A Tissue Regeneration Approach to Bone and Cartilage Repair [[electronic resource] /] / edited by Hala Zreiqat, Colin R. Dunstan, Vicki Rosen

• Pubblicazione: Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015
• Edizione: 1st ed. 2015.
• Descrizione fisica: 1 online resource (257 p.)
• Disciplina: 617.4710592
• Soggetto topico: Biomedical engineering; Biomaterials; Medical microbiology; Biophysics; Biological physics; Biomedical Engineering and Bioengineering; Medical Microbiology; Biological and Medical Physics, Biophysics
• Persona (resp. second.): ZreiqatHala; DunstanColin R; RosenVicki
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references at the end of each chapters.
• Nota di contenuto: Contents; Ligand-Receptor Interactions and Their Implications in Delivering Certain Signaling for Bone Regeneration ; Abstract ; 1 Introduction; 2 The Identification of BMPs as Members of the TGF-β Family; 3 Experimental Models for Evaluating Bone Formation; 4 Regulation of Ligand Modifications; 5 Regulation of Receptor Activation; 6 Regulation by Antagonists; 7 Regulation of Intracellular Signaling Effectors; 8 Cross-Talk with Other Signaling Molecules; 9 Conclusions; References; BMPs and Wnts in Bone and Cartilage Regeneration ; Abstract ; 1 BMP Signaling in Bone and Cartilage Regeneration ; 1.1 Bmp-21.2 Bmp-4; 1.2.1 Cartilage Repair; 1.2.2 Bone-Tendon-Muscle Interaction; 1.3 Bmp-6; 1.3.1 Cartilage Repair; 1.3.2 Bone Regeneration; 1.4 Bmp-7; 1.4.1 Cartilage Repair and Arthritis; 1.4.2 Meniscus Repair; 1.4.3 Fracture and Spinal Fusion; 1.5 Bmp-9; 1.6 Cross-Talk Between BMP and Wnt Signaling; 2 Wntβ-Catenin Signaling in Bone and Cartilage Regeneration; 2.1 Scl-Ab; 2.1.1 Scl-Ab in Ovariectomy-Induced Bone Loss; 2.1.2 Scl-Ab in Bone Mechanical Strength; 2.1.3 Scl-Ab in Bone Fracture Healing; 2.1.4 Scl-Ab in Osteogenesis Imperfecta; 2.1.5 Potential Side Effect; 2.2 Dkk1-Ab; References ; Osteocytes and Bone Regeneration Abstract ; 1 Introduction; 2 Bone Matrix Repair by Osteocytes; 2.1 Osteocyte Apoptosis and Bone Matrix Microdamage; 2.2 Mechanisms of Osteocyte Mediated Matrix Repair; 2.2.1 RANKL Mediated Osteoclastogenesis; 2.2.2 Osteocyte Induction of Angiogenesis; 2.2.3 Osteocytic Osteolysis; 2.2.4 Osteocyte Control of Bone Matrix Mineralisation; 3 Osteocytes in Fracture; 4 Osteocytes as Regulators of Bone Formation; 5 Summary; References; Skeletal Stem Cells for Bone and Cartilage Tissue Regeneration ; Abstract ; 1 Bone Marrow Microenvironment and Bone Marrow Stem Cells ; 2 MSCs: Road to Clinical Use2.1 MSC Homing to Injured Tissues; 3 Specific Uses of BMSCs in Skeletal Regeneration; 3.1 Fractures and Bone Defects; 3.2 Osteoporosis; 3.3 Cartilage Repair and Rheumatic Diseases; 4 Concluding Remarks; References; Manipulation of Macrophages to Enhance Bone Repair and Regeneration ; Abstract ; 1 Introduction; 2 Role of Inflammation in Bone Healing; 3 Impact of Chronic Inflammation on Bone Healing; 4 Macrophage Polarization as a Potential Therapeutic Strategy; 5 Strategies to Actively Manipulate Macrophage Behavior; 5.1 Cell Delivery; 5.2 Drug and Protein Delivery ; 5.3 Physical Modification of Scaffold Properties5.4 Selectively Delivery to Macrophages Using Nanoparticles; 6 Conclusions; References; Cartilage Regeneration Using Induced Pluripotent Stem Cell Technologies ; Abstract ; 1 The Structure and Limited Repair Capacity of Cartilage; 2 Cell Transplantation into Articular Cartilage Defects; 3 The Use of iPSC-Derived Chondrocytes; 3.1 Generation of iPSCs; 3.2 Improvement of the Safety of iPSCs; 3.3 Transplantation of iPSC-Derived Chondrocytes into Articular Cartilage Defects of Patients; 3.4 Development of an iPSC Library ; 4 Use of Chondrogenic Cells Generated by Direct Conversion
• Sommario/riassunto: Reviewing exhaustively the current state of the art of tissue engineering strategies for regenerating bones and joints through the use of biomaterials, growth factors and stem cells, along with an investigation of the interactions between biomaterials, bone cells, growth factors and added stem cells and how together skeletal tissues can be optimised, this book serves to highlight the importance of biomaterials composition, surface topography, architectural and mechanical properties in providing support for tissue regeneration. Maximizing reader insights into the importance of the interplay of these attributes with bone cells (osteoblasts, osteocytes and osteoclasts) and cartilage cells (chondrocytes), this book also provides a detailed reference as to how key signalling pathways are activated. The contribution of growth factors to drive tissue regeneration and stem cell recruitment is discussed along with a review the potential and challenges of adult or embryonic mesenchymal stem cells to further enhance the formation of new bone and cartilage tissues. This book serves to demonstrate the interconnectedness of biomaterials, bone/cartilage cells, growth factors and stem cells in determining the regenerative process and thus the clinical outcome.
• Titolo autorizzato: Tissue Regeneration Approach to Bone and Cartilage Repair
• ISBN: 3-319-13266-0
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910299704303321
• Lo trovi qui: Univ. Federico II
• Serie: Mechanical Engineering Series, . 0941-5122