Formulating Poorly Water Soluble Drugs / / edited by Robert O. Williams III, Alan B. Watts, Dave A. Miller
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| Titolo: |
Formulating Poorly Water Soluble Drugs / / edited by Robert O. Williams III, Alan B. Watts, Dave A. Miller
|
| Pubblicazione: | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 |
| Edizione: | 2nd ed. 2016. |
| Descrizione fisica: | 1 online resource (XIV, 779 p. 210 illus., 84 illus. in color.) |
| Disciplina: | 615.19 |
| Soggetto topico: | Pharmaceutical technology |
| Pharmaceutical Sciences/Technology | |
| Persona (resp. second.): | Williams IIIRobert O |
| WattsAlan B | |
| MillerDave A | |
| Nota di bibliografia: | Includes bibliographical references and index. |
| Nota di contenuto: | Route-Specific Challenges in Delivery of Poorly Water Soluble Drugs -- Optimizing the Formulation of Poorly Water Soluble Drugs -- Solid-State Techniques for Improving Solubility -- Mechanical Particle Size Reduction Techniques -- Solubilized Formulations -- Injectable Formulations of Poorly Water Soluble Drugs -- Design and Development of Self-Emulsifying Lipid Formulations for Improving Oral Bioavailability of Poorly Water-Soluble and Lipophilic Drugs -- Structured Development Approach for Amorphous Systems -- Melt Extrusion -- Spray Drying Technology -- Pharmaceutical Cryogenic Technologies -- Precipitation Technologies for Nanoparticle Production -- Emerging Technologies to Increase the Bioavailability of Poorly Water Soluble Drugs -- Regulatory Considerations for Development and Commercialization of Poorly Water Soluble Drugs. |
| Sommario/riassunto: | The objective of this volume is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. A pharmaceutical scientist’s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound’s physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at minimum a working knowledge of each of the abovementioned facets and detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop. |
| Titolo autorizzato: | Formulating Poorly Water Soluble Drugs |
| ISBN: | 3-319-42609-5 |
| Formato: | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione: | Inglese |
| Record Nr.: | 9910155318903321 |
| Lo trovi qui: | Univ. Federico II |
| Opac: | Controlla la disponibilità qui |
Serie:
AAPS Advances in the Pharmaceutical Sciences Series, . 2210-7371 ; ; 22