Molecular approaches to human polygenic disease
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| Titolo: |
Molecular approaches to human polygenic disease
|
| Pubblicazione: | Chichester ; ; New York, : Wiley, 1987 |
| Descrizione fisica: | 1 online resource (286 p.) |
| Disciplina: | 616 |
| 616.042 | |
| Soggetto topico: | Genetic disorders |
| Medical genetics | |
| Molecular genetics | |
| Altri autori: |
BockGregory
CollinsGeralyn M
|
| Note generali: | "Symposium on Molecular Approaches to Human Polygenic Disease, held at the Ciba Foundation, London, 25-27 November 1986". |
| Editors: Gregory Bock (organizer) and Geralyn Collins. | |
| Nota di bibliografia: | Includes bibliographies and indexes. |
| Nota di contenuto: | MOLECULAR APPROACHES TO HUMAN POLYGENIC DISEASE; Contents; Participants; Introduction; Human gene mapping; Genetics of coronary heart disease and its risk factors; The LDL receptor: oligonucleotide-directed mutagenesis of the cytoplasmic domain; Apolipoproteins, quantitative I i poprotei n traits and mu It ifactorial hyperli pidaemia; Structure and evolution of human apolipoprotein genes: identification of regulatory elements of the human apolipoprotein Egene; General discussion |
| Genetic architecture of inter-individual variabi I i ty i n apol i pop rot ei n , I i pop rot ei n and lipid phenotypesUse of DNA polymorphisms of the apolipoprotein genes to study the role of genetic variation in the determination of serum lipid levels; Hypertension and the genetics of red cell membrane abnormalities; The molecular genetics of diabetes mellitus; Searching for major genes for psychiatric disorders; The molecular genetics of HLA-related disorders; The human genome sequence and the analysis of multifactorial traits | |
| Gene therapy: efforts at developing large animal models for autologous bone marrow transplant and gene transfer with retroviral vectorsImplications of genetic research for control measures; Final general discussion; Chairman's summing-up; Index of contributors; Subject index | |
| Sommario/riassunto: | Many common human diseases have a multifactorial origin: they are influenced by a person's genetic predisposition as well as by factors in the environment. This volume deals with the application of recombinant DNA techniques to the identification of diseases that have more than one inherited component. Focus is on the polygenic factors responsible for coronary atherosclerosis. Several other disorders having a polygenic origin are also discussed, including hypertension, diabetes mellitus, psychiatric diseases, and autoimmune (HLA-related) disorders. Problems raised by the study of different fam |
| Titolo autorizzato: | Molecular approaches to human polygenic disease |
| ISBN: | 1-282-13790-5 |
| 9786612137907 | |
| 0-470-51350-0 | |
| 0-470-51351-9 | |
| Formato: | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione: | Inglese |
| Record Nr.: | 9910877600203321 |
| Lo trovi qui: | Univ. Federico II |
| Opac: | Controlla la disponibilità qui |
Serie:
Ciba Foundation symposium ; ; 130.