Novel infectious agents and the central nervous system [[electronic resource]]
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| Titolo: |
Novel infectious agents and the central nervous system [[electronic resource]]
|
| Pubblicazione: | Chichester ; ; New York, : Wiley, 1988 |
| Descrizione fisica: | 1 online resource (290 p.) |
| Disciplina: | 616.8 |
| 616.83 | |
| Soggetto topico: | Central nervous system - Diseases - Etiology |
| Scrapie | |
| Prions | |
| Soggetto genere / forma: | Electronic books. |
| Note generali: | "A Wiley-Interscience publication." |
| Papers and discussions from the Symposium on Novel Infectious Agents and the Central Nervous System, held at the Ciba Foundation, London, June 30-July 2, 1987. | |
| Nota di bibliografia: | Includes bibliographies and indexes. |
| Nota di contenuto: | NOVEL INFECTIOUS AGENTSANDTHE CENTRAL NERVOUS SYSTEM; Contents; Participants; Introduction; The clinical neurology and epidemiology of Creutzfeldt-Jakob disease, with special reference to iatrogenic cases; Neuropathology of unconventional virus infections: molecu lar pathology of spongiform change and amyloid plaque deposit ion; Pathogenesis of experimental scrapie; Genetic aspects of unconventional virus infections: the basis of the virino hypothesis; Genetic control of prion incubation period in mice; Developmental regulation of prion protein mRNA in brain |
| Potential involvement of retroviral elements in human dementiasScrapie: a virus-induced amyloidosis of the brain; Scrapie-associated fibrils, PrP protein and the Sinc gene; A modified host protein model of scrapie; Properties of scrapie prion proteins in liposomes and amyloid rods; In vitro expression of cloned PrP cDNA derived from scrapie-infected mouse brain: lack of transmission of scrapie infectivity; Search for a scrapie-specific nucleic acid: a progress report; Pathogenesis of amyloid formation in Alzheimer's disease, Down's syndrome and scrapie | |
| Novel mechanisms of degeneration of the central newous system - prion structure and biologyFinal general discussion; Summary; Index of contributors; Subject index | |
| Sommario/riassunto: | The term ``unconventional virus'' refers to virus-like agents that differ from conventional viruses in significant respects--resistance to agents that inactivate normal viruses, for example. Certain rare and fatal neurological disorders, such as the Creutzfeldt-Jacob syndrome and the Gerstmann-Straussler syndrome, are clearly produced by virus-like infectious agents, but the nature of these agents is not understood. This volume brings together the latest information on one such disease: Scrapie, a disease occurring in sheep. It discusses the nature of this infectious agent and insights gained |
| Titolo autorizzato: | Novel infectious agents and the central nervous system |
| ISBN: | 1-282-34597-4 |
| 9786612345975 | |
| 0-470-51361-6 | |
| 0-470-51362-4 | |
| Formato: | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione: | Inglese |
| Record Nr.: | 9910144728603321 |
| Lo trovi qui: | Univ. Federico II |
| Opac: | Controlla la disponibilità qui |
Serie:
Ciba Foundation symposium ; ; 135.