. Degradation of Oxidatively Damaged Proteins -- 8.1. The Proteasomal System -- 8.2. The Lysosomal System -- 9. Detection of Protein Damage -- 9.1. Protein Carbonyls -- 9.2. Protein Thiol Groups -- 9.3. Protein-bound Nitrotyrosine -- Conclusions -- References -- Lipid Peroxidation -- Abbreviations -- 1. Introduction -- 2. Origin and Physiological Role of PUFAs -- 3. Lipid Peroxidation in Cellular Membranes -- 4. Mechanisms of Lipid Peroxidation -- 5. Enzymatic Lipid Peroxidation by Lipoxygenases -- 6. Non-enzymatic Lipid Peroxidation -- 7. Peroxidation Products of Membrane Phospholipids -- 8. Generation of Oxidized Phospholipids by Lipid Peroxidation -- 9. Generation of Hydroxy-alkenals by Lipid Peroxidation of n-3 and n-6 PUFAs -- 10. Biomarkers of Lipid Peroxidation: Isoprostanes, Isofurans and Neuroprostanes -- 11. Analytical Methods for Studying Lipid Peroxidation in Membranes -- 12. Covalent Modification of Proteins and Amino-phospholipids by Lipid Peroxidation Products -- 13. Damage of Cellular Membranes by Lipid Peroxidation -- 14. In Vivo Reactivity of Hydroxy-Alkenals -- 15. 4-HNE Regulates Mitochondrial Uncoupling -- 16. Hydroxy-alkenals as Second Messengers -- Conclusions -- Acknowledgments -- References -- Lipid Nitration -- Introduction -- 2. Nitration of Biomolecules -- 3. Biological Aspects and Distribution of Unsaturated Fatty Acids -- 4. Nitration Chemistry in Hydrophobic Compartments -- 5. Mechanisms of Fatty Acid nitration -- 5.1. Nitric Oxide-dependent Mechanisms -- 5.2. Nitrogen Dioxide-dependent Mechanisms -- 5.3. Peroxynitrite-dependent Mechanisms -- 6. Biochemical Characterization of Nitro-fatty Acids -- 7. Biological Stability of Nitro-fatty Acids: NO-donor Properties and Post-translational Modification of Proteins.
8. Metabolic Fate of Nitro-fatty Acids -- 9. Cell Signaling and Anti-inflammatory Properties of Nitrated Lipids -- 9.1. Inhibition of Inflammatory Cell Function -- 9.2. Modulation of Transcription Factors -- 10. In Vivo Detection of Nitrosyl-fatty Acids: Current Knowledge, Challenges and Potential Pitfalls -- Conclusions -- Acknowledgments -- References -- DNA Oxidation -- 1. Introduction -- 2. Oxidation of DNA Components by Free Radicals: Mechanistic Aspects of Formation of Single Lesions -- 2.1. One Electron and HO-mediated Formation of DNA Lesions -- 2.2. Thymine -- 2.3. Cytosine -- 2.4. Guanine -- 2.5. Adenine -- 2.6. Singlet Oxygen-mediated DNA Oxidation -- 3. Complex DNA Lesions Generated by a Single Oxidation Event -- 3.1. DNA-protein Cross-links -- 3.2. Complex Lesions Arising from Sugar Oxidation -- 3.3. Tandem DNA Lesions -- 4. Method for Measuring Oxidative DNA Lesions in Cells -- 4.1. Direct Approaches -- 4.2. Indirect Approaches -- Conclusions -- References -- Methods of Investigation of Selected Radical Oxygen/Nitrogen Species in Cell-free and Cellular Systems -- 1. Introduction -- 2. General Principles of the Detection of Free Radicals in Chemical and Biological Systems -- 2.1. Methods of Investigation of Free Radicals -- 2.2. Probes for Free Radical Detection -- Spectrophotometric Probes -- Chemiluminescent Probes -- Fluorogenic Probes -- EPR Spin Traps and Probes -- The Properties of the Ideal Probe -- Reactivity of the Intermediates of the Reaction between the Probe and Radical R -- 2.3. Radical Footprints -- 2.4. Scavengers and Inhibitors -- 3. Methods of Generation and Detection of Selected Free Radicals -- 3.1. General Considerations -- 3.1.1. Methods of Free Radical Generation -- 3.1.1.1. Pulse Methods -- Pulse Radiolysis -- Laser Flash Photolysis -- Stopped Flow -- 3.1.1.2. Steady-state Methods.
a) Chemical (thermal) Generation of the Radicals -- b) Enzymatic Generation of the Radicals -- c) Radiation-chemical and Photolytic Generation -- 3.1.2. Principles of the Analytical Methods of Radical Detection -- Electron Paramagnetic Resonance (EPR) -- UV-Vis Absorption Spectroscopy -- Fluorescence Spectroscopy -- High Performance Liquid Chromatography (HPLC) -- 3.2. Superoxide Radical Anion (O2-) -- 3.2.1. Physicochemical Properties -- 3.2.2. Generation -- 3.2.2.1. Cell-free Systems -- Solutions of O2- in Aprotic Solvents -- Thermal Sources of Superoxide -- Radiolytic Generation of Superoxide -- Enzymatic Generation of Superoxide -- 3.2.2.2. Cellular Systems -- 3.2.3. Detection -- Ferricytochrome C Assay -- EPR Spin-trapping -- Measurement of Intracellular O2- Production -- Hydroethidine Assay -- Aconitase Inactivation Assay -- Other Assays for Intracellular Superoxide -- 3.2.4. Inhibitors of O2- Production and O2- Scavengers -- 3.3. Nitric Oxide (NO) -- 3.3.1. Physicochemical Properties -- 3.3.2. Generation -- 3.3.2.1. Cell-free Systems -- 3.3.2.2. Biological Systems -- 3.3.3. Detection -- 3.3.3.1. Cell-free Systems -- Electrochemical Detection -- Chemiluminescence Detection -- Oxyhemoglobin Assay -- Assays Based on Fluorescent Aromatic Triazole Formation -- EPR Spin-trapping -- Griess Assay for Nitrite Anion -- 3.3.3.2. Biological Systems -- 3.3.4. Inhibitors and Scavengers -- 3.4. Nitrogen Dioxide (NO2) -- 3.4.1. Physicochemical Properties -- 3.4.2. Generation -- 3.4.2.1. Cell-free Systems -- 3.4.2.2. Biological Systems -- 3.4.3. Detection -- 3.4.3.1. Cell-free Systems -- 3.4.3.2. Biological Systems -- 3.4.4. Inhibitors and Scavengers -- 3.5. Carbonate Radical Anion (CO3-) -- 3.5.1. Physicochemical Properties -- 3.5.2. Generation -- 3.5.2.1. Cell-free Systems -- 3.5.2.2. Biological Systems -- 3.5.3. Detection.
3.5.3.1. Cell-free Systems.
Record Nr. UNINA-9910818921503321
New York, : Nova Biomedical Books, 2012
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