Inflammation in Parkinson's Disease [[electronic resource] ] : Scientific and Clinical Aspects / / edited by Madhavi Thomas

• Pubblicazione: Cham : , : Springer International Publishing : , : Imprint : Springer, , 2014
• Edizione: 1st ed. 2014.
• Descrizione fisica: 1 online resource (236 p.)
• Disciplina: 612.015; 616.8/33
• Soggetto topico: Neurology ; Internal medicine; Medical biochemistry; Neurology; Internal Medicine; Medical Biochemistry
• Persona (resp. second.): ThomasMadhavi
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references at the end of each chapters and index.
• Nota di contenuto: Dedication; Foreword; Preface; Contents; Contributors; Parkinson's Disease: An Overview of Etiology, Clinical Manifestations, and Treatment; Clinical Features; Laboratory Studies; Etiology of PD; Selective Vulnerability of the Nigrostriatal Tract; Environmental Factors; Genetic Factors; α-Synuclein; Parkin; PINK1; DJ-1; LRRK2; UCH-L1; Gene-Environment Interactions; Infectious Etiologies for PD; PD as a Prion-Like Disease; Inflammation and PD; Oxidative Stress and PD; Mechanism of Action of PD Medications; Levodopa; Dopamine Agonists; MAO Inhibitors; COMT Inhibitors ; Anticholinergics and Amantadine Management of Motor Fluctuations and Dyskinesia; Management of Cognitive and Psychiatric Symptoms; Treatment of Nonmotor Symptoms; Neuroprotective Strategies; Surgical Treatment of Parkinson's Disease; References; Neuropathology of Parkinson's Disease; Introduction; Basic Neuropathology of PD; Degeneration of the Nigrostriatal System; Neuronal Vulnerability; Multiorgan Distribution of α-Synuclein and Lewy Pathologies; Development of α-Synuclein/Lewy Pathology; Structure and Molecular Components of Lewy Bodies; Pathobiological Role of Lewy Bodies ; Lewy Pathology Staging Incidental Lewy Body Disease; New Guidelines for Lewy Pathology; Interaction Between α-Syn and Other Proteins; Pathophysiology of Clinical Subtypes of Parkinson's Disease; Neuropathology of Cognitive Changes in Parkinson's Disease; Mild Cognitive Impairment in Parkinson's Disease; Parkinson's Disease and Dementia (PDD); Dementia with Lewy Bodies and Parkinson's Disease Dementia; Etiology and Pathogenesis of PD; Animal Models of Parkinson's Disease; Conclusion and Future Directions; References ; Role of the Innate and Adaptive Immune System in the Pathogenesis of PDIntroduction; Immune-Relevant Parkinson's Disease Pathology; Potential Inflammatory Etiology of Sporadic Parkinson's Disease; Evidence for Inflammation in PD; Microglial Activation and MHC in PD; T Lymphocytes in PD; Antibodies and B Lymphocytes in PD; Genetic Mutations that Cause PD and Adaptive Immunity; Immunomodulatory Therapies; Conclusion; References; "Good" and "Bad" Microglia in Parkinson's Disease: An Understanding of Homeostatic Mechanisms in Immunomodulation; Parkinson's Disease and Neuroinflammation ; Microglia Involvement in PD Pathogenesis "Good" Microglia and "Bad" Microglia; Regulatory Mechanisms of "Good" and "Bad" Microglia; Inducers and Effectors of "Bad" Microglia; Inducers of "Bad" Microglia; α-Synuclein Aggregates; Environmental Factors; LPS; MPTP; Effectors of "Bad" Microglia; NADPH Oxidase; Pro-inflammatory Factors; ROS and Superoxide; Regulation of "Good" Microglia; Counter-Regulation or Transrepression Pathways; Glucocorticoid Receptors; Estrogen Receptors; NR4A2; Peroxisome Proliferator-Activated Receptors; Anti-inflammatory Factors ; Neuron-Microglia Cross-Talk
• Sommario/riassunto: Inflammation in Parkinson’s Disease brings advances in research together with current literature and evidence. This concise volume covers the fundamentals of neuroimmunology and inflammatory models, the interactions between pathways of neurodegeneration and follows the concept of research work undertaken from basic science to clinical trials. Researchers, clinicians, and students interested in Parkinson's Disease are provided with a comprehensive view of translational research methods and an insight needed for developing future therapies aimed at disease modulation. .
• Titolo autorizzato: Inflammation in Parkinson's Disease
• ISBN: 3-319-08046-6
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910300358503321
• Lo trovi qui: Univ. Federico II