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Medicinal chemistry for practitioners / / Jie Jack Li
| Medicinal chemistry for practitioners / / Jie Jack Li |
| Autore | Li Jie Jack |
| Pubbl/distr/stampa | Hoboken, NJ : , : Wiley, , 2020 |
| Descrizione fisica | 1 online resource (408 pages) |
| Disciplina | 615.19 |
| Soggetto topico | Pharmaceutical chemistry |
| ISBN |
1-119-60730-2
1-119-60727-2 1-119-60731-0 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Drug targets -- Hit/lead discovery -- Pharmacokinetics (ADME) -- Introduction to bioisosteres -- Structural alerts for toxicity. |
| Record Nr. | UNINA-9910810298803321 |
Li Jie Jack
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| Hoboken, NJ : , : Wiley, , 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Modern organic synthesis in the laboratory [[electronic resource] ] : a collection of standard experimental procedures / / Jie Jack Li, Derek A. Pflum, and Chris Limberakis
| Modern organic synthesis in the laboratory [[electronic resource] ] : a collection of standard experimental procedures / / Jie Jack Li, Derek A. Pflum, and Chris Limberakis |
| Autore | Li Jie Jack |
| Pubbl/distr/stampa | New York, : Oxford University Press, 2007 |
| Descrizione fisica | 1 online resource (219 p.) |
| Disciplina | 547/.2078 |
| Altri autori (Persone) |
PflumDerek A
LimberakisChris |
| Collana | Oxford scholarship online |
| Soggetto topico |
Organic compounds - Synthesis
Chemistry, Organic |
| Soggetto genere / forma | Electronic books. |
| ISBN |
0-19-756237-X
1-281-16267-1 9786611162672 0-19-804063-6 1-4356-0954-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Foreword; Abbreviations and Acronyms; 1 Fundamental Techniques; 1.1 Safety!; 1.2 Useful Preparations; 1.3 Chromatography; 1.4 Crystallization; 1.5 Residual Solvent Peaks in Nuclear Magnetic Resonance; 2 Functional Group Manipulations; 2.1 Alcohol Oxidation State; 2.2 Ketone Oxidation State; 2.3 Acid Oxidation State; 3 Oxidation; 3.1 Alcohol to Ketone Oxidation State; 3.2 Alcohol to Acid Oxidation State; 3.3 Olefin to Diol; 3.4 Aldehyde to Acid Oxidation State; 3.5 Heteroatom Oxidations; 4 Reductions; 4.1 Alcohols to Alkanes; 4.2 Aldehydes, Amides, and Nitriles to Amines
4.3 Carboxylic Acids and Derivatives to Alcohols4.4 Esters and Other Carboxylic Acid Derivatives to Aldehydes; 4.5 Ketones or Aldehydes to Alcohols; 4.6 Ketones to Alkanes or Alkenes; 4.7 Reductive Dehalogenations; 4.8 Carbon-Carbon Double and Triple Bond Reductions; 4.9 Heteroatom-Heteroatom Reductions; 5 Carbon-Carbon Bond Formation; 5.1 Carbon-Carbon Forming Reactions (Single Bonds); 5.2 Carbon-Carbon Double Bonds (Olefin Formation); 5.3 Reactions that Form Multiple Carbon-Carbon Bonds; 6 Protecting Groups; 6.1 Alcohols and Phenols; 6.2 Amines and Anilines; 6.3 Aldehydes and Ketones; Index AB; C; D; E; F; G; H; I; J; K; L; M; N; O; P; Q; R; S; T; U; V; W; Y; Z |
| Record Nr. | UNINA-9910452154503321 |
|
Li Jie Jack
|
||
| New York, : Oxford University Press, 2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Modern organic synthesis in the laboratory [[electronic resource] ] : a collection of standard experimental procedures / / Jie Jack Li, Derek A. Pflum, and Chris Limberakis
| Modern organic synthesis in the laboratory [[electronic resource] ] : a collection of standard experimental procedures / / Jie Jack Li, Derek A. Pflum, and Chris Limberakis |
| Autore | Li Jie Jack |
| Pubbl/distr/stampa | New York, : Oxford University Press, 2007 |
| Descrizione fisica | 1 online resource (219 p.) |
| Disciplina | 547/.2078 |
| Altri autori (Persone) |
PflumDerek A
LimberakisChris |
| Collana | Oxford scholarship online |
| Soggetto topico |
Organic compounds - Synthesis
Chemistry, Organic |
| ISBN |
0-19-988489-7
0-19-756237-X 1-281-16267-1 9786611162672 0-19-804063-6 1-4356-0954-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Foreword; Abbreviations and Acronyms; 1 Fundamental Techniques; 1.1 Safety!; 1.2 Useful Preparations; 1.3 Chromatography; 1.4 Crystallization; 1.5 Residual Solvent Peaks in Nuclear Magnetic Resonance; 2 Functional Group Manipulations; 2.1 Alcohol Oxidation State; 2.2 Ketone Oxidation State; 2.3 Acid Oxidation State; 3 Oxidation; 3.1 Alcohol to Ketone Oxidation State; 3.2 Alcohol to Acid Oxidation State; 3.3 Olefin to Diol; 3.4 Aldehyde to Acid Oxidation State; 3.5 Heteroatom Oxidations; 4 Reductions; 4.1 Alcohols to Alkanes; 4.2 Aldehydes, Amides, and Nitriles to Amines
4.3 Carboxylic Acids and Derivatives to Alcohols4.4 Esters and Other Carboxylic Acid Derivatives to Aldehydes; 4.5 Ketones or Aldehydes to Alcohols; 4.6 Ketones to Alkanes or Alkenes; 4.7 Reductive Dehalogenations; 4.8 Carbon-Carbon Double and Triple Bond Reductions; 4.9 Heteroatom-Heteroatom Reductions; 5 Carbon-Carbon Bond Formation; 5.1 Carbon-Carbon Forming Reactions (Single Bonds); 5.2 Carbon-Carbon Double Bonds (Olefin Formation); 5.3 Reactions that Form Multiple Carbon-Carbon Bonds; 6 Protecting Groups; 6.1 Alcohols and Phenols; 6.2 Amines and Anilines; 6.3 Aldehydes and Ketones; Index AB; C; D; E; F; G; H; I; J; K; L; M; N; O; P; Q; R; S; T; U; V; W; Y; Z |
| Record Nr. | UNINA-9910778101803321 |
|
Li Jie Jack
|
||
| New York, : Oxford University Press, 2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Modern organic synthesis in the laboratory : a collection of standard experimental procedures / / Jie Jack Li, Derek A. Pflum, and Chris Limberakis
| Modern organic synthesis in the laboratory : a collection of standard experimental procedures / / Jie Jack Li, Derek A. Pflum, and Chris Limberakis |
| Autore | Li Jie Jack |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | New York, : Oxford University Press, 2007 |
| Descrizione fisica | 1 online resource (219 p.) |
| Disciplina | 547/.2078 |
| Altri autori (Persone) |
PflumDerek A
LimberakisChris |
| Collana | Oxford scholarship online |
| Soggetto topico |
Organic compounds - Synthesis
Chemistry, Organic |
| ISBN |
0-19-988489-7
0-19-756237-X 1-281-16267-1 9786611162672 0-19-804063-6 1-4356-0954-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Foreword; Abbreviations and Acronyms; 1 Fundamental Techniques; 1.1 Safety!; 1.2 Useful Preparations; 1.3 Chromatography; 1.4 Crystallization; 1.5 Residual Solvent Peaks in Nuclear Magnetic Resonance; 2 Functional Group Manipulations; 2.1 Alcohol Oxidation State; 2.2 Ketone Oxidation State; 2.3 Acid Oxidation State; 3 Oxidation; 3.1 Alcohol to Ketone Oxidation State; 3.2 Alcohol to Acid Oxidation State; 3.3 Olefin to Diol; 3.4 Aldehyde to Acid Oxidation State; 3.5 Heteroatom Oxidations; 4 Reductions; 4.1 Alcohols to Alkanes; 4.2 Aldehydes, Amides, and Nitriles to Amines
4.3 Carboxylic Acids and Derivatives to Alcohols4.4 Esters and Other Carboxylic Acid Derivatives to Aldehydes; 4.5 Ketones or Aldehydes to Alcohols; 4.6 Ketones to Alkanes or Alkenes; 4.7 Reductive Dehalogenations; 4.8 Carbon-Carbon Double and Triple Bond Reductions; 4.9 Heteroatom-Heteroatom Reductions; 5 Carbon-Carbon Bond Formation; 5.1 Carbon-Carbon Forming Reactions (Single Bonds); 5.2 Carbon-Carbon Double Bonds (Olefin Formation); 5.3 Reactions that Form Multiple Carbon-Carbon Bonds; 6 Protecting Groups; 6.1 Alcohols and Phenols; 6.2 Amines and Anilines; 6.3 Aldehydes and Ketones; Index AB; C; D; E; F; G; H; I; J; K; L; M; N; O; P; Q; R; S; T; U; V; W; Y; Z |
| Record Nr. | UNINA-9910813204903321 |
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Li Jie Jack
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| New York, : Oxford University Press, 2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Name reactions : a collection of detailed mechanisms and synthetic applications / / Jie Jack Li
| Name reactions : a collection of detailed mechanisms and synthetic applications / / Jie Jack Li |
| Autore | Li Jie Jack |
| Edizione | [Sixth edition.] |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2021] |
| Descrizione fisica | 1 online resource (XXII, 601 p. 1660 illus., 524 illus. in color.) |
| Disciplina | 541.39 |
| Soggetto topico | Chemical reactions |
| ISBN | 3-030-50865-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | From the Contents: Alder ene reaction -- Baran Reagents -- Bargellini Reaction -- Barton–Zard reaction -- Beirut reaction -- Boyland–Sims oxidation -- Cattallani Reaction -- Danheiser annulation -- Kolbe-Schmitt Reaction -- Larock Indole Synthesis -- Li A3 Reaction -- McMillan Catalyst -- Meth-Cohn Quinoline Synthesis -- Sanford Reaction -- Shi-White Reagent -- Stevens Rearrangement -- Stork–Danheiser alkylation -- Weinreb Amide -- Yu C-H Activation -- Zaitsev Elimination -- Zinin Benzidine Rearrangement (Semidine Rearrangement). |
| Record Nr. | UNINA-9910484662003321 |
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Li Jie Jack
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| Cham, Switzerland : , : Springer, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Name Reactions : A Collection of Detailed Mechanisms and Synthetic Applications Fifth Edition / / by Jie Jack Li
| Name Reactions : A Collection of Detailed Mechanisms and Synthetic Applications Fifth Edition / / by Jie Jack Li |
| Autore | Li Jie Jack |
| Edizione | [5th ed. 2014.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2014 |
| Descrizione fisica | 1 online resource (XXII, 681 p. 1729 illus., 15 illus. in color.) |
| Disciplina | 546 |
| Soggetto topico |
Organic chemistry
Inorganic chemistry Biochemistry Organic Chemistry Inorganic Chemistry Biochemistry, general |
| ISBN | 3-319-03979-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | From the Contents: Alder ene reaction -- Baran Reagents -- Bargellini Reaction -- Barton–Zard reaction -- Beirut reaction -- Boyland–Sims oxidation -- Cattallani Reaction -- Danheiser annulation -- Kolbe-Schmitt Reaction -- Larock Indole Synthesis -- Li A3 Reaction -- McMillan Catalyst -- Meth-Cohn Quinoline Synthesis -- Sanford Reaction -- Shi-White Reagent -- Stevens Rearrangement -- Stork–Danheiser alkylation -- Weinreb Amide -- Yu C-H Activation -- Zaitsev Elimination -- Zinin Benzidine Rearrangement (Semidine Rearrangement). |
| Record Nr. | UNINA-9910298649203321 |
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Li Jie Jack
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| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Palladium in Heterocyclic Chemistry [[electronic resource] ] : A Guide for the Synthetic Chemist
| Palladium in Heterocyclic Chemistry [[electronic resource] ] : A Guide for the Synthetic Chemist |
| Autore | Li Jie Jack |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Burlington, : Elsevier Science, 2006 |
| Descrizione fisica | 1 online resource (660 p.) |
| Disciplina | 547/.590459 |
| Altri autori (Persone) | GribbleGordon W |
| Collana | Tetrahedron organic chemistry series |
| Soggetto topico |
Heterocyclic compounds -- Synthesis
Heterocyclic compounds Organopalladium compounds |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-283-73488-5
0-08-091441-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Cover; I045116-FM; I045116-01; I045116-02; I045116-03; I045116-04; I045116-05; I045116-06; I045116-07; I045116-08; I045116-09; I045116-10; I045116-11; I045116-12; I045116-13; I045116-14; I045116-Idx |
| Record Nr. | UNINA-9910459983803321 |
|
Li Jie Jack
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| Burlington, : Elsevier Science, 2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Palladium in Heterocyclic Chemistry [[electronic resource] ] : A Guide for the Synthetic Chemist
| Palladium in Heterocyclic Chemistry [[electronic resource] ] : A Guide for the Synthetic Chemist |
| Autore | Li Jie Jack |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Burlington, : Elsevier Science, 2006 |
| Descrizione fisica | 1 online resource (660 p.) |
| Disciplina | 547/.590459 |
| Altri autori (Persone) | GribbleGordon W |
| Collana | Tetrahedron organic chemistry series |
| Soggetto topico |
Heterocyclic compounds -- Synthesis
Heterocyclic compounds Organopalladium compounds |
| ISBN |
1-283-73488-5
0-08-091441-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Cover; I045116-FM; I045116-01; I045116-02; I045116-03; I045116-04; I045116-05; I045116-06; I045116-07; I045116-08; I045116-09; I045116-10; I045116-11; I045116-12; I045116-13; I045116-14; I045116-Idx |
| Record Nr. | UNINA-9910785570303321 |
|
Li Jie Jack
|
||
| Burlington, : Elsevier Science, 2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Palladium in Heterocyclic Chemistry : A Guide for the Synthetic Chemist
| Palladium in Heterocyclic Chemistry : A Guide for the Synthetic Chemist |
| Autore | Li Jie Jack |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Burlington, : Elsevier Science, 2006 |
| Descrizione fisica | 1 online resource (660 p.) |
| Disciplina |
547/.590459
547.05636 |
| Altri autori (Persone) | GribbleGordon W |
| Collana | Tetrahedron organic chemistry series |
| Soggetto topico |
Heterocyclic compounds -- Synthesis
Heterocyclic compounds Organopalladium compounds |
| ISBN |
1-283-73488-5
0-08-091441-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Cover; I045116-FM; I045116-01; I045116-02; I045116-03; I045116-04; I045116-05; I045116-06; I045116-07; I045116-08; I045116-09; I045116-10; I045116-11; I045116-12; I045116-13; I045116-14; I045116-Idx |
| Record Nr. | UNINA-9910809271203321 |
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Li Jie Jack
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||
| Burlington, : Elsevier Science, 2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Top drugs : history, pharmacology, syntheses / / Jie Jack Li
| Top drugs : history, pharmacology, syntheses / / Jie Jack Li |
| Autore | Li Jie Jack |
| Pubbl/distr/stampa | New York, New York : , : Oxford University Press, , 2015 |
| Descrizione fisica | 1 online resource (219 p.) |
| Disciplina | 615.1 |
| Collana | Oxford scholarship online |
| Soggetto topico |
Drugs - History
Drugs - Design Pharmaceutical chemistry |
| Soggetto genere / forma | Electronic books. |
| ISBN |
0-19-756291-4
0-19-936260-2 0-19-936259-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Top Drugs History, Pharmacology, and Syntheses; Copyright; Dedication; Contents; Preface; Cardiovascular Drugs; Chapter 1: Atorvastatin Calcium (Lipitor); 1 HISTORY; 2 PHARMACOLOGY; 2.1 Mechanism of Action; 2.2 Structure-Activity Relationship; 2.3 Bioavailability, Metabolism, and Toxicology; 3 SYNTHESIS; 3.1 Discovery Route; 3.2 Process Route; 4 CONCLUDING REMARKS; 5 REFERENCES; Chapter 2: Clopidogrel Bisulfate (Plavix); 1 HISTORY; 2 PHARMACOLOGY; 2.1 Bioavailability, Metabolism, and Toxicology; 2.2 Mechanism of Action; 2.3 Structure-Activity Relationship; 3 SYNTHESIS
3.1 Discovery Route3.2 Process Route; 3.3 Synthesis of Radio-labeled API; 4 CONCLUDING REMARKS; 5 REFERENCES; Chapter 3: Amlodipine (Novasc); 1 HISTORY; 2 PHARMACOLOGY; 2.1 Mechanism of Action; 2.2 Structure-Activity Relationship; 2.3 Bioavailability, Metabolism, and Toxicology; 3 SYNTHESIS; 3.1 Discovery Route; 3.2 Process Route; 4 CONCLUDING REMARKS; 5 REFERENCES; Cancer Drugs; Chapter 4: Paclitaxel (Taxol); 1 HISTORY; 2 PHARMACOLOGY; 2.1 Mechanism of Action; 2.2 Structure-Activity Relationship; 2.3 Bioavailability, Metabolism, and Toxicology; 3 PROCESS SEMI-SYNTHESIS; 4 TOTAL SYNTHESIS 4.1 Holton's Synthesis4.2 Nicolaou's Synthesis; 4.3 Danishefsky's Synthesis; 4.4 Wender's Synthesis; 5 CONCLUDING REMARKS; 6 REFERENCES; Chapter 5: Imatinib Mesylate (Gleevec); 1 HISTORY; 1.1 A Brief History of Cancer Drugs; 1.2 Treatments of Chronic Myeloid Leukemia; 1.3 Protein Kinase Inhibitors; 1.4 Genesis of Gleevec; 2 PHARMACOLOGY; 2.1 Mechanism of Action; 2.2 Structure-Activity Relationship; 2.3 Bioavailability, Metabolism, and Toxicology; 3 SYNTHESIS; 3.1 Discovery Synthesis; 3.2 Process Synthesis; 4 CONCLUDING REMARKS; 5 REFERENCES; Drugs for Metabolic Diseases Chapter 6: Sitagliptin (Januvia)1 HISTORY OF DIABETES AND DIABETIC DRUGS; 1.1 Sulfonylureas; 1.2. Biguanides; 1.3 PPARγ Agonists ; 2 PHARMACOLOGY; 2.1 Mechanism of Action ; 2.2 Structure-Activity Relationship; 2.3 Bioavailability, Metabolism, and Toxicology; 3 SYNTHESES; 3.1 Discovery Synthesis; 3.2 Process/Manufacturing Synthesis; 4 CONCLUDING REMARKS; 5 REFERENCES; CNS Drugs; Chapter 7: Duloxetine Hydrochloride (Cymbalta) ; 1 HISTORY OF DEPRESSION AND ANTIDEPRESSANTS; 1.1 Monoamine Oxidase Inhibitors; 1.2 Tricyclic Antidepressants; 1.3 Selective Serotonin Reuptake Inhibitors 1.4 Serotonin and Norepinephrine Reuptake Inhibitors2 PHARMACOLOGY; 2.1 Mechanism of Action; 2.2 Structure-Activity Relationship; 2.3 Bioavailability, Metabolism, and Toxicology ; 3 SYNTHESIS; 3.1 Discovery Route; 3.2 Process Route; 4 CONCLUDING REMARKS; 5 REFERENCES; Chapter 8: Olanzapine (Zyprexa) ; 1 HISTORY OF SCHIZOPHRENIA AND ANTIPSYCHOTIC DRUGS ; 1.1 Typical Antipsychotics-The First Generation; 1.2 Atypical Antipsychotics-The Second Generation; 2 PHARMACOLOGY; 2.1 Mechanism of Action; 2.2 Structure-Activity Relationship; 2.3 Bioavailability, Metabolism, and Toxicology; 3 SYNTHESIS 3.1 Discovery Route |
| Record Nr. | UNINA-9910460278403321 |
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Li Jie Jack
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| New York, New York : , : Oxford University Press, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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