Pathology of genetically engineered and other mutant mice / / edited by Peter Vogel, John P. Sundberg, Jerrold M. Ward

• Pubblicazione: Hoboken, New Jersey : , : John Wiley & Sons, Incorporated, , [2022]; ©2022
• Descrizione fisica: 1 online resource (562 pages)
• Disciplina: 636.089607
• Soggetto topico: Veterinary pathology
• Soggetto genere / forma: Electronic books.
• Persona (resp. second.): VogelPeter <1956->; SundbergJohn P.; WardJerrold Michael <1942->
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Cover -- Title Page -- Copyright Page -- Contents -- List of Contributors -- Preface and Acknowledgments -- Chapter 1 Introduction to Mouse Pathology -- The Use of Mice in Medical Research -- Understanding Diseases Found in Mutant Animals -- Mouse Pathology - Nomenclature -- Mouse Genetic Nomenclature -- Tumor Pathology -- Immunohistochemistry (IHC), Scoring, Image Analysis, and Other Supportive Research Pathology Techniques -- Publication of Erroneous Pathology Data: Inadvertent Fraud? -- Overall Organization of the Book -- Acknowledgments -- References -- Chapter 2 The Mouse Online: Open Mouse Biology and Pathology Data Resources for Biomedical Research: -- Introduction -- FAIR Data Access and Databases of Databases -- General Information on Inbred Laboratory Mice -- Mouse Genome Informatics (http://www.informatics.jax.org) -- MouseMine (http://www.mousemine.org/mousemine/begin.do) -- Monarch (https://monarchinitiative.org) -- Alliance of Genome Resources (https://www.alliancegenome.org) -- Mouse Models of Human Cancer Database (MMHC, Formerly Mouse Tumor Biology Database) (http://tumor.informatics.jax.org/mtbwi/index.do) -- Mouse Genome Informatics SNP Database (http://www.informatics.jax.org/snp) -- Sanger Mouse SNP Database (https://www.sanger.ac.uk/sanger/Mouse_SnpViewer/rel-1505) -- Large Scale Mutagenesis -- International Mouse Phenotyping Consortium (IMPC -- https://www.mousephenotype.org) -- MUTAGENETIX (https://mutagenetix.utsouthwestern.edu) -- Background Strain Comparison Studies -- Mouse Phenome Database (https://phenome.jax.org) -- Mouse Pathology Image (Histopathology) Resources -- Pathbase, the European Mouse Pathology Database (http://www.pathbase.net) -- National Toxicology Program Neoplastic Lesion Atlas (https://ntp.niehs.nih.gov/nnl/index.htm). ; Noah's Arkive, Charles Louis Davis, and Samuel Wesley Thompson Foundation for the Advancement of Veterinary and Comparative Pathology (http://noahsarkive.cldavis.org/cgi-bin/show_image_info_page.cgi) -- Organ/Disease Specific Resources -- Bone Diseases: Skeletal Phenotyping of IMPC/KOMP Mice (http://www.bonebase.org) -- Skin Diseases: Skinbase (http://eulep.pdn.cam.ac.uk/~skinbase/index.php) -- GenitoUrinary Development Molecular Anatomy Project (GUDMAP) (https://www.gudmap.org) -- Mouse Brain Atlas (https://developingmouse.brain-map.org, https://mouse.brain-map.org) -- Atlas of Mouse Cardiovascular Development (https://www.devbio.pitt.edu/research/atlas-mouse-cardiovascular-development) -- Mouse/Human Disease Phenotype Databases -- Online Mendelian Inheritance in Man (OMIM) (https://www.ncbi.nlm.nih.gov/omim) -- Emouseatlas (https://www.emouseatlas.org/emap/home.html) -- Finding Mouse Models -- Use of Mouse Pathology Resources on Line -- Citations, and Licenses -- Acknowledgments -- References -- Chapter 3 Mouse Genetic Nomenclature: The Underpinning of Mouse Genetics -- Introduction -- Why Use Standardized Nomenclature? -- Inbred Mice -- Hybrid Mice (F1 and F2) -- Recombinant Inbred (RI) and Recombinant Congenic Mice -- Collaborative Cross (CC) Mice -- Congenic Mice -- Consomic Mice -- Conplastic Mice -- Outbred Mice -- Diversity Outbred (DO) Mice -- Nomenclature for Normal and Mutated Genes -- Spontaneous Mutations in Mice -- Non-engineered Induced Mutations -- Chromosomal Aberration Nomenclature -- Genetically Engineered Mice -- Targeted, Endonuclease-Mediated, Enhancer or Gene Trap, Transposon-Induced, and Transgenic Mutations -- Summary -- Acknowledgments -- References -- Chapter 4 Discovering and Validating Mouse Models of Human Diseases: The Cinderella Effect -- Introduction -- Basic Concepts of Defining a Mouse Model for a Human Disease. ; Large-Scale Mutagenesis Projects to Discover New Mouse Models -- From Human Polymorphism to Mouse Models -- New Mouse Genetic Tools -- Patient Derived Xenograft (PDX) Models -- Acknowledgments -- References -- Chapter 5 Embryos, Placentas, and Neonates -- Introduction -- Four-Dimensional Anatomy of the Developing Mouse -- Developmental Events in Embryos and Neonates -- Developmental Events in Placentation -- Technical Considerations for Pathologic Evaluation of Developing Mice -- Noninvasive Imaging of Developing Mice -- Anatomic Pathology Evaluation ofDeveloping Mice -- Clinical Pathology Evaluation of Developing Mice -- Pathologic Patterns in Mouse Embryos and Neonates -- Pathologic Patterns in Mouse Placenta -- Summary -- References -- Chapter 6 Ciliopathies -- Introduction -- Motile Ciliopathies -- Rhinosinusitis and Otitis Media -- Hydrocephalus -- Laterality Defects -- Infertility -- Sensory Ciliopathies -- Cystic Kidney Diseases -- Retinal Degeneration -- Heart Defects -- Skeletal Defects -- Brain Malformations -- Deafness -- Anosmia -- Obesity -- Genetic Background Effects -- References -- Chapter 7 Hematopoietic and Lymphoid Tissues -- Introduction -- Bone Marrow -- Lymphoid Tissues -- Primary Lymphoid Organs -- Secondary Lymphoid Organs -- Tertiary Lymphoid Organs -- Acknowledgments -- References -- Chapter 8 Mouse Hematolymphoid Neoplasms -- Introduction and Overview of the Classification of Leukemias and Lymphomas in the Mouse -- Nonlymphoid Hematopoietic Neoplasms in Mice -- Myeloid Leukemia (Granulocytic Leukemia, Myelogenous Leukemia, and Myelocytic Leukemia) -- Myelomonocytic Leukemia -- Monocytic Leukemia -- Erythroid Leukemia -- Megakaryocytic Leukemia -- Mast Cell and Basophil Leukemia -- Myeloid Proliferations (Nonreactive) -- Bone Marrow, Spleen, and Other Tissues -- Myeloid Dysplasia -- Nonlymphoid Hematopoietic Sarcomas. ; Myeloid Sarcoma -- Histiocytic Sarcoma -- Dendritic Cell Tumors/Histiocytosis -- Mast Cell Neoplasms -- Lymphoid Neoplasms -- Overview of Lymphoid Neoplasm Classification -- B-Cell Neoplasms -- T-Cell Neoplasia -- Mature T-Cell Neoplasms -- Final Considerations -- Acknowledgments -- References -- Chapter 9 Immunodeficient and Humanized Mice -- Introduction -- Nude Mice -- Prkdcscid, Rag1 and Rag2-Deficient,and Lystbg Mice -- NOD-Prkdcscid Mice -- IL-2RG-Deficient Mice -- Uses of Immunodeficient Mouse Models -- Xenotransplants of Solid and Hematopoietic Human Patient-Derived Tumors or Neoplastic Cell Lines -- Immunologic Reactions AgainstTransplanted Tumors -- Humanized Mice -- Common Lesions in Immunodeficient Mice -- Experimentally Induced Lesions -- Naturally Occurring Lesions - Infectious and Parasitic -- Naturally Occurring Lesions - Noninfectiousor Parasitic -- References -- Chapter 10 Skin, Hair, and Nails -- Introduction -- Normal Anatomy and Embryology of Mouse Skin, Hair, and Nails -- Practical Guidelines for the Biological Characterization of a New Mutation -- Categories of Disease of the Skin and Adnexa -- Hair Color (Pigmentation) Mutations -- Sebaceous and Eccrine Gland Defects and Scarring Alopecias -- Hair Follicle Cycling and Structural Defects of Hair Shafts -- Proliferative Skin Diseases -- Autoimmune Skin Diseases -- Skin Cancers -- Cancer-like Epidermal Response to Injury (Pseudoepitheliomatous/Pseudocarcinomatous Hyperplasia) -- Spontaneous Nonmelanoma Skin Cancers in Mice -- Two-stage Chemical Carcinogenesis -- UV Light-Induced Carcinogenesis -- Papillomaviruses -- Mouse Models of Melanoma -- Bullous and Acantholytic Skin Diseases: Pemphigus, Pemphigoid, and Epidermolysis Bullosa -- Structural and Growth Defects in Nails -- Summary -- Acknowledgments -- References -- Chapter 11 Mammary Gland -- Introduction. ; Anatomy, Histology, and Biology of Mouse Mammary Glands -- Mammary Gland Biology -- Pathology of the Mammary Gland -- Neoplastic Progression -- Mammary Tumor Invasion and Metastases -- Genetic Engineering of Mouse Mammary Gland -- Promoters -- Oncogenes and Tumor Suppressors -- Oncogene Addiction and Nononcogene Addiction (NOA) -- Metaplasia -- Host and Environmental Factors -- GEM Mammary Tumors -- How to Evaluate a Model -- Pathology -- Terminology, Classification, and Description -- Genotypes Predict Phenotypes -- Mouse Comparisons with Human (Table 11.1) -- Important Techniques for the Evaluation of the Mammary Gland -- Preparation of Mammary Gland Whole Mounts -- Preparation of Lung Whole Mounts -- Fixation and Processing -- Immunohistochemistry (IHC) -- Mammary Gland Transplantation -- Host Response -- Case Study: 129S6/SvEvTac-Stat1tm1Rds Mammary Biology and Tumorigenesis (Figures 11.2, 11.7, and 11.10) -- Mammary Growth and Development -- Summary -- Internet Resources -- References -- Chapter 12 The Respiratory Tract -- Introduction -- The Upper Respiratory Tract -- Anatomy and Histology -- Developmental Defects -- Pathology of the Nose -- The Lung -- Anatomy and Histology -- Lung Necropsy and Histology Protocols -- Immunohistochemistry of the Lung -- Lung Development -- Congenital Diaphragmatic Hernia -- Approaches to Phenotyping the Respiratory System -- Pathology of the Lung -- Spontaneous Lung Lesions in Mice -- Disease Models -- Scoring of Lung Lesions -- Infectious Disease Models -- Mouse Models of Human Pulmonary Genetic Disorders -- Asthma -- Pulmonary Fibrosis Models -- Lung Tumors -- References -- Chapter 13 The Gastrointestinal Tract -- Introduction -- Stomach -- Anatomy and Histology -- Necropsy, Trimming, and Embedding Protocol -- Pathology of the Human Stomach -- Pathology of the Mouse Stomach -- Genetically Engineered Mice. ; Neoplasms and Other Proliferative Lesions.
• Titolo autorizzato: Pathology of Genetically Engineered and Other Mutant Mice
• ISBN: 1-119-62459-2; 1-119-62460-6; 1-119-62458-4
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910555295403321
• Lo trovi qui: Univ. Federico II