Yeast Membrane Transport / / edited by José Ramos, Hana Sychrová, Maik Kschischo

• Pubblicazione: Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016
• Edizione: 1st ed. 2016.
• Descrizione fisica: 1 online resource (381 p.)
• Disciplina: 589.23
• Soggetto topico: Cell membranes ; Biotechnology; Membrane Biology
• Persona (resp. second.): RamosJosé; SychrováHana; KschischoMaik
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references at the end of each chapters and index.
• Nota di contenuto: Preface; Contents; 1 Membrane Transport in Yeast, An Introduction; 1.1 Importance of Membrane Transport Processes; 1.2 Why Yeast?; 1.3 A Bit of "History"; 1.4 Mechanistic Processes Involved in Membrane Transport; 1.5 A Comment on Intracellular Membranes; 1.6 Are There Still New Interesting Discoveries in Yeast?; 1.7 Basic Versus Applied Research in Membrane Transport; 1.8 Overview of the Contributions; References; 2 Cell Surface Interference with Plasma Membrane and Transport Processes in Yeasts; 2.1 Introduction; 2.2 An Overview of the Structure and Biophysical Properties of Yeast Cell Wall ; 2.3 Cell Wall Porosity and Impact for Material Exchange2.4 Biosorbant and Selective Molecular Sieve Properties of the Yeast Cell Wall; 2.5 Inference of Cell Wall in Metal Ions Uptake and Ionome Homeostasis; 2.6 Inference of Cell Wall with Membrane Fluidity and Transport Processes from Genome Scale Analyses; 2.7 Summing Up; References; 3 Proton Transport and pH Control in Fungi; 3.1 Introduction; 3.2 The Physiological Context of pH Homeostasis in S. cerevisiae; 3.3 The Plasma Membrane H+-pump Pma1 and Organellar V-ATPases: Central Players in Cellular pH Control ; 3.3.1 Pma1 Structure, Function, and Genetics3.3.2 V-ATPases: Structure, Function, and Genetics; 3.3.3 Regulation of Pma1; 3.3.4 Regulation of V-ATPases; 3.3.5 Coordination of V-ATPase and Pma1 Activity; 3.3.6 Other Regulators of Cellular pH in Yeast; 3.4 Genomic Perspectives on H+-Transport and pH Control; 3.4.1 pH Measurements Across Deletion Mutant Arrays; 3.4.2 A Systems-Level View of Cytosolic pH Control; 3.4.3 A Systems-Level View of Vacuolar pH Control; 3.4.4 Cellular Responses to pH Stress; 3.5 pH as a Growth Signal in S. cerevisiae; 3.6 Proton Transport and pH Control in Other Fungi ; 3.6.1 V-ATPase and Pma1 in Neurospora crassa3.6.2 pH Control in Pathogenic Fungi; 3.7 Conclusions and Future Directions; References; 4 Function and Regulation of Fungal Amino Acid Transporters: Insights from Predicted Structure; 4.1 Introduction; 4.2 Classification of Fungal Amino Acid Transporters; 4.3 Structure-Function Relationships and Determination of Specificity in the YAT Family; 4.3.1 The YAT-Family Proteins Adopt the LeuT Fold; 4.3.2 Using Structural Models to Study Substrate Binding and Translocation in YATs; 4.3.2.1 Residues Mediating Recognition of the Amino-Acid Backbone ; 4.3.2.2 Residues in Several TMs Mediate Recognition of Amino Acid Side Chains4.3.2.3 Role of Proximal and Middle Gate Residues; 4.3.2.4 Role of Distal Gate Residues; 4.3.3 Genetically Isolated Specificity-Affecting YAT Mutants Altered in TM Domains; 4.3.4 Role of Intracellular and Extracellular Loops in Substrate Selectivity; 4.3.5 Summary; 4.4 Substrate-Mediated Endocytosis; 4.4.1 Inhibition of Transporters by Selective Endocytosis: General Principles; 4.4.2 Substrate-Induced Endocytosis of Fungal Amino Acid Transporters ; 4.4.2.1 Endocytosis in Response to Increased Intracellular Levels of Amino Acids
• Sommario/riassunto: This contributed volume reviews the recent progress in our understanding of membrane transport in yeast including both Saccharomyces cerevisiae and non-conventional yeasts. The articles provide a summary of the key transport processes and put these in a systems biology context of cellular regulation, signal reception and homeostasis. After a general introduction, readers will find review articles covering the mechanisms and regulation of transport for various substrates ranging from diverse nutrients to cations, water and protons. These articles are complemented by a chapter on extremophilic yeast, a chapter on the mathematical modelling of ion transport and two chapters on the role of transport in pathogenic yeasts and antifungal drug resistance. Each article provides both a general overview of the main transport characteristics of a specific substrate or group of substrates and the unique details that only an expert working in the field is able to transmit to the reader. Researchers and students of the topic will find this book to be a useful resource for membrane transport in yeast collecting information in one complete volume, which is otherwise scattered across many papers. This might also be interesting for scientists investigating other species in order to compare transport mechanisms with known functions in yeast with the cells on which they work.
• Titolo autorizzato: Yeast Membrane Transport
• ISBN: 3-319-25304-2
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910253883303321
• Lo trovi qui: Univ. Federico II
• Serie: Advances in Experimental Medicine and Biology, . 0065-2598 ; ; 892