The chemical biology of nucleic acids [[electronic resource] /] / edited by Günter Mayer

• Pubblicazione: Chichester, UK, : Wiley, 2010
• Edizione: 1st ed.
• Descrizione fisica: 1 online resource (496 p.)
• Disciplina: 547.7; 572.8
• Soggetto topico: Nucleic acids; Biomolecules
• Altri autori: MayerGünter <1972->
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: The Chemical Biology of Nucleic Acids; Contents; Foreword; Preface; List of Contributors; 1 Chemical Synthesis of Modified RNA; 2 Expansion of the Genetic Alphabet in Nucleic Acids by Creating New Base Pairs; 3 Chemical Biology of DNA Replication: Probing DNA Polymerase Selectivity Mechanisms with Modified Nucleotides; 4 Nucleic Acid-templated Chemistry; 5 Chemical Biology of Peptide Nucleic Acids (PNAs); 6 The Interactions of Small Molecules with DNA and RNA; 7 The Architectural Motifs of Folded RNAs; 8 Genesis and Biological Applications of Locked Nucleic Acids (LNAs) ; 9 Small Non-coding RNA in Bacteria10 MicroRNA-guided Gene Silencing; 11 Nucleic Acid-based Therapies; 12 Innate Immune Recognition of Nucleic Acids; 13 Light-responsive Nucleic Acids for the Spatiotemporal Control of Biological Processes; 14 DNA Methylation; 15 Frameworks for Programming RNA Devices; 16 RNA as a Catalyst: The Diels-Alderase Ribozyme; 17 Evolving an Understanding of RNA Function by In Vitro Approaches; 18 The Chemical Biology of Aptamers: Synthesis and Applications; 19 Nucleic Acids as Detection Tools; 20 Bacterial Riboswitch Discovery and Analysis; Index; Color Plates
• Sommario/riassunto: With extensive coverage of synthesis techniques and applications, this text describes chemical biology techniques which have gained significant impetus during the last five years. It focuses on the methods for obtaining modified and native nucleic acids, and their biological applications. Topics covered include: chemical synthesis of modified RNAexpansion of the genetic alphabet in nucleic acids by creating new base pairschemical biology of DNA replication: probing DNA polymerase selectivity mechanisms with modified nucleotidesnucleic-acid-temp
• Titolo autorizzato: The chemical biology of nucleic acids
• ISBN: 1-282-68356-X; 9786612683565; 0-470-66400-2; 0-470-66401-0
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910829979403321
• Lo trovi qui: Univ. Federico II